PSAA_YERPE
ID PSAA_YERPE Reviewed; 158 AA.
AC P31522; Q0WHB0;
DT 01-JUL-1993, integrated into UniProtKB/Swiss-Prot.
DT 01-JUL-1993, sequence version 1.
DT 03-AUG-2022, entry version 131.
DE RecName: Full=pH 6 antigen;
DE AltName: Full=Adhesin;
DE AltName: Full=Antigen 4;
DE Flags: Precursor;
GN Name=psaA; OrderedLocusNames=YPO1303, y2882, YP_1289;
OS Yersinia pestis.
OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC Yersiniaceae; Yersinia.
OX NCBI_TaxID=632;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=KIM5 / Biovar Mediaevalis;
RX PubMed=8100346; DOI=10.1111/j.1365-2958.1993.tb01575.x;
RA Lindler L.E., Tall B.D.;
RT "Yersinia pestis pH 6 antigen forms fimbriae and is induced by
RT intracellular association with macrophages.";
RL Mol. Microbiol. 8:311-324(1993).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=EV 76;
RA Cherepavov P.A.;
RL Submitted (MAY-1996) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CO-92 / Biovar Orientalis;
RX PubMed=11586360; DOI=10.1038/35097083;
RA Parkhill J., Wren B.W., Thomson N.R., Titball R.W., Holden M.T.G.,
RA Prentice M.B., Sebaihia M., James K.D., Churcher C.M., Mungall K.L.,
RA Baker S., Basham D., Bentley S.D., Brooks K., Cerdeno-Tarraga A.-M.,
RA Chillingworth T., Cronin A., Davies R.M., Davis P., Dougan G., Feltwell T.,
RA Hamlin N., Holroyd S., Jagels K., Karlyshev A.V., Leather S., Moule S.,
RA Oyston P.C.F., Quail M.A., Rutherford K.M., Simmonds M., Skelton J.,
RA Stevens K., Whitehead S., Barrell B.G.;
RT "Genome sequence of Yersinia pestis, the causative agent of plague.";
RL Nature 413:523-527(2001).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=KIM10+ / Biovar Mediaevalis;
RX PubMed=12142430; DOI=10.1128/jb.184.16.4601-4611.2002;
RA Deng W., Burland V., Plunkett G. III, Boutin A., Mayhew G.F., Liss P.,
RA Perna N.T., Rose D.J., Mau B., Zhou S., Schwartz D.C., Fetherston J.D.,
RA Lindler L.E., Brubaker R.R., Plano G.V., Straley S.C., McDonough K.A.,
RA Nilles M.L., Matson J.S., Blattner F.R., Perry R.D.;
RT "Genome sequence of Yersinia pestis KIM.";
RL J. Bacteriol. 184:4601-4611(2002).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=91001 / Biovar Mediaevalis;
RX PubMed=15368893; DOI=10.1093/dnares/11.3.179;
RA Song Y., Tong Z., Wang J., Wang L., Guo Z., Han Y., Zhang J., Pei D.,
RA Zhou D., Qin H., Pang X., Han Y., Zhai J., Li M., Cui B., Qi Z., Jin L.,
RA Dai R., Chen F., Li S., Ye C., Du Z., Lin W., Wang J., Yu J., Yang H.,
RA Wang J., Huang P., Yang R.;
RT "Complete genome sequence of Yersinia pestis strain 91001, an isolate
RT avirulent to humans.";
RL DNA Res. 11:179-197(2004).
CC -!- FUNCTION: Fibrillar structure, part of fimbriae, necessary for full
CC virulence.
CC -!- SUBUNIT: Forms a homomer composed of subunits assembled in a large
CC structure.
CC -!- SUBCELLULAR LOCATION: Fimbrium.
CC -!- INDUCTION: Expressed inside macrophages under acidic pH and at 37
CC degrees Celsius.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAM86433.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC Sequence=AAS61532.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; M86713; AAA27662.1; -; Genomic_DNA.
DR EMBL; X97759; CAA66355.1; -; Genomic_DNA.
DR EMBL; AL590842; CAL19956.1; -; Genomic_DNA.
DR EMBL; AE009952; AAM86433.1; ALT_INIT; Genomic_DNA.
DR EMBL; AE017042; AAS61532.1; ALT_INIT; Genomic_DNA.
DR PIR; AB0159; AB0159.
DR PIR; S32926; S32926.
DR RefSeq; WP_002208794.1; NZ_WUCM01000013.1.
DR RefSeq; YP_002346328.1; NC_003143.1.
DR PDB; 4F8L; X-ray; 1.50 A; A=27-158.
DR PDB; 4F8N; X-ray; 2.50 A; A=27-158.
DR PDB; 4F8O; X-ray; 1.90 A; A=27-158.
DR PDB; 4F8P; X-ray; 2.05 A; A/B=27-158.
DR PDB; 5LN4; X-ray; 2.36 A; A/B/C=27-42, A/B/C=46-158.
DR PDBsum; 4F8L; -.
DR PDBsum; 4F8N; -.
DR PDBsum; 4F8O; -.
DR PDBsum; 4F8P; -.
DR PDBsum; 5LN4; -.
DR AlphaFoldDB; P31522; -.
DR SMR; P31522; -.
DR IntAct; P31522; 1.
DR MINT; P31522; -.
DR STRING; 214092.YPO1303; -.
DR UniLectin; P31522; -.
DR PaxDb; P31522; -.
DR DNASU; 1147829; -.
DR EnsemblBacteria; AAM86433; AAM86433; y2882.
DR EnsemblBacteria; AAS61532; AAS61532; YP_1289.
DR GeneID; 66842232; -.
DR KEGG; ype:YPO1303; -.
DR KEGG; ypk:y2882; -.
DR KEGG; ypm:YP_1289; -.
DR PATRIC; fig|214092.21.peg.1613; -.
DR eggNOG; ENOG5030CGZ; Bacteria.
DR HOGENOM; CLU_1660052_0_0_6; -.
DR Proteomes; UP000000815; Chromosome.
DR Proteomes; UP000001019; Chromosome.
DR Proteomes; UP000002490; Chromosome.
DR GO; GO:0009289; C:pilus; IEA:UniProtKB-SubCell.
DR PROSITE; PS51257; PROKAR_LIPOPROTEIN; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Fimbrium; Reference proteome; Signal; Virulence.
FT SIGNAL 1..26
FT CHAIN 27..158
FT /note="pH 6 antigen"
FT /id="PRO_0000009240"
FT STRAND 48..53
FT /evidence="ECO:0007829|PDB:4F8L"
FT STRAND 59..62
FT /evidence="ECO:0007829|PDB:4F8L"
FT STRAND 67..75
FT /evidence="ECO:0007829|PDB:4F8L"
FT STRAND 82..87
FT /evidence="ECO:0007829|PDB:4F8L"
FT HELIX 89..91
FT /evidence="ECO:0007829|PDB:4F8L"
FT TURN 92..94
FT /evidence="ECO:0007829|PDB:4F8L"
FT STRAND 95..98
FT /evidence="ECO:0007829|PDB:4F8L"
FT STRAND 103..105
FT /evidence="ECO:0007829|PDB:4F8L"
FT STRAND 107..114
FT /evidence="ECO:0007829|PDB:4F8L"
FT HELIX 115..117
FT /evidence="ECO:0007829|PDB:4F8L"
FT STRAND 119..123
FT /evidence="ECO:0007829|PDB:4F8L"
FT STRAND 126..128
FT /evidence="ECO:0007829|PDB:4F8N"
FT STRAND 130..136
FT /evidence="ECO:0007829|PDB:4F8L"
FT STRAND 144..158
FT /evidence="ECO:0007829|PDB:4F8L"
SQ SEQUENCE 158 AA; 17233 MW; E475AEE11C5DC2FC CRC64;
MKMKCFAKNA LAVTTLMIAA CGMANASTVI NSKDVSGEVT VKQGNTFHVD FAPNTGEIFA
GKQPGDVTMF TLTMGDTAPH GGWRLIPTGD SKGGYMISAD GDYVGLYSYM MSWVGIDNNW
YINDDSPKDI KDHLYVKAGT VLKPTTYKFT GRVEEYVF
