ID   PSA1_CHICK              Reviewed;         260 AA.
AC   O42265;
DT   08-DEC-2000, integrated into UniProtKB/Swiss-Prot.
DT   01-AUG-1998, sequence version 2.
DT   03-AUG-2022, entry version 129.
DE   RecName: Full=Proteasome subunit alpha type-1;
DE   AltName: Full=Macropain subunit C2;
DE   AltName: Full=Multicatalytic endopeptidase complex subunit C2;
DE   AltName: Full=Proteasome component C2;
GN   Name=PSMA1;
OS   Gallus gallus (Chicken).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC   Phasianinae; Gallus.
OX   NCBI_TaxID=9031;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RA   Singh I., Wagner B.J.;
RT   "Cloning of a chick homologue of human proteasome subunit C2.";
RL   Submitted (MAY-1998) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Component of the 20S core proteasome complex involved in the
CC       proteolytic degradation of most intracellular proteins. This complex
CC       plays numerous essential roles within the cell by associating with
CC       different regulatory particles. Associated with two 19S regulatory
CC       particles, forms the 26S proteasome and thus participates in the ATP-
CC       dependent degradation of ubiquitinated proteins. The 26S proteasome
CC       plays a key role in the maintenance of protein homeostasis by removing
CC       misfolded or damaged proteins that could impair cellular functions, and
CC       by removing proteins whose functions are no longer required. Associated
CC       with the PA200 or PA28, the 20S proteasome mediates ubiquitin-
CC       independent protein degradation. This type of proteolysis is required
CC       in several pathways including spermatogenesis (20S-PA200 complex) or
CC       generation of a subset of MHC class I-presented antigenic peptides
CC       (20S-PA28 complex). {ECO:0000250|UniProtKB:P25786}.
CC   -!- SUBUNIT: The 26S proteasome consists of a 20S proteasome core and two
CC       19S regulatory subunits. The 20S proteasome core is a barrel-shaped
CC       complex made of 28 subunits that are arranged in four stacked rings.
CC       The two outer rings are each formed by seven alpha subunits, and the
CC       two inner rings are formed by seven beta subunits. The proteolytic
CC       activity is exerted by three beta-subunits PSMB5, PSMB6 and PSMB7.
CC       {ECO:0000250|UniProtKB:P25786}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:P25786}. Nucleus
CC       {ECO:0000250|UniProtKB:P25786}.
CC   -!- SIMILARITY: Belongs to the peptidase T1A family. {ECO:0000255|PROSITE-
CC       ProRule:PRU00808}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AF027978; AAC16604.1; -; mRNA.
DR   RefSeq; NP_990351.1; NM_205020.1.
DR   AlphaFoldDB; O42265; -.
DR   SMR; O42265; -.
DR   STRING; 9031.ENSGALP00000009681; -.
DR   PaxDb; O42265; -.
DR   GeneID; 395874; -.
DR   KEGG; gga:395874; -.
DR   CTD; 5682; -.
DR   VEuPathDB; HostDB:geneid_395874; -.
DR   eggNOG; KOG0863; Eukaryota.
DR   InParanoid; O42265; -.
DR   OrthoDB; 1222564at2759; -.
DR   PhylomeDB; O42265; -.
DR   PRO; PR:O42265; -.
DR   Proteomes; UP000000539; Unplaced.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0005839; C:proteasome core complex; ISS:UniProtKB.
DR   GO; GO:0019773; C:proteasome core complex, alpha-subunit complex; ISS:UniProtKB.
DR   GO; GO:0010498; P:proteasomal protein catabolic process; IBA:GO_Central.
DR   GO; GO:0006511; P:ubiquitin-dependent protein catabolic process; IEA:InterPro.
DR   CDD; cd03749; proteasome_alpha_type_1; 1.
DR   Gene3D; 3.60.20.10; -; 1.
DR   InterPro; IPR029055; Ntn_hydrolases_N.
DR   InterPro; IPR023332; Proteasome_alpha-type.
DR   InterPro; IPR035144; Proteasome_alpha1.
DR   InterPro; IPR000426; Proteasome_asu_N.
DR   InterPro; IPR001353; Proteasome_sua/b.
DR   PANTHER; PTHR11599:SF12; PTHR11599:SF12; 1.
DR   Pfam; PF00227; Proteasome; 1.
DR   Pfam; PF10584; Proteasome_A_N; 1.
DR   SMART; SM00948; Proteasome_A_N; 1.
DR   SUPFAM; SSF56235; SSF56235; 1.
DR   PROSITE; PS00388; PROTEASOME_ALPHA_1; 1.
DR   PROSITE; PS51475; PROTEASOME_ALPHA_2; 1.
PE   2: Evidence at transcript level;
KW   Cytoplasm; Nucleus; Proteasome; Reference proteome.
FT   CHAIN           1..260
FT                   /note="Proteasome subunit alpha type-1"
FT                   /id="PRO_0000124065"
FT   REGION          231..260
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        232..260
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   260 AA;  28925 MW;  86E89FD70EAB7938 CRC64;
     MLPVAGSDVT VWSPQGRIHQ IEYAMEAVKQ GSATVGLKSK THAVLVALKR AQSELAAHQK
     KILYVDNHIG ISIAGLTADA RLLCNFMRQE CLDSRFVFDR PLPVSRLVSL IGSKTQIPTQ
     RYGRRPYGVG LLIAGYDDMG PHIFQTCPSA NYFDCKAMSI GARSQSARNY LERHMTEFTD
     CNLNELVKHG LRALRETLPA EQDLTTKNVS IGIVGKDMEF TIYDDDDVAP FLEGLEERPQ
     RKPALPADEP AEKAEEPMEH