PSA1_YEAST
ID PSA1_YEAST Reviewed; 252 AA.
AC P21243; D6VUC6; P15708;
DT 01-MAY-1991, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-1991, sequence version 1.
DT 03-AUG-2022, entry version 235.
DE RecName: Full=Proteasome subunit alpha type-1;
DE AltName: Full=Macropain subunit C7-alpha;
DE AltName: Full=Multicatalytic endopeptidase complex C7;
DE AltName: Full=Proteasome component C7-alpha;
DE AltName: Full=Proteasome component Y8;
DE AltName: Full=Proteinase YSCE subunit 7;
DE AltName: Full=SCL1 suppressor protein;
GN Name=SCL1; Synonyms=PRC2, PRS2; OrderedLocusNames=YGL011C;
OS Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Saccharomycetaceae; Saccharomyces.
OX NCBI_TaxID=559292;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=2684789; DOI=10.1016/0378-1119(89)90113-3;
RA Balzi E., Chen W., Capieaux E., McCusker J.H., Haber J.E., Goffeau A.;
RT "The suppressor gene scl1+ of Saccharomyces cerevisiae is essential for
RT growth.";
RL Gene 83:271-279(1989).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA], AND PROTEIN SEQUENCE OF 174-187 AND 189-198.
RX PubMed=1697860; DOI=10.1016/s0021-9258(17)46265-x;
RA Fujiwara T., Tanaka K., Orino E., Yoshimura T., Kumatori A., Tamura T.,
RA Chung C.H., Nakai T., Yamaguchi K., Shin S., Kakizuka A., Nakanishi S.,
RA Ichihara A.;
RT "Proteasomes are essential for yeast proliferation. cDNA cloning and gene
RT disruption of two major subunits.";
RL J. Biol. Chem. 265:16604-16613(1990).
RN [3]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND PARTIAL PROTEIN SEQUENCE.
RC STRAIN=ATCC 26786 / X2180-1A;
RX PubMed=1898763; DOI=10.1128/mcb.11.1.344-353.1991;
RA Emori Y., Tsukahara T., Kawasaki H., Ishiura S., Sugita H., Suzuki K.;
RT "Molecular cloning and functional analysis of three subunits of yeast
RT proteasome.";
RL Mol. Cell. Biol. 11:344-353(1991).
RN [4]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=ATCC 46191 / IL125-2B;
RX PubMed=1882553; DOI=10.1002/yea.320070311;
RA Chen W., Balzi E., Capieaux E., Choder M., Goffeau A.;
RT "The DNA sequencing of the 17 kb HindIII fragment spanning the LEU1 and
RT ATE1 loci on chromosome VII from Saccharomyces cerevisiae reveals the PDR6
RT gene, a new member of the genetic network controlling pleiotropic drug
RT resistance.";
RL Yeast 7:287-299(1991).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=9169869;
RA Tettelin H., Agostoni-Carbone M.L., Albermann K., Albers M., Arroyo J.,
RA Backes U., Barreiros T., Bertani I., Bjourson A.J., Brueckner M.,
RA Bruschi C.V., Carignani G., Castagnoli L., Cerdan E., Clemente M.L.,
RA Coblenz A., Coglievina M., Coissac E., Defoor E., Del Bino S., Delius H.,
RA Delneri D., de Wergifosse P., Dujon B., Durand P., Entian K.-D., Eraso P.,
RA Escribano V., Fabiani L., Fartmann B., Feroli F., Feuermann M.,
RA Frontali L., Garcia-Gonzalez M., Garcia-Saez M.I., Goffeau A.,
RA Guerreiro P., Hani J., Hansen M., Hebling U., Hernandez K., Heumann K.,
RA Hilger F., Hofmann B., Indge K.J., James C.M., Klima R., Koetter P.,
RA Kramer B., Kramer W., Lauquin G., Leuther H., Louis E.J., Maillier E.,
RA Marconi A., Martegani E., Mazon M.J., Mazzoni C., McReynolds A.D.K.,
RA Melchioretto P., Mewes H.-W., Minenkova O., Mueller-Auer S., Nawrocki A.,
RA Netter P., Neu R., Nombela C., Oliver S.G., Panzeri L., Paoluzi S.,
RA Plevani P., Portetelle D., Portillo F., Potier S., Purnelle B., Rieger M.,
RA Riles L., Rinaldi T., Robben J., Rodrigues-Pousada C.,
RA Rodriguez-Belmonte E., Rodriguez-Torres A.M., Rose M., Ruzzi M.,
RA Saliola M., Sanchez-Perez M., Schaefer B., Schaefer M., Scharfe M.,
RA Schmidheini T., Schreer A., Skala J., Souciet J.-L., Steensma H.Y.,
RA Talla E., Thierry A., Vandenbol M., van der Aart Q.J.M., Van Dyck L.,
RA Vanoni M., Verhasselt P., Voet M., Volckaert G., Wambutt R., Watson M.D.,
RA Weber N., Wedler E., Wedler H., Wipfli P., Wolf K., Wright L.F.,
RA Zaccaria P., Zimmermann M., Zollner A., Kleine K.;
RT "The nucleotide sequence of Saccharomyces cerevisiae chromosome VII.";
RL Nature 387:81-84(1997).
RN [6]
RP GENOME REANNOTATION.
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=24374639; DOI=10.1534/g3.113.008995;
RA Engel S.R., Dietrich F.S., Fisk D.G., Binkley G., Balakrishnan R.,
RA Costanzo M.C., Dwight S.S., Hitz B.C., Karra K., Nash R.S., Weng S.,
RA Wong E.D., Lloyd P., Skrzypek M.S., Miyasato S.R., Simison M., Cherry J.M.;
RT "The reference genome sequence of Saccharomyces cerevisiae: Then and now.";
RL G3 (Bethesda) 4:389-398(2014).
RN [7]
RP INTERACTION WITH CIC1.
RX PubMed=11500370; DOI=10.1093/emboj/20.16.4423;
RA Jaeger S., Strayle J., Heinemeyer W., Wolf D.H.;
RT "Cic1, an adaptor protein specifically linking the 26S proteasome to its
RT substrate, the SCF component Cdc4.";
RL EMBO J. 20:4423-4431(2001).
RN [8]
RP SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
RX PubMed=14562095; DOI=10.1038/nature02026;
RA Huh W.-K., Falvo J.V., Gerke L.C., Carroll A.S., Howson R.W.,
RA Weissman J.S., O'Shea E.K.;
RT "Global analysis of protein localization in budding yeast.";
RL Nature 425:686-691(2003).
RN [9]
RP LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
RX PubMed=14562106; DOI=10.1038/nature02046;
RA Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N.,
RA O'Shea E.K., Weissman J.S.;
RT "Global analysis of protein expression in yeast.";
RL Nature 425:737-741(2003).
RN [10]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-237, AND IDENTIFICATION BY
RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=18407956; DOI=10.1074/mcp.m700468-mcp200;
RA Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.;
RT "A multidimensional chromatography technology for in-depth phosphoproteome
RT analysis.";
RL Mol. Cell. Proteomics 7:1389-1396(2008).
RN [11]
RP ACETYLATION [LARGE SCALE ANALYSIS] AT SER-2, CLEAVAGE OF INITIATOR
RP METHIONINE [LARGE SCALE ANALYSIS], AND IDENTIFICATION BY MASS SPECTROMETRY
RP [LARGE SCALE ANALYSIS].
RX PubMed=22814378; DOI=10.1073/pnas.1210303109;
RA Van Damme P., Lasa M., Polevoda B., Gazquez C., Elosegui-Artola A.,
RA Kim D.S., De Juan-Pardo E., Demeyer K., Hole K., Larrea E., Timmerman E.,
RA Prieto J., Arnesen T., Sherman F., Gevaert K., Aldabe R.;
RT "N-terminal acetylome analyses and functional insights of the N-terminal
RT acetyltransferase NatB.";
RL Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012).
RN [12]
RP UBIQUITINATION [LARGE SCALE ANALYSIS] AT LYS-232, AND IDENTIFICATION BY
RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=22106047; DOI=10.1002/pmic.201100166;
RA Starita L.M., Lo R.S., Eng J.K., von Haller P.D., Fields S.;
RT "Sites of ubiquitin attachment in Saccharomyces cerevisiae.";
RL Proteomics 12:236-240(2012).
RN [13]
RP X-RAY CRYSTALLOGRAPHY (1.9 ANGSTROMS) OF 10-252 OF COMPLEX WITH THE 20S
RP PROTEASOME.
RX PubMed=9087403; DOI=10.1038/386463a0;
RA Groll M., Ditzel L., Loewe J., Stock D., Bochtler M., Bartunik H.D.,
RA Huber R.;
RT "Structure of 20S proteasome from yeast at 2.4-A resolution.";
RL Nature 386:463-471(1997).
RN [14]
RP X-RAY CRYSTALLOGRAPHY (3.2 ANGSTROMS) OF COMPLEX WITH THE 20S PROTEASOME.
RX PubMed=11081519; DOI=10.1038/35040607;
RA Whitby F.G., Masters E.I., Kramer L., Knowlton J.R., Yao Y., Wang C.C.,
RA Hill C.P.;
RT "Structural basis for the activation of 20S proteasomes by 11S
RT regulators.";
RL Nature 408:115-120(2000).
RN [15]
RP X-RAY CRYSTALLOGRAPHY (2.4 ANGSTROMS) OF 10-252 OF COMPLEX WITH THE 20S
RP PROTEASOME.
RX PubMed=11062564; DOI=10.1038/80992;
RA Groll M., Bajorek M., Koehler A., Moroder L., Rubin D.M., Huber R.,
RA Glickman M.H., Finley D.;
RT "A gated channel into the proteasome core particle.";
RL Nat. Struct. Biol. 7:1062-1067(2000).
RN [16]
RP X-RAY CRYSTALLOGRAPHY (3.0 ANGSTROMS) OF 10-252 OF COMPLEX WITH THE 20S
RP PROTEASOME.
RX PubMed=11493007; DOI=10.1006/jmbi.2001.4869;
RA Groll M., Koguchi Y., Huber R., Kohno J.;
RT "Crystal structure of the 20 S proteasome:TMC-95A complex: a non-covalent
RT proteasome inhibitor.";
RL J. Mol. Biol. 311:543-548(2001).
RN [17]
RP X-RAY CRYSTALLOGRAPHY (2.81 ANGSTROMS) OF 10-252 OF COMPLEX WITH THE 20S
RP PROTEASOME.
RX PubMed=16793518; DOI=10.1016/j.chembiol.2006.04.005;
RA Groll M., Goetz M., Kaiser M., Weyher E., Moroder L.;
RT "TMC-95-based inhibitor design provides evidence for the catalytic
RT versatility of the proteasome.";
RL Chem. Biol. 13:607-614(2006).
RN [18]
RP X-RAY CRYSTALLOGRAPHY (2.8 ANGSTROMS) OF 10-252 OF COMPLEX WITH THE 20S
RP PROTEASOME.
RX PubMed=16608349; DOI=10.1021/ja058320b;
RA Groll M., Huber R., Potts B.C.M.;
RT "Crystal structures of salinosporamide A (NPI-0052) and B (NPI-0047) in
RT complex with the 20S proteasome reveal important consequences of beta-
RT lactone ring opening and a mechanism for irreversible binding.";
RL J. Am. Chem. Soc. 128:5136-5141(2006).
RN [19]
RP X-RAY CRYSTALLOGRAPHY (2.8 ANGSTROMS) OF 10-252 OF COMPLEX WITH THE 20S
RP PROTEASOME.
RX PubMed=16531229; DOI=10.1016/j.str.2005.11.019;
RA Groll M., Berkers C.R., Ploegh H.L., Ovaa H.;
RT "Crystal structure of the boronic acid-based proteasome inhibitor
RT bortezomib in complex with the yeast 20S proteasome.";
RL Structure 14:451-456(2006).
RN [20]
RP X-RAY CRYSTALLOGRAPHY (3.0 ANGSTROMS) OF 10-252 IN COMPLEX WITH THE
RP PROTEASOME.
RX PubMed=20227375; DOI=10.1016/j.molcel.2010.02.002;
RA Sadre-Bazzaz K., Whitby F.G., Robinson H., Formosa T., Hill C.P.;
RT "Structure of a Blm10 complex reveals common mechanisms for proteasome
RT binding and gate opening.";
RL Mol. Cell 37:728-735(2010).
RN [21]
RP STRUCTURE BY ELECTRON MICROSCOPY (7.4 ANGSTROMS) OF THE 26S PROTEASOME.
RX PubMed=22927375; DOI=10.1073/pnas.1213333109;
RA Beck F., Unverdorben P., Bohn S., Schweitzer A., Pfeifer G., Sakata E.,
RA Nickell S., Plitzko J.M., Villa E., Baumeister W., Forster F.;
RT "Near-atomic resolution structural model of the yeast 26S proteasome.";
RL Proc. Natl. Acad. Sci. U.S.A. 109:14870-14875(2012).
CC -!- FUNCTION: The proteasome degrades poly-ubiquitinated proteins in the
CC cytoplasm and in the nucleus. It is essential for the regulated
CC turnover of proteins and for the removal of misfolded proteins. The
CC proteasome is a multicatalytic proteinase complex that is characterized
CC by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu
CC adjacent to the leaving group at neutral or slightly basic pH. It has
CC an ATP-dependent proteolytic activity.
CC -!- SUBUNIT: The 26S proteasome consists of a 20S proteasome core and two
CC 19S regulatory subunits. The 20S proteasome core is composed of 28
CC subunits that are arranged in four stacked rings, resulting in a
CC barrel-shaped structure. The two end rings are each formed by seven
CC alpha subunits, and the two central rings are each formed by seven beta
CC subunits. The catalytic chamber with the active sites is on the inside
CC of the barrel. Interacts with CIC1. {ECO:0000269|PubMed:11500370,
CC ECO:0000269|PubMed:20227375}.
CC -!- INTERACTION:
CC P21243; P21242: PRE10; NbExp=10; IntAct=EBI-13975, EBI-13963;
CC P21243; P30656: PRE2; NbExp=8; IntAct=EBI-13975, EBI-14001;
CC P21243; P23639: PRE8; NbExp=8; IntAct=EBI-13975, EBI-13959;
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:14562095}. Nucleus
CC {ECO:0000269|PubMed:14562095}.
CC -!- MISCELLANEOUS: Present with 15200 molecules/cell in log phase SD
CC medium. {ECO:0000269|PubMed:14562106}.
CC -!- SIMILARITY: Belongs to the peptidase T1A family. {ECO:0000255|PROSITE-
CC ProRule:PRU00808}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAA35020.1; Type=Frameshift; Evidence={ECO:0000305};
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DR EMBL; M31430; AAA35020.1; ALT_FRAME; Genomic_DNA.
DR EMBL; X56971; CAA40292.1; -; Genomic_DNA.
DR EMBL; M55440; AAA35228.1; -; mRNA.
DR EMBL; M63641; AAA34909.1; -; Genomic_DNA.
DR EMBL; X56732; CAA40056.1; -; Genomic_DNA.
DR EMBL; S58126; AAD13894.1; -; Genomic_DNA.
DR EMBL; Z72533; CAA96711.1; -; Genomic_DNA.
DR EMBL; BK006941; DAA08087.1; -; Genomic_DNA.
DR PIR; S11199; SNBYS1.
DR RefSeq; NP_011504.3; NM_001180876.3.
DR PDB; 1FNT; X-ray; 3.20 A; A/O=1-252.
DR PDB; 1G0U; X-ray; 2.40 A; G/U=1-252.
DR PDB; 1G65; X-ray; 2.25 A; G/U=10-252.
DR PDB; 1JD2; X-ray; 3.00 A; 2/G=10-252.
DR PDB; 1RYP; X-ray; 1.90 A; A/O=10-252.
DR PDB; 1Z7Q; X-ray; 3.22 A; A/O=1-252.
DR PDB; 2F16; X-ray; 2.80 A; G/U=10-252.
DR PDB; 2FAK; X-ray; 2.80 A; G/U=10-252.
DR PDB; 2GPL; X-ray; 2.81 A; G/U=10-252.
DR PDB; 2ZCY; X-ray; 2.90 A; G/U=1-252.
DR PDB; 3BDM; X-ray; 2.70 A; G/U=1-252.
DR PDB; 3D29; X-ray; 2.60 A; G/U=12-252.
DR PDB; 3DY3; X-ray; 2.81 A; G/U=10-252.
DR PDB; 3DY4; X-ray; 2.80 A; G/U=10-252.
DR PDB; 3E47; X-ray; 3.00 A; G/U=10-252.
DR PDB; 3GPJ; X-ray; 2.70 A; G/U=10-252.
DR PDB; 3GPT; X-ray; 2.41 A; G/U=10-252.
DR PDB; 3GPW; X-ray; 2.50 A; G/U=10-252.
DR PDB; 3HYE; X-ray; 2.50 A; G/U=10-252.
DR PDB; 3JCO; EM; 4.80 A; A/a=1-252.
DR PDB; 3JCP; EM; 4.60 A; A/a=1-252.
DR PDB; 3MG0; X-ray; 2.68 A; G/U=10-252.
DR PDB; 3MG4; X-ray; 3.11 A; G/U=10-252.
DR PDB; 3MG6; X-ray; 2.60 A; G/U=1-252.
DR PDB; 3MG7; X-ray; 2.78 A; G/U=1-252.
DR PDB; 3MG8; X-ray; 2.59 A; G/U=1-252.
DR PDB; 3NZJ; X-ray; 2.40 A; G/U=1-252.
DR PDB; 3NZW; X-ray; 2.50 A; G/U=1-252.
DR PDB; 3NZX; X-ray; 2.70 A; G/U=1-252.
DR PDB; 3OEU; X-ray; 2.60 A; G/U=10-252.
DR PDB; 3OEV; X-ray; 2.85 A; G/U=10-252.
DR PDB; 3OKJ; X-ray; 2.70 A; G/U=10-252.
DR PDB; 3SDI; X-ray; 2.65 A; G/U=10-252.
DR PDB; 3SDK; X-ray; 2.70 A; G/U=10-252.
DR PDB; 3SHJ; X-ray; 2.80 A; G/U=10-252.
DR PDB; 3TDD; X-ray; 2.70 A; G/U=10-252.
DR PDB; 3UN4; X-ray; 3.40 A; G/U=1-252.
DR PDB; 3UN8; X-ray; 2.70 A; G/U=1-252.
DR PDB; 3WXR; X-ray; 3.15 A; A/O=1-252.
DR PDB; 4CR2; EM; 7.70 A; A=1-252.
DR PDB; 4CR3; EM; 9.30 A; A=1-252.
DR PDB; 4CR4; EM; 8.80 A; A=1-252.
DR PDB; 4EU2; X-ray; 2.51 A; A/O=10-250.
DR PDB; 4FZC; X-ray; 2.80 A; G/U=10-252.
DR PDB; 4FZG; X-ray; 3.00 A; G/U=10-252.
DR PDB; 4G4S; X-ray; 2.49 A; A=1-252.
DR PDB; 4GK7; X-ray; 2.80 A; G/U=10-252.
DR PDB; 4HNP; X-ray; 2.80 A; G/U=10-252.
DR PDB; 4HRC; X-ray; 2.80 A; G/U=10-252.
DR PDB; 4HRD; X-ray; 2.80 A; G/U=10-252.
DR PDB; 4INR; X-ray; 2.70 A; G/U=1-252.
DR PDB; 4INT; X-ray; 2.90 A; G/U=1-252.
DR PDB; 4INU; X-ray; 3.10 A; G/U=1-252.
DR PDB; 4J70; X-ray; 2.80 A; G/U=1-252.
DR PDB; 4JSQ; X-ray; 2.80 A; G/U=1-252.
DR PDB; 4JSU; X-ray; 2.90 A; G/U=1-252.
DR PDB; 4JT0; X-ray; 3.10 A; G/U=1-252.
DR PDB; 4LQI; X-ray; 2.70 A; G/U=10-252.
DR PDB; 4LTC; X-ray; 2.50 A; G/U=1-252.
DR PDB; 4NNN; X-ray; 2.50 A; G/U=1-252.
DR PDB; 4NNW; X-ray; 2.60 A; G/U=1-252.
DR PDB; 4NO1; X-ray; 2.50 A; G/U=1-252.
DR PDB; 4NO6; X-ray; 3.00 A; G/U=1-252.
DR PDB; 4NO8; X-ray; 2.70 A; G/U=1-252.
DR PDB; 4NO9; X-ray; 2.90 A; G/U=1-252.
DR PDB; 4Q1S; X-ray; 2.60 A; G/U=1-252.
DR PDB; 4QBY; X-ray; 3.00 A; G/U=1-252.
DR PDB; 4QLQ; X-ray; 2.40 A; G/U=1-252.
DR PDB; 4QLS; X-ray; 2.80 A; G/U=1-252.
DR PDB; 4QLT; X-ray; 2.80 A; G/U=1-252.
DR PDB; 4QLU; X-ray; 2.80 A; G/U=1-252.
DR PDB; 4QLV; X-ray; 2.90 A; G/U=1-252.
DR PDB; 4QUX; X-ray; 3.00 A; G/U=1-252.
DR PDB; 4QUY; X-ray; 2.80 A; G/U=1-252.
DR PDB; 4QV0; X-ray; 3.10 A; G/U=1-252.
DR PDB; 4QV1; X-ray; 2.50 A; G/U=1-252.
DR PDB; 4QV3; X-ray; 3.00 A; G/U=1-252.
DR PDB; 4QV4; X-ray; 2.70 A; G/U=1-252.
DR PDB; 4QV5; X-ray; 2.70 A; G/U=1-252.
DR PDB; 4QV6; X-ray; 2.80 A; G/U=1-252.
DR PDB; 4QV7; X-ray; 2.60 A; G/U=1-252.
DR PDB; 4QV8; X-ray; 2.90 A; G/U=1-252.
DR PDB; 4QV9; X-ray; 2.60 A; G/U=1-252.
DR PDB; 4QVL; X-ray; 2.80 A; G/U=1-252.
DR PDB; 4QVM; X-ray; 2.80 A; G/U=1-252.
DR PDB; 4QVN; X-ray; 2.90 A; G/U=1-252.
DR PDB; 4QVP; X-ray; 2.30 A; G/U=1-252.
DR PDB; 4QVQ; X-ray; 2.60 A; G/U=1-252.
DR PDB; 4QVV; X-ray; 2.80 A; G/U=1-252.
DR PDB; 4QVW; X-ray; 3.00 A; G/U=1-252.
DR PDB; 4QVY; X-ray; 2.51 A; G/U=1-252.
DR PDB; 4QW0; X-ray; 2.90 A; G/U=1-252.
DR PDB; 4QW1; X-ray; 2.90 A; G/U=1-252.
DR PDB; 4QW3; X-ray; 2.90 A; G/U=1-252.
DR PDB; 4QW4; X-ray; 2.80 A; G/U=1-252.
DR PDB; 4QW5; X-ray; 3.00 A; G/U=1-252.
DR PDB; 4QW6; X-ray; 2.90 A; G/U=1-252.
DR PDB; 4QW7; X-ray; 2.70 A; G/U=1-252.
DR PDB; 4QWF; X-ray; 3.00 A; G/U=1-252.
DR PDB; 4QWG; X-ray; 2.60 A; G/U=1-252.
DR PDB; 4QWI; X-ray; 2.60 A; G/U=1-252.
DR PDB; 4QWJ; X-ray; 2.90 A; G/U=1-252.
DR PDB; 4QWK; X-ray; 2.80 A; G/U=1-252.
DR PDB; 4QWL; X-ray; 2.60 A; G/U=1-252.
DR PDB; 4QWR; X-ray; 2.90 A; G/U=1-252.
DR PDB; 4QWS; X-ray; 3.00 A; G/U=1-252.
DR PDB; 4QWU; X-ray; 3.00 A; G/U=1-252.
DR PDB; 4QWX; X-ray; 2.90 A; G/U=1-252.
DR PDB; 4QXJ; X-ray; 2.80 A; G/U=1-252.
DR PDB; 4QZ0; X-ray; 3.00 A; G/U=1-252.
DR PDB; 4QZ1; X-ray; 3.00 A; G/U=1-252.
DR PDB; 4QZ2; X-ray; 2.70 A; G/U=1-252.
DR PDB; 4QZ3; X-ray; 2.80 A; G/U=1-252.
DR PDB; 4QZ4; X-ray; 3.00 A; G/U=1-252.
DR PDB; 4QZ5; X-ray; 2.80 A; G/U=1-252.
DR PDB; 4QZ6; X-ray; 2.90 A; G/U=1-252.
DR PDB; 4QZ7; X-ray; 2.80 A; G/U=1-252.
DR PDB; 4QZW; X-ray; 3.00 A; G/U=1-252.
DR PDB; 4QZX; X-ray; 2.60 A; G/U=1-252.
DR PDB; 4QZZ; X-ray; 2.90 A; G/U=1-252.
DR PDB; 4R00; X-ray; 2.80 A; G/U=1-252.
DR PDB; 4R02; X-ray; 2.50 A; G/U=1-252.
DR PDB; 4R17; X-ray; 2.10 A; G/U=1-252.
DR PDB; 4R18; X-ray; 2.40 A; G/U=1-252.
DR PDB; 4RUR; X-ray; 2.50 A; G/U=1-252.
DR PDB; 4V7O; X-ray; 3.00 A; AA/AC/BA/BO=10-252.
DR PDB; 4X6Z; X-ray; 2.70 A; A/O=1-252.
DR PDB; 4Y69; X-ray; 2.90 A; G/U=1-252.
DR PDB; 4Y6A; X-ray; 2.60 A; G/U=1-252.
DR PDB; 4Y6V; X-ray; 2.80 A; G/U=1-252.
DR PDB; 4Y6Z; X-ray; 2.70 A; G/U=1-252.
DR PDB; 4Y70; X-ray; 2.40 A; G/U=1-252.
DR PDB; 4Y74; X-ray; 2.70 A; G/U=1-252.
DR PDB; 4Y75; X-ray; 2.80 A; G/U=1-252.
DR PDB; 4Y77; X-ray; 2.50 A; G/U=1-252.
DR PDB; 4Y78; X-ray; 2.80 A; G/U=1-252.
DR PDB; 4Y7W; X-ray; 2.50 A; G/U=1-252.
DR PDB; 4Y7X; X-ray; 2.60 A; G/U=1-252.
DR PDB; 4Y7Y; X-ray; 2.40 A; G/U=1-252.
DR PDB; 4Y80; X-ray; 2.50 A; G/U=1-252.
DR PDB; 4Y81; X-ray; 2.80 A; G/U=1-252.
DR PDB; 4Y82; X-ray; 2.80 A; G/U=1-252.
DR PDB; 4Y84; X-ray; 2.70 A; G/U=1-252.
DR PDB; 4Y8G; X-ray; 2.60 A; G/U=1-252.
DR PDB; 4Y8H; X-ray; 2.50 A; G/U=1-252.
DR PDB; 4Y8I; X-ray; 2.60 A; G/U=1-252.
DR PDB; 4Y8J; X-ray; 2.70 A; G/U=1-252.
DR PDB; 4Y8K; X-ray; 2.60 A; G/U=1-252.
DR PDB; 4Y8L; X-ray; 2.40 A; G/U=1-252.
DR PDB; 4Y8M; X-ray; 2.80 A; G/U=1-252.
DR PDB; 4Y8N; X-ray; 2.60 A; G/U=1-252.
DR PDB; 4Y8O; X-ray; 2.70 A; G/U=1-252.
DR PDB; 4Y8P; X-ray; 2.80 A; G/U=1-252.
DR PDB; 4Y8Q; X-ray; 2.60 A; G/U=1-252.
DR PDB; 4Y8R; X-ray; 2.70 A; G/U=1-252.
DR PDB; 4Y8S; X-ray; 2.70 A; G/U=1-252.
DR PDB; 4Y8T; X-ray; 2.70 A; G/U=1-252.
DR PDB; 4Y8U; X-ray; 2.90 A; G/U=1-252.
DR PDB; 4Y9Y; X-ray; 2.80 A; G/U=1-252.
DR PDB; 4Y9Z; X-ray; 2.80 A; G/U=1-252.
DR PDB; 4YA0; X-ray; 2.80 A; G/U=1-252.
DR PDB; 4YA1; X-ray; 2.90 A; G/U=1-252.
DR PDB; 4YA2; X-ray; 2.70 A; G/U=1-252.
DR PDB; 4YA3; X-ray; 2.70 A; G/U=1-252.
DR PDB; 4YA4; X-ray; 2.90 A; G/U=1-252.
DR PDB; 4YA5; X-ray; 2.50 A; G/U=1-252.
DR PDB; 4YA7; X-ray; 2.70 A; G/U=1-252.
DR PDB; 4YA9; X-ray; 2.70 A; G/U=1-252.
DR PDB; 4Z1L; X-ray; 3.00 A; G/U=1-252.
DR PDB; 5A5B; EM; 9.50 A; A=1-252.
DR PDB; 5AHJ; X-ray; 2.80 A; G/U=1-252.
DR PDB; 5BOU; X-ray; 2.60 A; G/U=1-252.
DR PDB; 5BXL; X-ray; 2.80 A; G/U=1-252.
DR PDB; 5BXN; X-ray; 2.80 A; G/U=1-252.
DR PDB; 5CGF; X-ray; 2.80 A; G/U=1-252.
DR PDB; 5CGG; X-ray; 2.90 A; G/U=1-252.
DR PDB; 5CGH; X-ray; 2.50 A; G/U=1-252.
DR PDB; 5CGI; X-ray; 2.80 A; G/U=1-252.
DR PDB; 5CZ4; X-ray; 2.30 A; G/U=1-252.
DR PDB; 5CZ5; X-ray; 2.80 A; G/U=1-252.
DR PDB; 5CZ6; X-ray; 2.70 A; G/U=1-252.
DR PDB; 5CZ7; X-ray; 2.50 A; G/U=1-252.
DR PDB; 5CZ8; X-ray; 2.80 A; G/U=1-252.
DR PDB; 5CZ9; X-ray; 2.90 A; G/U=1-252.
DR PDB; 5CZA; X-ray; 2.50 A; G/U=1-252.
DR PDB; 5D0S; X-ray; 2.50 A; G/U=1-252.
DR PDB; 5D0T; X-ray; 2.60 A; G/U=1-252.
DR PDB; 5D0V; X-ray; 2.90 A; G/U=1-252.
DR PDB; 5D0W; X-ray; 2.80 A; G/U=1-252.
DR PDB; 5D0X; X-ray; 2.60 A; G/U=1-252.
DR PDB; 5D0Z; X-ray; 2.90 A; G/U=1-252.
DR PDB; 5DKI; X-ray; 2.80 A; G/U=1-252.
DR PDB; 5DKJ; X-ray; 2.80 A; G/U=1-252.
DR PDB; 5FG7; X-ray; 2.70 A; G/U=1-252.
DR PDB; 5FG9; X-ray; 2.60 A; G/U=1-252.
DR PDB; 5FGA; X-ray; 2.70 A; G/U=1-252.
DR PDB; 5FGD; X-ray; 2.80 A; G/U=1-252.
DR PDB; 5FGE; X-ray; 2.60 A; G/U=1-252.
DR PDB; 5FGF; X-ray; 2.60 A; G/U=1-252.
DR PDB; 5FGG; X-ray; 2.70 A; G/U=1-252.
DR PDB; 5FGH; X-ray; 2.80 A; G/U=1-252.
DR PDB; 5FGI; X-ray; 2.90 A; G/U=1-252.
DR PDB; 5FHS; X-ray; 2.70 A; G/U=1-252.
DR PDB; 5JHR; X-ray; 2.90 A; G/U=1-252.
DR PDB; 5JHS; X-ray; 3.00 A; G/U=1-252.
DR PDB; 5L52; X-ray; 2.70 A; G/U=1-252.
DR PDB; 5L54; X-ray; 2.80 A; G/U=1-252.
DR PDB; 5L55; X-ray; 2.90 A; G/U=1-252.
DR PDB; 5L5A; X-ray; 2.40 A; G/U=1-252.
DR PDB; 5L5B; X-ray; 2.80 A; G/U=1-252.
DR PDB; 5L5D; X-ray; 2.80 A; G/U=1-252.
DR PDB; 5L5E; X-ray; 2.90 A; G/U=1-252.
DR PDB; 5L5F; X-ray; 2.50 A; G/U=1-252.
DR PDB; 5L5H; X-ray; 2.60 A; G/U=1-252.
DR PDB; 5L5I; X-ray; 2.90 A; G/U=1-252.
DR PDB; 5L5J; X-ray; 2.90 A; G/U=1-252.
DR PDB; 5L5O; X-ray; 2.60 A; G/U=1-252.
DR PDB; 5L5P; X-ray; 2.80 A; G/U=1-252.
DR PDB; 5L5Q; X-ray; 2.80 A; G/U=1-252.
DR PDB; 5L5R; X-ray; 2.90 A; G/U=1-252.
DR PDB; 5L5S; X-ray; 2.60 A; G/U=1-252.
DR PDB; 5L5T; X-ray; 2.90 A; G/U=1-252.
DR PDB; 5L5U; X-ray; 2.60 A; G/U=1-252.
DR PDB; 5L5V; X-ray; 2.70 A; G/U=1-252.
DR PDB; 5L5W; X-ray; 2.80 A; G/U=1-252.
DR PDB; 5L5X; X-ray; 2.90 A; G/U=1-252.
DR PDB; 5L5Y; X-ray; 2.70 A; G/U=1-252.
DR PDB; 5L5Z; X-ray; 2.70 A; G/U=1-252.
DR PDB; 5L60; X-ray; 2.70 A; G/U=1-252.
DR PDB; 5L61; X-ray; 2.80 A; G/U=1-252.
DR PDB; 5L62; X-ray; 2.80 A; G/U=1-252.
DR PDB; 5L63; X-ray; 2.70 A; G/U=1-252.
DR PDB; 5L64; X-ray; 2.70 A; G/U=1-252.
DR PDB; 5L65; X-ray; 2.90 A; G/U=1-252.
DR PDB; 5L66; X-ray; 2.80 A; G/U=1-252.
DR PDB; 5L67; X-ray; 2.60 A; G/U=1-252.
DR PDB; 5L68; X-ray; 2.80 A; G/U=1-252.
DR PDB; 5L69; X-ray; 2.70 A; G/U=1-252.
DR PDB; 5L6A; X-ray; 2.80 A; G/U=1-252.
DR PDB; 5L6B; X-ray; 2.60 A; G/U=1-252.
DR PDB; 5L6C; X-ray; 2.60 A; G/U=1-252.
DR PDB; 5LAI; X-ray; 2.50 A; G/U=1-252.
DR PDB; 5LAJ; X-ray; 2.90 A; G/U=1-252.
DR PDB; 5LTT; X-ray; 2.70 A; G/U=1-252.
DR PDB; 5M2B; X-ray; 2.70 A; G/U=1-252.
DR PDB; 5MP9; EM; 4.10 A; A/a=1-252.
DR PDB; 5MPA; EM; 4.50 A; A/a=1-252.
DR PDB; 5MPB; EM; 7.80 A; A/a=1-252.
DR PDB; 5MPC; EM; 7.70 A; A/a=1-252.
DR PDB; 5NIF; X-ray; 3.00 A; A/O=1-252.
DR PDB; 5WVI; EM; 6.30 A; A/c=1-252.
DR PDB; 5WVK; EM; 4.20 A; A/c=1-252.
DR PDB; 6EF0; EM; 4.43 A; A=11-248.
DR PDB; 6EF1; EM; 4.73 A; A=13-251.
DR PDB; 6EF2; EM; 4.27 A; A=10-247.
DR PDB; 6EF3; EM; 4.17 A; A=1-252.
DR PDB; 6FVT; EM; 4.10 A; A/a=11-251.
DR PDB; 6FVU; EM; 4.50 A; A/a=10-251.
DR PDB; 6FVV; EM; 5.40 A; A/a=11-251.
DR PDB; 6FVW; EM; 4.50 A; A/a=8-251.
DR PDB; 6FVX; EM; 4.90 A; A/a=10-251.
DR PDB; 6FVY; EM; 6.10 A; A/a=8-251.
DR PDB; 6G7F; X-ray; 2.70 A; G/U=1-252.
DR PDB; 6G8M; X-ray; 2.70 A; G/U=1-252.
DR PDB; 6G8N; X-ray; 3.00 A; G/U=1-252.
DR PDB; 6GOP; X-ray; 2.90 A; G/U=1-252.
DR PDB; 6H39; X-ray; 2.50 A; G/U=1-252.
DR PDB; 6HTB; X-ray; 2.70 A; G/U=1-252.
DR PDB; 6HTC; X-ray; 2.80 A; G/U=1-252.
DR PDB; 6HTD; X-ray; 3.00 A; G/U=1-252.
DR PDB; 6HTP; X-ray; 3.00 A; G/U=1-252.
DR PDB; 6HTR; X-ray; 2.60 A; G/U=1-252.
DR PDB; 6HUB; X-ray; 2.90 A; G/U=1-252.
DR PDB; 6HUC; X-ray; 3.00 A; G/U=1-252.
DR PDB; 6HUQ; X-ray; 3.00 A; G/U=1-252.
DR PDB; 6HUU; X-ray; 2.80 A; G/U=1-252.
DR PDB; 6HUV; X-ray; 3.10 A; G/U=1-252.
DR PDB; 6HV3; X-ray; 2.70 A; G/U=1-252.
DR PDB; 6HV4; X-ray; 3.00 A; G/U=1-252.
DR PDB; 6HV5; X-ray; 3.00 A; G/U=1-252.
DR PDB; 6HV7; X-ray; 3.40 A; G/U=1-252.
DR PDB; 6HVA; X-ray; 2.90 A; G/U=1-252.
DR PDB; 6HVR; X-ray; 2.70 A; G/U=1-252.
DR PDB; 6HVS; X-ray; 3.10 A; G/U=1-252.
DR PDB; 6HVT; X-ray; 2.90 A; G/U=1-252.
DR PDB; 6HVU; X-ray; 2.90 A; G/U=1-252.
DR PDB; 6HVV; X-ray; 2.70 A; G/U=1-252.
DR PDB; 6HVW; X-ray; 3.00 A; G/U=1-252.
DR PDB; 6HVX; X-ray; 2.80 A; G/U=1-252.
DR PDB; 6HVY; X-ray; 2.70 A; G/U=1-252.
DR PDB; 6HW0; X-ray; 2.80 A; G/U=1-252.
DR PDB; 6HW3; X-ray; 2.60 A; G/U=1-252.
DR PDB; 6HW4; X-ray; 2.90 A; G/U=1-252.
DR PDB; 6HW5; X-ray; 2.90 A; G/U=1-252.
DR PDB; 6HW6; X-ray; 2.70 A; G/U=1-252.
DR PDB; 6HW7; X-ray; 2.70 A; G/U=1-252.
DR PDB; 6HW8; X-ray; 2.80 A; G/U=1-252.
DR PDB; 6HW9; X-ray; 2.80 A; G/U=1-252.
DR PDB; 6HWA; X-ray; 2.80 A; G/U=1-252.
DR PDB; 6HWB; X-ray; 2.60 A; G/U=1-252.
DR PDB; 6HWC; X-ray; 2.80 A; G/U=1-252.
DR PDB; 6HWD; X-ray; 2.80 A; G/U=1-252.
DR PDB; 6HWE; X-ray; 2.30 A; G/U=1-252.
DR PDB; 6HWF; X-ray; 2.50 A; G/U=1-252.
DR PDB; 6J2C; EM; 7.00 A; A/c=1-252.
DR PDB; 6J2N; EM; 7.50 A; A/c=1-252.
DR PDB; 6J2Q; EM; 3.80 A; A/c=1-252.
DR PDB; 6J2X; EM; 3.80 A; A/c=1-252.
DR PDB; 6J30; EM; 4.50 A; A/c=1-252.
DR PDB; 6ZOU; X-ray; 2.90 A; G/U=1-252.
DR PDB; 6ZP6; X-ray; 2.80 A; G/U=1-252.
DR PDB; 6ZP8; X-ray; 3.00 A; G/U=1-252.
DR PDB; 7LS5; EM; 2.74 A; A/O=1-252.
DR PDB; 7LS6; EM; 3.17 A; A=1-252.
DR PDB; 7LSX; EM; 3.61 A; A=1-252.
DR PDB; 7QO3; EM; 6.10 A; A/a=1-252.
DR PDB; 7QO5; EM; 6.00 A; A/a=1-252.
DR PDBsum; 1FNT; -.
DR PDBsum; 1G0U; -.
DR PDBsum; 1G65; -.
DR PDBsum; 1JD2; -.
DR PDBsum; 1RYP; -.
DR PDBsum; 1Z7Q; -.
DR PDBsum; 2F16; -.
DR PDBsum; 2FAK; -.
DR PDBsum; 2GPL; -.
DR PDBsum; 2ZCY; -.
DR PDBsum; 3BDM; -.
DR PDBsum; 3D29; -.
DR PDBsum; 3DY3; -.
DR PDBsum; 3DY4; -.
DR PDBsum; 3E47; -.
DR PDBsum; 3GPJ; -.
DR PDBsum; 3GPT; -.
DR PDBsum; 3GPW; -.
DR PDBsum; 3HYE; -.
DR PDBsum; 3JCO; -.
DR PDBsum; 3JCP; -.
DR PDBsum; 3MG0; -.
DR PDBsum; 3MG4; -.
DR PDBsum; 3MG6; -.
DR PDBsum; 3MG7; -.
DR PDBsum; 3MG8; -.
DR PDBsum; 3NZJ; -.
DR PDBsum; 3NZW; -.
DR PDBsum; 3NZX; -.
DR PDBsum; 3OEU; -.
DR PDBsum; 3OEV; -.
DR PDBsum; 3OKJ; -.
DR PDBsum; 3SDI; -.
DR PDBsum; 3SDK; -.
DR PDBsum; 3SHJ; -.
DR PDBsum; 3TDD; -.
DR PDBsum; 3UN4; -.
DR PDBsum; 3UN8; -.
DR PDBsum; 3WXR; -.
DR PDBsum; 4CR2; -.
DR PDBsum; 4CR3; -.
DR PDBsum; 4CR4; -.
DR PDBsum; 4EU2; -.
DR PDBsum; 4FZC; -.
DR PDBsum; 4FZG; -.
DR PDBsum; 4G4S; -.
DR PDBsum; 4GK7; -.
DR PDBsum; 4HNP; -.
DR PDBsum; 4HRC; -.
DR PDBsum; 4HRD; -.
DR PDBsum; 4INR; -.
DR PDBsum; 4INT; -.
DR PDBsum; 4INU; -.
DR PDBsum; 4J70; -.
DR PDBsum; 4JSQ; -.
DR PDBsum; 4JSU; -.
DR PDBsum; 4JT0; -.
DR PDBsum; 4LQI; -.
DR PDBsum; 4LTC; -.
DR PDBsum; 4NNN; -.
DR PDBsum; 4NNW; -.
DR PDBsum; 4NO1; -.
DR PDBsum; 4NO6; -.
DR PDBsum; 4NO8; -.
DR PDBsum; 4NO9; -.
DR PDBsum; 4Q1S; -.
DR PDBsum; 4QBY; -.
DR PDBsum; 4QLQ; -.
DR PDBsum; 4QLS; -.
DR PDBsum; 4QLT; -.
DR PDBsum; 4QLU; -.
DR PDBsum; 4QLV; -.
DR PDBsum; 4QUX; -.
DR PDBsum; 4QUY; -.
DR PDBsum; 4QV0; -.
DR PDBsum; 4QV1; -.
DR PDBsum; 4QV3; -.
DR PDBsum; 4QV4; -.
DR PDBsum; 4QV5; -.
DR PDBsum; 4QV6; -.
DR PDBsum; 4QV7; -.
DR PDBsum; 4QV8; -.
DR PDBsum; 4QV9; -.
DR PDBsum; 4QVL; -.
DR PDBsum; 4QVM; -.
DR PDBsum; 4QVN; -.
DR PDBsum; 4QVP; -.
DR PDBsum; 4QVQ; -.
DR PDBsum; 4QVV; -.
DR PDBsum; 4QVW; -.
DR PDBsum; 4QVY; -.
DR PDBsum; 4QW0; -.
DR PDBsum; 4QW1; -.
DR PDBsum; 4QW3; -.
DR PDBsum; 4QW4; -.
DR PDBsum; 4QW5; -.
DR PDBsum; 4QW6; -.
DR PDBsum; 4QW7; -.
DR PDBsum; 4QWF; -.
DR PDBsum; 4QWG; -.
DR PDBsum; 4QWI; -.
DR PDBsum; 4QWJ; -.
DR PDBsum; 4QWK; -.
DR PDBsum; 4QWL; -.
DR PDBsum; 4QWR; -.
DR PDBsum; 4QWS; -.
DR PDBsum; 4QWU; -.
DR PDBsum; 4QWX; -.
DR PDBsum; 4QXJ; -.
DR PDBsum; 4QZ0; -.
DR PDBsum; 4QZ1; -.
DR PDBsum; 4QZ2; -.
DR PDBsum; 4QZ3; -.
DR PDBsum; 4QZ4; -.
DR PDBsum; 4QZ5; -.
DR PDBsum; 4QZ6; -.
DR PDBsum; 4QZ7; -.
DR PDBsum; 4QZW; -.
DR PDBsum; 4QZX; -.
DR PDBsum; 4QZZ; -.
DR PDBsum; 4R00; -.
DR PDBsum; 4R02; -.
DR PDBsum; 4R17; -.
DR PDBsum; 4R18; -.
DR PDBsum; 4RUR; -.
DR PDBsum; 4V7O; -.
DR PDBsum; 4X6Z; -.
DR PDBsum; 4Y69; -.
DR PDBsum; 4Y6A; -.
DR PDBsum; 4Y6V; -.
DR PDBsum; 4Y6Z; -.
DR PDBsum; 4Y70; -.
DR PDBsum; 4Y74; -.
DR PDBsum; 4Y75; -.
DR PDBsum; 4Y77; -.
DR PDBsum; 4Y78; -.
DR PDBsum; 4Y7W; -.
DR PDBsum; 4Y7X; -.
DR PDBsum; 4Y7Y; -.
DR PDBsum; 4Y80; -.
DR PDBsum; 4Y81; -.
DR PDBsum; 4Y82; -.
DR PDBsum; 4Y84; -.
DR PDBsum; 4Y8G; -.
DR PDBsum; 4Y8H; -.
DR PDBsum; 4Y8I; -.
DR PDBsum; 4Y8J; -.
DR PDBsum; 4Y8K; -.
DR PDBsum; 4Y8L; -.
DR PDBsum; 4Y8M; -.
DR PDBsum; 4Y8N; -.
DR PDBsum; 4Y8O; -.
DR PDBsum; 4Y8P; -.
DR PDBsum; 4Y8Q; -.
DR PDBsum; 4Y8R; -.
DR PDBsum; 4Y8S; -.
DR PDBsum; 4Y8T; -.
DR PDBsum; 4Y8U; -.
DR PDBsum; 4Y9Y; -.
DR PDBsum; 4Y9Z; -.
DR PDBsum; 4YA0; -.
DR PDBsum; 4YA1; -.
DR PDBsum; 4YA2; -.
DR PDBsum; 4YA3; -.
DR PDBsum; 4YA4; -.
DR PDBsum; 4YA5; -.
DR PDBsum; 4YA7; -.
DR PDBsum; 4YA9; -.
DR PDBsum; 4Z1L; -.
DR PDBsum; 5A5B; -.
DR PDBsum; 5AHJ; -.
DR PDBsum; 5BOU; -.
DR PDBsum; 5BXL; -.
DR PDBsum; 5BXN; -.
DR PDBsum; 5CGF; -.
DR PDBsum; 5CGG; -.
DR PDBsum; 5CGH; -.
DR PDBsum; 5CGI; -.
DR PDBsum; 5CZ4; -.
DR PDBsum; 5CZ5; -.
DR PDBsum; 5CZ6; -.
DR PDBsum; 5CZ7; -.
DR PDBsum; 5CZ8; -.
DR PDBsum; 5CZ9; -.
DR PDBsum; 5CZA; -.
DR PDBsum; 5D0S; -.
DR PDBsum; 5D0T; -.
DR PDBsum; 5D0V; -.
DR PDBsum; 5D0W; -.
DR PDBsum; 5D0X; -.
DR PDBsum; 5D0Z; -.
DR PDBsum; 5DKI; -.
DR PDBsum; 5DKJ; -.
DR PDBsum; 5FG7; -.
DR PDBsum; 5FG9; -.
DR PDBsum; 5FGA; -.
DR PDBsum; 5FGD; -.
DR PDBsum; 5FGE; -.
DR PDBsum; 5FGF; -.
DR PDBsum; 5FGG; -.
DR PDBsum; 5FGH; -.
DR PDBsum; 5FGI; -.
DR PDBsum; 5FHS; -.
DR PDBsum; 5JHR; -.
DR PDBsum; 5JHS; -.
DR PDBsum; 5L52; -.
DR PDBsum; 5L54; -.
DR PDBsum; 5L55; -.
DR PDBsum; 5L5A; -.
DR PDBsum; 5L5B; -.
DR PDBsum; 5L5D; -.
DR PDBsum; 5L5E; -.
DR PDBsum; 5L5F; -.
DR PDBsum; 5L5H; -.
DR PDBsum; 5L5I; -.
DR PDBsum; 5L5J; -.
DR PDBsum; 5L5O; -.
DR PDBsum; 5L5P; -.
DR PDBsum; 5L5Q; -.
DR PDBsum; 5L5R; -.
DR PDBsum; 5L5S; -.
DR PDBsum; 5L5T; -.
DR PDBsum; 5L5U; -.
DR PDBsum; 5L5V; -.
DR PDBsum; 5L5W; -.
DR PDBsum; 5L5X; -.
DR PDBsum; 5L5Y; -.
DR PDBsum; 5L5Z; -.
DR PDBsum; 5L60; -.
DR PDBsum; 5L61; -.
DR PDBsum; 5L62; -.
DR PDBsum; 5L63; -.
DR PDBsum; 5L64; -.
DR PDBsum; 5L65; -.
DR PDBsum; 5L66; -.
DR PDBsum; 5L67; -.
DR PDBsum; 5L68; -.
DR PDBsum; 5L69; -.
DR PDBsum; 5L6A; -.
DR PDBsum; 5L6B; -.
DR PDBsum; 5L6C; -.
DR PDBsum; 5LAI; -.
DR PDBsum; 5LAJ; -.
DR PDBsum; 5LTT; -.
DR PDBsum; 5M2B; -.
DR PDBsum; 5MP9; -.
DR PDBsum; 5MPA; -.
DR PDBsum; 5MPB; -.
DR PDBsum; 5MPC; -.
DR PDBsum; 5NIF; -.
DR PDBsum; 5WVI; -.
DR PDBsum; 5WVK; -.
DR PDBsum; 6EF0; -.
DR PDBsum; 6EF1; -.
DR PDBsum; 6EF2; -.
DR PDBsum; 6EF3; -.
DR PDBsum; 6FVT; -.
DR PDBsum; 6FVU; -.
DR PDBsum; 6FVV; -.
DR PDBsum; 6FVW; -.
DR PDBsum; 6FVX; -.
DR PDBsum; 6FVY; -.
DR PDBsum; 6G7F; -.
DR PDBsum; 6G8M; -.
DR PDBsum; 6G8N; -.
DR PDBsum; 6GOP; -.
DR PDBsum; 6H39; -.
DR PDBsum; 6HTB; -.
DR PDBsum; 6HTC; -.
DR PDBsum; 6HTD; -.
DR PDBsum; 6HTP; -.
DR PDBsum; 6HTR; -.
DR PDBsum; 6HUB; -.
DR PDBsum; 6HUC; -.
DR PDBsum; 6HUQ; -.
DR PDBsum; 6HUU; -.
DR PDBsum; 6HUV; -.
DR PDBsum; 6HV3; -.
DR PDBsum; 6HV4; -.
DR PDBsum; 6HV5; -.
DR PDBsum; 6HV7; -.
DR PDBsum; 6HVA; -.
DR PDBsum; 6HVR; -.
DR PDBsum; 6HVS; -.
DR PDBsum; 6HVT; -.
DR PDBsum; 6HVU; -.
DR PDBsum; 6HVV; -.
DR PDBsum; 6HVW; -.
DR PDBsum; 6HVX; -.
DR PDBsum; 6HVY; -.
DR PDBsum; 6HW0; -.
DR PDBsum; 6HW3; -.
DR PDBsum; 6HW4; -.
DR PDBsum; 6HW5; -.
DR PDBsum; 6HW6; -.
DR PDBsum; 6HW7; -.
DR PDBsum; 6HW8; -.
DR PDBsum; 6HW9; -.
DR PDBsum; 6HWA; -.
DR PDBsum; 6HWB; -.
DR PDBsum; 6HWC; -.
DR PDBsum; 6HWD; -.
DR PDBsum; 6HWE; -.
DR PDBsum; 6HWF; -.
DR PDBsum; 6J2C; -.
DR PDBsum; 6J2N; -.
DR PDBsum; 6J2Q; -.
DR PDBsum; 6J2X; -.
DR PDBsum; 6J30; -.
DR PDBsum; 6ZOU; -.
DR PDBsum; 6ZP6; -.
DR PDBsum; 6ZP8; -.
DR PDBsum; 7LS5; -.
DR PDBsum; 7LS6; -.
DR PDBsum; 7LSX; -.
DR PDBsum; 7QO3; -.
DR PDBsum; 7QO5; -.
DR AlphaFoldDB; P21243; -.
DR SMR; P21243; -.
DR BioGRID; 33235; 384.
DR ComplexPortal; CPX-2262; 26S Proteasome complex.
DR DIP; DIP-2810N; -.
DR IntAct; P21243; 30.
DR MINT; P21243; -.
DR STRING; 4932.YGL011C; -.
DR MEROPS; T01.971; -.
DR iPTMnet; P21243; -.
DR UCD-2DPAGE; P21243; -.
DR MaxQB; P21243; -.
DR PaxDb; P21243; -.
DR PRIDE; P21243; -.
DR EnsemblFungi; YGL011C_mRNA; YGL011C; YGL011C.
DR GeneID; 852873; -.
DR KEGG; sce:YGL011C; -.
DR SGD; S000002979; SCL1.
DR VEuPathDB; FungiDB:YGL011C; -.
DR eggNOG; KOG0182; Eukaryota.
DR GeneTree; ENSGT00550000074807; -.
DR HOGENOM; CLU_035750_4_1_1; -.
DR InParanoid; P21243; -.
DR OMA; YGYDMPV; -.
DR BioCyc; YEAST:G3O-30533-MON; -.
DR BRENDA; 3.4.25.1; 984.
DR Reactome; R-SCE-1236978; Cross-presentation of soluble exogenous antigens (endosomes).
DR Reactome; R-SCE-382556; ABC-family proteins mediated transport.
DR Reactome; R-SCE-5668541; TNFR2 non-canonical NF-kB pathway.
DR Reactome; R-SCE-5687128; MAPK6/MAPK4 signaling.
DR Reactome; R-SCE-5689880; Ub-specific processing proteases.
DR Reactome; R-SCE-68949; Orc1 removal from chromatin.
DR Reactome; R-SCE-69017; CDK-mediated phosphorylation and removal of Cdc6.
DR Reactome; R-SCE-69601; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A.
DR Reactome; R-SCE-75815; Ubiquitin-dependent degradation of Cyclin D.
DR Reactome; R-SCE-8854050; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis.
DR Reactome; R-SCE-8948751; Regulation of PTEN stability and activity.
DR Reactome; R-SCE-8951664; Neddylation.
DR Reactome; R-SCE-9755511; KEAP1-NFE2L2 pathway.
DR Reactome; R-SCE-983168; Antigen processing: Ubiquitination & Proteasome degradation.
DR EvolutionaryTrace; P21243; -.
DR PRO; PR:P21243; -.
DR Proteomes; UP000002311; Chromosome VII.
DR RNAct; P21243; protein.
DR GO; GO:0005737; C:cytoplasm; IC:SGD.
DR GO; GO:0005739; C:mitochondrion; HDA:SGD.
DR GO; GO:0042175; C:nuclear outer membrane-endoplasmic reticulum membrane network; IC:SGD.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0000502; C:proteasome complex; IPI:ComplexPortal.
DR GO; GO:0005839; C:proteasome core complex; IBA:GO_Central.
DR GO; GO:0019773; C:proteasome core complex, alpha-subunit complex; IDA:SGD.
DR GO; GO:0034515; C:proteasome storage granule; IC:SGD.
DR GO; GO:0010498; P:proteasomal protein catabolic process; IBA:GO_Central.
DR GO; GO:0010499; P:proteasomal ubiquitin-independent protein catabolic process; IDA:SGD.
DR GO; GO:0043161; P:proteasome-mediated ubiquitin-dependent protein catabolic process; IDA:SGD.
DR CDD; cd03754; proteasome_alpha_type_6; 1.
DR Gene3D; 3.60.20.10; -; 1.
DR InterPro; IPR029055; Ntn_hydrolases_N.
DR InterPro; IPR023332; Proteasome_alpha-type.
DR InterPro; IPR000426; Proteasome_asu_N.
DR InterPro; IPR001353; Proteasome_sua/b.
DR InterPro; IPR034642; Proteasome_subunit_alpha6.
DR Pfam; PF00227; Proteasome; 1.
DR Pfam; PF10584; Proteasome_A_N; 1.
DR SMART; SM00948; Proteasome_A_N; 1.
DR SUPFAM; SSF56235; SSF56235; 1.
DR PROSITE; PS00388; PROTEASOME_ALPHA_1; 1.
DR PROSITE; PS51475; PROTEASOME_ALPHA_2; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Acetylation; Cytoplasm; Direct protein sequencing;
KW Isopeptide bond; Nucleus; Phosphoprotein; Proteasome; Reference proteome;
KW Ubl conjugation.
FT INIT_MET 1
FT /note="Removed"
FT /evidence="ECO:0007744|PubMed:22814378"
FT CHAIN 2..252
FT /note="Proteasome subunit alpha type-1"
FT /id="PRO_0000124141"
FT MOD_RES 2
FT /note="N-acetylserine"
FT /evidence="ECO:0007744|PubMed:22814378"
FT MOD_RES 237
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:18407956"
FT CROSSLNK 232
FT /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
FT G-Cter in ubiquitin)"
FT /evidence="ECO:0007744|PubMed:22106047"
FT HELIX 11..14
FT /evidence="ECO:0007829|PDB:1RYP"
FT STRAND 16..18
FT /evidence="ECO:0007829|PDB:1RYP"
FT TURN 21..23
FT /evidence="ECO:0007829|PDB:1JD2"
FT HELIX 26..34
FT /evidence="ECO:0007829|PDB:1RYP"
FT TURN 35..38
FT /evidence="ECO:0007829|PDB:1RYP"
FT STRAND 42..46
FT /evidence="ECO:0007829|PDB:1RYP"
FT STRAND 48..56
FT /evidence="ECO:0007829|PDB:1RYP"
FT STRAND 62..64
FT /evidence="ECO:0007829|PDB:3D29"
FT HELIX 66..68
FT /evidence="ECO:0007829|PDB:1RYP"
FT STRAND 71..74
FT /evidence="ECO:0007829|PDB:1RYP"
FT STRAND 76..78
FT /evidence="ECO:0007829|PDB:1RYP"
FT STRAND 80..85
FT /evidence="ECO:0007829|PDB:1RYP"
FT HELIX 87..108
FT /evidence="ECO:0007829|PDB:1RYP"
FT HELIX 114..130
FT /evidence="ECO:0007829|PDB:1RYP"
FT STRAND 131..134
FT /evidence="ECO:0007829|PDB:4QVP"
FT STRAND 140..147
FT /evidence="ECO:0007829|PDB:1RYP"
FT TURN 148..150
FT /evidence="ECO:0007829|PDB:1RYP"
FT STRAND 151..157
FT /evidence="ECO:0007829|PDB:1RYP"
FT TURN 159..161
FT /evidence="ECO:0007829|PDB:1G0U"
FT STRAND 163..172
FT /evidence="ECO:0007829|PDB:1RYP"
FT HELIX 175..189
FT /evidence="ECO:0007829|PDB:1RYP"
FT STRAND 191..193
FT /evidence="ECO:0007829|PDB:1RYP"
FT HELIX 199..214
FT /evidence="ECO:0007829|PDB:1RYP"
FT STRAND 222..229
FT /evidence="ECO:0007829|PDB:1RYP"
FT STRAND 232..235
FT /evidence="ECO:0007829|PDB:1RYP"
FT HELIX 238..248
FT /evidence="ECO:0007829|PDB:1RYP"
FT TURN 249..251
FT /evidence="ECO:0007829|PDB:1G65"
SQ SEQUENCE 252 AA; 28001 MW; 5B938C862BC8D7EB CRC64;
MSGAAAASAA GYDRHITIFS PEGRLYQVEY AFKATNQTNI NSLAVRGKDC TVVISQKKVP
DKLLDPTTVS YIFCISRTIG MVVNGPIPDA RNAALRAKAE AAEFRYKYGY DMPCDVLAKR
MANLSQIYTQ RAYMRPLGVI LTFVSVDEEL GPSIYKTDPA GYYVGYKATA TGPKQQEITT
NLENHFKKSK IDHINEESWE KVVEFAITHM IDALGTEFSK NDLEVGVATK DKFFTLSAEN
IEERLVAIAE QD
