PSA3_YEAST
ID PSA3_YEAST Reviewed; 258 AA.
AC P23638; D6VUR7;
DT 01-NOV-1991, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1991, sequence version 1.
DT 03-AUG-2022, entry version 220.
DE RecName: Full=Proteasome subunit alpha type-3;
DE AltName: Full=Macropain subunit Y13;
DE AltName: Full=Multicatalytic endopeptidase complex subunit Y13;
DE AltName: Full=Proteasome component Y13;
DE AltName: Full=Proteinase YSCE subunit 13;
GN Name=PRE9; Synonyms=PRS5; OrderedLocusNames=YGR135W;
OS Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Saccharomycetaceae; Saccharomyces.
OX NCBI_TaxID=559292;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND PROTEIN SEQUENCE OF 73-92; 120-139
RP AND 200-236.
RC STRAIN=ATCC 26786 / X2180-1A;
RX PubMed=1898763; DOI=10.1128/mcb.11.1.344-353.1991;
RA Emori Y., Tsukahara T., Kawasaki H., Ishiura S., Sugita H., Suzuki K.;
RT "Molecular cloning and functional analysis of three subunits of yeast
RT proteasome.";
RL Mol. Cell. Biol. 11:344-353(1991).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=9169869;
RA Tettelin H., Agostoni-Carbone M.L., Albermann K., Albers M., Arroyo J.,
RA Backes U., Barreiros T., Bertani I., Bjourson A.J., Brueckner M.,
RA Bruschi C.V., Carignani G., Castagnoli L., Cerdan E., Clemente M.L.,
RA Coblenz A., Coglievina M., Coissac E., Defoor E., Del Bino S., Delius H.,
RA Delneri D., de Wergifosse P., Dujon B., Durand P., Entian K.-D., Eraso P.,
RA Escribano V., Fabiani L., Fartmann B., Feroli F., Feuermann M.,
RA Frontali L., Garcia-Gonzalez M., Garcia-Saez M.I., Goffeau A.,
RA Guerreiro P., Hani J., Hansen M., Hebling U., Hernandez K., Heumann K.,
RA Hilger F., Hofmann B., Indge K.J., James C.M., Klima R., Koetter P.,
RA Kramer B., Kramer W., Lauquin G., Leuther H., Louis E.J., Maillier E.,
RA Marconi A., Martegani E., Mazon M.J., Mazzoni C., McReynolds A.D.K.,
RA Melchioretto P., Mewes H.-W., Minenkova O., Mueller-Auer S., Nawrocki A.,
RA Netter P., Neu R., Nombela C., Oliver S.G., Panzeri L., Paoluzi S.,
RA Plevani P., Portetelle D., Portillo F., Potier S., Purnelle B., Rieger M.,
RA Riles L., Rinaldi T., Robben J., Rodrigues-Pousada C.,
RA Rodriguez-Belmonte E., Rodriguez-Torres A.M., Rose M., Ruzzi M.,
RA Saliola M., Sanchez-Perez M., Schaefer B., Schaefer M., Scharfe M.,
RA Schmidheini T., Schreer A., Skala J., Souciet J.-L., Steensma H.Y.,
RA Talla E., Thierry A., Vandenbol M., van der Aart Q.J.M., Van Dyck L.,
RA Vanoni M., Verhasselt P., Voet M., Volckaert G., Wambutt R., Watson M.D.,
RA Weber N., Wedler E., Wedler H., Wipfli P., Wolf K., Wright L.F.,
RA Zaccaria P., Zimmermann M., Zollner A., Kleine K.;
RT "The nucleotide sequence of Saccharomyces cerevisiae chromosome VII.";
RL Nature 387:81-84(1997).
RN [3]
RP GENOME REANNOTATION.
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=24374639; DOI=10.1534/g3.113.008995;
RA Engel S.R., Dietrich F.S., Fisk D.G., Binkley G., Balakrishnan R.,
RA Costanzo M.C., Dwight S.S., Hitz B.C., Karra K., Nash R.S., Weng S.,
RA Wong E.D., Lloyd P., Skrzypek M.S., Miyasato S.R., Simison M., Cherry J.M.;
RT "The reference genome sequence of Saccharomyces cerevisiae: Then and now.";
RL G3 (Bethesda) 4:389-398(2014).
RN [4]
RP LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
RX PubMed=14562106; DOI=10.1038/nature02046;
RA Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N.,
RA O'Shea E.K., Weissman J.S.;
RT "Global analysis of protein expression in yeast.";
RL Nature 425:737-741(2003).
RN [5]
RP UBIQUITINATION [LARGE SCALE ANALYSIS] AT LYS-199, AND IDENTIFICATION BY
RP MASS SPECTROMETRY.
RX PubMed=14557538; DOI=10.1073/pnas.2135500100;
RA Hitchcock A.L., Auld K., Gygi S.P., Silver P.A.;
RT "A subset of membrane-associated proteins is ubiquitinated in response to
RT mutations in the endoplasmic reticulum degradation machinery.";
RL Proc. Natl. Acad. Sci. U.S.A. 100:12735-12740(2003).
RN [6]
RP UBIQUITINATION [LARGE SCALE ANALYSIS] AT LYS-100; LYS-199 AND LYS-231, AND
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=22106047; DOI=10.1002/pmic.201100166;
RA Starita L.M., Lo R.S., Eng J.K., von Haller P.D., Fields S.;
RT "Sites of ubiquitin attachment in Saccharomyces cerevisiae.";
RL Proteomics 12:236-240(2012).
RN [7]
RP X-RAY CRYSTALLOGRAPHY (1.9 ANGSTROMS) OF 2-245 OF COMPLEX WITH THE 20S
RP PROTEASOME.
RX PubMed=9087403; DOI=10.1038/386463a0;
RA Groll M., Ditzel L., Loewe J., Stock D., Bochtler M., Bartunik H.D.,
RA Huber R.;
RT "Structure of 20S proteasome from yeast at 2.4-A resolution.";
RL Nature 386:463-471(1997).
RN [8]
RP X-RAY CRYSTALLOGRAPHY (3.2 ANGSTROMS) OF 1-245 OF COMPLEX WITH THE 20S
RP PROTEASOME AND A 11S REGULATORY COMPLEX.
RX PubMed=11081519; DOI=10.1038/35040607;
RA Whitby F.G., Masters E.I., Kramer L., Knowlton J.R., Yao Y., Wang C.C.,
RA Hill C.P.;
RT "Structural basis for the activation of 20S proteasomes by 11S
RT regulators.";
RL Nature 408:115-120(2000).
RN [9]
RP X-RAY CRYSTALLOGRAPHY (2.4 ANGSTROMS) OF 1-245 OF COMPLEX WITH THE 20S
RP PROTEASOME.
RX PubMed=11062564; DOI=10.1038/80992;
RA Groll M., Bajorek M., Koehler A., Moroder L., Rubin D.M., Huber R.,
RA Glickman M.H., Finley D.;
RT "A gated channel into the proteasome core particle.";
RL Nat. Struct. Biol. 7:1062-1067(2000).
RN [10]
RP X-RAY CRYSTALLOGRAPHY (2.81 ANGSTROMS) OF 2-245 OF COMPLEX WITH THE 20S
RP PROTEASOME AND A TMC-95-BASED INHIBITOR.
RX PubMed=16793518; DOI=10.1016/j.chembiol.2006.04.005;
RA Groll M., Goetz M., Kaiser M., Weyher E., Moroder L.;
RT "TMC-95-based inhibitor design provides evidence for the catalytic
RT versatility of the proteasome.";
RL Chem. Biol. 13:607-614(2006).
RN [11]
RP X-RAY CRYSTALLOGRAPHY (2.8 ANGSTROMS) OF 2-245 OF COMPLEX WITH THE 20S
RP PROTEASOME AND SALINOSPORAMIDE.
RX PubMed=16608349; DOI=10.1021/ja058320b;
RA Groll M., Huber R., Potts B.C.M.;
RT "Crystal structures of salinosporamide A (NPI-0052) and B (NPI-0047) in
RT complex with the 20S proteasome reveal important consequences of beta-
RT lactone ring opening and a mechanism for irreversible binding.";
RL J. Am. Chem. Soc. 128:5136-5141(2006).
RN [12]
RP X-RAY CRYSTALLOGRAPHY (2.8 ANGSTROMS) OF 2-245 OF COMPLEX WITH THE 20S
RP PROTEASOME AND BORTEZOMIB.
RX PubMed=16531229; DOI=10.1016/j.str.2005.11.019;
RA Groll M., Berkers C.R., Ploegh H.L., Ovaa H.;
RT "Crystal structure of the boronic acid-based proteasome inhibitor
RT bortezomib in complex with the yeast 20S proteasome.";
RL Structure 14:451-456(2006).
RN [13]
RP X-RAY CRYSTALLOGRAPHY (3.0 ANGSTROMS) OF 14-245 IN COMPLEX WITH THE
RP PROTEASOME.
RX PubMed=20227375; DOI=10.1016/j.molcel.2010.02.002;
RA Sadre-Bazzaz K., Whitby F.G., Robinson H., Formosa T., Hill C.P.;
RT "Structure of a Blm10 complex reveals common mechanisms for proteasome
RT binding and gate opening.";
RL Mol. Cell 37:728-735(2010).
RN [14]
RP STRUCTURE BY ELECTRON MICROSCOPY (7.4 ANGSTROMS) OF THE 26S PROTEASOME.
RX PubMed=22927375; DOI=10.1073/pnas.1213333109;
RA Beck F., Unverdorben P., Bohn S., Schweitzer A., Pfeifer G., Sakata E.,
RA Nickell S., Plitzko J.M., Villa E., Baumeister W., Forster F.;
RT "Near-atomic resolution structural model of the yeast 26S proteasome.";
RL Proc. Natl. Acad. Sci. U.S.A. 109:14870-14875(2012).
CC -!- FUNCTION: The proteasome degrades poly-ubiquitinated proteins in the
CC cytoplasm and in the nucleus. It is essential for the regulated
CC turnover of proteins and for the removal of misfolded proteins. The
CC proteasome is a multicatalytic proteinase complex that is characterized
CC by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu
CC adjacent to the leaving group at neutral or slightly basic pH. It has
CC an ATP-dependent proteolytic activity.
CC -!- SUBUNIT: The 26S proteasome consists of a 20S proteasome core and two
CC 19S regulatory subunits. The 20S proteasome core is composed of 28
CC subunits that are arranged in four stacked rings, resulting in a
CC barrel-shaped structure. The two end rings are each formed by seven
CC alpha subunits, and the two central rings are each formed by seven beta
CC subunits. The catalytic chamber with the active sites is on the inside
CC of the barrel. {ECO:0000269|PubMed:20227375}.
CC -!- INTERACTION:
CC P23638; P30656: PRE2; NbExp=2; IntAct=EBI-13967, EBI-14001;
CC P23638; P23639: PRE8; NbExp=3; IntAct=EBI-13967, EBI-13959;
CC -!- SUBCELLULAR LOCATION: Cytoplasm. Nucleus.
CC -!- MISCELLANEOUS: Present with 17100 molecules/cell in log phase SD
CC medium. {ECO:0000269|PubMed:14562106}.
CC -!- SIMILARITY: Belongs to the peptidase T1A family. {ECO:0000255|PROSITE-
CC ProRule:PRU00808}.
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DR EMBL; M63851; AAA34907.1; -; Genomic_DNA.
DR EMBL; X56730; CAA40054.1; -; Genomic_DNA.
DR EMBL; Z72920; CAA97148.1; -; Genomic_DNA.
DR EMBL; BK006941; DAA08228.1; -; Genomic_DNA.
DR PIR; S12940; SNBYY3.
DR RefSeq; NP_011651.3; NM_001181264.3.
DR PDB; 1FNT; X-ray; 3.20 A; C/Q=1-245.
DR PDB; 1G0U; X-ray; 2.40 A; B/P=1-245.
DR PDB; 1G65; X-ray; 2.25 A; B/P=2-245.
DR PDB; 1JD2; X-ray; 3.00 A; B/W=2-245.
DR PDB; 1RYP; X-ray; 1.90 A; C/Q=2-245.
DR PDB; 1Z7Q; X-ray; 3.22 A; C/Q=1-258.
DR PDB; 2F16; X-ray; 2.80 A; B/P=2-245.
DR PDB; 2FAK; X-ray; 2.80 A; B/P=2-245.
DR PDB; 2GPL; X-ray; 2.81 A; B/P=2-245.
DR PDB; 2ZCY; X-ray; 2.90 A; B/P=1-258.
DR PDB; 3BDM; X-ray; 2.70 A; B/P=1-258.
DR PDB; 3D29; X-ray; 2.60 A; B/P=2-245.
DR PDB; 3DY3; X-ray; 2.81 A; B/P=2-245.
DR PDB; 3DY4; X-ray; 2.80 A; B/P=2-245.
DR PDB; 3E47; X-ray; 3.00 A; B/P=2-245.
DR PDB; 3GPJ; X-ray; 2.70 A; B/P=2-245.
DR PDB; 3GPT; X-ray; 2.41 A; B/P=2-245.
DR PDB; 3GPW; X-ray; 2.50 A; B/P=2-245.
DR PDB; 3HYE; X-ray; 2.50 A; B/P=2-245.
DR PDB; 3JCO; EM; 4.80 A; C/c=1-258.
DR PDB; 3JCP; EM; 4.60 A; C/c=1-258.
DR PDB; 3MG0; X-ray; 2.68 A; B/P=2-245.
DR PDB; 3MG4; X-ray; 3.11 A; B/P=2-245.
DR PDB; 3MG6; X-ray; 2.60 A; B/P=1-245.
DR PDB; 3MG7; X-ray; 2.78 A; B/P=1-245.
DR PDB; 3MG8; X-ray; 2.59 A; B/P=1-245.
DR PDB; 3NZJ; X-ray; 2.40 A; B/P=1-258.
DR PDB; 3NZW; X-ray; 2.50 A; B/P=1-258.
DR PDB; 3NZX; X-ray; 2.70 A; B/P=1-258.
DR PDB; 3OEU; X-ray; 2.60 A; B/P=11-245.
DR PDB; 3OEV; X-ray; 2.85 A; B/P=11-245.
DR PDB; 3OKJ; X-ray; 2.70 A; B/P=2-245.
DR PDB; 3SDI; X-ray; 2.65 A; B/P=11-245.
DR PDB; 3SDK; X-ray; 2.70 A; B/P=11-245.
DR PDB; 3SHJ; X-ray; 2.80 A; B/P=2-245.
DR PDB; 3TDD; X-ray; 2.70 A; B/P=2-245.
DR PDB; 3UN4; X-ray; 3.40 A; B/P=1-258.
DR PDB; 3UN8; X-ray; 2.70 A; B/P=1-258.
DR PDB; 3WXR; X-ray; 3.15 A; C/Q=1-258.
DR PDB; 4CR2; EM; 7.70 A; C=1-258.
DR PDB; 4CR3; EM; 9.30 A; C=1-258.
DR PDB; 4CR4; EM; 8.80 A; C=1-258.
DR PDB; 4EU2; X-ray; 2.51 A; C/Q=2-245.
DR PDB; 4FZC; X-ray; 2.80 A; B/P=2-245.
DR PDB; 4FZG; X-ray; 3.00 A; B/P=2-245.
DR PDB; 4G4S; X-ray; 2.49 A; C=1-258.
DR PDB; 4GK7; X-ray; 2.80 A; B/P=2-245.
DR PDB; 4HNP; X-ray; 2.80 A; B/P=2-245.
DR PDB; 4HRC; X-ray; 2.80 A; B/P=2-245.
DR PDB; 4HRD; X-ray; 2.80 A; B/P=2-245.
DR PDB; 4INR; X-ray; 2.70 A; B/P=1-258.
DR PDB; 4INT; X-ray; 2.90 A; B/P=1-258.
DR PDB; 4INU; X-ray; 3.10 A; B/P=1-258.
DR PDB; 4J70; X-ray; 2.80 A; B/P=1-258.
DR PDB; 4JSQ; X-ray; 2.80 A; B/P=1-258.
DR PDB; 4JSU; X-ray; 2.90 A; B/P=1-258.
DR PDB; 4JT0; X-ray; 3.10 A; B/P=1-258.
DR PDB; 4LQI; X-ray; 2.70 A; B/P=2-245.
DR PDB; 4LTC; X-ray; 2.50 A; B/P=1-258.
DR PDB; 4NNN; X-ray; 2.50 A; B/P=1-258.
DR PDB; 4NNW; X-ray; 2.60 A; B/P=1-258.
DR PDB; 4NO1; X-ray; 2.50 A; B/P=1-258.
DR PDB; 4NO6; X-ray; 3.00 A; B/P=1-258.
DR PDB; 4NO8; X-ray; 2.70 A; B/P=1-258.
DR PDB; 4NO9; X-ray; 2.90 A; B/P=1-258.
DR PDB; 4Q1S; X-ray; 2.60 A; B/P=1-258.
DR PDB; 4QBY; X-ray; 3.00 A; B/P=1-258.
DR PDB; 4QLQ; X-ray; 2.40 A; B/P=1-258.
DR PDB; 4QLS; X-ray; 2.80 A; B/P=1-258.
DR PDB; 4QLT; X-ray; 2.80 A; B/P=1-258.
DR PDB; 4QLU; X-ray; 2.80 A; B/P=1-258.
DR PDB; 4QLV; X-ray; 2.90 A; B/P=1-258.
DR PDB; 4QUX; X-ray; 3.00 A; B/P=1-258.
DR PDB; 4QUY; X-ray; 2.80 A; B/P=1-258.
DR PDB; 4QV0; X-ray; 3.10 A; B/P=1-258.
DR PDB; 4QV1; X-ray; 2.50 A; B/P=1-258.
DR PDB; 4QV3; X-ray; 3.00 A; B/P=1-258.
DR PDB; 4QV4; X-ray; 2.70 A; B/P=1-258.
DR PDB; 4QV5; X-ray; 2.70 A; B/P=1-258.
DR PDB; 4QV6; X-ray; 2.80 A; B/P=1-258.
DR PDB; 4QV7; X-ray; 2.60 A; B/P=1-258.
DR PDB; 4QV8; X-ray; 2.90 A; B/P=1-258.
DR PDB; 4QV9; X-ray; 2.60 A; B/P=1-258.
DR PDB; 4QVL; X-ray; 2.80 A; B/P=1-258.
DR PDB; 4QVM; X-ray; 2.80 A; B/P=1-258.
DR PDB; 4QVN; X-ray; 2.90 A; B/P=1-258.
DR PDB; 4QVP; X-ray; 2.30 A; B/P=1-258.
DR PDB; 4QVQ; X-ray; 2.60 A; B/P=1-258.
DR PDB; 4QVV; X-ray; 2.80 A; B/P=1-258.
DR PDB; 4QVW; X-ray; 3.00 A; B/P=1-258.
DR PDB; 4QVY; X-ray; 2.51 A; B/P=1-258.
DR PDB; 4QW0; X-ray; 2.90 A; B/P=1-258.
DR PDB; 4QW1; X-ray; 2.90 A; B/P=1-258.
DR PDB; 4QW3; X-ray; 2.90 A; B/P=1-258.
DR PDB; 4QW4; X-ray; 2.80 A; B/P=1-258.
DR PDB; 4QW5; X-ray; 3.00 A; B/P=1-258.
DR PDB; 4QW6; X-ray; 2.90 A; B/P=1-258.
DR PDB; 4QW7; X-ray; 2.70 A; B/P=1-258.
DR PDB; 4QWF; X-ray; 3.00 A; B/P=1-258.
DR PDB; 4QWG; X-ray; 2.60 A; B/P=1-258.
DR PDB; 4QWI; X-ray; 2.60 A; B/P=1-258.
DR PDB; 4QWJ; X-ray; 2.90 A; B/P=1-258.
DR PDB; 4QWK; X-ray; 2.80 A; B/P=1-258.
DR PDB; 4QWL; X-ray; 2.60 A; B/P=1-258.
DR PDB; 4QWR; X-ray; 2.90 A; B/P=1-258.
DR PDB; 4QWS; X-ray; 3.00 A; B/P=1-258.
DR PDB; 4QWU; X-ray; 3.00 A; B/P=1-258.
DR PDB; 4QWX; X-ray; 2.90 A; B/P=1-258.
DR PDB; 4QXJ; X-ray; 2.80 A; B/P=1-258.
DR PDB; 4QZ0; X-ray; 3.00 A; B/P=1-258.
DR PDB; 4QZ1; X-ray; 3.00 A; B/P=1-258.
DR PDB; 4QZ2; X-ray; 2.70 A; B/P=1-258.
DR PDB; 4QZ3; X-ray; 2.80 A; B/P=1-258.
DR PDB; 4QZ4; X-ray; 3.00 A; B/P=1-258.
DR PDB; 4QZ5; X-ray; 2.80 A; B/P=1-258.
DR PDB; 4QZ6; X-ray; 2.90 A; B/P=1-258.
DR PDB; 4QZ7; X-ray; 2.80 A; B/P=1-258.
DR PDB; 4QZW; X-ray; 3.00 A; B/P=1-258.
DR PDB; 4QZX; X-ray; 2.60 A; B/P=1-258.
DR PDB; 4QZZ; X-ray; 2.90 A; B/P=1-258.
DR PDB; 4R00; X-ray; 2.80 A; B/P=1-258.
DR PDB; 4R02; X-ray; 2.50 A; B/P=1-258.
DR PDB; 4R17; X-ray; 2.10 A; B/P=1-258.
DR PDB; 4R18; X-ray; 2.40 A; B/P=1-258.
DR PDB; 4RUR; X-ray; 2.50 A; B/P=1-258.
DR PDB; 4V7O; X-ray; 3.00 A; AH/AT/BC/BQ=14-245.
DR PDB; 4X6Z; X-ray; 2.70 A; C/Q=1-258.
DR PDB; 4Y69; X-ray; 2.90 A; B/P=1-258.
DR PDB; 4Y6A; X-ray; 2.60 A; B/P=1-258.
DR PDB; 4Y6V; X-ray; 2.80 A; B/P=1-258.
DR PDB; 4Y6Z; X-ray; 2.70 A; B/P=1-258.
DR PDB; 4Y70; X-ray; 2.40 A; B/P=1-258.
DR PDB; 4Y74; X-ray; 2.70 A; B/P=1-258.
DR PDB; 4Y75; X-ray; 2.80 A; B/P=1-258.
DR PDB; 4Y77; X-ray; 2.50 A; B/P=1-258.
DR PDB; 4Y78; X-ray; 2.80 A; B/P=1-258.
DR PDB; 4Y7W; X-ray; 2.50 A; B/P=1-258.
DR PDB; 4Y7X; X-ray; 2.60 A; B/P=1-258.
DR PDB; 4Y7Y; X-ray; 2.40 A; B/P=1-258.
DR PDB; 4Y80; X-ray; 2.50 A; B/P=1-258.
DR PDB; 4Y81; X-ray; 2.80 A; B/P=1-258.
DR PDB; 4Y82; X-ray; 2.80 A; B/P=1-258.
DR PDB; 4Y84; X-ray; 2.70 A; B/P=1-258.
DR PDB; 4Y8G; X-ray; 2.60 A; B/P=1-258.
DR PDB; 4Y8H; X-ray; 2.50 A; B/P=1-258.
DR PDB; 4Y8I; X-ray; 2.60 A; B/P=1-258.
DR PDB; 4Y8J; X-ray; 2.70 A; B/P=1-258.
DR PDB; 4Y8K; X-ray; 2.60 A; B/P=1-258.
DR PDB; 4Y8L; X-ray; 2.40 A; B/P=1-258.
DR PDB; 4Y8M; X-ray; 2.80 A; B/P=1-258.
DR PDB; 4Y8N; X-ray; 2.60 A; B/P=1-258.
DR PDB; 4Y8O; X-ray; 2.70 A; B/P=1-258.
DR PDB; 4Y8P; X-ray; 2.80 A; B/P=1-258.
DR PDB; 4Y8Q; X-ray; 2.60 A; B/P=1-258.
DR PDB; 4Y8R; X-ray; 2.70 A; B/P=1-258.
DR PDB; 4Y8S; X-ray; 2.70 A; B/P=1-258.
DR PDB; 4Y8T; X-ray; 2.70 A; B/P=1-258.
DR PDB; 4Y8U; X-ray; 2.90 A; B/P=1-258.
DR PDB; 4Y9Y; X-ray; 2.80 A; B/P=1-258.
DR PDB; 4Y9Z; X-ray; 2.80 A; B/P=1-258.
DR PDB; 4YA0; X-ray; 2.80 A; B/P=1-258.
DR PDB; 4YA1; X-ray; 2.90 A; B/P=1-258.
DR PDB; 4YA2; X-ray; 2.70 A; B/P=1-258.
DR PDB; 4YA3; X-ray; 2.70 A; B/P=1-258.
DR PDB; 4YA4; X-ray; 2.90 A; B/P=1-258.
DR PDB; 4YA5; X-ray; 2.50 A; B/P=1-258.
DR PDB; 4YA7; X-ray; 2.70 A; B/P=1-258.
DR PDB; 4YA9; X-ray; 2.70 A; B/P=1-258.
DR PDB; 4Z1L; X-ray; 3.00 A; B/P=1-258.
DR PDB; 5A5B; EM; 9.50 A; C=1-258.
DR PDB; 5AHJ; X-ray; 2.80 A; B/P=1-258.
DR PDB; 5BOU; X-ray; 2.60 A; B/P=1-258.
DR PDB; 5BXL; X-ray; 2.80 A; B/P=1-258.
DR PDB; 5BXN; X-ray; 2.80 A; B/P=1-258.
DR PDB; 5CGF; X-ray; 2.80 A; B/P=1-258.
DR PDB; 5CGG; X-ray; 2.90 A; B/P=1-258.
DR PDB; 5CGH; X-ray; 2.50 A; B/P=1-258.
DR PDB; 5CGI; X-ray; 2.80 A; B/P=1-258.
DR PDB; 5CZ4; X-ray; 2.30 A; B/P=1-258.
DR PDB; 5CZ5; X-ray; 2.80 A; B/P=1-258.
DR PDB; 5CZ6; X-ray; 2.70 A; B/P=1-258.
DR PDB; 5CZ7; X-ray; 2.50 A; B/P=1-258.
DR PDB; 5CZ8; X-ray; 2.80 A; B/P=1-258.
DR PDB; 5CZ9; X-ray; 2.90 A; B/P=1-258.
DR PDB; 5CZA; X-ray; 2.50 A; B/P=1-258.
DR PDB; 5D0S; X-ray; 2.50 A; B/P=1-258.
DR PDB; 5D0T; X-ray; 2.60 A; B/P=1-258.
DR PDB; 5D0V; X-ray; 2.90 A; B/P=1-258.
DR PDB; 5D0W; X-ray; 2.80 A; B/P=1-258.
DR PDB; 5D0X; X-ray; 2.60 A; B/P=1-258.
DR PDB; 5D0Z; X-ray; 2.90 A; B/P=1-258.
DR PDB; 5DKI; X-ray; 2.80 A; B/P=1-258.
DR PDB; 5DKJ; X-ray; 2.80 A; B/P=1-258.
DR PDB; 5FG7; X-ray; 2.70 A; B/P=1-258.
DR PDB; 5FG9; X-ray; 2.60 A; B/P=1-258.
DR PDB; 5FGA; X-ray; 2.70 A; B/P=1-258.
DR PDB; 5FGD; X-ray; 2.80 A; B/P=1-258.
DR PDB; 5FGE; X-ray; 2.60 A; B/P=1-258.
DR PDB; 5FGF; X-ray; 2.60 A; B/P=1-258.
DR PDB; 5FGG; X-ray; 2.70 A; B/P=1-258.
DR PDB; 5FGH; X-ray; 2.80 A; B/P=1-258.
DR PDB; 5FGI; X-ray; 2.90 A; B/P=1-258.
DR PDB; 5FHS; X-ray; 2.70 A; B/P=1-258.
DR PDB; 5JHR; X-ray; 2.90 A; B/P=1-258.
DR PDB; 5JHS; X-ray; 3.00 A; B/P=1-258.
DR PDB; 5L52; X-ray; 2.70 A; B/P=1-258.
DR PDB; 5L54; X-ray; 2.80 A; B/P=1-258.
DR PDB; 5L55; X-ray; 2.90 A; B/P=1-258.
DR PDB; 5L5A; X-ray; 2.40 A; B/P=1-258.
DR PDB; 5L5B; X-ray; 2.80 A; B/P=1-258.
DR PDB; 5L5D; X-ray; 2.80 A; B/P=1-258.
DR PDB; 5L5E; X-ray; 2.90 A; B/P=1-258.
DR PDB; 5L5F; X-ray; 2.50 A; B/P=1-258.
DR PDB; 5L5H; X-ray; 2.60 A; B/P=1-258.
DR PDB; 5L5I; X-ray; 2.90 A; B/P=1-258.
DR PDB; 5L5J; X-ray; 2.90 A; B/P=1-258.
DR PDB; 5L5O; X-ray; 2.60 A; B/P=1-258.
DR PDB; 5L5P; X-ray; 2.80 A; B/P=1-258.
DR PDB; 5L5Q; X-ray; 2.80 A; B/P=1-258.
DR PDB; 5L5R; X-ray; 2.90 A; B/P=1-258.
DR PDB; 5L5S; X-ray; 2.60 A; B/P=1-258.
DR PDB; 5L5T; X-ray; 2.90 A; B/P=1-258.
DR PDB; 5L5U; X-ray; 2.60 A; B/P=1-258.
DR PDB; 5L5V; X-ray; 2.70 A; B/P=1-258.
DR PDB; 5L5W; X-ray; 2.80 A; B/P=1-258.
DR PDB; 5L5X; X-ray; 2.90 A; B/P=1-258.
DR PDB; 5L5Y; X-ray; 2.70 A; B/P=1-258.
DR PDB; 5L5Z; X-ray; 2.70 A; B/P=1-258.
DR PDB; 5L60; X-ray; 2.70 A; B/P=1-258.
DR PDB; 5L61; X-ray; 2.80 A; B/P=1-258.
DR PDB; 5L62; X-ray; 2.80 A; B/P=1-258.
DR PDB; 5L63; X-ray; 2.70 A; B/P=1-258.
DR PDB; 5L64; X-ray; 2.70 A; B/P=1-258.
DR PDB; 5L65; X-ray; 2.90 A; B/P=1-258.
DR PDB; 5L66; X-ray; 2.80 A; B/P=1-258.
DR PDB; 5L67; X-ray; 2.60 A; B/P=1-258.
DR PDB; 5L68; X-ray; 2.80 A; B/P=1-258.
DR PDB; 5L69; X-ray; 2.70 A; B/P=1-258.
DR PDB; 5L6A; X-ray; 2.80 A; B/P=1-258.
DR PDB; 5L6B; X-ray; 2.60 A; B/P=1-258.
DR PDB; 5L6C; X-ray; 2.60 A; B/P=1-258.
DR PDB; 5LAI; X-ray; 2.50 A; B/P=1-258.
DR PDB; 5LAJ; X-ray; 2.90 A; B/P=1-258.
DR PDB; 5LTT; X-ray; 2.70 A; B/P=1-258.
DR PDB; 5M2B; X-ray; 2.70 A; B/P=1-258.
DR PDB; 5MP9; EM; 4.10 A; C/c=1-258.
DR PDB; 5MPA; EM; 4.50 A; C/c=1-258.
DR PDB; 5MPB; EM; 7.80 A; C/c=1-258.
DR PDB; 5MPC; EM; 7.70 A; C/c=1-258.
DR PDB; 5NIF; X-ray; 3.00 A; C/Q=1-258.
DR PDB; 5WVI; EM; 6.30 A; C/d=1-258.
DR PDB; 5WVK; EM; 4.20 A; C/d=1-258.
DR PDB; 6EF0; EM; 4.43 A; C=1-244.
DR PDB; 6EF1; EM; 4.73 A; C=8-245.
DR PDB; 6EF2; EM; 4.27 A; C=4-244.
DR PDB; 6EF3; EM; 4.17 A; C=1-258.
DR PDB; 6FVT; EM; 4.10 A; C/c=2-245.
DR PDB; 6FVU; EM; 4.50 A; C/c=2-245.
DR PDB; 6FVV; EM; 5.40 A; C/c=2-245.
DR PDB; 6FVW; EM; 4.50 A; C/c=5-245.
DR PDB; 6FVX; EM; 4.90 A; C/c=5-245.
DR PDB; 6FVY; EM; 6.10 A; C/c=5-245.
DR PDB; 6G7F; X-ray; 2.70 A; B/P=1-258.
DR PDB; 6G8M; X-ray; 2.70 A; B/P=1-258.
DR PDB; 6G8N; X-ray; 3.00 A; B/P=1-258.
DR PDB; 6GOP; X-ray; 2.90 A; B/P=1-258.
DR PDB; 6H39; X-ray; 2.50 A; B/P=1-258.
DR PDB; 6HTB; X-ray; 2.70 A; B/P=1-258.
DR PDB; 6HTC; X-ray; 2.80 A; B/P=1-258.
DR PDB; 6HTD; X-ray; 3.00 A; B/P=1-258.
DR PDB; 6HTP; X-ray; 3.00 A; B/P=1-258.
DR PDB; 6HTR; X-ray; 2.60 A; B/P=1-258.
DR PDB; 6HUB; X-ray; 2.90 A; B/P=1-258.
DR PDB; 6HUC; X-ray; 3.00 A; B/P=1-258.
DR PDB; 6HUQ; X-ray; 3.00 A; B/P=1-258.
DR PDB; 6HUU; X-ray; 2.80 A; B/P=1-258.
DR PDB; 6HUV; X-ray; 3.10 A; B/P=1-258.
DR PDB; 6HV3; X-ray; 2.70 A; B/P=1-258.
DR PDB; 6HV4; X-ray; 3.00 A; B/P=1-258.
DR PDB; 6HV5; X-ray; 3.00 A; B/P=1-258.
DR PDB; 6HV7; X-ray; 3.40 A; B/P=1-258.
DR PDB; 6HVA; X-ray; 2.90 A; B/P=1-258.
DR PDB; 6HVR; X-ray; 2.70 A; B/P=1-258.
DR PDB; 6HVS; X-ray; 3.10 A; B/P=1-258.
DR PDB; 6HVT; X-ray; 2.90 A; B/P=1-258.
DR PDB; 6HVU; X-ray; 2.90 A; B/P=1-258.
DR PDB; 6HVV; X-ray; 2.70 A; B/P=1-258.
DR PDB; 6HVW; X-ray; 3.00 A; B/P=1-258.
DR PDB; 6HVX; X-ray; 2.80 A; B/P=1-258.
DR PDB; 6HVY; X-ray; 2.70 A; B/P=1-258.
DR PDB; 6HW0; X-ray; 2.80 A; B/P=1-258.
DR PDB; 6HW3; X-ray; 2.60 A; B/P=1-258.
DR PDB; 6HW4; X-ray; 2.90 A; B/P=1-258.
DR PDB; 6HW5; X-ray; 2.90 A; B/P=1-258.
DR PDB; 6HW6; X-ray; 2.70 A; B/P=1-258.
DR PDB; 6HW7; X-ray; 2.70 A; B/P=1-258.
DR PDB; 6HW8; X-ray; 2.80 A; B/P=1-258.
DR PDB; 6HW9; X-ray; 2.80 A; B/P=1-258.
DR PDB; 6HWA; X-ray; 2.80 A; B/P=1-258.
DR PDB; 6HWB; X-ray; 2.60 A; B/P=1-258.
DR PDB; 6HWC; X-ray; 2.80 A; B/P=1-258.
DR PDB; 6HWD; X-ray; 2.80 A; B/P=1-258.
DR PDB; 6HWE; X-ray; 2.30 A; B/P=1-258.
DR PDB; 6HWF; X-ray; 2.50 A; B/P=1-258.
DR PDB; 6J2C; EM; 7.00 A; C/d=1-258.
DR PDB; 6J2N; EM; 7.50 A; C/d=1-258.
DR PDB; 6J2Q; EM; 3.80 A; C/d=1-258.
DR PDB; 6J2X; EM; 3.80 A; C/d=1-258.
DR PDB; 6J30; EM; 4.50 A; C/d=1-258.
DR PDB; 6ZOU; X-ray; 2.90 A; B/P=1-258.
DR PDB; 6ZP6; X-ray; 2.80 A; B/P=1-258.
DR PDB; 6ZP8; X-ray; 3.00 A; B/P=1-258.
DR PDB; 7LS5; EM; 2.74 A; C/Q=1-258.
DR PDB; 7LS6; EM; 3.17 A; C=1-258.
DR PDB; 7LSX; EM; 3.61 A; C=1-258.
DR PDB; 7QO3; EM; 6.10 A; C/c=1-258.
DR PDB; 7QO5; EM; 6.00 A; C/c=1-258.
DR PDBsum; 1FNT; -.
DR PDBsum; 1G0U; -.
DR PDBsum; 1G65; -.
DR PDBsum; 1JD2; -.
DR PDBsum; 1RYP; -.
DR PDBsum; 1Z7Q; -.
DR PDBsum; 2F16; -.
DR PDBsum; 2FAK; -.
DR PDBsum; 2GPL; -.
DR PDBsum; 2ZCY; -.
DR PDBsum; 3BDM; -.
DR PDBsum; 3D29; -.
DR PDBsum; 3DY3; -.
DR PDBsum; 3DY4; -.
DR PDBsum; 3E47; -.
DR PDBsum; 3GPJ; -.
DR PDBsum; 3GPT; -.
DR PDBsum; 3GPW; -.
DR PDBsum; 3HYE; -.
DR PDBsum; 3JCO; -.
DR PDBsum; 3JCP; -.
DR PDBsum; 3MG0; -.
DR PDBsum; 3MG4; -.
DR PDBsum; 3MG6; -.
DR PDBsum; 3MG7; -.
DR PDBsum; 3MG8; -.
DR PDBsum; 3NZJ; -.
DR PDBsum; 3NZW; -.
DR PDBsum; 3NZX; -.
DR PDBsum; 3OEU; -.
DR PDBsum; 3OEV; -.
DR PDBsum; 3OKJ; -.
DR PDBsum; 3SDI; -.
DR PDBsum; 3SDK; -.
DR PDBsum; 3SHJ; -.
DR PDBsum; 3TDD; -.
DR PDBsum; 3UN4; -.
DR PDBsum; 3UN8; -.
DR PDBsum; 3WXR; -.
DR PDBsum; 4CR2; -.
DR PDBsum; 4CR3; -.
DR PDBsum; 4CR4; -.
DR PDBsum; 4EU2; -.
DR PDBsum; 4FZC; -.
DR PDBsum; 4FZG; -.
DR PDBsum; 4G4S; -.
DR PDBsum; 4GK7; -.
DR PDBsum; 4HNP; -.
DR PDBsum; 4HRC; -.
DR PDBsum; 4HRD; -.
DR PDBsum; 4INR; -.
DR PDBsum; 4INT; -.
DR PDBsum; 4INU; -.
DR PDBsum; 4J70; -.
DR PDBsum; 4JSQ; -.
DR PDBsum; 4JSU; -.
DR PDBsum; 4JT0; -.
DR PDBsum; 4LQI; -.
DR PDBsum; 4LTC; -.
DR PDBsum; 4NNN; -.
DR PDBsum; 4NNW; -.
DR PDBsum; 4NO1; -.
DR PDBsum; 4NO6; -.
DR PDBsum; 4NO8; -.
DR PDBsum; 4NO9; -.
DR PDBsum; 4Q1S; -.
DR PDBsum; 4QBY; -.
DR PDBsum; 4QLQ; -.
DR PDBsum; 4QLS; -.
DR PDBsum; 4QLT; -.
DR PDBsum; 4QLU; -.
DR PDBsum; 4QLV; -.
DR PDBsum; 4QUX; -.
DR PDBsum; 4QUY; -.
DR PDBsum; 4QV0; -.
DR PDBsum; 4QV1; -.
DR PDBsum; 4QV3; -.
DR PDBsum; 4QV4; -.
DR PDBsum; 4QV5; -.
DR PDBsum; 4QV6; -.
DR PDBsum; 4QV7; -.
DR PDBsum; 4QV8; -.
DR PDBsum; 4QV9; -.
DR PDBsum; 4QVL; -.
DR PDBsum; 4QVM; -.
DR PDBsum; 4QVN; -.
DR PDBsum; 4QVP; -.
DR PDBsum; 4QVQ; -.
DR PDBsum; 4QVV; -.
DR PDBsum; 4QVW; -.
DR PDBsum; 4QVY; -.
DR PDBsum; 4QW0; -.
DR PDBsum; 4QW1; -.
DR PDBsum; 4QW3; -.
DR PDBsum; 4QW4; -.
DR PDBsum; 4QW5; -.
DR PDBsum; 4QW6; -.
DR PDBsum; 4QW7; -.
DR PDBsum; 4QWF; -.
DR PDBsum; 4QWG; -.
DR PDBsum; 4QWI; -.
DR PDBsum; 4QWJ; -.
DR PDBsum; 4QWK; -.
DR PDBsum; 4QWL; -.
DR PDBsum; 4QWR; -.
DR PDBsum; 4QWS; -.
DR PDBsum; 4QWU; -.
DR PDBsum; 4QWX; -.
DR PDBsum; 4QXJ; -.
DR PDBsum; 4QZ0; -.
DR PDBsum; 4QZ1; -.
DR PDBsum; 4QZ2; -.
DR PDBsum; 4QZ3; -.
DR PDBsum; 4QZ4; -.
DR PDBsum; 4QZ5; -.
DR PDBsum; 4QZ6; -.
DR PDBsum; 4QZ7; -.
DR PDBsum; 4QZW; -.
DR PDBsum; 4QZX; -.
DR PDBsum; 4QZZ; -.
DR PDBsum; 4R00; -.
DR PDBsum; 4R02; -.
DR PDBsum; 4R17; -.
DR PDBsum; 4R18; -.
DR PDBsum; 4RUR; -.
DR PDBsum; 4V7O; -.
DR PDBsum; 4X6Z; -.
DR PDBsum; 4Y69; -.
DR PDBsum; 4Y6A; -.
DR PDBsum; 4Y6V; -.
DR PDBsum; 4Y6Z; -.
DR PDBsum; 4Y70; -.
DR PDBsum; 4Y74; -.
DR PDBsum; 4Y75; -.
DR PDBsum; 4Y77; -.
DR PDBsum; 4Y78; -.
DR PDBsum; 4Y7W; -.
DR PDBsum; 4Y7X; -.
DR PDBsum; 4Y7Y; -.
DR PDBsum; 4Y80; -.
DR PDBsum; 4Y81; -.
DR PDBsum; 4Y82; -.
DR PDBsum; 4Y84; -.
DR PDBsum; 4Y8G; -.
DR PDBsum; 4Y8H; -.
DR PDBsum; 4Y8I; -.
DR PDBsum; 4Y8J; -.
DR PDBsum; 4Y8K; -.
DR PDBsum; 4Y8L; -.
DR PDBsum; 4Y8M; -.
DR PDBsum; 4Y8N; -.
DR PDBsum; 4Y8O; -.
DR PDBsum; 4Y8P; -.
DR PDBsum; 4Y8Q; -.
DR PDBsum; 4Y8R; -.
DR PDBsum; 4Y8S; -.
DR PDBsum; 4Y8T; -.
DR PDBsum; 4Y8U; -.
DR PDBsum; 4Y9Y; -.
DR PDBsum; 4Y9Z; -.
DR PDBsum; 4YA0; -.
DR PDBsum; 4YA1; -.
DR PDBsum; 4YA2; -.
DR PDBsum; 4YA3; -.
DR PDBsum; 4YA4; -.
DR PDBsum; 4YA5; -.
DR PDBsum; 4YA7; -.
DR PDBsum; 4YA9; -.
DR PDBsum; 4Z1L; -.
DR PDBsum; 5A5B; -.
DR PDBsum; 5AHJ; -.
DR PDBsum; 5BOU; -.
DR PDBsum; 5BXL; -.
DR PDBsum; 5BXN; -.
DR PDBsum; 5CGF; -.
DR PDBsum; 5CGG; -.
DR PDBsum; 5CGH; -.
DR PDBsum; 5CGI; -.
DR PDBsum; 5CZ4; -.
DR PDBsum; 5CZ5; -.
DR PDBsum; 5CZ6; -.
DR PDBsum; 5CZ7; -.
DR PDBsum; 5CZ8; -.
DR PDBsum; 5CZ9; -.
DR PDBsum; 5CZA; -.
DR PDBsum; 5D0S; -.
DR PDBsum; 5D0T; -.
DR PDBsum; 5D0V; -.
DR PDBsum; 5D0W; -.
DR PDBsum; 5D0X; -.
DR PDBsum; 5D0Z; -.
DR PDBsum; 5DKI; -.
DR PDBsum; 5DKJ; -.
DR PDBsum; 5FG7; -.
DR PDBsum; 5FG9; -.
DR PDBsum; 5FGA; -.
DR PDBsum; 5FGD; -.
DR PDBsum; 5FGE; -.
DR PDBsum; 5FGF; -.
DR PDBsum; 5FGG; -.
DR PDBsum; 5FGH; -.
DR PDBsum; 5FGI; -.
DR PDBsum; 5FHS; -.
DR PDBsum; 5JHR; -.
DR PDBsum; 5JHS; -.
DR PDBsum; 5L52; -.
DR PDBsum; 5L54; -.
DR PDBsum; 5L55; -.
DR PDBsum; 5L5A; -.
DR PDBsum; 5L5B; -.
DR PDBsum; 5L5D; -.
DR PDBsum; 5L5E; -.
DR PDBsum; 5L5F; -.
DR PDBsum; 5L5H; -.
DR PDBsum; 5L5I; -.
DR PDBsum; 5L5J; -.
DR PDBsum; 5L5O; -.
DR PDBsum; 5L5P; -.
DR PDBsum; 5L5Q; -.
DR PDBsum; 5L5R; -.
DR PDBsum; 5L5S; -.
DR PDBsum; 5L5T; -.
DR PDBsum; 5L5U; -.
DR PDBsum; 5L5V; -.
DR PDBsum; 5L5W; -.
DR PDBsum; 5L5X; -.
DR PDBsum; 5L5Y; -.
DR PDBsum; 5L5Z; -.
DR PDBsum; 5L60; -.
DR PDBsum; 5L61; -.
DR PDBsum; 5L62; -.
DR PDBsum; 5L63; -.
DR PDBsum; 5L64; -.
DR PDBsum; 5L65; -.
DR PDBsum; 5L66; -.
DR PDBsum; 5L67; -.
DR PDBsum; 5L68; -.
DR PDBsum; 5L69; -.
DR PDBsum; 5L6A; -.
DR PDBsum; 5L6B; -.
DR PDBsum; 5L6C; -.
DR PDBsum; 5LAI; -.
DR PDBsum; 5LAJ; -.
DR PDBsum; 5LTT; -.
DR PDBsum; 5M2B; -.
DR PDBsum; 5MP9; -.
DR PDBsum; 5MPA; -.
DR PDBsum; 5MPB; -.
DR PDBsum; 5MPC; -.
DR PDBsum; 5NIF; -.
DR PDBsum; 5WVI; -.
DR PDBsum; 5WVK; -.
DR PDBsum; 6EF0; -.
DR PDBsum; 6EF1; -.
DR PDBsum; 6EF2; -.
DR PDBsum; 6EF3; -.
DR PDBsum; 6FVT; -.
DR PDBsum; 6FVU; -.
DR PDBsum; 6FVV; -.
DR PDBsum; 6FVW; -.
DR PDBsum; 6FVX; -.
DR PDBsum; 6FVY; -.
DR PDBsum; 6G7F; -.
DR PDBsum; 6G8M; -.
DR PDBsum; 6G8N; -.
DR PDBsum; 6GOP; -.
DR PDBsum; 6H39; -.
DR PDBsum; 6HTB; -.
DR PDBsum; 6HTC; -.
DR PDBsum; 6HTD; -.
DR PDBsum; 6HTP; -.
DR PDBsum; 6HTR; -.
DR PDBsum; 6HUB; -.
DR PDBsum; 6HUC; -.
DR PDBsum; 6HUQ; -.
DR PDBsum; 6HUU; -.
DR PDBsum; 6HUV; -.
DR PDBsum; 6HV3; -.
DR PDBsum; 6HV4; -.
DR PDBsum; 6HV5; -.
DR PDBsum; 6HV7; -.
DR PDBsum; 6HVA; -.
DR PDBsum; 6HVR; -.
DR PDBsum; 6HVS; -.
DR PDBsum; 6HVT; -.
DR PDBsum; 6HVU; -.
DR PDBsum; 6HVV; -.
DR PDBsum; 6HVW; -.
DR PDBsum; 6HVX; -.
DR PDBsum; 6HVY; -.
DR PDBsum; 6HW0; -.
DR PDBsum; 6HW3; -.
DR PDBsum; 6HW4; -.
DR PDBsum; 6HW5; -.
DR PDBsum; 6HW6; -.
DR PDBsum; 6HW7; -.
DR PDBsum; 6HW8; -.
DR PDBsum; 6HW9; -.
DR PDBsum; 6HWA; -.
DR PDBsum; 6HWB; -.
DR PDBsum; 6HWC; -.
DR PDBsum; 6HWD; -.
DR PDBsum; 6HWE; -.
DR PDBsum; 6HWF; -.
DR PDBsum; 6J2C; -.
DR PDBsum; 6J2N; -.
DR PDBsum; 6J2Q; -.
DR PDBsum; 6J2X; -.
DR PDBsum; 6J30; -.
DR PDBsum; 6ZOU; -.
DR PDBsum; 6ZP6; -.
DR PDBsum; 6ZP8; -.
DR PDBsum; 7LS5; -.
DR PDBsum; 7LS6; -.
DR PDBsum; 7LSX; -.
DR PDBsum; 7QO3; -.
DR PDBsum; 7QO5; -.
DR AlphaFoldDB; P23638; -.
DR SMR; P23638; -.
DR BioGRID; 33383; 534.
DR ComplexPortal; CPX-2262; 26S Proteasome complex.
DR DIP; DIP-2823N; -.
DR IntAct; P23638; 20.
DR MINT; P23638; -.
DR STRING; 4932.YGR135W; -.
DR MEROPS; T01.973; -.
DR iPTMnet; P23638; -.
DR MaxQB; P23638; -.
DR PaxDb; P23638; -.
DR PRIDE; P23638; -.
DR EnsemblFungi; YGR135W_mRNA; YGR135W; YGR135W.
DR GeneID; 853036; -.
DR KEGG; sce:YGR135W; -.
DR SGD; S000003367; PRE9.
DR VEuPathDB; FungiDB:YGR135W; -.
DR eggNOG; KOG0178; Eukaryota.
DR GeneTree; ENSGT00550000074827; -.
DR HOGENOM; CLU_035750_4_3_1; -.
DR InParanoid; P23638; -.
DR OMA; YVLNDNM; -.
DR BioCyc; YEAST:G3O-30841-MON; -.
DR Reactome; R-SCE-1236978; Cross-presentation of soluble exogenous antigens (endosomes).
DR Reactome; R-SCE-382556; ABC-family proteins mediated transport.
DR Reactome; R-SCE-5668541; TNFR2 non-canonical NF-kB pathway.
DR Reactome; R-SCE-5687128; MAPK6/MAPK4 signaling.
DR Reactome; R-SCE-5689880; Ub-specific processing proteases.
DR Reactome; R-SCE-68949; Orc1 removal from chromatin.
DR Reactome; R-SCE-69017; CDK-mediated phosphorylation and removal of Cdc6.
DR Reactome; R-SCE-69601; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A.
DR Reactome; R-SCE-75815; Ubiquitin-dependent degradation of Cyclin D.
DR Reactome; R-SCE-8854050; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis.
DR Reactome; R-SCE-8948751; Regulation of PTEN stability and activity.
DR Reactome; R-SCE-8951664; Neddylation.
DR Reactome; R-SCE-9755511; KEAP1-NFE2L2 pathway.
DR Reactome; R-SCE-983168; Antigen processing: Ubiquitination & Proteasome degradation.
DR EvolutionaryTrace; P23638; -.
DR PRO; PR:P23638; -.
DR Proteomes; UP000002311; Chromosome VII.
DR RNAct; P23638; protein.
DR GO; GO:0005829; C:cytosol; IBA:GO_Central.
DR GO; GO:0042175; C:nuclear outer membrane-endoplasmic reticulum membrane network; IC:SGD.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0000502; C:proteasome complex; IPI:ComplexPortal.
DR GO; GO:0005839; C:proteasome core complex; IBA:GO_Central.
DR GO; GO:0019773; C:proteasome core complex, alpha-subunit complex; IDA:SGD.
DR GO; GO:0034515; C:proteasome storage granule; IDA:SGD.
DR GO; GO:0010498; P:proteasomal protein catabolic process; IBA:GO_Central.
DR GO; GO:0010499; P:proteasomal ubiquitin-independent protein catabolic process; IDA:SGD.
DR GO; GO:0080129; P:proteasome core complex assembly; IMP:SGD.
DR GO; GO:0043161; P:proteasome-mediated ubiquitin-dependent protein catabolic process; IDA:SGD.
DR Gene3D; 3.60.20.10; -; 1.
DR InterPro; IPR029055; Ntn_hydrolases_N.
DR InterPro; IPR023332; Proteasome_alpha-type.
DR InterPro; IPR000426; Proteasome_asu_N.
DR InterPro; IPR016050; Proteasome_bsu_CS.
DR InterPro; IPR001353; Proteasome_sua/b.
DR InterPro; IPR034647; Proteasome_subunit_alpha4.
DR PANTHER; PTHR11599:SF13; PTHR11599:SF13; 1.
DR Pfam; PF00227; Proteasome; 1.
DR Pfam; PF10584; Proteasome_A_N; 1.
DR SMART; SM00948; Proteasome_A_N; 1.
DR SUPFAM; SSF56235; SSF56235; 1.
DR PROSITE; PS00388; PROTEASOME_ALPHA_1; 1.
DR PROSITE; PS51475; PROTEASOME_ALPHA_2; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Cytoplasm; Direct protein sequencing; Isopeptide bond;
KW Nucleus; Proteasome; Reference proteome; Ubl conjugation.
FT CHAIN 1..258
FT /note="Proteasome subunit alpha type-3"
FT /id="PRO_0000124116"
FT CROSSLNK 100
FT /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
FT G-Cter in ubiquitin)"
FT /evidence="ECO:0007744|PubMed:22106047"
FT CROSSLNK 199
FT /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
FT G-Cter in ubiquitin)"
FT /evidence="ECO:0007744|PubMed:22106047"
FT CROSSLNK 231
FT /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
FT G-Cter in ubiquitin)"
FT /evidence="ECO:0007744|PubMed:22106047"
FT HELIX 4..6
FT /evidence="ECO:0007829|PDB:1RYP"
FT HELIX 20..29
FT /evidence="ECO:0007829|PDB:1RYP"
FT STRAND 35..40
FT /evidence="ECO:0007829|PDB:1RYP"
FT STRAND 43..49
FT /evidence="ECO:0007829|PDB:1RYP"
FT STRAND 55..57
FT /evidence="ECO:0007829|PDB:1RYP"
FT HELIX 59..61
FT /evidence="ECO:0007829|PDB:5CZ4"
FT STRAND 64..79
FT /evidence="ECO:0007829|PDB:1RYP"
FT HELIX 81..102
FT /evidence="ECO:0007829|PDB:1RYP"
FT HELIX 108..124
FT /evidence="ECO:0007829|PDB:1RYP"
FT STRAND 125..127
FT /evidence="ECO:0007829|PDB:1RYP"
FT STRAND 133..141
FT /evidence="ECO:0007829|PDB:1RYP"
FT TURN 142..144
FT /evidence="ECO:0007829|PDB:1RYP"
FT STRAND 145..151
FT /evidence="ECO:0007829|PDB:1RYP"
FT STRAND 157..166
FT /evidence="ECO:0007829|PDB:1RYP"
FT HELIX 169..179
FT /evidence="ECO:0007829|PDB:1RYP"
FT HELIX 186..200
FT /evidence="ECO:0007829|PDB:1RYP"
FT STRAND 202..205
FT /evidence="ECO:0007829|PDB:1RYP"
FT HELIX 208..210
FT /evidence="ECO:0007829|PDB:1RYP"
FT STRAND 211..217
FT /evidence="ECO:0007829|PDB:1RYP"
FT STRAND 220..224
FT /evidence="ECO:0007829|PDB:1RYP"
FT STRAND 226..229
FT /evidence="ECO:0007829|PDB:1RYP"
FT HELIX 232..241
FT /evidence="ECO:0007829|PDB:1RYP"
FT TURN 242..244
FT /evidence="ECO:0007829|PDB:3BDM"
SQ SEQUENCE 258 AA; 28714 MW; B43BB05233A01A9E CRC64;
MGSRRYDSRT TIFSPEGRLY QVEYALESIS HAGTAIGIMA SDGIVLAAER KVTSTLLEQD
TSTEKLYKLN DKIAVAVAGL TADAEILINT ARIHAQNYLK TYNEDIPVEI LVRRLSDIKQ
GYTQHGGLRP FGVSFIYAGY DDRYGYQLYT SNPSGNYTGW KAISVGANTS AAQTLLQMDY
KDDMKVDDAI ELALKTLSKT TDSSALTYDR LEFATIRKGA NDGEVYQKIF KPQEIKDILV
KTGITKKDED EEADEDMK
