PSA2_YEAST
ID PSA2_YEAST Reviewed; 250 AA.
AC P23639; D6W0J3;
DT 01-NOV-1991, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1991, sequence version 1.
DT 03-AUG-2022, entry version 225.
DE RecName: Full=Proteasome subunit alpha type-2;
DE AltName: Full=Macropain subunit Y7;
DE AltName: Full=Multicatalytic endopeptidase complex subunit Y7;
DE AltName: Full=Proteasome component Y7;
DE AltName: Full=Proteinase YSCE subunit 7;
GN Name=PRE8; Synonyms=PRS4; OrderedLocusNames=YML092C;
OS Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Saccharomycetaceae; Saccharomyces.
OX NCBI_TaxID=559292;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND PARTIAL PROTEIN SEQUENCE.
RC STRAIN=ATCC 26786 / X2180-1A;
RX PubMed=1898763; DOI=10.1128/mcb.11.1.344-353.1991;
RA Emori Y., Tsukahara T., Kawasaki H., Ishiura S., Sugita H., Suzuki K.;
RT "Molecular cloning and functional analysis of three subunits of yeast
RT proteasome.";
RL Mol. Cell. Biol. 11:344-353(1991).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=9169872;
RA Bowman S., Churcher C.M., Badcock K., Brown D., Chillingworth T.,
RA Connor R., Dedman K., Devlin K., Gentles S., Hamlin N., Hunt S., Jagels K.,
RA Lye G., Moule S., Odell C., Pearson D., Rajandream M.A., Rice P.,
RA Skelton J., Walsh S.V., Whitehead S., Barrell B.G.;
RT "The nucleotide sequence of Saccharomyces cerevisiae chromosome XIII.";
RL Nature 387:90-93(1997).
RN [3]
RP GENOME REANNOTATION.
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=24374639; DOI=10.1534/g3.113.008995;
RA Engel S.R., Dietrich F.S., Fisk D.G., Binkley G., Balakrishnan R.,
RA Costanzo M.C., Dwight S.S., Hitz B.C., Karra K., Nash R.S., Weng S.,
RA Wong E.D., Lloyd P., Skrzypek M.S., Miyasato S.R., Simison M., Cherry J.M.;
RT "The reference genome sequence of Saccharomyces cerevisiae: Then and now.";
RL G3 (Bethesda) 4:389-398(2014).
RN [4]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=17322287; DOI=10.1101/gr.6037607;
RA Hu Y., Rolfs A., Bhullar B., Murthy T.V.S., Zhu C., Berger M.F.,
RA Camargo A.A., Kelley F., McCarron S., Jepson D., Richardson A., Raphael J.,
RA Moreira D., Taycher E., Zuo D., Mohr S., Kane M.F., Williamson J.,
RA Simpson A.J.G., Bulyk M.L., Harlow E., Marsischky G., Kolodner R.D.,
RA LaBaer J.;
RT "Approaching a complete repository of sequence-verified protein-encoding
RT clones for Saccharomyces cerevisiae.";
RL Genome Res. 17:536-543(2007).
RN [5]
RP LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
RX PubMed=14562106; DOI=10.1038/nature02046;
RA Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N.,
RA O'Shea E.K., Weissman J.S.;
RT "Global analysis of protein expression in yeast.";
RL Nature 425:737-741(2003).
RN [6]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=18407956; DOI=10.1074/mcp.m700468-mcp200;
RA Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.;
RT "A multidimensional chromatography technology for in-depth phosphoproteome
RT analysis.";
RL Mol. Cell. Proteomics 7:1389-1396(2008).
RN [7]
RP UBIQUITINATION [LARGE SCALE ANALYSIS] AT LYS-108, AND IDENTIFICATION BY
RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=22106047; DOI=10.1002/pmic.201100166;
RA Starita L.M., Lo R.S., Eng J.K., von Haller P.D., Fields S.;
RT "Sites of ubiquitin attachment in Saccharomyces cerevisiae.";
RL Proteomics 12:236-240(2012).
RN [8]
RP X-RAY CRYSTALLOGRAPHY (1.9 ANGSTROMS) OF COMPLEX WITH THE 20S PROTEASOME.
RX PubMed=9087403; DOI=10.1038/386463a0;
RA Groll M., Ditzel L., Loewe J., Stock D., Bochtler M., Bartunik H.D.,
RA Huber R.;
RT "Structure of 20S proteasome from yeast at 2.4-A resolution.";
RL Nature 386:463-471(1997).
RN [9]
RP X-RAY CRYSTALLOGRAPHY (3.2 ANGSTROMS) OF COMPLEX WITH THE 20S PROTEASOME
RP AND A 11S REGULATORY COMPLEX.
RX PubMed=11081519; DOI=10.1038/35040607;
RA Whitby F.G., Masters E.I., Kramer L., Knowlton J.R., Yao Y., Wang C.C.,
RA Hill C.P.;
RT "Structural basis for the activation of 20S proteasomes by 11S
RT regulators.";
RL Nature 408:115-120(2000).
RN [10]
RP X-RAY CRYSTALLOGRAPHY (2.4 ANGSTROMS) OF COMPLEX WITH THE 20S PROTEASOME.
RX PubMed=11062564; DOI=10.1038/80992;
RA Groll M., Bajorek M., Koehler A., Moroder L., Rubin D.M., Huber R.,
RA Glickman M.H., Finley D.;
RT "A gated channel into the proteasome core particle.";
RL Nat. Struct. Biol. 7:1062-1067(2000).
RN [11]
RP X-RAY CRYSTALLOGRAPHY (2.81 ANGSTROMS) OF COMPLEX WITH THE 20S PROTEASOME
RP AND A TMC-95-BASED INHIBITOR.
RX PubMed=16793518; DOI=10.1016/j.chembiol.2006.04.005;
RA Groll M., Goetz M., Kaiser M., Weyher E., Moroder L.;
RT "TMC-95-based inhibitor design provides evidence for the catalytic
RT versatility of the proteasome.";
RL Chem. Biol. 13:607-614(2006).
RN [12]
RP X-RAY CRYSTALLOGRAPHY (2.8 ANGSTROMS) OF COMPLEX WITH THE 20S PROTEASOME
RP AND SALINOSPORAMIDE.
RX PubMed=16608349; DOI=10.1021/ja058320b;
RA Groll M., Huber R., Potts B.C.M.;
RT "Crystal structures of salinosporamide A (NPI-0052) and B (NPI-0047) in
RT complex with the 20S proteasome reveal important consequences of beta-
RT lactone ring opening and a mechanism for irreversible binding.";
RL J. Am. Chem. Soc. 128:5136-5141(2006).
RN [13]
RP X-RAY CRYSTALLOGRAPHY (2.8 ANGSTROMS) OF COMPLEX WITH THE 20S PROTEASOME
RP AND BORTEZOMIB.
RX PubMed=16531229; DOI=10.1016/j.str.2005.11.019;
RA Groll M., Berkers C.R., Ploegh H.L., Ovaa H.;
RT "Crystal structure of the boronic acid-based proteasome inhibitor
RT bortezomib in complex with the yeast 20S proteasome.";
RL Structure 14:451-456(2006).
RN [14]
RP X-RAY CRYSTALLOGRAPHY (3.0 ANGSTROMS) OF 20-250 IN COMPLEX WITH THE
RP PROTEASOME.
RX PubMed=20227375; DOI=10.1016/j.molcel.2010.02.002;
RA Sadre-Bazzaz K., Whitby F.G., Robinson H., Formosa T., Hill C.P.;
RT "Structure of a Blm10 complex reveals common mechanisms for proteasome
RT binding and gate opening.";
RL Mol. Cell 37:728-735(2010).
RN [15]
RP STRUCTURE BY ELECTRON MICROSCOPY (7.4 ANGSTROMS) OF THE 26S PROTEASOME.
RX PubMed=22927375; DOI=10.1073/pnas.1213333109;
RA Beck F., Unverdorben P., Bohn S., Schweitzer A., Pfeifer G., Sakata E.,
RA Nickell S., Plitzko J.M., Villa E., Baumeister W., Forster F.;
RT "Near-atomic resolution structural model of the yeast 26S proteasome.";
RL Proc. Natl. Acad. Sci. U.S.A. 109:14870-14875(2012).
CC -!- FUNCTION: The proteasome degrades poly-ubiquitinated proteins in the
CC cytoplasm and in the nucleus. It is essential for the regulated
CC turnover of proteins and for the removal of misfolded proteins. The
CC proteasome is a multicatalytic proteinase complex that is characterized
CC by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu
CC adjacent to the leaving group at neutral or slightly basic pH. It has
CC an ATP-dependent proteolytic activity.
CC -!- SUBUNIT: The 26S proteasome consists of a 20S proteasome core and two
CC 19S regulatory subunits. The 20S proteasome core is composed of 28
CC subunits that are arranged in four stacked rings, resulting in a
CC barrel-shaped structure. The two end rings are each formed by seven
CC alpha subunits, and the two central rings are each formed by seven beta
CC subunits. The catalytic chamber with the active sites is on the inside
CC of the barrel. {ECO:0000269|PubMed:20227375}.
CC -!- INTERACTION:
CC P23639; P23638: PRE9; NbExp=3; IntAct=EBI-13959, EBI-13967;
CC P23639; P21243: SCL1; NbExp=8; IntAct=EBI-13959, EBI-13975;
CC -!- SUBCELLULAR LOCATION: Cytoplasm. Nucleus.
CC -!- MISCELLANEOUS: Present with 7060 molecules/cell in log phase SD medium.
CC {ECO:0000269|PubMed:14562106}.
CC -!- SIMILARITY: Belongs to the peptidase T1A family. {ECO:0000255|PROSITE-
CC ProRule:PRU00808}.
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DR EMBL; X56731; CAA40055.1; -; Genomic_DNA.
DR EMBL; Z46660; CAA86646.1; -; Genomic_DNA.
DR EMBL; AY557762; AAS56088.1; -; Genomic_DNA.
DR EMBL; BK006946; DAA09807.1; -; Genomic_DNA.
DR PIR; S12938; SNBYY7.
DR RefSeq; NP_013618.1; NM_001182451.1.
DR PDB; 1FNT; X-ray; 3.20 A; B/P=1-250.
DR PDB; 1G0U; X-ray; 2.40 A; A/O=1-250.
DR PDB; 1G65; X-ray; 2.25 A; A/O=1-250.
DR PDB; 1JD2; X-ray; 3.00 A; A/V=1-250.
DR PDB; 1RYP; X-ray; 1.90 A; B/P=1-250.
DR PDB; 1Z7Q; X-ray; 3.22 A; B/P=1-250.
DR PDB; 2F16; X-ray; 2.80 A; A/O=1-250.
DR PDB; 2FAK; X-ray; 2.80 A; A/O=1-250.
DR PDB; 2GPL; X-ray; 2.81 A; A/O=1-250.
DR PDB; 2ZCY; X-ray; 2.90 A; A/O=1-250.
DR PDB; 3BDM; X-ray; 2.70 A; A/O=1-250.
DR PDB; 3D29; X-ray; 2.60 A; A/O=1-250.
DR PDB; 3DY3; X-ray; 2.81 A; A/O=1-250.
DR PDB; 3DY4; X-ray; 2.80 A; A/O=1-250.
DR PDB; 3E47; X-ray; 3.00 A; A/O=1-250.
DR PDB; 3GPJ; X-ray; 2.70 A; A/O=1-250.
DR PDB; 3GPT; X-ray; 2.41 A; A/O=1-250.
DR PDB; 3GPW; X-ray; 2.50 A; A/O=1-250.
DR PDB; 3HYE; X-ray; 2.50 A; A/O=1-250.
DR PDB; 3JCO; EM; 4.80 A; B/b=1-250.
DR PDB; 3JCP; EM; 4.60 A; B/b=1-250.
DR PDB; 3MG0; X-ray; 2.68 A; A/O=1-250.
DR PDB; 3MG4; X-ray; 3.11 A; A/O=1-250.
DR PDB; 3MG6; X-ray; 2.60 A; A/O=1-250.
DR PDB; 3MG7; X-ray; 2.78 A; A/O=1-250.
DR PDB; 3MG8; X-ray; 2.59 A; A/O=1-250.
DR PDB; 3NZJ; X-ray; 2.40 A; A/O=1-250.
DR PDB; 3NZW; X-ray; 2.50 A; A/O=1-250.
DR PDB; 3NZX; X-ray; 2.70 A; A/O=1-250.
DR PDB; 3OEU; X-ray; 2.60 A; A/O=1-250.
DR PDB; 3OEV; X-ray; 2.85 A; A/O=1-250.
DR PDB; 3OKJ; X-ray; 2.70 A; A/O=1-250.
DR PDB; 3SDI; X-ray; 2.65 A; A/O=1-250.
DR PDB; 3SDK; X-ray; 2.70 A; A/O=1-250.
DR PDB; 3SHJ; X-ray; 2.80 A; A/O=1-250.
DR PDB; 3TDD; X-ray; 2.70 A; A/O=1-250.
DR PDB; 3UN4; X-ray; 3.40 A; A/O=1-250.
DR PDB; 3UN8; X-ray; 2.70 A; A/O=1-250.
DR PDB; 3WXR; X-ray; 3.15 A; B/P=1-250.
DR PDB; 4CR2; EM; 7.70 A; B=1-250.
DR PDB; 4CR3; EM; 9.30 A; B=1-250.
DR PDB; 4CR4; EM; 8.80 A; B=1-250.
DR PDB; 4EU2; X-ray; 2.51 A; B/P=1-250.
DR PDB; 4FZC; X-ray; 2.80 A; A/O=1-250.
DR PDB; 4FZG; X-ray; 3.00 A; A/O=1-250.
DR PDB; 4G4S; X-ray; 2.49 A; B=1-250.
DR PDB; 4GK7; X-ray; 2.80 A; A/O=1-250.
DR PDB; 4HNP; X-ray; 2.80 A; A/O=1-250.
DR PDB; 4HRC; X-ray; 2.80 A; A/O=2-250.
DR PDB; 4HRD; X-ray; 2.80 A; A/O=1-250.
DR PDB; 4INR; X-ray; 2.70 A; A/O=1-250.
DR PDB; 4INT; X-ray; 2.90 A; A/O=1-250.
DR PDB; 4INU; X-ray; 3.10 A; A/O=1-250.
DR PDB; 4J70; X-ray; 2.80 A; A/O=1-250.
DR PDB; 4JSQ; X-ray; 2.80 A; A/O=1-250.
DR PDB; 4JSU; X-ray; 2.90 A; A/O=1-250.
DR PDB; 4JT0; X-ray; 3.10 A; A/O=1-250.
DR PDB; 4LQI; X-ray; 2.70 A; A/O=1-250.
DR PDB; 4LTC; X-ray; 2.50 A; A/O=1-250.
DR PDB; 4NNN; X-ray; 2.50 A; A/O=1-250.
DR PDB; 4NNW; X-ray; 2.60 A; A/O=1-250.
DR PDB; 4NO1; X-ray; 2.50 A; A/O=1-250.
DR PDB; 4NO6; X-ray; 3.00 A; A/O=1-250.
DR PDB; 4NO8; X-ray; 2.70 A; A/O=1-250.
DR PDB; 4NO9; X-ray; 2.90 A; A/O=1-250.
DR PDB; 4Q1S; X-ray; 2.60 A; A/O=1-250.
DR PDB; 4QBY; X-ray; 3.00 A; A/O=1-250.
DR PDB; 4QLQ; X-ray; 2.40 A; A/O=1-250.
DR PDB; 4QLS; X-ray; 2.80 A; A/O=1-250.
DR PDB; 4QLT; X-ray; 2.80 A; A/O=1-250.
DR PDB; 4QLU; X-ray; 2.80 A; A/O=1-250.
DR PDB; 4QLV; X-ray; 2.90 A; A/O=1-250.
DR PDB; 4QUX; X-ray; 3.00 A; A/O=1-250.
DR PDB; 4QUY; X-ray; 2.80 A; A/O=1-250.
DR PDB; 4QV0; X-ray; 3.10 A; A/O=1-250.
DR PDB; 4QV1; X-ray; 2.50 A; A/O=1-250.
DR PDB; 4QV3; X-ray; 3.00 A; A/O=1-250.
DR PDB; 4QV4; X-ray; 2.70 A; A/O=1-250.
DR PDB; 4QV5; X-ray; 2.70 A; A/O=1-250.
DR PDB; 4QV6; X-ray; 2.80 A; A/O=1-250.
DR PDB; 4QV7; X-ray; 2.60 A; A/O=1-250.
DR PDB; 4QV8; X-ray; 2.90 A; A/O=1-250.
DR PDB; 4QV9; X-ray; 2.60 A; A/O=1-250.
DR PDB; 4QVL; X-ray; 2.80 A; A/O=1-250.
DR PDB; 4QVM; X-ray; 2.80 A; A/O=1-250.
DR PDB; 4QVN; X-ray; 2.90 A; A/O=1-250.
DR PDB; 4QVP; X-ray; 2.30 A; A/O=1-250.
DR PDB; 4QVQ; X-ray; 2.60 A; A/O=1-250.
DR PDB; 4QVV; X-ray; 2.80 A; A/O=1-250.
DR PDB; 4QVW; X-ray; 3.00 A; A/O=1-250.
DR PDB; 4QVY; X-ray; 2.51 A; A/O=1-250.
DR PDB; 4QW0; X-ray; 2.90 A; A/O=1-250.
DR PDB; 4QW1; X-ray; 2.90 A; A/O=1-250.
DR PDB; 4QW3; X-ray; 2.90 A; A/O=1-250.
DR PDB; 4QW4; X-ray; 2.80 A; A/O=1-250.
DR PDB; 4QW5; X-ray; 3.00 A; A/O=1-250.
DR PDB; 4QW6; X-ray; 2.90 A; A/O=1-250.
DR PDB; 4QW7; X-ray; 2.70 A; A/O=1-250.
DR PDB; 4QWF; X-ray; 3.00 A; A/O=1-250.
DR PDB; 4QWG; X-ray; 2.60 A; A/O=1-250.
DR PDB; 4QWI; X-ray; 2.60 A; A/O=1-250.
DR PDB; 4QWJ; X-ray; 2.90 A; A/O=1-250.
DR PDB; 4QWK; X-ray; 2.80 A; A/O=1-250.
DR PDB; 4QWL; X-ray; 2.60 A; A/O=1-250.
DR PDB; 4QWR; X-ray; 2.90 A; A/O=1-250.
DR PDB; 4QWS; X-ray; 3.00 A; A/O=1-250.
DR PDB; 4QWU; X-ray; 3.00 A; A/O=1-250.
DR PDB; 4QWX; X-ray; 2.90 A; A/O=1-250.
DR PDB; 4QXJ; X-ray; 2.80 A; A/O=1-250.
DR PDB; 4QZ0; X-ray; 3.00 A; A/O=1-250.
DR PDB; 4QZ1; X-ray; 3.00 A; A/O=1-250.
DR PDB; 4QZ2; X-ray; 2.70 A; A/O=1-250.
DR PDB; 4QZ3; X-ray; 2.80 A; A/O=1-250.
DR PDB; 4QZ4; X-ray; 3.00 A; A/O=1-250.
DR PDB; 4QZ5; X-ray; 2.80 A; A/O=1-250.
DR PDB; 4QZ6; X-ray; 2.90 A; A/O=1-250.
DR PDB; 4QZ7; X-ray; 2.80 A; A/O=1-250.
DR PDB; 4QZW; X-ray; 3.00 A; A/O=1-250.
DR PDB; 4QZX; X-ray; 2.60 A; A/O=1-250.
DR PDB; 4QZZ; X-ray; 2.90 A; A/O=1-250.
DR PDB; 4R00; X-ray; 2.80 A; A/O=1-250.
DR PDB; 4R02; X-ray; 2.50 A; A/O=1-250.
DR PDB; 4R17; X-ray; 2.10 A; A/O=1-250.
DR PDB; 4R18; X-ray; 2.40 A; A/O=1-250.
DR PDB; 4RUR; X-ray; 2.50 A; A/O=1-250.
DR PDB; 4V7O; X-ray; 3.00 A; AG/AS/BB/BP=20-250.
DR PDB; 4X6Z; X-ray; 2.70 A; B/P=1-250.
DR PDB; 4Y69; X-ray; 2.90 A; A/O=1-250.
DR PDB; 4Y6A; X-ray; 2.60 A; A/O=1-250.
DR PDB; 4Y6V; X-ray; 2.80 A; A/O=1-250.
DR PDB; 4Y6Z; X-ray; 2.70 A; A/O=1-250.
DR PDB; 4Y70; X-ray; 2.40 A; A/O=1-250.
DR PDB; 4Y74; X-ray; 2.70 A; A/O=1-250.
DR PDB; 4Y75; X-ray; 2.80 A; A/O=1-250.
DR PDB; 4Y77; X-ray; 2.50 A; A/O=1-250.
DR PDB; 4Y78; X-ray; 2.80 A; A/O=1-250.
DR PDB; 4Y7W; X-ray; 2.50 A; A/O=1-250.
DR PDB; 4Y7X; X-ray; 2.60 A; A/O=1-250.
DR PDB; 4Y7Y; X-ray; 2.40 A; A/O=1-250.
DR PDB; 4Y80; X-ray; 2.50 A; A/O=1-250.
DR PDB; 4Y81; X-ray; 2.80 A; A/O=1-250.
DR PDB; 4Y82; X-ray; 2.80 A; A/O=1-250.
DR PDB; 4Y84; X-ray; 2.70 A; A/O=1-250.
DR PDB; 4Y8G; X-ray; 2.60 A; A/O=1-250.
DR PDB; 4Y8H; X-ray; 2.50 A; A/O=1-250.
DR PDB; 4Y8I; X-ray; 2.60 A; A/O=1-250.
DR PDB; 4Y8J; X-ray; 2.70 A; A/O=1-250.
DR PDB; 4Y8K; X-ray; 2.60 A; A/O=1-250.
DR PDB; 4Y8L; X-ray; 2.40 A; A/O=1-250.
DR PDB; 4Y8M; X-ray; 2.80 A; A/O=1-250.
DR PDB; 4Y8N; X-ray; 2.60 A; A/O=1-250.
DR PDB; 4Y8O; X-ray; 2.70 A; A/O=1-250.
DR PDB; 4Y8P; X-ray; 2.80 A; A/O=1-250.
DR PDB; 4Y8Q; X-ray; 2.60 A; A/O=1-250.
DR PDB; 4Y8R; X-ray; 2.70 A; A/O=1-250.
DR PDB; 4Y8S; X-ray; 2.70 A; A/O=1-250.
DR PDB; 4Y8T; X-ray; 2.70 A; A/O=1-250.
DR PDB; 4Y8U; X-ray; 2.90 A; A/O=1-250.
DR PDB; 4Y9Y; X-ray; 2.80 A; A/O=1-250.
DR PDB; 4Y9Z; X-ray; 2.80 A; A/O=1-250.
DR PDB; 4YA0; X-ray; 2.80 A; A/O=1-250.
DR PDB; 4YA1; X-ray; 2.90 A; A/O=1-250.
DR PDB; 4YA2; X-ray; 2.70 A; A/O=1-250.
DR PDB; 4YA3; X-ray; 2.70 A; A/O=1-250.
DR PDB; 4YA4; X-ray; 2.90 A; A/O=1-250.
DR PDB; 4YA5; X-ray; 2.50 A; A/O=1-250.
DR PDB; 4YA7; X-ray; 2.70 A; A/O=1-250.
DR PDB; 4YA9; X-ray; 2.70 A; A/O=1-250.
DR PDB; 4Z1L; X-ray; 3.00 A; A/O=1-250.
DR PDB; 5A5B; EM; 9.50 A; B=1-250.
DR PDB; 5AHJ; X-ray; 2.80 A; A/O=1-250.
DR PDB; 5BOU; X-ray; 2.60 A; A/O=1-250.
DR PDB; 5BXL; X-ray; 2.80 A; A/O=1-250.
DR PDB; 5BXN; X-ray; 2.80 A; A/O=1-250.
DR PDB; 5CGF; X-ray; 2.80 A; A/O=1-250.
DR PDB; 5CGG; X-ray; 2.90 A; A/O=1-250.
DR PDB; 5CGH; X-ray; 2.50 A; A/O=1-250.
DR PDB; 5CGI; X-ray; 2.80 A; A/O=1-250.
DR PDB; 5CZ4; X-ray; 2.30 A; A/O=1-250.
DR PDB; 5CZ5; X-ray; 2.80 A; A/O=1-250.
DR PDB; 5CZ6; X-ray; 2.70 A; A/O=1-250.
DR PDB; 5CZ7; X-ray; 2.50 A; A/O=1-250.
DR PDB; 5CZ8; X-ray; 2.80 A; A/O=1-250.
DR PDB; 5CZ9; X-ray; 2.90 A; A/O=1-250.
DR PDB; 5CZA; X-ray; 2.50 A; A/O=1-250.
DR PDB; 5D0S; X-ray; 2.50 A; A/O=1-250.
DR PDB; 5D0T; X-ray; 2.60 A; A/O=1-250.
DR PDB; 5D0V; X-ray; 2.90 A; A/O=1-250.
DR PDB; 5D0W; X-ray; 2.80 A; A/O=1-250.
DR PDB; 5D0X; X-ray; 2.60 A; A/O=1-250.
DR PDB; 5D0Z; X-ray; 2.90 A; A/O=1-250.
DR PDB; 5DKI; X-ray; 2.80 A; A/O=1-250.
DR PDB; 5DKJ; X-ray; 2.80 A; A/O=1-250.
DR PDB; 5FG7; X-ray; 2.70 A; A/O=1-250.
DR PDB; 5FG9; X-ray; 2.60 A; A/O=1-250.
DR PDB; 5FGA; X-ray; 2.70 A; A/O=1-250.
DR PDB; 5FGD; X-ray; 2.80 A; A/O=1-250.
DR PDB; 5FGE; X-ray; 2.60 A; A/O=1-250.
DR PDB; 5FGF; X-ray; 2.60 A; A/O=1-250.
DR PDB; 5FGG; X-ray; 2.70 A; A/O=1-250.
DR PDB; 5FGH; X-ray; 2.80 A; A/O=1-250.
DR PDB; 5FGI; X-ray; 2.90 A; A/O=1-250.
DR PDB; 5FHS; X-ray; 2.70 A; A/O=1-250.
DR PDB; 5JHR; X-ray; 2.90 A; A/O=1-250.
DR PDB; 5JHS; X-ray; 3.00 A; A/O=1-250.
DR PDB; 5L52; X-ray; 2.70 A; A/O=1-250.
DR PDB; 5L54; X-ray; 2.80 A; A/O=1-250.
DR PDB; 5L55; X-ray; 2.90 A; A/O=1-250.
DR PDB; 5L5A; X-ray; 2.40 A; A/O=1-250.
DR PDB; 5L5B; X-ray; 2.80 A; A/O=1-250.
DR PDB; 5L5D; X-ray; 2.80 A; A/O=1-250.
DR PDB; 5L5E; X-ray; 2.90 A; A/O=1-250.
DR PDB; 5L5F; X-ray; 2.50 A; A/O=1-250.
DR PDB; 5L5H; X-ray; 2.60 A; A/O=1-250.
DR PDB; 5L5I; X-ray; 2.90 A; A/O=1-250.
DR PDB; 5L5J; X-ray; 2.90 A; A/O=1-250.
DR PDB; 5L5O; X-ray; 2.60 A; A/O=1-250.
DR PDB; 5L5P; X-ray; 2.80 A; A/O=1-250.
DR PDB; 5L5Q; X-ray; 2.80 A; A/O=1-250.
DR PDB; 5L5R; X-ray; 2.90 A; A/O=1-250.
DR PDB; 5L5S; X-ray; 2.60 A; A/O=1-250.
DR PDB; 5L5T; X-ray; 2.90 A; A/O=1-250.
DR PDB; 5L5U; X-ray; 2.60 A; A/O=1-250.
DR PDB; 5L5V; X-ray; 2.70 A; A/O=1-250.
DR PDB; 5L5W; X-ray; 2.80 A; A/O=1-250.
DR PDB; 5L5X; X-ray; 2.90 A; A/O=1-250.
DR PDB; 5L5Y; X-ray; 2.70 A; A/O=1-250.
DR PDB; 5L5Z; X-ray; 2.70 A; A/O=1-250.
DR PDB; 5L60; X-ray; 2.70 A; A/O=1-250.
DR PDB; 5L61; X-ray; 2.80 A; A/O=1-250.
DR PDB; 5L62; X-ray; 2.80 A; A/O=1-250.
DR PDB; 5L63; X-ray; 2.70 A; A/O=1-250.
DR PDB; 5L64; X-ray; 2.70 A; A/O=1-250.
DR PDB; 5L65; X-ray; 2.90 A; A/O=1-250.
DR PDB; 5L66; X-ray; 2.80 A; A/O=1-250.
DR PDB; 5L67; X-ray; 2.60 A; A/O=1-250.
DR PDB; 5L68; X-ray; 2.80 A; A/O=1-250.
DR PDB; 5L69; X-ray; 2.70 A; A/O=1-250.
DR PDB; 5L6A; X-ray; 2.80 A; A/O=1-250.
DR PDB; 5L6B; X-ray; 2.60 A; A/O=1-250.
DR PDB; 5L6C; X-ray; 2.60 A; A/O=1-250.
DR PDB; 5LAI; X-ray; 2.50 A; A/O=1-250.
DR PDB; 5LAJ; X-ray; 2.90 A; A/O=1-250.
DR PDB; 5LTT; X-ray; 2.70 A; A/O=1-250.
DR PDB; 5M2B; X-ray; 2.70 A; A/O=1-250.
DR PDB; 5MP9; EM; 4.10 A; B/b=1-250.
DR PDB; 5MPA; EM; 4.50 A; B/b=1-250.
DR PDB; 5MPB; EM; 7.80 A; B/b=1-250.
DR PDB; 5MPC; EM; 7.70 A; B/b=1-250.
DR PDB; 5NIF; X-ray; 3.00 A; B/P=1-250.
DR PDB; 5WVI; EM; 6.30 A; B/j=1-250.
DR PDB; 5WVK; EM; 4.20 A; B/j=1-250.
DR PDB; 6EF0; EM; 4.43 A; B=1-250.
DR PDB; 6EF1; EM; 4.73 A; B=1-250.
DR PDB; 6EF2; EM; 4.27 A; B=1-249.
DR PDB; 6EF3; EM; 4.17 A; B=1-250.
DR PDB; 6FVT; EM; 4.10 A; B/b=2-250.
DR PDB; 6FVU; EM; 4.50 A; B/b=2-250.
DR PDB; 6FVV; EM; 5.40 A; B/b=2-250.
DR PDB; 6FVW; EM; 4.50 A; B/b=4-250.
DR PDB; 6FVX; EM; 4.90 A; B/b=5-250.
DR PDB; 6FVY; EM; 6.10 A; B/b=3-250.
DR PDB; 6G7F; X-ray; 2.70 A; A/O=1-250.
DR PDB; 6G8M; X-ray; 2.70 A; A/O=1-250.
DR PDB; 6G8N; X-ray; 3.00 A; A/O=1-250.
DR PDB; 6GOP; X-ray; 2.90 A; A/O=1-250.
DR PDB; 6H39; X-ray; 2.50 A; A/O=1-250.
DR PDB; 6HTB; X-ray; 2.70 A; A/O=1-250.
DR PDB; 6HTC; X-ray; 2.80 A; A/O=1-250.
DR PDB; 6HTD; X-ray; 3.00 A; A/O=1-250.
DR PDB; 6HTP; X-ray; 3.00 A; A/O=1-250.
DR PDB; 6HTR; X-ray; 2.60 A; A/O=1-250.
DR PDB; 6HUB; X-ray; 2.90 A; A/O=1-250.
DR PDB; 6HUC; X-ray; 3.00 A; A/O=1-250.
DR PDB; 6HUQ; X-ray; 3.00 A; A/O=1-250.
DR PDB; 6HUU; X-ray; 2.80 A; A/O=1-250.
DR PDB; 6HUV; X-ray; 3.10 A; A/O=1-250.
DR PDB; 6HV3; X-ray; 2.70 A; A/O=1-250.
DR PDB; 6HV4; X-ray; 3.00 A; A/O=1-250.
DR PDB; 6HV5; X-ray; 3.00 A; A/O=1-250.
DR PDB; 6HV7; X-ray; 3.40 A; A/O=1-250.
DR PDB; 6HVA; X-ray; 2.90 A; A/O=1-250.
DR PDB; 6HVR; X-ray; 2.70 A; A/O=1-250.
DR PDB; 6HVS; X-ray; 3.10 A; A/O=1-250.
DR PDB; 6HVT; X-ray; 2.90 A; A/O=1-250.
DR PDB; 6HVU; X-ray; 2.90 A; A/O=1-250.
DR PDB; 6HVV; X-ray; 2.70 A; A/O=1-250.
DR PDB; 6HVW; X-ray; 3.00 A; A/O=1-250.
DR PDB; 6HVX; X-ray; 2.80 A; A/O=1-250.
DR PDB; 6HVY; X-ray; 2.70 A; A/O=1-250.
DR PDB; 6HW0; X-ray; 2.80 A; A/O=1-250.
DR PDB; 6HW3; X-ray; 2.60 A; A/O=1-250.
DR PDB; 6HW4; X-ray; 2.90 A; A/O=1-250.
DR PDB; 6HW5; X-ray; 2.90 A; A/O=1-250.
DR PDB; 6HW6; X-ray; 2.70 A; A/O=1-250.
DR PDB; 6HW7; X-ray; 2.70 A; A/O=1-250.
DR PDB; 6HW8; X-ray; 2.80 A; A/O=1-250.
DR PDB; 6HW9; X-ray; 2.80 A; A/O=1-250.
DR PDB; 6HWA; X-ray; 2.80 A; A/O=1-250.
DR PDB; 6HWB; X-ray; 2.60 A; A/O=1-250.
DR PDB; 6HWC; X-ray; 2.80 A; A/O=1-250.
DR PDB; 6HWD; X-ray; 2.80 A; A/O=1-250.
DR PDB; 6HWE; X-ray; 2.30 A; A/O=1-250.
DR PDB; 6HWF; X-ray; 2.50 A; A/O=1-250.
DR PDB; 6J2C; EM; 7.00 A; B/j=1-250.
DR PDB; 6J2N; EM; 7.50 A; B/j=1-250.
DR PDB; 6J2Q; EM; 3.80 A; B/j=1-250.
DR PDB; 6J2X; EM; 3.80 A; B/j=1-250.
DR PDB; 6J30; EM; 4.50 A; B/j=1-250.
DR PDB; 6ZOU; X-ray; 2.90 A; A/O=1-250.
DR PDB; 6ZP6; X-ray; 2.80 A; A/O=1-250.
DR PDB; 6ZP8; X-ray; 3.00 A; A/O=1-250.
DR PDB; 7LS5; EM; 2.74 A; B/P=1-250.
DR PDB; 7LS6; EM; 3.17 A; B=1-250.
DR PDB; 7LSX; EM; 3.61 A; B=1-250.
DR PDB; 7QO3; EM; 6.10 A; B/b=1-250.
DR PDB; 7QO5; EM; 6.00 A; B/b=1-250.
DR PDBsum; 1FNT; -.
DR PDBsum; 1G0U; -.
DR PDBsum; 1G65; -.
DR PDBsum; 1JD2; -.
DR PDBsum; 1RYP; -.
DR PDBsum; 1Z7Q; -.
DR PDBsum; 2F16; -.
DR PDBsum; 2FAK; -.
DR PDBsum; 2GPL; -.
DR PDBsum; 2ZCY; -.
DR PDBsum; 3BDM; -.
DR PDBsum; 3D29; -.
DR PDBsum; 3DY3; -.
DR PDBsum; 3DY4; -.
DR PDBsum; 3E47; -.
DR PDBsum; 3GPJ; -.
DR PDBsum; 3GPT; -.
DR PDBsum; 3GPW; -.
DR PDBsum; 3HYE; -.
DR PDBsum; 3JCO; -.
DR PDBsum; 3JCP; -.
DR PDBsum; 3MG0; -.
DR PDBsum; 3MG4; -.
DR PDBsum; 3MG6; -.
DR PDBsum; 3MG7; -.
DR PDBsum; 3MG8; -.
DR PDBsum; 3NZJ; -.
DR PDBsum; 3NZW; -.
DR PDBsum; 3NZX; -.
DR PDBsum; 3OEU; -.
DR PDBsum; 3OEV; -.
DR PDBsum; 3OKJ; -.
DR PDBsum; 3SDI; -.
DR PDBsum; 3SDK; -.
DR PDBsum; 3SHJ; -.
DR PDBsum; 3TDD; -.
DR PDBsum; 3UN4; -.
DR PDBsum; 3UN8; -.
DR PDBsum; 3WXR; -.
DR PDBsum; 4CR2; -.
DR PDBsum; 4CR3; -.
DR PDBsum; 4CR4; -.
DR PDBsum; 4EU2; -.
DR PDBsum; 4FZC; -.
DR PDBsum; 4FZG; -.
DR PDBsum; 4G4S; -.
DR PDBsum; 4GK7; -.
DR PDBsum; 4HNP; -.
DR PDBsum; 4HRC; -.
DR PDBsum; 4HRD; -.
DR PDBsum; 4INR; -.
DR PDBsum; 4INT; -.
DR PDBsum; 4INU; -.
DR PDBsum; 4J70; -.
DR PDBsum; 4JSQ; -.
DR PDBsum; 4JSU; -.
DR PDBsum; 4JT0; -.
DR PDBsum; 4LQI; -.
DR PDBsum; 4LTC; -.
DR PDBsum; 4NNN; -.
DR PDBsum; 4NNW; -.
DR PDBsum; 4NO1; -.
DR PDBsum; 4NO6; -.
DR PDBsum; 4NO8; -.
DR PDBsum; 4NO9; -.
DR PDBsum; 4Q1S; -.
DR PDBsum; 4QBY; -.
DR PDBsum; 4QLQ; -.
DR PDBsum; 4QLS; -.
DR PDBsum; 4QLT; -.
DR PDBsum; 4QLU; -.
DR PDBsum; 4QLV; -.
DR PDBsum; 4QUX; -.
DR PDBsum; 4QUY; -.
DR PDBsum; 4QV0; -.
DR PDBsum; 4QV1; -.
DR PDBsum; 4QV3; -.
DR PDBsum; 4QV4; -.
DR PDBsum; 4QV5; -.
DR PDBsum; 4QV6; -.
DR PDBsum; 4QV7; -.
DR PDBsum; 4QV8; -.
DR PDBsum; 4QV9; -.
DR PDBsum; 4QVL; -.
DR PDBsum; 4QVM; -.
DR PDBsum; 4QVN; -.
DR PDBsum; 4QVP; -.
DR PDBsum; 4QVQ; -.
DR PDBsum; 4QVV; -.
DR PDBsum; 4QVW; -.
DR PDBsum; 4QVY; -.
DR PDBsum; 4QW0; -.
DR PDBsum; 4QW1; -.
DR PDBsum; 4QW3; -.
DR PDBsum; 4QW4; -.
DR PDBsum; 4QW5; -.
DR PDBsum; 4QW6; -.
DR PDBsum; 4QW7; -.
DR PDBsum; 4QWF; -.
DR PDBsum; 4QWG; -.
DR PDBsum; 4QWI; -.
DR PDBsum; 4QWJ; -.
DR PDBsum; 4QWK; -.
DR PDBsum; 4QWL; -.
DR PDBsum; 4QWR; -.
DR PDBsum; 4QWS; -.
DR PDBsum; 4QWU; -.
DR PDBsum; 4QWX; -.
DR PDBsum; 4QXJ; -.
DR PDBsum; 4QZ0; -.
DR PDBsum; 4QZ1; -.
DR PDBsum; 4QZ2; -.
DR PDBsum; 4QZ3; -.
DR PDBsum; 4QZ4; -.
DR PDBsum; 4QZ5; -.
DR PDBsum; 4QZ6; -.
DR PDBsum; 4QZ7; -.
DR PDBsum; 4QZW; -.
DR PDBsum; 4QZX; -.
DR PDBsum; 4QZZ; -.
DR PDBsum; 4R00; -.
DR PDBsum; 4R02; -.
DR PDBsum; 4R17; -.
DR PDBsum; 4R18; -.
DR PDBsum; 4RUR; -.
DR PDBsum; 4V7O; -.
DR PDBsum; 4X6Z; -.
DR PDBsum; 4Y69; -.
DR PDBsum; 4Y6A; -.
DR PDBsum; 4Y6V; -.
DR PDBsum; 4Y6Z; -.
DR PDBsum; 4Y70; -.
DR PDBsum; 4Y74; -.
DR PDBsum; 4Y75; -.
DR PDBsum; 4Y77; -.
DR PDBsum; 4Y78; -.
DR PDBsum; 4Y7W; -.
DR PDBsum; 4Y7X; -.
DR PDBsum; 4Y7Y; -.
DR PDBsum; 4Y80; -.
DR PDBsum; 4Y81; -.
DR PDBsum; 4Y82; -.
DR PDBsum; 4Y84; -.
DR PDBsum; 4Y8G; -.
DR PDBsum; 4Y8H; -.
DR PDBsum; 4Y8I; -.
DR PDBsum; 4Y8J; -.
DR PDBsum; 4Y8K; -.
DR PDBsum; 4Y8L; -.
DR PDBsum; 4Y8M; -.
DR PDBsum; 4Y8N; -.
DR PDBsum; 4Y8O; -.
DR PDBsum; 4Y8P; -.
DR PDBsum; 4Y8Q; -.
DR PDBsum; 4Y8R; -.
DR PDBsum; 4Y8S; -.
DR PDBsum; 4Y8T; -.
DR PDBsum; 4Y8U; -.
DR PDBsum; 4Y9Y; -.
DR PDBsum; 4Y9Z; -.
DR PDBsum; 4YA0; -.
DR PDBsum; 4YA1; -.
DR PDBsum; 4YA2; -.
DR PDBsum; 4YA3; -.
DR PDBsum; 4YA4; -.
DR PDBsum; 4YA5; -.
DR PDBsum; 4YA7; -.
DR PDBsum; 4YA9; -.
DR PDBsum; 4Z1L; -.
DR PDBsum; 5A5B; -.
DR PDBsum; 5AHJ; -.
DR PDBsum; 5BOU; -.
DR PDBsum; 5BXL; -.
DR PDBsum; 5BXN; -.
DR PDBsum; 5CGF; -.
DR PDBsum; 5CGG; -.
DR PDBsum; 5CGH; -.
DR PDBsum; 5CGI; -.
DR PDBsum; 5CZ4; -.
DR PDBsum; 5CZ5; -.
DR PDBsum; 5CZ6; -.
DR PDBsum; 5CZ7; -.
DR PDBsum; 5CZ8; -.
DR PDBsum; 5CZ9; -.
DR PDBsum; 5CZA; -.
DR PDBsum; 5D0S; -.
DR PDBsum; 5D0T; -.
DR PDBsum; 5D0V; -.
DR PDBsum; 5D0W; -.
DR PDBsum; 5D0X; -.
DR PDBsum; 5D0Z; -.
DR PDBsum; 5DKI; -.
DR PDBsum; 5DKJ; -.
DR PDBsum; 5FG7; -.
DR PDBsum; 5FG9; -.
DR PDBsum; 5FGA; -.
DR PDBsum; 5FGD; -.
DR PDBsum; 5FGE; -.
DR PDBsum; 5FGF; -.
DR PDBsum; 5FGG; -.
DR PDBsum; 5FGH; -.
DR PDBsum; 5FGI; -.
DR PDBsum; 5FHS; -.
DR PDBsum; 5JHR; -.
DR PDBsum; 5JHS; -.
DR PDBsum; 5L52; -.
DR PDBsum; 5L54; -.
DR PDBsum; 5L55; -.
DR PDBsum; 5L5A; -.
DR PDBsum; 5L5B; -.
DR PDBsum; 5L5D; -.
DR PDBsum; 5L5E; -.
DR PDBsum; 5L5F; -.
DR PDBsum; 5L5H; -.
DR PDBsum; 5L5I; -.
DR PDBsum; 5L5J; -.
DR PDBsum; 5L5O; -.
DR PDBsum; 5L5P; -.
DR PDBsum; 5L5Q; -.
DR PDBsum; 5L5R; -.
DR PDBsum; 5L5S; -.
DR PDBsum; 5L5T; -.
DR PDBsum; 5L5U; -.
DR PDBsum; 5L5V; -.
DR PDBsum; 5L5W; -.
DR PDBsum; 5L5X; -.
DR PDBsum; 5L5Y; -.
DR PDBsum; 5L5Z; -.
DR PDBsum; 5L60; -.
DR PDBsum; 5L61; -.
DR PDBsum; 5L62; -.
DR PDBsum; 5L63; -.
DR PDBsum; 5L64; -.
DR PDBsum; 5L65; -.
DR PDBsum; 5L66; -.
DR PDBsum; 5L67; -.
DR PDBsum; 5L68; -.
DR PDBsum; 5L69; -.
DR PDBsum; 5L6A; -.
DR PDBsum; 5L6B; -.
DR PDBsum; 5L6C; -.
DR PDBsum; 5LAI; -.
DR PDBsum; 5LAJ; -.
DR PDBsum; 5LTT; -.
DR PDBsum; 5M2B; -.
DR PDBsum; 5MP9; -.
DR PDBsum; 5MPA; -.
DR PDBsum; 5MPB; -.
DR PDBsum; 5MPC; -.
DR PDBsum; 5NIF; -.
DR PDBsum; 5WVI; -.
DR PDBsum; 5WVK; -.
DR PDBsum; 6EF0; -.
DR PDBsum; 6EF1; -.
DR PDBsum; 6EF2; -.
DR PDBsum; 6EF3; -.
DR PDBsum; 6FVT; -.
DR PDBsum; 6FVU; -.
DR PDBsum; 6FVV; -.
DR PDBsum; 6FVW; -.
DR PDBsum; 6FVX; -.
DR PDBsum; 6FVY; -.
DR PDBsum; 6G7F; -.
DR PDBsum; 6G8M; -.
DR PDBsum; 6G8N; -.
DR PDBsum; 6GOP; -.
DR PDBsum; 6H39; -.
DR PDBsum; 6HTB; -.
DR PDBsum; 6HTC; -.
DR PDBsum; 6HTD; -.
DR PDBsum; 6HTP; -.
DR PDBsum; 6HTR; -.
DR PDBsum; 6HUB; -.
DR PDBsum; 6HUC; -.
DR PDBsum; 6HUQ; -.
DR PDBsum; 6HUU; -.
DR PDBsum; 6HUV; -.
DR PDBsum; 6HV3; -.
DR PDBsum; 6HV4; -.
DR PDBsum; 6HV5; -.
DR PDBsum; 6HV7; -.
DR PDBsum; 6HVA; -.
DR PDBsum; 6HVR; -.
DR PDBsum; 6HVS; -.
DR PDBsum; 6HVT; -.
DR PDBsum; 6HVU; -.
DR PDBsum; 6HVV; -.
DR PDBsum; 6HVW; -.
DR PDBsum; 6HVX; -.
DR PDBsum; 6HVY; -.
DR PDBsum; 6HW0; -.
DR PDBsum; 6HW3; -.
DR PDBsum; 6HW4; -.
DR PDBsum; 6HW5; -.
DR PDBsum; 6HW6; -.
DR PDBsum; 6HW7; -.
DR PDBsum; 6HW8; -.
DR PDBsum; 6HW9; -.
DR PDBsum; 6HWA; -.
DR PDBsum; 6HWB; -.
DR PDBsum; 6HWC; -.
DR PDBsum; 6HWD; -.
DR PDBsum; 6HWE; -.
DR PDBsum; 6HWF; -.
DR PDBsum; 6J2C; -.
DR PDBsum; 6J2N; -.
DR PDBsum; 6J2Q; -.
DR PDBsum; 6J2X; -.
DR PDBsum; 6J30; -.
DR PDBsum; 6ZOU; -.
DR PDBsum; 6ZP6; -.
DR PDBsum; 6ZP8; -.
DR PDBsum; 7LS5; -.
DR PDBsum; 7LS6; -.
DR PDBsum; 7LSX; -.
DR PDBsum; 7QO3; -.
DR PDBsum; 7QO5; -.
DR AlphaFoldDB; P23639; -.
DR SMR; P23639; -.
DR BioGRID; 35051; 270.
DR ComplexPortal; CPX-2262; 26S Proteasome complex.
DR DIP; DIP-2822N; -.
DR IntAct; P23639; 23.
DR MINT; P23639; -.
DR STRING; 4932.YML092C; -.
DR BindingDB; P23639; -.
DR iPTMnet; P23639; -.
DR MaxQB; P23639; -.
DR PaxDb; P23639; -.
DR PRIDE; P23639; -.
DR EnsemblFungi; YML092C_mRNA; YML092C; YML092C.
DR GeneID; 854882; -.
DR KEGG; sce:YML092C; -.
DR SGD; S000004557; PRE8.
DR VEuPathDB; FungiDB:YML092C; -.
DR eggNOG; KOG0181; Eukaryota.
DR GeneTree; ENSGT00550000074870; -.
DR HOGENOM; CLU_035750_4_1_1; -.
DR InParanoid; P23639; -.
DR OMA; YQEQIPT; -.
DR BioCyc; YEAST:G3O-32677-MON; -.
DR Reactome; R-SCE-1236978; Cross-presentation of soluble exogenous antigens (endosomes).
DR Reactome; R-SCE-382556; ABC-family proteins mediated transport.
DR Reactome; R-SCE-5668541; TNFR2 non-canonical NF-kB pathway.
DR Reactome; R-SCE-5687128; MAPK6/MAPK4 signaling.
DR Reactome; R-SCE-5689880; Ub-specific processing proteases.
DR Reactome; R-SCE-6798695; Neutrophil degranulation.
DR Reactome; R-SCE-68949; Orc1 removal from chromatin.
DR Reactome; R-SCE-69017; CDK-mediated phosphorylation and removal of Cdc6.
DR Reactome; R-SCE-69601; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A.
DR Reactome; R-SCE-75815; Ubiquitin-dependent degradation of Cyclin D.
DR Reactome; R-SCE-8854050; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis.
DR Reactome; R-SCE-8948751; Regulation of PTEN stability and activity.
DR Reactome; R-SCE-8951664; Neddylation.
DR Reactome; R-SCE-9755511; KEAP1-NFE2L2 pathway.
DR Reactome; R-SCE-983168; Antigen processing: Ubiquitination & Proteasome degradation.
DR EvolutionaryTrace; P23639; -.
DR PRO; PR:P23639; -.
DR Proteomes; UP000002311; Chromosome XIII.
DR RNAct; P23639; protein.
DR GO; GO:0005737; C:cytoplasm; IC:SGD.
DR GO; GO:0042175; C:nuclear outer membrane-endoplasmic reticulum membrane network; IC:SGD.
DR GO; GO:0005634; C:nucleus; IC:SGD.
DR GO; GO:0000502; C:proteasome complex; IPI:ComplexPortal.
DR GO; GO:0005839; C:proteasome core complex; IBA:GO_Central.
DR GO; GO:0019773; C:proteasome core complex, alpha-subunit complex; IDA:SGD.
DR GO; GO:0034515; C:proteasome storage granule; IDA:SGD.
DR GO; GO:0010498; P:proteasomal protein catabolic process; IBA:GO_Central.
DR GO; GO:0010499; P:proteasomal ubiquitin-independent protein catabolic process; IDA:SGD.
DR GO; GO:0043161; P:proteasome-mediated ubiquitin-dependent protein catabolic process; IDA:SGD.
DR Gene3D; 3.60.20.10; -; 1.
DR InterPro; IPR029055; Ntn_hydrolases_N.
DR InterPro; IPR023332; Proteasome_alpha-type.
DR InterPro; IPR000426; Proteasome_asu_N.
DR InterPro; IPR001353; Proteasome_sua/b.
DR InterPro; IPR034644; Proteasome_subunit_alpha2.
DR PANTHER; PTHR11599:SF16; PTHR11599:SF16; 1.
DR Pfam; PF00227; Proteasome; 1.
DR Pfam; PF10584; Proteasome_A_N; 1.
DR SMART; SM00948; Proteasome_A_N; 1.
DR SUPFAM; SSF56235; SSF56235; 1.
DR PROSITE; PS00388; PROTEASOME_ALPHA_1; 1.
DR PROSITE; PS51475; PROTEASOME_ALPHA_2; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Cytoplasm; Direct protein sequencing; Isopeptide bond;
KW Nucleus; Proteasome; Reference proteome; Ubl conjugation.
FT CHAIN 1..250
FT /note="Proteasome subunit alpha type-2"
FT /id="PRO_0000124090"
FT CROSSLNK 108
FT /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
FT G-Cter in ubiquitin)"
FT /evidence="ECO:0007744|PubMed:22106047"
FT STRAND 7..10
FT /evidence="ECO:0007829|PDB:1G65"
FT TURN 14..16
FT /evidence="ECO:0007829|PDB:1G0U"
FT HELIX 19..29
FT /evidence="ECO:0007829|PDB:1RYP"
FT STRAND 34..39
FT /evidence="ECO:0007829|PDB:1RYP"
FT STRAND 42..48
FT /evidence="ECO:0007829|PDB:1RYP"
FT STRAND 54..56
FT /evidence="ECO:0007829|PDB:1RYP"
FT HELIX 58..60
FT /evidence="ECO:0007829|PDB:1RYP"
FT STRAND 63..68
FT /evidence="ECO:0007829|PDB:1RYP"
FT STRAND 71..77
FT /evidence="ECO:0007829|PDB:1RYP"
FT HELIX 79..95
FT /evidence="ECO:0007829|PDB:1RYP"
FT HELIX 98..101
FT /evidence="ECO:0007829|PDB:1RYP"
FT HELIX 107..120
FT /evidence="ECO:0007829|PDB:1RYP"
FT TURN 121..123
FT /evidence="ECO:0007829|PDB:1RYP"
FT STRAND 125..127
FT /evidence="ECO:0007829|PDB:7LS6"
FT STRAND 132..140
FT /evidence="ECO:0007829|PDB:1RYP"
FT TURN 141..143
FT /evidence="ECO:0007829|PDB:1RYP"
FT STRAND 144..150
FT /evidence="ECO:0007829|PDB:1RYP"
FT STRAND 156..165
FT /evidence="ECO:0007829|PDB:1RYP"
FT HELIX 168..178
FT /evidence="ECO:0007829|PDB:1RYP"
FT HELIX 185..199
FT /evidence="ECO:0007829|PDB:1RYP"
FT TURN 206..208
FT /evidence="ECO:0007829|PDB:1RYP"
FT STRAND 209..214
FT /evidence="ECO:0007829|PDB:1RYP"
FT HELIX 219..221
FT /evidence="ECO:0007829|PDB:1RYP"
FT STRAND 223..226
FT /evidence="ECO:0007829|PDB:1RYP"
FT STRAND 234..237
FT /evidence="ECO:0007829|PDB:1RYP"
FT HELIX 240..247
FT /evidence="ECO:0007829|PDB:1RYP"
SQ SEQUENCE 250 AA; 27162 MW; 12D7DFB1AA10E9FE CRC64;
MTDRYSFSLT TFSPSGKLGQ IDYALTAVKQ GVTSLGIKAT NGVVIATEKK SSSPLAMSET
LSKVSLLTPD IGAVYSGMGP DYRVLVDKSR KVAHTSYKRI YGEYPPTKLL VSEVAKIMQE
ATQSGGVRPF GVSLLIAGHD EFNGFSLYQV DPSGSYFPWK ATAIGKGSVA AKTFLEKRWN
DELELEDAIH IALLTLKESV EGEFNGDTIE LAIIGDENPD LLGYTGIPTD KGPRFRKLTS
QEINDRLEAL
