ID   ATG5_ORYSJ              Reviewed;         380 AA.
AC   Q6ZGL4; A3A2G8; B7E8S0; Q0E4I4;
DT   03-OCT-2006, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   03-AUG-2022, entry version 96.
DE   RecName: Full=Autophagy protein 5;
GN   Name=ATG5; Synonyms=APG5; OrderedLocusNames=Os02g0117800, LOC_Os02g02570;
GN   ORFNames=OJ1217_F02.1, OJ1442_E05.32, OsJ_004990;
OS   Oryza sativa subsp. japonica (Rice).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; Liliopsida; Poales; Poaceae; BOP clade;
OC   Oryzoideae; Oryzeae; Oryzinae; Oryza; Oryza sativa.
OX   NCBI_TaxID=39947;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. Nipponbare;
RX   PubMed=16100779; DOI=10.1038/nature03895;
RG   International rice genome sequencing project (IRGSP);
RT   "The map-based sequence of the rice genome.";
RL   Nature 436:793-800(2005).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=cv. Nipponbare;
RX   PubMed=18089549; DOI=10.1093/nar/gkm978;
RG   The rice annotation project (RAP);
RT   "The rice annotation project database (RAP-DB): 2008 update.";
RL   Nucleic Acids Res. 36:D1028-D1033(2008).
RN   [3]
RP   GENOME REANNOTATION.
RC   STRAIN=cv. Nipponbare;
RX   PubMed=24280374; DOI=10.1186/1939-8433-6-4;
RA   Kawahara Y., de la Bastide M., Hamilton J.P., Kanamori H., McCombie W.R.,
RA   Ouyang S., Schwartz D.C., Tanaka T., Wu J., Zhou S., Childs K.L.,
RA   Davidson R.M., Lin H., Quesada-Ocampo L., Vaillancourt B., Sakai H.,
RA   Lee S.S., Kim J., Numa H., Itoh T., Buell C.R., Matsumoto T.;
RT   "Improvement of the Oryza sativa Nipponbare reference genome using next
RT   generation sequence and optical map data.";
RL   Rice 6:4-4(2013).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. Nipponbare;
RX   PubMed=15685292; DOI=10.1371/journal.pbio.0030038;
RA   Yu J., Wang J., Lin W., Li S., Li H., Zhou J., Ni P., Dong W., Hu S.,
RA   Zeng C., Zhang J., Zhang Y., Li R., Xu Z., Li S., Li X., Zheng H., Cong L.,
RA   Lin L., Yin J., Geng J., Li G., Shi J., Liu J., Lv H., Li J., Wang J.,
RA   Deng Y., Ran L., Shi X., Wang X., Wu Q., Li C., Ren X., Wang J., Wang X.,
RA   Li D., Liu D., Zhang X., Ji Z., Zhao W., Sun Y., Zhang Z., Bao J., Han Y.,
RA   Dong L., Ji J., Chen P., Wu S., Liu J., Xiao Y., Bu D., Tan J., Yang L.,
RA   Ye C., Zhang J., Xu J., Zhou Y., Yu Y., Zhang B., Zhuang S., Wei H.,
RA   Liu B., Lei M., Yu H., Li Y., Xu H., Wei S., He X., Fang L., Zhang Z.,
RA   Zhang Y., Huang X., Su Z., Tong W., Li J., Tong Z., Li S., Ye J., Wang L.,
RA   Fang L., Lei T., Chen C.-S., Chen H.-C., Xu Z., Li H., Huang H., Zhang F.,
RA   Xu H., Li N., Zhao C., Li S., Dong L., Huang Y., Li L., Xi Y., Qi Q.,
RA   Li W., Zhang B., Hu W., Zhang Y., Tian X., Jiao Y., Liang X., Jin J.,
RA   Gao L., Zheng W., Hao B., Liu S.-M., Wang W., Yuan L., Cao M.,
RA   McDermott J., Samudrala R., Wang J., Wong G.K.-S., Yang H.;
RT   "The genomes of Oryza sativa: a history of duplications.";
RL   PLoS Biol. 3:266-281(2005).
RN   [5]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=cv. Nipponbare;
RX   PubMed=12869764; DOI=10.1126/science.1081288;
RG   The rice full-length cDNA consortium;
RT   "Collection, mapping, and annotation of over 28,000 cDNA clones from
RT   japonica rice.";
RL   Science 301:376-379(2003).
CC   -!- FUNCTION: Required for autophagy. Conjugation to ATG12 is essential for
CC       plant nutrient recycling (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Conjugated to ATG12. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC   -!- PTM: Conjugated to ATG12; which is essential for autophagy.
CC       {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the ATG5 family. {ECO:0000305}.
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DR   EMBL; AP004084; BAD07611.1; -; Genomic_DNA.
DR   EMBL; AP004121; BAD07730.1; -; Genomic_DNA.
DR   EMBL; AP008208; BAF07604.1; -; Genomic_DNA.
DR   EMBL; AP014958; BAS76673.1; -; Genomic_DNA.
DR   EMBL; CM000139; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AK063557; BAG88767.1; -; mRNA.
DR   RefSeq; XP_015627449.1; XM_015771963.1.
DR   AlphaFoldDB; Q6ZGL4; -.
DR   SMR; Q6ZGL4; -.
DR   STRING; 4530.OS02T0117800-01; -.
DR   PaxDb; Q6ZGL4; -.
DR   PRIDE; Q6ZGL4; -.
DR   EnsemblPlants; Os02t0117800-01; Os02t0117800-01; Os02g0117800.
DR   GeneID; 4328092; -.
DR   Gramene; Os02t0117800-01; Os02t0117800-01; Os02g0117800.
DR   KEGG; osa:4328092; -.
DR   eggNOG; KOG2976; Eukaryota.
DR   HOGENOM; CLU_051894_0_0_1; -.
DR   InParanoid; Q6ZGL4; -.
DR   OMA; RDDEAGW; -.
DR   OrthoDB; 457861at2759; -.
DR   Proteomes; UP000000763; Chromosome 2.
DR   Proteomes; UP000007752; Chromosome 2.
DR   Proteomes; UP000059680; Chromosome 2.
DR   Genevisible; Q6ZGL4; OS.
DR   GO; GO:0034274; C:Atg12-Atg5-Atg16 complex; IBA:GO_Central.
DR   GO; GO:0034045; C:phagophore assembly site membrane; IBA:GO_Central.
DR   GO; GO:0000045; P:autophagosome assembly; IBA:GO_Central.
DR   GO; GO:0000422; P:autophagy of mitochondrion; IBA:GO_Central.
DR   GO; GO:0044804; P:autophagy of nucleus; IBA:GO_Central.
DR   GO; GO:0006501; P:C-terminal protein lipidation; IBA:GO_Central.
DR   GO; GO:0006995; P:cellular response to nitrogen starvation; IBA:GO_Central.
DR   GO; GO:0050832; P:defense response to fungus; IEA:EnsemblPlants.
DR   GO; GO:0010150; P:leaf senescence; IEA:EnsemblPlants.
DR   GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR   Gene3D; 1.10.246.190; -; 1.
DR   Gene3D; 3.10.20.620; -; 1.
DR   InterPro; IPR007239; Atg5.
DR   InterPro; IPR042526; Atg5_HR.
DR   InterPro; IPR042527; Atg5_UblA_dom.
DR   PANTHER; PTHR13040; PTHR13040; 1.
DR   Pfam; PF04106; APG5; 1.
PE   2: Evidence at transcript level;
KW   Autophagy; Cytoplasm; Isopeptide bond; Protein transport;
KW   Reference proteome; Transport; Ubl conjugation.
FT   CHAIN           1..380
FT                   /note="Autophagy protein 5"
FT                   /id="PRO_0000250586"
FT   REGION          194..214
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          283..309
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        293..309
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   CROSSLNK        138
FT                   /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
FT                   G-Cter in ATG12)"
FT                   /evidence="ECO:0000250"
FT   CONFLICT        41
FT                   /note="P -> T (in Ref. 4; CM000139)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   380 AA;  42349 MW;  7290577F0BAF92AA CRC64;
     MAAQRDDEAG WSAEAARRVW GGAVPLQVHL HDADVTTLPP PPPFLTLGPR IGYLPLLVPI
     IKAHFSSTLP PGIDTVWFEY KGLPLKWYIP IGVLYDLLCA DPERPWNLTV HFRGYPSEIL
     TLCDGEDSVK WSYMNSLKEA AFIITGNSKN VMNMSQADQG ALWQSVMKGN LDGYMNISTR
     LKLGPFEEDC LVRTSSVEGQ QGSDEPESPG SGKPCRVPVR LYVRSVQEDL YDLEDALPVG
     DWESISYINR PFEVRREEGR SYITLEHALK TLLPEFFSSK ASRIPDDSET APQAPDSAPN
     DDSDVTPRSC EKLESSASSS PQEANVANKG KIVKLVRVQG IEVDMDIPFL WVANNLKNPE
     CYLHICVYVG TRKREPKDGR