PSA5_YEAST
ID PSA5_YEAST Reviewed; 260 AA.
AC P32379; D6VV33;
DT 01-OCT-1993, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-1996, sequence version 2.
DT 03-AUG-2022, entry version 223.
DE RecName: Full=Proteasome subunit alpha type-5;
DE AltName: Full=Macropain subunit PUP2;
DE AltName: Full=Multicatalytic endopeptidase complex subunit PUP2;
DE AltName: Full=Proteasome component PUP2;
DE AltName: Full=Proteinase YSCE subunit PUP2;
GN Name=PUP2; Synonyms=DOA5; OrderedLocusNames=YGR253C; ORFNames=G9155;
OS Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Saccharomycetaceae; Saccharomyces.
OX NCBI_TaxID=559292;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=1544471; DOI=10.1016/0014-5793(92)80095-x;
RA Georgatsou E., Georgakopoulos T., Thireos G.;
RT "Molecular cloning of an essential yeast gene encoding a proteasomal
RT subunit.";
RL FEBS Lett. 299:39-43(1992).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND MUTAGENESIS OF GLY-49.
RX PubMed=7781614; DOI=10.1002/j.1460-2075.1995.tb07260.x;
RA Chen P., Hochstrasser M.;
RT "Biogenesis, structure and function of the yeast 20S proteasome.";
RL EMBO J. 14:2620-2630(1995).
RN [3]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=9133741;
RX DOI=10.1002/(sici)1097-0061(19970330)13:4<369::aid-yea81>3.0.co;2-v;
RA Mazzoni C., Ruzzi M., Rinaldi T., Solinas F., Montebove F., Frontali L.;
RT "Sequence analysis of a 10.5 kb DNA fragment from the yeast chromosome VII
RT reveals the presence of three new open reading frames and of a tRNAThr
RT gene.";
RL Yeast 13:369-372(1997).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=9169869;
RA Tettelin H., Agostoni-Carbone M.L., Albermann K., Albers M., Arroyo J.,
RA Backes U., Barreiros T., Bertani I., Bjourson A.J., Brueckner M.,
RA Bruschi C.V., Carignani G., Castagnoli L., Cerdan E., Clemente M.L.,
RA Coblenz A., Coglievina M., Coissac E., Defoor E., Del Bino S., Delius H.,
RA Delneri D., de Wergifosse P., Dujon B., Durand P., Entian K.-D., Eraso P.,
RA Escribano V., Fabiani L., Fartmann B., Feroli F., Feuermann M.,
RA Frontali L., Garcia-Gonzalez M., Garcia-Saez M.I., Goffeau A.,
RA Guerreiro P., Hani J., Hansen M., Hebling U., Hernandez K., Heumann K.,
RA Hilger F., Hofmann B., Indge K.J., James C.M., Klima R., Koetter P.,
RA Kramer B., Kramer W., Lauquin G., Leuther H., Louis E.J., Maillier E.,
RA Marconi A., Martegani E., Mazon M.J., Mazzoni C., McReynolds A.D.K.,
RA Melchioretto P., Mewes H.-W., Minenkova O., Mueller-Auer S., Nawrocki A.,
RA Netter P., Neu R., Nombela C., Oliver S.G., Panzeri L., Paoluzi S.,
RA Plevani P., Portetelle D., Portillo F., Potier S., Purnelle B., Rieger M.,
RA Riles L., Rinaldi T., Robben J., Rodrigues-Pousada C.,
RA Rodriguez-Belmonte E., Rodriguez-Torres A.M., Rose M., Ruzzi M.,
RA Saliola M., Sanchez-Perez M., Schaefer B., Schaefer M., Scharfe M.,
RA Schmidheini T., Schreer A., Skala J., Souciet J.-L., Steensma H.Y.,
RA Talla E., Thierry A., Vandenbol M., van der Aart Q.J.M., Van Dyck L.,
RA Vanoni M., Verhasselt P., Voet M., Volckaert G., Wambutt R., Watson M.D.,
RA Weber N., Wedler E., Wedler H., Wipfli P., Wolf K., Wright L.F.,
RA Zaccaria P., Zimmermann M., Zollner A., Kleine K.;
RT "The nucleotide sequence of Saccharomyces cerevisiae chromosome VII.";
RL Nature 387:81-84(1997).
RN [5]
RP GENOME REANNOTATION.
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=24374639; DOI=10.1534/g3.113.008995;
RA Engel S.R., Dietrich F.S., Fisk D.G., Binkley G., Balakrishnan R.,
RA Costanzo M.C., Dwight S.S., Hitz B.C., Karra K., Nash R.S., Weng S.,
RA Wong E.D., Lloyd P., Skrzypek M.S., Miyasato S.R., Simison M., Cherry J.M.;
RT "The reference genome sequence of Saccharomyces cerevisiae: Then and now.";
RL G3 (Bethesda) 4:389-398(2014).
RN [6]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=17322287; DOI=10.1101/gr.6037607;
RA Hu Y., Rolfs A., Bhullar B., Murthy T.V.S., Zhu C., Berger M.F.,
RA Camargo A.A., Kelley F., McCarron S., Jepson D., Richardson A., Raphael J.,
RA Moreira D., Taycher E., Zuo D., Mohr S., Kane M.F., Williamson J.,
RA Simpson A.J.G., Bulyk M.L., Harlow E., Marsischky G., Kolodner R.D.,
RA LaBaer J.;
RT "Approaching a complete repository of sequence-verified protein-encoding
RT clones for Saccharomyces cerevisiae.";
RL Genome Res. 17:536-543(2007).
RN [7]
RP LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
RX PubMed=14562106; DOI=10.1038/nature02046;
RA Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N.,
RA O'Shea E.K., Weissman J.S.;
RT "Global analysis of protein expression in yeast.";
RL Nature 425:737-741(2003).
RN [8]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-55; SER-56 AND SER-251, AND
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC STRAIN=ADR376;
RX PubMed=17330950; DOI=10.1021/pr060559j;
RA Li X., Gerber S.A., Rudner A.D., Beausoleil S.A., Haas W., Villen J.,
RA Elias J.E., Gygi S.P.;
RT "Large-scale phosphorylation analysis of alpha-factor-arrested
RT Saccharomyces cerevisiae.";
RL J. Proteome Res. 6:1190-1197(2007).
RN [9]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-251, AND IDENTIFICATION BY
RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=18407956; DOI=10.1074/mcp.m700468-mcp200;
RA Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.;
RT "A multidimensional chromatography technology for in-depth phosphoproteome
RT analysis.";
RL Mol. Cell. Proteomics 7:1389-1396(2008).
RN [10]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-251, AND IDENTIFICATION BY
RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=19779198; DOI=10.1126/science.1172867;
RA Holt L.J., Tuch B.B., Villen J., Johnson A.D., Gygi S.P., Morgan D.O.;
RT "Global analysis of Cdk1 substrate phosphorylation sites provides insights
RT into evolution.";
RL Science 325:1682-1686(2009).
RN [11]
RP X-RAY CRYSTALLOGRAPHY (1.9 ANGSTROMS) OF 9-250 OF COMPLEX WITH THE 20S
RP PROTEASOME.
RX PubMed=9087403; DOI=10.1038/386463a0;
RA Groll M., Ditzel L., Loewe J., Stock D., Bochtler M., Bartunik H.D.,
RA Huber R.;
RT "Structure of 20S proteasome from yeast at 2.4-A resolution.";
RL Nature 386:463-471(1997).
RN [12]
RP X-RAY CRYSTALLOGRAPHY (3.2 ANGSTROMS).
RX PubMed=11081519; DOI=10.1038/35040607;
RA Whitby F.G., Masters E.I., Kramer L., Knowlton J.R., Yao Y., Wang C.C.,
RA Hill C.P.;
RT "Structural basis for the activation of 20S proteasomes by 11S
RT regulators.";
RL Nature 408:115-120(2000).
RN [13]
RP X-RAY CRYSTALLOGRAPHY (2.4 ANGSTROMS) OF 1-250 OF COMPLEX WITH THE 20S
RP PROTEASOME.
RX PubMed=11062564; DOI=10.1038/80992;
RA Groll M., Bajorek M., Koehler A., Moroder L., Rubin D.M., Huber R.,
RA Glickman M.H., Finley D.;
RT "A gated channel into the proteasome core particle.";
RL Nat. Struct. Biol. 7:1062-1067(2000).
RN [14]
RP X-RAY CRYSTALLOGRAPHY (3.0 ANGSTROMS) OF 9-250 OF COMPLEX WITH THE 20S
RP PROTEASOME.
RX PubMed=11493007; DOI=10.1006/jmbi.2001.4869;
RA Groll M., Koguchi Y., Huber R., Kohno J.;
RT "Crystal structure of the 20 S proteasome:TMC-95A complex: a non-covalent
RT proteasome inhibitor.";
RL J. Mol. Biol. 311:543-548(2001).
RN [15]
RP X-RAY CRYSTALLOGRAPHY (2.81 ANGSTROMS) OF 9-250 OF COMPLEX WITH THE 20S
RP PROTEASOME.
RX PubMed=16793518; DOI=10.1016/j.chembiol.2006.04.005;
RA Groll M., Goetz M., Kaiser M., Weyher E., Moroder L.;
RT "TMC-95-based inhibitor design provides evidence for the catalytic
RT versatility of the proteasome.";
RL Chem. Biol. 13:607-614(2006).
RN [16]
RP X-RAY CRYSTALLOGRAPHY (2.8 ANGSTROMS) OF 9-250 OF COMPLEX WITH THE 20S
RP PROTEASOME.
RX PubMed=16608349; DOI=10.1021/ja058320b;
RA Groll M., Huber R., Potts B.C.M.;
RT "Crystal structures of salinosporamide A (NPI-0052) and B (NPI-0047) in
RT complex with the 20S proteasome reveal important consequences of beta-
RT lactone ring opening and a mechanism for irreversible binding.";
RL J. Am. Chem. Soc. 128:5136-5141(2006).
RN [17]
RP X-RAY CRYSTALLOGRAPHY (2.8 ANGSTROMS) OF 9-250 OF COMPLEX WITH THE 20S
RP PROTEASOME.
RX PubMed=16531229; DOI=10.1016/j.str.2005.11.019;
RA Groll M., Berkers C.R., Ploegh H.L., Ovaa H.;
RT "Crystal structure of the boronic acid-based proteasome inhibitor
RT bortezomib in complex with the yeast 20S proteasome.";
RL Structure 14:451-456(2006).
RN [18]
RP X-RAY CRYSTALLOGRAPHY (3.0 ANGSTROMS) OF 1-250 IN COMPLEX WITH THE
RP PROTEASOME.
RX PubMed=20227375; DOI=10.1016/j.molcel.2010.02.002;
RA Sadre-Bazzaz K., Whitby F.G., Robinson H., Formosa T., Hill C.P.;
RT "Structure of a Blm10 complex reveals common mechanisms for proteasome
RT binding and gate opening.";
RL Mol. Cell 37:728-735(2010).
RN [19]
RP STRUCTURE BY ELECTRON MICROSCOPY (7.4 ANGSTROMS) OF THE 26S PROTEASOME.
RX PubMed=22927375; DOI=10.1073/pnas.1213333109;
RA Beck F., Unverdorben P., Bohn S., Schweitzer A., Pfeifer G., Sakata E.,
RA Nickell S., Plitzko J.M., Villa E., Baumeister W., Forster F.;
RT "Near-atomic resolution structural model of the yeast 26S proteasome.";
RL Proc. Natl. Acad. Sci. U.S.A. 109:14870-14875(2012).
CC -!- FUNCTION: The proteasome degrades poly-ubiquitinated proteins in the
CC cytoplasm and in the nucleus. It is essential for the regulated
CC turnover of proteins and for the removal of misfolded proteins. The
CC proteasome is a multicatalytic proteinase complex that is characterized
CC by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu
CC adjacent to the leaving group at neutral or slightly basic pH. It has
CC an ATP-dependent proteolytic activity.
CC -!- SUBUNIT: The 26S proteasome consists of a 20S proteasome core and two
CC 19S regulatory subunits. The 20S proteasome core is composed of 28
CC subunits that are arranged in four stacked rings, resulting in a
CC barrel-shaped structure. The two end rings are each formed by seven
CC alpha subunits, and the two central rings are each formed by seven beta
CC subunits. The catalytic chamber with the active sites is on the inside
CC of the barrel. {ECO:0000269|PubMed:20227375}.
CC -!- INTERACTION:
CC P32379; Q12245: POC4; NbExp=2; IntAct=EBI-13971, EBI-2343020;
CC -!- SUBCELLULAR LOCATION: Cytoplasm. Nucleus.
CC -!- MISCELLANEOUS: Present with 17100 molecules/cell in log phase SD
CC medium. {ECO:0000269|PubMed:14562106}.
CC -!- SIMILARITY: Belongs to the peptidase T1A family. {ECO:0000255|PROSITE-
CC ProRule:PRU00808}.
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DR EMBL; X64918; CAA46111.1; -; Genomic_DNA.
DR EMBL; X99228; CAA67615.1; -; Genomic_DNA.
DR EMBL; Z73038; CAA97282.1; -; Genomic_DNA.
DR EMBL; AY558511; AAS56837.1; -; Genomic_DNA.
DR EMBL; BK006941; DAA08344.1; -; Genomic_DNA.
DR PIR; S64585; S64585.
DR RefSeq; NP_011769.1; NM_001181382.1.
DR PDB; 1FNT; X-ray; 3.20 A; E/S=1-260.
DR PDB; 1G0U; X-ray; 2.40 A; D/R=1-250.
DR PDB; 1G65; X-ray; 2.25 A; D/R=9-250.
DR PDB; 1JD2; X-ray; 3.00 A; D/Y=9-120, D/Y=131-250.
DR PDB; 1RYP; X-ray; 1.90 A; E/S=9-250.
DR PDB; 1Z7Q; X-ray; 3.22 A; E/S=1-260.
DR PDB; 2F16; X-ray; 2.80 A; D/R=9-250.
DR PDB; 2FAK; X-ray; 2.80 A; D/R=9-250.
DR PDB; 2GPL; X-ray; 2.81 A; D/R=9-250.
DR PDB; 2Z5C; X-ray; 2.90 A; C/F=1-260.
DR PDB; 2ZCY; X-ray; 2.90 A; D/R=1-260.
DR PDB; 3BDM; X-ray; 2.70 A; D/R=1-260.
DR PDB; 3D29; X-ray; 2.60 A; D/R=9-250.
DR PDB; 3DY3; X-ray; 2.81 A; D/R=9-250.
DR PDB; 3DY4; X-ray; 2.80 A; D/R=9-250.
DR PDB; 3E47; X-ray; 3.00 A; D/R=9-250.
DR PDB; 3GPJ; X-ray; 2.70 A; D/R=9-250.
DR PDB; 3GPT; X-ray; 2.41 A; D/R=9-250.
DR PDB; 3GPW; X-ray; 2.50 A; D/R=9-250.
DR PDB; 3HYE; X-ray; 2.50 A; D/R=9-250.
DR PDB; 3JCO; EM; 4.80 A; E/e=1-260.
DR PDB; 3JCP; EM; 4.60 A; E/e=1-260.
DR PDB; 3MG0; X-ray; 2.68 A; D/R=9-250.
DR PDB; 3MG4; X-ray; 3.11 A; D/R=9-250.
DR PDB; 3MG6; X-ray; 2.60 A; D/R=1-250.
DR PDB; 3MG7; X-ray; 2.78 A; D/R=1-250.
DR PDB; 3MG8; X-ray; 2.59 A; D/R=1-250.
DR PDB; 3NZJ; X-ray; 2.40 A; D/R=1-260.
DR PDB; 3NZW; X-ray; 2.50 A; D/R=1-260.
DR PDB; 3NZX; X-ray; 2.70 A; D/R=1-260.
DR PDB; 3OEU; X-ray; 2.60 A; D/R=1-260.
DR PDB; 3OEV; X-ray; 2.85 A; D/R=1-260.
DR PDB; 3OKJ; X-ray; 2.70 A; D/R=9-250.
DR PDB; 3SDI; X-ray; 2.65 A; D/R=1-260.
DR PDB; 3SDK; X-ray; 2.70 A; D/R=1-260.
DR PDB; 3SHJ; X-ray; 2.80 A; D/R=9-250.
DR PDB; 3TDD; X-ray; 2.70 A; D/R=9-250.
DR PDB; 3UN4; X-ray; 3.40 A; D/R=1-260.
DR PDB; 3UN8; X-ray; 2.70 A; D/R=1-260.
DR PDB; 3WXR; X-ray; 3.15 A; E/S=1-260.
DR PDB; 4CR2; EM; 7.70 A; E=1-260.
DR PDB; 4CR3; EM; 9.30 A; E=1-260.
DR PDB; 4CR4; EM; 8.80 A; E=1-260.
DR PDB; 4EU2; X-ray; 2.51 A; E/S=9-250.
DR PDB; 4FZC; X-ray; 2.80 A; D/R=9-250.
DR PDB; 4FZG; X-ray; 3.00 A; D/R=9-250.
DR PDB; 4G4S; X-ray; 2.49 A; E=1-260.
DR PDB; 4GK7; X-ray; 2.80 A; D/R=9-250.
DR PDB; 4HNP; X-ray; 2.80 A; D/R=9-250.
DR PDB; 4HRC; X-ray; 2.80 A; D/R=9-250.
DR PDB; 4HRD; X-ray; 2.80 A; D/R=9-250.
DR PDB; 4INR; X-ray; 2.70 A; D/R=1-260.
DR PDB; 4INT; X-ray; 2.90 A; D/R=1-260.
DR PDB; 4INU; X-ray; 3.10 A; D/R=1-260.
DR PDB; 4J70; X-ray; 2.80 A; D/R=1-260.
DR PDB; 4JSQ; X-ray; 2.80 A; D/R=1-260.
DR PDB; 4JSU; X-ray; 2.90 A; D/R=1-260.
DR PDB; 4JT0; X-ray; 3.10 A; D/R=1-260.
DR PDB; 4LQI; X-ray; 2.70 A; D/R=9-250.
DR PDB; 4LTC; X-ray; 2.50 A; D/R=1-260.
DR PDB; 4NNN; X-ray; 2.50 A; D/R=1-260.
DR PDB; 4NNW; X-ray; 2.60 A; D/R=1-260.
DR PDB; 4NO1; X-ray; 2.50 A; D/R=1-260.
DR PDB; 4NO6; X-ray; 3.00 A; D/R=1-260.
DR PDB; 4NO8; X-ray; 2.70 A; D/R=1-260.
DR PDB; 4NO9; X-ray; 2.90 A; D/R=1-260.
DR PDB; 4Q1S; X-ray; 2.60 A; D/R=1-260.
DR PDB; 4QBY; X-ray; 3.00 A; D/R=1-260.
DR PDB; 4QLQ; X-ray; 2.40 A; D/R=1-260.
DR PDB; 4QLS; X-ray; 2.80 A; D/R=1-260.
DR PDB; 4QLT; X-ray; 2.80 A; D/R=1-260.
DR PDB; 4QLU; X-ray; 2.80 A; D/R=1-260.
DR PDB; 4QLV; X-ray; 2.90 A; D/R=1-260.
DR PDB; 4QUX; X-ray; 3.00 A; D/R=1-260.
DR PDB; 4QUY; X-ray; 2.80 A; D/R=1-260.
DR PDB; 4QV0; X-ray; 3.10 A; D/R=1-260.
DR PDB; 4QV1; X-ray; 2.50 A; D/R=1-260.
DR PDB; 4QV3; X-ray; 3.00 A; D/R=1-260.
DR PDB; 4QV4; X-ray; 2.70 A; D/R=1-260.
DR PDB; 4QV5; X-ray; 2.70 A; D/R=1-260.
DR PDB; 4QV6; X-ray; 2.80 A; D/R=1-260.
DR PDB; 4QV7; X-ray; 2.60 A; D/R=1-260.
DR PDB; 4QV8; X-ray; 2.90 A; D/R=1-260.
DR PDB; 4QV9; X-ray; 2.60 A; D/R=1-260.
DR PDB; 4QVL; X-ray; 2.80 A; D/R=1-260.
DR PDB; 4QVM; X-ray; 2.80 A; D/R=1-260.
DR PDB; 4QVN; X-ray; 2.90 A; D/R=1-260.
DR PDB; 4QVP; X-ray; 2.30 A; D/R=1-260.
DR PDB; 4QVQ; X-ray; 2.60 A; D/R=1-260.
DR PDB; 4QVV; X-ray; 2.80 A; D/R=1-260.
DR PDB; 4QVW; X-ray; 3.00 A; D/R=1-260.
DR PDB; 4QVY; X-ray; 2.51 A; D/R=1-260.
DR PDB; 4QW0; X-ray; 2.90 A; D/R=1-260.
DR PDB; 4QW1; X-ray; 2.90 A; D/R=1-260.
DR PDB; 4QW3; X-ray; 2.90 A; D/R=1-260.
DR PDB; 4QW4; X-ray; 2.80 A; D/R=1-260.
DR PDB; 4QW5; X-ray; 3.00 A; D/R=1-260.
DR PDB; 4QW6; X-ray; 2.90 A; D/R=1-260.
DR PDB; 4QW7; X-ray; 2.70 A; D/R=1-260.
DR PDB; 4QWF; X-ray; 3.00 A; D/R=1-260.
DR PDB; 4QWG; X-ray; 2.60 A; D/R=1-260.
DR PDB; 4QWI; X-ray; 2.60 A; D/R=1-260.
DR PDB; 4QWJ; X-ray; 2.90 A; D/R=1-260.
DR PDB; 4QWK; X-ray; 2.80 A; D/R=1-260.
DR PDB; 4QWL; X-ray; 2.60 A; D/R=1-260.
DR PDB; 4QWR; X-ray; 2.90 A; D/R=1-260.
DR PDB; 4QWS; X-ray; 3.00 A; D/R=1-260.
DR PDB; 4QWU; X-ray; 3.00 A; D/R=1-260.
DR PDB; 4QWX; X-ray; 2.90 A; D/R=1-260.
DR PDB; 4QXJ; X-ray; 2.80 A; D/R=1-260.
DR PDB; 4QZ0; X-ray; 3.00 A; D/R=1-260.
DR PDB; 4QZ1; X-ray; 3.00 A; D/R=1-260.
DR PDB; 4QZ2; X-ray; 2.70 A; D/R=1-260.
DR PDB; 4QZ3; X-ray; 2.80 A; D/R=1-260.
DR PDB; 4QZ4; X-ray; 3.00 A; D/R=1-260.
DR PDB; 4QZ5; X-ray; 2.80 A; D/R=1-260.
DR PDB; 4QZ6; X-ray; 2.90 A; D/R=1-260.
DR PDB; 4QZ7; X-ray; 2.80 A; D/R=1-260.
DR PDB; 4QZW; X-ray; 3.00 A; D/R=1-260.
DR PDB; 4QZX; X-ray; 2.60 A; D/R=1-260.
DR PDB; 4QZZ; X-ray; 2.90 A; D/R=1-260.
DR PDB; 4R00; X-ray; 2.80 A; D/R=1-260.
DR PDB; 4R02; X-ray; 2.50 A; D/R=1-260.
DR PDB; 4R17; X-ray; 2.10 A; D/R=1-260.
DR PDB; 4R18; X-ray; 2.40 A; D/R=1-260.
DR PDB; 4RUR; X-ray; 2.50 A; D/R=1-260.
DR PDB; 4V7O; X-ray; 3.00 A; AJ/AV/BE/BS=1-250.
DR PDB; 4X6Z; X-ray; 2.70 A; E/S=1-260.
DR PDB; 4Y69; X-ray; 2.90 A; D/R=1-260.
DR PDB; 4Y6A; X-ray; 2.60 A; D/R=1-260.
DR PDB; 4Y6V; X-ray; 2.80 A; D/R=1-260.
DR PDB; 4Y6Z; X-ray; 2.70 A; D/R=1-260.
DR PDB; 4Y70; X-ray; 2.40 A; D/R=1-260.
DR PDB; 4Y74; X-ray; 2.70 A; D/R=1-260.
DR PDB; 4Y75; X-ray; 2.80 A; D/R=1-260.
DR PDB; 4Y77; X-ray; 2.50 A; D/R=1-260.
DR PDB; 4Y78; X-ray; 2.80 A; D/R=1-260.
DR PDB; 4Y7W; X-ray; 2.50 A; D/R=1-260.
DR PDB; 4Y7X; X-ray; 2.60 A; D/R=1-260.
DR PDB; 4Y7Y; X-ray; 2.40 A; D/R=1-260.
DR PDB; 4Y80; X-ray; 2.50 A; D/R=1-260.
DR PDB; 4Y81; X-ray; 2.80 A; D/R=1-260.
DR PDB; 4Y82; X-ray; 2.80 A; D/R=1-260.
DR PDB; 4Y84; X-ray; 2.70 A; D/R=1-260.
DR PDB; 4Y8G; X-ray; 2.60 A; D/R=1-260.
DR PDB; 4Y8H; X-ray; 2.50 A; D/R=1-260.
DR PDB; 4Y8I; X-ray; 2.60 A; D/R=1-260.
DR PDB; 4Y8J; X-ray; 2.70 A; D/R=1-260.
DR PDB; 4Y8K; X-ray; 2.60 A; D/R=1-260.
DR PDB; 4Y8L; X-ray; 2.40 A; D/R=1-260.
DR PDB; 4Y8M; X-ray; 2.80 A; D/R=1-260.
DR PDB; 4Y8N; X-ray; 2.60 A; D/R=1-260.
DR PDB; 4Y8O; X-ray; 2.70 A; D/R=1-260.
DR PDB; 4Y8P; X-ray; 2.80 A; D/R=1-260.
DR PDB; 4Y8Q; X-ray; 2.60 A; D/R=1-260.
DR PDB; 4Y8R; X-ray; 2.70 A; D/R=1-260.
DR PDB; 4Y8S; X-ray; 2.70 A; D/R=1-260.
DR PDB; 4Y8T; X-ray; 2.70 A; D/R=1-260.
DR PDB; 4Y8U; X-ray; 2.90 A; D/R=1-260.
DR PDB; 4Y9Y; X-ray; 2.80 A; D/R=1-260.
DR PDB; 4Y9Z; X-ray; 2.80 A; D/R=1-260.
DR PDB; 4YA0; X-ray; 2.80 A; D/R=1-260.
DR PDB; 4YA1; X-ray; 2.90 A; D/R=1-260.
DR PDB; 4YA2; X-ray; 2.70 A; D/R=1-260.
DR PDB; 4YA3; X-ray; 2.70 A; D/R=1-260.
DR PDB; 4YA4; X-ray; 2.90 A; D/R=1-260.
DR PDB; 4YA5; X-ray; 2.50 A; D/R=1-260.
DR PDB; 4YA7; X-ray; 2.70 A; D/R=1-260.
DR PDB; 4YA9; X-ray; 2.70 A; D/R=1-260.
DR PDB; 4Z1L; X-ray; 3.00 A; D/R=1-260.
DR PDB; 5A5B; EM; 9.50 A; E=1-260.
DR PDB; 5AHJ; X-ray; 2.80 A; D/R=1-260.
DR PDB; 5BOU; X-ray; 2.60 A; D/R=1-260.
DR PDB; 5BXL; X-ray; 2.80 A; D/R=1-260.
DR PDB; 5BXN; X-ray; 2.80 A; D/R=1-260.
DR PDB; 5CGF; X-ray; 2.80 A; D/R=1-260.
DR PDB; 5CGG; X-ray; 2.90 A; D/R=1-260.
DR PDB; 5CGH; X-ray; 2.50 A; D/R=1-260.
DR PDB; 5CGI; X-ray; 2.80 A; D/R=1-260.
DR PDB; 5CZ4; X-ray; 2.30 A; D/R=1-260.
DR PDB; 5CZ5; X-ray; 2.80 A; D/R=1-260.
DR PDB; 5CZ6; X-ray; 2.70 A; D/R=1-260.
DR PDB; 5CZ7; X-ray; 2.50 A; D/R=1-260.
DR PDB; 5CZ8; X-ray; 2.80 A; D/R=1-260.
DR PDB; 5CZ9; X-ray; 2.90 A; D/R=1-260.
DR PDB; 5CZA; X-ray; 2.50 A; D/R=1-260.
DR PDB; 5D0S; X-ray; 2.50 A; D/R=1-260.
DR PDB; 5D0T; X-ray; 2.60 A; D/R=1-260.
DR PDB; 5D0V; X-ray; 2.90 A; D/R=1-260.
DR PDB; 5D0W; X-ray; 2.80 A; D/R=1-260.
DR PDB; 5D0X; X-ray; 2.60 A; D/R=1-260.
DR PDB; 5D0Z; X-ray; 2.90 A; D/R=1-260.
DR PDB; 5DKI; X-ray; 2.80 A; D/R=1-260.
DR PDB; 5DKJ; X-ray; 2.80 A; D/R=1-260.
DR PDB; 5FG7; X-ray; 2.70 A; D/R=1-260.
DR PDB; 5FG9; X-ray; 2.60 A; D/R=1-260.
DR PDB; 5FGA; X-ray; 2.70 A; D/R=1-260.
DR PDB; 5FGD; X-ray; 2.80 A; D/R=1-260.
DR PDB; 5FGE; X-ray; 2.60 A; D/R=1-260.
DR PDB; 5FGF; X-ray; 2.60 A; D/R=1-260.
DR PDB; 5FGG; X-ray; 2.70 A; D/R=1-260.
DR PDB; 5FGH; X-ray; 2.80 A; D/R=1-260.
DR PDB; 5FGI; X-ray; 2.90 A; D/R=1-260.
DR PDB; 5FHS; X-ray; 2.70 A; D/R=1-260.
DR PDB; 5JHR; X-ray; 2.90 A; D/R=1-260.
DR PDB; 5JHS; X-ray; 3.00 A; D/R=1-260.
DR PDB; 5L52; X-ray; 2.70 A; D/R=1-260.
DR PDB; 5L54; X-ray; 2.80 A; D/R=1-260.
DR PDB; 5L55; X-ray; 2.90 A; D/R=1-260.
DR PDB; 5L5A; X-ray; 2.40 A; D/R=1-260.
DR PDB; 5L5B; X-ray; 2.80 A; D/R=1-260.
DR PDB; 5L5D; X-ray; 2.80 A; D/R=1-260.
DR PDB; 5L5E; X-ray; 2.90 A; D/R=1-260.
DR PDB; 5L5F; X-ray; 2.50 A; D/R=1-260.
DR PDB; 5L5H; X-ray; 2.60 A; D/R=1-260.
DR PDB; 5L5I; X-ray; 2.90 A; D/R=1-260.
DR PDB; 5L5J; X-ray; 2.90 A; D/R=1-260.
DR PDB; 5L5O; X-ray; 2.60 A; D/R=1-260.
DR PDB; 5L5P; X-ray; 2.80 A; D/R=1-260.
DR PDB; 5L5Q; X-ray; 2.80 A; D/R=1-260.
DR PDB; 5L5R; X-ray; 2.90 A; D/R=1-260.
DR PDB; 5L5S; X-ray; 2.60 A; D/R=1-260.
DR PDB; 5L5T; X-ray; 2.90 A; D/R=1-260.
DR PDB; 5L5U; X-ray; 2.60 A; D/R=1-260.
DR PDB; 5L5V; X-ray; 2.70 A; D/R=1-260.
DR PDB; 5L5W; X-ray; 2.80 A; D/R=1-260.
DR PDB; 5L5X; X-ray; 2.90 A; D/R=1-260.
DR PDB; 5L5Y; X-ray; 2.70 A; D/R=1-260.
DR PDB; 5L5Z; X-ray; 2.70 A; D/R=1-260.
DR PDB; 5L60; X-ray; 2.70 A; D/R=1-260.
DR PDB; 5L61; X-ray; 2.80 A; D/R=1-260.
DR PDB; 5L62; X-ray; 2.80 A; D/R=1-260.
DR PDB; 5L63; X-ray; 2.70 A; D/R=1-260.
DR PDB; 5L64; X-ray; 2.70 A; D/R=1-260.
DR PDB; 5L65; X-ray; 2.90 A; D/R=1-260.
DR PDB; 5L66; X-ray; 2.80 A; D/R=1-260.
DR PDB; 5L67; X-ray; 2.60 A; D/R=1-260.
DR PDB; 5L68; X-ray; 2.80 A; D/R=1-260.
DR PDB; 5L69; X-ray; 2.70 A; D/R=1-260.
DR PDB; 5L6A; X-ray; 2.80 A; D/R=1-260.
DR PDB; 5L6B; X-ray; 2.60 A; D/R=1-260.
DR PDB; 5L6C; X-ray; 2.60 A; D/R=1-260.
DR PDB; 5LAI; X-ray; 2.50 A; D/R=1-260.
DR PDB; 5LAJ; X-ray; 2.90 A; D/R=1-260.
DR PDB; 5LTT; X-ray; 2.70 A; D/R=1-260.
DR PDB; 5M2B; X-ray; 2.70 A; D/R=1-260.
DR PDB; 5MP9; EM; 4.10 A; E/e=1-260.
DR PDB; 5MPA; EM; 4.50 A; E/e=1-260.
DR PDB; 5MPB; EM; 7.80 A; E/e=1-260.
DR PDB; 5MPC; EM; 7.70 A; E/e=1-260.
DR PDB; 5NIF; X-ray; 3.00 A; E/S=1-260.
DR PDB; 5WVI; EM; 6.30 A; E/m=1-260.
DR PDB; 5WVK; EM; 4.20 A; E/m=1-260.
DR PDB; 6EF0; EM; 4.43 A; E=1-249.
DR PDB; 6EF1; EM; 4.73 A; E=9-250.
DR PDB; 6EF2; EM; 4.27 A; E=2-248.
DR PDB; 6EF3; EM; 4.17 A; E=1-260.
DR PDB; 6FVT; EM; 4.10 A; E/e=7-250.
DR PDB; 6FVU; EM; 4.50 A; E/e=2-250.
DR PDB; 6FVV; EM; 5.40 A; E/e=7-250.
DR PDB; 6FVW; EM; 4.50 A; E/e=6-250.
DR PDB; 6FVX; EM; 4.90 A; E/e=7-250.
DR PDB; 6FVY; EM; 6.10 A; E/e=6-250.
DR PDB; 6G7F; X-ray; 2.70 A; D/R=1-260.
DR PDB; 6G8M; X-ray; 2.70 A; D/R=1-260.
DR PDB; 6G8N; X-ray; 3.00 A; D/R=1-260.
DR PDB; 6GOP; X-ray; 2.90 A; D/R=1-260.
DR PDB; 6H39; X-ray; 2.50 A; D/R=1-260.
DR PDB; 6HTB; X-ray; 2.70 A; D/R=1-260.
DR PDB; 6HTC; X-ray; 2.80 A; D/R=1-260.
DR PDB; 6HTD; X-ray; 3.00 A; D/R=1-260.
DR PDB; 6HTP; X-ray; 3.00 A; D/R=1-260.
DR PDB; 6HTR; X-ray; 2.60 A; D/R=1-260.
DR PDB; 6HUB; X-ray; 2.90 A; D/R=1-260.
DR PDB; 6HUC; X-ray; 3.00 A; D/R=1-260.
DR PDB; 6HUQ; X-ray; 3.00 A; D/R=1-260.
DR PDB; 6HUU; X-ray; 2.80 A; D/R=1-260.
DR PDB; 6HUV; X-ray; 3.10 A; D/R=1-260.
DR PDB; 6HV3; X-ray; 2.70 A; D/R=1-260.
DR PDB; 6HV4; X-ray; 3.00 A; D/R=1-260.
DR PDB; 6HV5; X-ray; 3.00 A; D/R=1-260.
DR PDB; 6HV7; X-ray; 3.40 A; D/R=1-260.
DR PDB; 6HVA; X-ray; 2.90 A; D/R=1-260.
DR PDB; 6HVR; X-ray; 2.70 A; D/R=1-260.
DR PDB; 6HVS; X-ray; 3.10 A; D/R=1-260.
DR PDB; 6HVT; X-ray; 2.90 A; D/R=1-260.
DR PDB; 6HVU; X-ray; 2.90 A; D/R=1-260.
DR PDB; 6HVV; X-ray; 2.70 A; D/R=1-260.
DR PDB; 6HVW; X-ray; 3.00 A; D/R=1-260.
DR PDB; 6HVX; X-ray; 2.80 A; D/R=1-260.
DR PDB; 6HVY; X-ray; 2.70 A; D/R=1-260.
DR PDB; 6HW0; X-ray; 2.80 A; D/R=1-260.
DR PDB; 6HW3; X-ray; 2.60 A; D/R=1-260.
DR PDB; 6HW4; X-ray; 2.90 A; D/R=1-260.
DR PDB; 6HW5; X-ray; 2.90 A; D/R=1-260.
DR PDB; 6HW6; X-ray; 2.70 A; D/R=1-260.
DR PDB; 6HW7; X-ray; 2.70 A; D/R=1-260.
DR PDB; 6HW8; X-ray; 2.80 A; D/R=1-260.
DR PDB; 6HW9; X-ray; 2.80 A; D/R=1-260.
DR PDB; 6HWA; X-ray; 2.80 A; D/R=1-260.
DR PDB; 6HWB; X-ray; 2.60 A; D/R=1-260.
DR PDB; 6HWC; X-ray; 2.80 A; D/R=1-260.
DR PDB; 6HWD; X-ray; 2.80 A; D/R=1-260.
DR PDB; 6HWE; X-ray; 2.30 A; D/R=1-260.
DR PDB; 6HWF; X-ray; 2.50 A; D/R=1-260.
DR PDB; 6J2C; EM; 7.00 A; E/m=1-260.
DR PDB; 6J2N; EM; 7.50 A; E/m=1-260.
DR PDB; 6J2Q; EM; 3.80 A; E/m=1-260.
DR PDB; 6J2X; EM; 3.80 A; E/m=1-260.
DR PDB; 6J30; EM; 4.50 A; E/m=1-260.
DR PDB; 6ZOU; X-ray; 2.90 A; D/R=1-260.
DR PDB; 6ZP6; X-ray; 2.80 A; D/R=1-260.
DR PDB; 6ZP8; X-ray; 3.00 A; D/R=1-260.
DR PDB; 7LS5; EM; 2.74 A; E/S=1-260.
DR PDB; 7LS6; EM; 3.17 A; E=1-260.
DR PDB; 7LSX; EM; 3.61 A; E=1-260.
DR PDB; 7O2L; X-ray; 3.00 A; D/R=1-260.
DR PDB; 7QO3; EM; 6.10 A; E/e=1-260.
DR PDB; 7QO5; EM; 6.00 A; E/e=1-260.
DR PDBsum; 1FNT; -.
DR PDBsum; 1G0U; -.
DR PDBsum; 1G65; -.
DR PDBsum; 1JD2; -.
DR PDBsum; 1RYP; -.
DR PDBsum; 1Z7Q; -.
DR PDBsum; 2F16; -.
DR PDBsum; 2FAK; -.
DR PDBsum; 2GPL; -.
DR PDBsum; 2Z5C; -.
DR PDBsum; 2ZCY; -.
DR PDBsum; 3BDM; -.
DR PDBsum; 3D29; -.
DR PDBsum; 3DY3; -.
DR PDBsum; 3DY4; -.
DR PDBsum; 3E47; -.
DR PDBsum; 3GPJ; -.
DR PDBsum; 3GPT; -.
DR PDBsum; 3GPW; -.
DR PDBsum; 3HYE; -.
DR PDBsum; 3JCO; -.
DR PDBsum; 3JCP; -.
DR PDBsum; 3MG0; -.
DR PDBsum; 3MG4; -.
DR PDBsum; 3MG6; -.
DR PDBsum; 3MG7; -.
DR PDBsum; 3MG8; -.
DR PDBsum; 3NZJ; -.
DR PDBsum; 3NZW; -.
DR PDBsum; 3NZX; -.
DR PDBsum; 3OEU; -.
DR PDBsum; 3OEV; -.
DR PDBsum; 3OKJ; -.
DR PDBsum; 3SDI; -.
DR PDBsum; 3SDK; -.
DR PDBsum; 3SHJ; -.
DR PDBsum; 3TDD; -.
DR PDBsum; 3UN4; -.
DR PDBsum; 3UN8; -.
DR PDBsum; 3WXR; -.
DR PDBsum; 4CR2; -.
DR PDBsum; 4CR3; -.
DR PDBsum; 4CR4; -.
DR PDBsum; 4EU2; -.
DR PDBsum; 4FZC; -.
DR PDBsum; 4FZG; -.
DR PDBsum; 4G4S; -.
DR PDBsum; 4GK7; -.
DR PDBsum; 4HNP; -.
DR PDBsum; 4HRC; -.
DR PDBsum; 4HRD; -.
DR PDBsum; 4INR; -.
DR PDBsum; 4INT; -.
DR PDBsum; 4INU; -.
DR PDBsum; 4J70; -.
DR PDBsum; 4JSQ; -.
DR PDBsum; 4JSU; -.
DR PDBsum; 4JT0; -.
DR PDBsum; 4LQI; -.
DR PDBsum; 4LTC; -.
DR PDBsum; 4NNN; -.
DR PDBsum; 4NNW; -.
DR PDBsum; 4NO1; -.
DR PDBsum; 4NO6; -.
DR PDBsum; 4NO8; -.
DR PDBsum; 4NO9; -.
DR PDBsum; 4Q1S; -.
DR PDBsum; 4QBY; -.
DR PDBsum; 4QLQ; -.
DR PDBsum; 4QLS; -.
DR PDBsum; 4QLT; -.
DR PDBsum; 4QLU; -.
DR PDBsum; 4QLV; -.
DR PDBsum; 4QUX; -.
DR PDBsum; 4QUY; -.
DR PDBsum; 4QV0; -.
DR PDBsum; 4QV1; -.
DR PDBsum; 4QV3; -.
DR PDBsum; 4QV4; -.
DR PDBsum; 4QV5; -.
DR PDBsum; 4QV6; -.
DR PDBsum; 4QV7; -.
DR PDBsum; 4QV8; -.
DR PDBsum; 4QV9; -.
DR PDBsum; 4QVL; -.
DR PDBsum; 4QVM; -.
DR PDBsum; 4QVN; -.
DR PDBsum; 4QVP; -.
DR PDBsum; 4QVQ; -.
DR PDBsum; 4QVV; -.
DR PDBsum; 4QVW; -.
DR PDBsum; 4QVY; -.
DR PDBsum; 4QW0; -.
DR PDBsum; 4QW1; -.
DR PDBsum; 4QW3; -.
DR PDBsum; 4QW4; -.
DR PDBsum; 4QW5; -.
DR PDBsum; 4QW6; -.
DR PDBsum; 4QW7; -.
DR PDBsum; 4QWF; -.
DR PDBsum; 4QWG; -.
DR PDBsum; 4QWI; -.
DR PDBsum; 4QWJ; -.
DR PDBsum; 4QWK; -.
DR PDBsum; 4QWL; -.
DR PDBsum; 4QWR; -.
DR PDBsum; 4QWS; -.
DR PDBsum; 4QWU; -.
DR PDBsum; 4QWX; -.
DR PDBsum; 4QXJ; -.
DR PDBsum; 4QZ0; -.
DR PDBsum; 4QZ1; -.
DR PDBsum; 4QZ2; -.
DR PDBsum; 4QZ3; -.
DR PDBsum; 4QZ4; -.
DR PDBsum; 4QZ5; -.
DR PDBsum; 4QZ6; -.
DR PDBsum; 4QZ7; -.
DR PDBsum; 4QZW; -.
DR PDBsum; 4QZX; -.
DR PDBsum; 4QZZ; -.
DR PDBsum; 4R00; -.
DR PDBsum; 4R02; -.
DR PDBsum; 4R17; -.
DR PDBsum; 4R18; -.
DR PDBsum; 4RUR; -.
DR PDBsum; 4V7O; -.
DR PDBsum; 4X6Z; -.
DR PDBsum; 4Y69; -.
DR PDBsum; 4Y6A; -.
DR PDBsum; 4Y6V; -.
DR PDBsum; 4Y6Z; -.
DR PDBsum; 4Y70; -.
DR PDBsum; 4Y74; -.
DR PDBsum; 4Y75; -.
DR PDBsum; 4Y77; -.
DR PDBsum; 4Y78; -.
DR PDBsum; 4Y7W; -.
DR PDBsum; 4Y7X; -.
DR PDBsum; 4Y7Y; -.
DR PDBsum; 4Y80; -.
DR PDBsum; 4Y81; -.
DR PDBsum; 4Y82; -.
DR PDBsum; 4Y84; -.
DR PDBsum; 4Y8G; -.
DR PDBsum; 4Y8H; -.
DR PDBsum; 4Y8I; -.
DR PDBsum; 4Y8J; -.
DR PDBsum; 4Y8K; -.
DR PDBsum; 4Y8L; -.
DR PDBsum; 4Y8M; -.
DR PDBsum; 4Y8N; -.
DR PDBsum; 4Y8O; -.
DR PDBsum; 4Y8P; -.
DR PDBsum; 4Y8Q; -.
DR PDBsum; 4Y8R; -.
DR PDBsum; 4Y8S; -.
DR PDBsum; 4Y8T; -.
DR PDBsum; 4Y8U; -.
DR PDBsum; 4Y9Y; -.
DR PDBsum; 4Y9Z; -.
DR PDBsum; 4YA0; -.
DR PDBsum; 4YA1; -.
DR PDBsum; 4YA2; -.
DR PDBsum; 4YA3; -.
DR PDBsum; 4YA4; -.
DR PDBsum; 4YA5; -.
DR PDBsum; 4YA7; -.
DR PDBsum; 4YA9; -.
DR PDBsum; 4Z1L; -.
DR PDBsum; 5A5B; -.
DR PDBsum; 5AHJ; -.
DR PDBsum; 5BOU; -.
DR PDBsum; 5BXL; -.
DR PDBsum; 5BXN; -.
DR PDBsum; 5CGF; -.
DR PDBsum; 5CGG; -.
DR PDBsum; 5CGH; -.
DR PDBsum; 5CGI; -.
DR PDBsum; 5CZ4; -.
DR PDBsum; 5CZ5; -.
DR PDBsum; 5CZ6; -.
DR PDBsum; 5CZ7; -.
DR PDBsum; 5CZ8; -.
DR PDBsum; 5CZ9; -.
DR PDBsum; 5CZA; -.
DR PDBsum; 5D0S; -.
DR PDBsum; 5D0T; -.
DR PDBsum; 5D0V; -.
DR PDBsum; 5D0W; -.
DR PDBsum; 5D0X; -.
DR PDBsum; 5D0Z; -.
DR PDBsum; 5DKI; -.
DR PDBsum; 5DKJ; -.
DR PDBsum; 5FG7; -.
DR PDBsum; 5FG9; -.
DR PDBsum; 5FGA; -.
DR PDBsum; 5FGD; -.
DR PDBsum; 5FGE; -.
DR PDBsum; 5FGF; -.
DR PDBsum; 5FGG; -.
DR PDBsum; 5FGH; -.
DR PDBsum; 5FGI; -.
DR PDBsum; 5FHS; -.
DR PDBsum; 5JHR; -.
DR PDBsum; 5JHS; -.
DR PDBsum; 5L52; -.
DR PDBsum; 5L54; -.
DR PDBsum; 5L55; -.
DR PDBsum; 5L5A; -.
DR PDBsum; 5L5B; -.
DR PDBsum; 5L5D; -.
DR PDBsum; 5L5E; -.
DR PDBsum; 5L5F; -.
DR PDBsum; 5L5H; -.
DR PDBsum; 5L5I; -.
DR PDBsum; 5L5J; -.
DR PDBsum; 5L5O; -.
DR PDBsum; 5L5P; -.
DR PDBsum; 5L5Q; -.
DR PDBsum; 5L5R; -.
DR PDBsum; 5L5S; -.
DR PDBsum; 5L5T; -.
DR PDBsum; 5L5U; -.
DR PDBsum; 5L5V; -.
DR PDBsum; 5L5W; -.
DR PDBsum; 5L5X; -.
DR PDBsum; 5L5Y; -.
DR PDBsum; 5L5Z; -.
DR PDBsum; 5L60; -.
DR PDBsum; 5L61; -.
DR PDBsum; 5L62; -.
DR PDBsum; 5L63; -.
DR PDBsum; 5L64; -.
DR PDBsum; 5L65; -.
DR PDBsum; 5L66; -.
DR PDBsum; 5L67; -.
DR PDBsum; 5L68; -.
DR PDBsum; 5L69; -.
DR PDBsum; 5L6A; -.
DR PDBsum; 5L6B; -.
DR PDBsum; 5L6C; -.
DR PDBsum; 5LAI; -.
DR PDBsum; 5LAJ; -.
DR PDBsum; 5LTT; -.
DR PDBsum; 5M2B; -.
DR PDBsum; 5MP9; -.
DR PDBsum; 5MPA; -.
DR PDBsum; 5MPB; -.
DR PDBsum; 5MPC; -.
DR PDBsum; 5NIF; -.
DR PDBsum; 5WVI; -.
DR PDBsum; 5WVK; -.
DR PDBsum; 6EF0; -.
DR PDBsum; 6EF1; -.
DR PDBsum; 6EF2; -.
DR PDBsum; 6EF3; -.
DR PDBsum; 6FVT; -.
DR PDBsum; 6FVU; -.
DR PDBsum; 6FVV; -.
DR PDBsum; 6FVW; -.
DR PDBsum; 6FVX; -.
DR PDBsum; 6FVY; -.
DR PDBsum; 6G7F; -.
DR PDBsum; 6G8M; -.
DR PDBsum; 6G8N; -.
DR PDBsum; 6GOP; -.
DR PDBsum; 6H39; -.
DR PDBsum; 6HTB; -.
DR PDBsum; 6HTC; -.
DR PDBsum; 6HTD; -.
DR PDBsum; 6HTP; -.
DR PDBsum; 6HTR; -.
DR PDBsum; 6HUB; -.
DR PDBsum; 6HUC; -.
DR PDBsum; 6HUQ; -.
DR PDBsum; 6HUU; -.
DR PDBsum; 6HUV; -.
DR PDBsum; 6HV3; -.
DR PDBsum; 6HV4; -.
DR PDBsum; 6HV5; -.
DR PDBsum; 6HV7; -.
DR PDBsum; 6HVA; -.
DR PDBsum; 6HVR; -.
DR PDBsum; 6HVS; -.
DR PDBsum; 6HVT; -.
DR PDBsum; 6HVU; -.
DR PDBsum; 6HVV; -.
DR PDBsum; 6HVW; -.
DR PDBsum; 6HVX; -.
DR PDBsum; 6HVY; -.
DR PDBsum; 6HW0; -.
DR PDBsum; 6HW3; -.
DR PDBsum; 6HW4; -.
DR PDBsum; 6HW5; -.
DR PDBsum; 6HW6; -.
DR PDBsum; 6HW7; -.
DR PDBsum; 6HW8; -.
DR PDBsum; 6HW9; -.
DR PDBsum; 6HWA; -.
DR PDBsum; 6HWB; -.
DR PDBsum; 6HWC; -.
DR PDBsum; 6HWD; -.
DR PDBsum; 6HWE; -.
DR PDBsum; 6HWF; -.
DR PDBsum; 6J2C; -.
DR PDBsum; 6J2N; -.
DR PDBsum; 6J2Q; -.
DR PDBsum; 6J2X; -.
DR PDBsum; 6J30; -.
DR PDBsum; 6ZOU; -.
DR PDBsum; 6ZP6; -.
DR PDBsum; 6ZP8; -.
DR PDBsum; 7LS5; -.
DR PDBsum; 7LS6; -.
DR PDBsum; 7LSX; -.
DR PDBsum; 7O2L; -.
DR PDBsum; 7QO3; -.
DR PDBsum; 7QO5; -.
DR AlphaFoldDB; P32379; -.
DR SMR; P32379; -.
DR BioGRID; 33504; 191.
DR ComplexPortal; CPX-2262; 26S Proteasome complex.
DR DIP; DIP-1193N; -.
DR IntAct; P32379; 13.
DR MINT; P32379; -.
DR STRING; 4932.YGR253C; -.
DR iPTMnet; P32379; -.
DR MaxQB; P32379; -.
DR PaxDb; P32379; -.
DR PRIDE; P32379; -.
DR EnsemblFungi; YGR253C_mRNA; YGR253C; YGR253C.
DR GeneID; 853168; -.
DR KEGG; sce:YGR253C; -.
DR SGD; S000003485; PUP2.
DR VEuPathDB; FungiDB:YGR253C; -.
DR eggNOG; KOG0176; Eukaryota.
DR GeneTree; ENSGT00550000074958; -.
DR HOGENOM; CLU_035750_4_2_1; -.
DR InParanoid; P32379; -.
DR OMA; FQVEYAR; -.
DR BioCyc; YEAST:G3O-30926-MON; -.
DR Reactome; R-SCE-1236978; Cross-presentation of soluble exogenous antigens (endosomes).
DR Reactome; R-SCE-382556; ABC-family proteins mediated transport.
DR Reactome; R-SCE-5668541; TNFR2 non-canonical NF-kB pathway.
DR Reactome; R-SCE-5687128; MAPK6/MAPK4 signaling.
DR Reactome; R-SCE-5689880; Ub-specific processing proteases.
DR Reactome; R-SCE-6798695; Neutrophil degranulation.
DR Reactome; R-SCE-68949; Orc1 removal from chromatin.
DR Reactome; R-SCE-69017; CDK-mediated phosphorylation and removal of Cdc6.
DR Reactome; R-SCE-69601; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A.
DR Reactome; R-SCE-75815; Ubiquitin-dependent degradation of Cyclin D.
DR Reactome; R-SCE-8854050; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis.
DR Reactome; R-SCE-8948751; Regulation of PTEN stability and activity.
DR Reactome; R-SCE-8951664; Neddylation.
DR Reactome; R-SCE-9755511; KEAP1-NFE2L2 pathway.
DR Reactome; R-SCE-983168; Antigen processing: Ubiquitination & Proteasome degradation.
DR EvolutionaryTrace; P32379; -.
DR PRO; PR:P32379; -.
DR Proteomes; UP000002311; Chromosome VII.
DR RNAct; P32379; protein.
DR GO; GO:0005737; C:cytoplasm; IC:SGD.
DR GO; GO:0042175; C:nuclear outer membrane-endoplasmic reticulum membrane network; IC:SGD.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0000502; C:proteasome complex; IPI:ComplexPortal.
DR GO; GO:0005839; C:proteasome core complex; IBA:GO_Central.
DR GO; GO:0019773; C:proteasome core complex, alpha-subunit complex; IDA:SGD.
DR GO; GO:0034515; C:proteasome storage granule; IDA:SGD.
DR GO; GO:0010498; P:proteasomal protein catabolic process; IBA:GO_Central.
DR GO; GO:0010499; P:proteasomal ubiquitin-independent protein catabolic process; IDA:SGD.
DR GO; GO:0043161; P:proteasome-mediated ubiquitin-dependent protein catabolic process; IDA:SGD.
DR CDD; cd03753; proteasome_alpha_type_5; 1.
DR Gene3D; 3.60.20.10; -; 1.
DR InterPro; IPR029055; Ntn_hydrolases_N.
DR InterPro; IPR023332; Proteasome_alpha-type.
DR InterPro; IPR033812; Proteasome_alpha_type_5.
DR InterPro; IPR000426; Proteasome_asu_N.
DR InterPro; IPR001353; Proteasome_sua/b.
DR Pfam; PF00227; Proteasome; 1.
DR Pfam; PF10584; Proteasome_A_N; 1.
DR SMART; SM00948; Proteasome_A_N; 1.
DR SUPFAM; SSF56235; SSF56235; 1.
DR PROSITE; PS00388; PROTEASOME_ALPHA_1; 1.
DR PROSITE; PS51475; PROTEASOME_ALPHA_2; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Cytoplasm; Nucleus; Phosphoprotein; Proteasome;
KW Reference proteome.
FT CHAIN 1..260
FT /note="Proteasome subunit alpha type-5"
FT /id="PRO_0000124129"
FT MOD_RES 55
FT /note="Phosphothreonine"
FT /evidence="ECO:0007744|PubMed:17330950"
FT MOD_RES 56
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:17330950"
FT MOD_RES 251
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:17330950,
FT ECO:0007744|PubMed:18407956, ECO:0007744|PubMed:19779198"
FT MUTAGEN 49
FT /note="G->D: In DOA5-1; slight decrease in activity."
FT /evidence="ECO:0000269|PubMed:7781614"
FT CONFLICT 192
FT /note="T -> S (in Ref. 1; CAA46111)"
FT /evidence="ECO:0000305"
FT STRAND 19..21
FT /evidence="ECO:0007829|PDB:4QBY"
FT HELIX 22..31
FT /evidence="ECO:0007829|PDB:1RYP"
FT STRAND 37..41
FT /evidence="ECO:0007829|PDB:1RYP"
FT STRAND 46..51
FT /evidence="ECO:0007829|PDB:1RYP"
FT STRAND 55..59
FT /evidence="ECO:0007829|PDB:1G65"
FT HELIX 61..63
FT /evidence="ECO:0007829|PDB:1RYP"
FT STRAND 67..71
FT /evidence="ECO:0007829|PDB:1RYP"
FT STRAND 74..81
FT /evidence="ECO:0007829|PDB:1RYP"
FT HELIX 82..84
FT /evidence="ECO:0007829|PDB:1RYP"
FT HELIX 85..103
FT /evidence="ECO:0007829|PDB:1RYP"
FT HELIX 109..117
FT /evidence="ECO:0007829|PDB:1RYP"
FT TURN 118..121
FT /evidence="ECO:0007829|PDB:1RYP"
FT STRAND 124..126
FT /evidence="ECO:0007829|PDB:1RYP"
FT STRAND 128..130
FT /evidence="ECO:0007829|PDB:4LTC"
FT STRAND 134..136
FT /evidence="ECO:0007829|PDB:1RYP"
FT STRAND 139..148
FT /evidence="ECO:0007829|PDB:1RYP"
FT TURN 149..151
FT /evidence="ECO:0007829|PDB:1RYP"
FT STRAND 152..158
FT /evidence="ECO:0007829|PDB:1RYP"
FT TURN 160..162
FT /evidence="ECO:0007829|PDB:4G4S"
FT STRAND 164..173
FT /evidence="ECO:0007829|PDB:1RYP"
FT HELIX 176..186
FT /evidence="ECO:0007829|PDB:1RYP"
FT HELIX 193..207
FT /evidence="ECO:0007829|PDB:1RYP"
FT STRAND 208..210
FT /evidence="ECO:0007829|PDB:1FNT"
FT STRAND 216..223
FT /evidence="ECO:0007829|PDB:1RYP"
FT TURN 224..226
FT /evidence="ECO:0007829|PDB:1RYP"
FT STRAND 227..230
FT /evidence="ECO:0007829|PDB:1RYP"
FT HELIX 233..247
FT /evidence="ECO:0007829|PDB:1RYP"
SQ SEQUENCE 260 AA; 28617 MW; E8EDEB212BF4EC6E CRC64;
MFLTRSEYDR GVSTFSPEGR LFQVEYSLEA IKLGSTAIGI ATKEGVVLGV EKRATSPLLE
SDSIEKIVEI DRHIGCAMSG LTADARSMIE HARTAAVTHN LYYDEDINVE SLTQSVCDLA
LRFGEGASGE ERLMSRPFGV ALLIAGHDAD DGYQLFHAEP SGTFYRYNAK AIGSGSEGAQ
AELLNEWHSS LTLKEAELLV LKILKQVMEE KLDENNAQLS CITKQDGFKI YDNEKTAELI
KELKEKEAAE SPEEADVEMS
