ID   PS4_PSEPD               Reviewed;          23 AA.
AC   P83191;
DT   20-JUN-2002, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2002, sequence version 1.
DT   25-MAY-2022, entry version 44.
DE   RecName: Full=Pseudin-4 {ECO:0000303|PubMed:11689009};
OS   Pseudis paradoxa (Paradoxical frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Neobatrachia; Hyloidea; Hylidae; Hylinae; Dendropsophini;
OC   Pseudis.
OX   NCBI_TaxID=43558;
RN   [1]
RP   PROTEIN SEQUENCE, FUNCTION, MASS SPECTROMETRY, AND SUBCELLULAR LOCATION.
RC   TISSUE=Skin;
RX   PubMed=11689009; DOI=10.1006/bbrc.2001.5884;
RA   Olson L. III, Soto A.M., Knoop F.C., Conlon J.M.;
RT   "Pseudin-2: an antimicrobial peptide with low hemolytic activity from the
RT   skin of the paradoxical frog.";
RL   Biochem. Biophys. Res. Commun. 288:1001-1005(2001).
CC   -!- FUNCTION: Possesses antifungal activity against C.albicans and is also
CC       active against E.coli and S.aureus. {ECO:0000269|PubMed:11689009}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:11689009}.
CC   -!- TISSUE SPECIFICITY: Expressed by the skin glands.
CC       {ECO:0000305|PubMed:11689009}.
CC   -!- MASS SPECTROMETRY: Mass=2512; Method=Electrospray;
CC       Evidence={ECO:0000269|PubMed:11689009};
CC   -!- SIMILARITY: Belongs to the frog skin active peptide (FSAP) family.
CC       Pseudin subfamily. {ECO:0000305}.
CC   -!- WEB RESOURCE: Name=The antimicrobial peptide database;
CC       URL="https://wangapd3.com/database/query_output.php?ID=00478";
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   AlphaFoldDB; P83191; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0042742; P:defense response to bacterium; IEA:UniProtKB-KW.
DR   GO; GO:0050832; P:defense response to fungus; IDA:UniProtKB.
DR   GO; GO:0045087; P:innate immune response; IEA:UniProtKB-KW.
DR   GO; GO:0031640; P:killing of cells of another organism; IEA:UniProtKB-KW.
DR   GO; GO:0006805; P:xenobiotic metabolic process; IDA:UniProtKB.
DR   InterPro; IPR013156; Antimicrobial_19.
DR   Pfam; PF08225; Antimicrobial19; 1.
PE   1: Evidence at protein level;
KW   Amphibian defense peptide; Antibiotic; Antimicrobial;
KW   Direct protein sequencing; Fungicide; Immunity; Innate immunity; Secreted.
FT   PEPTIDE         1..23
FT                   /note="Pseudin-4"
FT                   /evidence="ECO:0000269|PubMed:11689009"
FT                   /id="PRO_0000043831"
SQ   SEQUENCE   23 AA;  2512 MW;  DF3AAB75B37D2373 CRC64;
     GINTLKKVIQ GLHEVIKLVS NHA