ID   PSA7A_XENLA             Reviewed;         248 AA.
AC   Q9PVY6; Q5XHI5;
DT   08-DEC-2000, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-2000, sequence version 1.
DT   03-AUG-2022, entry version 111.
DE   RecName: Full=Proteasome subunit alpha type-7-A;
DE   AltName: Full=Proteasome subunit alpha 4-A;
GN   Name=psma7-a;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Ovary;
RX   PubMed=10548731; DOI=10.1016/s0378-1119(99)00406-0;
RA   Tokumoto M., Horiguchi R., Nagahama Y., Tokumoto T.;
RT   "Identification of the Xenopus 20S proteasome alpha 4 subunit which is
RT   modified in the meiotic cell cycle.";
RL   Gene 239:301-308(1999).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Embryo;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (OCT-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: The proteasome is a multicatalytic proteinase complex which
CC       is characterized by its ability to cleave peptides with Arg, Phe, Tyr,
CC       Leu, and Glu adjacent to the leaving group at neutral or slightly basic
CC       pH. The proteasome has an ATP-dependent proteolytic activity.
CC   -!- SUBUNIT: The 26S proteasome consists of a 20S proteasome core and two
CC       19S regulatory subunits. The 20S proteasome core is composed of 28
CC       subunits that are arranged in four stacked rings, resulting in a
CC       barrel-shaped structure. The two end rings are each formed by seven
CC       alpha subunits, and the two central rings are each formed by seven beta
CC       subunits. The catalytic chamber with the active sites is on the inside
CC       of the barrel (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.
CC   -!- PTM: Phosphorylated in G2 phase.
CC   -!- SIMILARITY: Belongs to the peptidase T1A family. {ECO:0000255|PROSITE-
CC       ProRule:PRU00808}.
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DR   EMBL; AB004782; BAA86962.1; -; mRNA.
DR   EMBL; BC084072; AAH84072.1; -; mRNA.
DR   RefSeq; NP_001081054.1; NM_001087585.1.
DR   AlphaFoldDB; Q9PVY6; -.
DR   SMR; Q9PVY6; -.
DR   BioGRID; 98959; 2.
DR   MEROPS; T01.978; -.
DR   DNASU; 394357; -.
DR   GeneID; 394357; -.
DR   KEGG; xla:394357; -.
DR   CTD; 394357; -.
DR   Xenbase; XB-GENE-974602; psma7.L.
DR   OMA; KICMLDH; -.
DR   OrthoDB; 1222564at2759; -.
DR   Proteomes; UP000186698; Chromosome 9_10L.
DR   Bgee; 394357; Expressed in oocyte and 19 other tissues.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0005839; C:proteasome core complex; ISS:UniProtKB.
DR   GO; GO:0019773; C:proteasome core complex, alpha-subunit complex; ISS:UniProtKB.
DR   GO; GO:0006511; P:ubiquitin-dependent protein catabolic process; IEA:InterPro.
DR   Gene3D; 3.60.20.10; -; 1.
DR   InterPro; IPR029055; Ntn_hydrolases_N.
DR   InterPro; IPR023332; Proteasome_alpha-type.
DR   InterPro; IPR035190; Proteasome_alpha7.
DR   InterPro; IPR000426; Proteasome_asu_N.
DR   InterPro; IPR001353; Proteasome_sua/b.
DR   PANTHER; PTHR11599:SF40; PTHR11599:SF40; 1.
DR   Pfam; PF00227; Proteasome; 1.
DR   Pfam; PF10584; Proteasome_A_N; 1.
DR   SMART; SM00948; Proteasome_A_N; 1.
DR   SUPFAM; SSF56235; SSF56235; 1.
DR   PROSITE; PS00388; PROTEASOME_ALPHA_1; 1.
DR   PROSITE; PS51475; PROTEASOME_ALPHA_2; 1.
PE   2: Evidence at transcript level;
KW   Cytoplasm; Nucleus; Phosphoprotein; Proteasome; Reference proteome.
FT   CHAIN           1..248
FT                   /note="Proteasome subunit alpha type-7-A"
FT                   /id="PRO_0000124147"
SQ   SEQUENCE   248 AA;  28036 MW;  B62213FED11C3A60 CRC64;
     MSYDRAITVF SPDGHLFQVE YAQEAVKKGS TAVGVRGKEI VVLGVEKKSV AKLQDERTVR
     KICALDENVF MAFAGLTADA RIVINRARVE CQSHRLTVED PVTVEYITRY IASLKQRYTQ
     SNGRRPFGIS ALIVGFDFDG TPRLYQTDPS GTYHAWKANA IGRGAKSVRE FLEKHYTDEA
     IETDDLTIKL VIKALLEVVQ SGGKNIELAV MRRDQPLKIL NPEEIERYVA EIEKEKEENE
     KKKQKKTT