ID   ATG5_ORYSI              Reviewed;         380 AA.
AC   A2X052;
DT   15-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT   15-MAY-2007, sequence version 2.
DT   25-MAY-2022, entry version 54.
DE   RecName: Full=Autophagy protein 5;
GN   Name=ATG5; Synonyms=APG5; ORFNames=OsI_005445;
OS   Oryza sativa subsp. indica (Rice).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; Liliopsida; Poales; Poaceae; BOP clade;
OC   Oryzoideae; Oryzeae; Oryzinae; Oryza; Oryza sativa.
OX   NCBI_TaxID=39946;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. 93-11;
RX   PubMed=15685292; DOI=10.1371/journal.pbio.0030038;
RA   Yu J., Wang J., Lin W., Li S., Li H., Zhou J., Ni P., Dong W., Hu S.,
RA   Zeng C., Zhang J., Zhang Y., Li R., Xu Z., Li S., Li X., Zheng H., Cong L.,
RA   Lin L., Yin J., Geng J., Li G., Shi J., Liu J., Lv H., Li J., Wang J.,
RA   Deng Y., Ran L., Shi X., Wang X., Wu Q., Li C., Ren X., Wang J., Wang X.,
RA   Li D., Liu D., Zhang X., Ji Z., Zhao W., Sun Y., Zhang Z., Bao J., Han Y.,
RA   Dong L., Ji J., Chen P., Wu S., Liu J., Xiao Y., Bu D., Tan J., Yang L.,
RA   Ye C., Zhang J., Xu J., Zhou Y., Yu Y., Zhang B., Zhuang S., Wei H.,
RA   Liu B., Lei M., Yu H., Li Y., Xu H., Wei S., He X., Fang L., Zhang Z.,
RA   Zhang Y., Huang X., Su Z., Tong W., Li J., Tong Z., Li S., Ye J., Wang L.,
RA   Fang L., Lei T., Chen C.-S., Chen H.-C., Xu Z., Li H., Huang H., Zhang F.,
RA   Xu H., Li N., Zhao C., Li S., Dong L., Huang Y., Li L., Xi Y., Qi Q.,
RA   Li W., Zhang B., Hu W., Zhang Y., Tian X., Jiao Y., Liang X., Jin J.,
RA   Gao L., Zheng W., Hao B., Liu S.-M., Wang W., Yuan L., Cao M.,
RA   McDermott J., Samudrala R., Wang J., Wong G.K.-S., Yang H.;
RT   "The genomes of Oryza sativa: a history of duplications.";
RL   PLoS Biol. 3:266-281(2005).
CC   -!- FUNCTION: Required for autophagy. Conjugation to ATG12 is essential for
CC       plant nutrient recycling (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Conjugated to ATG12. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC   -!- PTM: Conjugated to ATG12; which is essential for autophagy.
CC       {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the ATG5 family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=CM000127; Type=Frameshift; Evidence={ECO:0000305};
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DR   EMBL; CM000127; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   AlphaFoldDB; A2X052; -.
DR   SMR; A2X052; -.
DR   STRING; 39946.A2X052; -.
DR   PRIDE; A2X052; -.
DR   Proteomes; UP000007015; Chromosome 2.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0006914; P:autophagy; IEA:UniProtKB-KW.
DR   GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR   Gene3D; 1.10.246.190; -; 1.
DR   Gene3D; 3.10.20.620; -; 1.
DR   InterPro; IPR007239; Atg5.
DR   InterPro; IPR042526; Atg5_HR.
DR   InterPro; IPR042527; Atg5_UblA_dom.
DR   PANTHER; PTHR13040; PTHR13040; 1.
DR   Pfam; PF04106; APG5; 1.
PE   3: Inferred from homology;
KW   Autophagy; Cytoplasm; Isopeptide bond; Protein transport;
KW   Reference proteome; Transport; Ubl conjugation.
FT   CHAIN           1..380
FT                   /note="Autophagy protein 5"
FT                   /id="PRO_0000287218"
FT   REGION          194..215
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          283..309
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        293..309
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   CROSSLNK        138
FT                   /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
FT                   G-Cter in ATG12)"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   380 AA;  42333 MW;  7290533E4BAF9986 CRC64;
     MAAQRDDEAG WSAEAARRVW GGAVPLQVHL HDADVTTLPP PPPFLTLGPR IGYLPLLVPI
     IKAHFSSTLP PGIDTVWFEY KGLPLKWYIP IGVLYDLLCA DPERPWNLTV HFRGYPSEIL
     TPCDGEDSVK WSYMNSLKEA AFIITGNSKN VMNMSQADQG ALWQSVMKGN LDGYMNISTR
     LKLGPFEEDC LVRTSSVEGQ QGSDEPESPG SGKPCRVPVR LYVRSVQEDL YDLEDALPVG
     DWESISYINR PFEVRREEGR SYITLEHALK TLLPEFFSSK ASRIPDDSET APQAPDSAPN
     DDSDVTPRSC EKLESSASSS PQEANVANKG KIVKLVRVQG IEVDMDIPFL WVANNLKNPE
     CYLHICVYVG TRKREPKDGR