ID   ATG5_PENRW              Reviewed;         317 AA.
AC   A7KAL6; B6HBL1;
DT   05-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT   11-SEP-2007, sequence version 1.
DT   03-AUG-2022, entry version 70.
DE   RecName: Full=Autophagy protein 5;
GN   Name=atg5; ORFNames=Pc18g04440;
OS   Penicillium rubens (strain ATCC 28089 / DSM 1075 / NRRL 1951 / Wisconsin
OS   54-1255) (Penicillium chrysogenum).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Eurotiales; Aspergillaceae; Penicillium;
OC   Penicillium chrysogenum species complex.
OX   NCBI_TaxID=500485;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND FUNCTION.
RX   PubMed=17204848; DOI=10.4161/auto.3595;
RA   Meijer W.H., van der Klei I.J., Veenhuis M., Kiel J.A.K.W.;
RT   "ATG genes involved in non-selective autophagy are conserved from yeast to
RT   man, but the selective Cvt and pexophagy pathways also require organism-
RT   specific genes.";
RL   Autophagy 3:106-116(2007).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 28089 / DSM 1075 / NRRL 1951 / Wisconsin 54-1255;
RX   PubMed=18820685; DOI=10.1038/nbt.1498;
RA   van den Berg M.A., Albang R., Albermann K., Badger J.H., Daran J.-M.,
RA   Driessen A.J.M., Garcia-Estrada C., Fedorova N.D., Harris D.M.,
RA   Heijne W.H.M., Joardar V.S., Kiel J.A.K.W., Kovalchuk A., Martin J.F.,
RA   Nierman W.C., Nijland J.G., Pronk J.T., Roubos J.A., van der Klei I.J.,
RA   van Peij N.N.M.E., Veenhuis M., von Doehren H., Wagner C., Wortman J.R.,
RA   Bovenberg R.A.L.;
RT   "Genome sequencing and analysis of the filamentous fungus Penicillium
RT   chrysogenum.";
RL   Nat. Biotechnol. 26:1161-1168(2008).
CC   -!- FUNCTION: Involved in cytoplasm to vacuole transport (Cvt) and
CC       autophagic vesicle formation. Autophagy is essential for maintenance of
CC       amino acid levels and protein synthesis under nitrogen starvation.
CC       Required for selective autophagic degradation of the nucleus
CC       (nucleophagy). Also required for mitophagy, which eliminates defective
CC       or superfluous mitochondria in order to fulfill cellular energy
CC       requirements and prevent excess ROS production. Conjugation with atg12,
CC       through a ubiquitin-like conjugating system involving atg7 as an E1-
CC       like activating enzyme and atg10 as an E2-like conjugating enzyme, is
CC       essential for its function. The atg12-atg5 conjugate acts as an E3-like
CC       enzyme which is required for lipidation of atg8 and atg8 association to
CC       the vesicle membranes (By similarity). {ECO:0000250,
CC       ECO:0000269|PubMed:17204848}.
CC   -!- SUBUNIT: Conjugated with atg12. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Preautophagosomal structure membrane
CC       {ECO:0000250}; Peripheral membrane protein {ECO:0000250}.
CC   -!- PTM: Conjugated to atg12; which is essential for autophagy.
CC       {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the ATG5 family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; EF107738; ABO31076.1; -; Genomic_DNA.
DR   EMBL; AM920433; CAP94668.1; -; Genomic_DNA.
DR   RefSeq; XP_002562278.1; XM_002562232.1.
DR   AlphaFoldDB; A7KAL6; -.
DR   SMR; A7KAL6; -.
DR   STRING; 1108849.XP_002562278.1; -.
DR   EnsemblFungi; CAP94668; CAP94668; PCH_Pc18g04440.
DR   GeneID; 8306920; -.
DR   KEGG; pcs:Pc18g04440; -.
DR   VEuPathDB; FungiDB:PCH_Pc18g04440; -.
DR   eggNOG; KOG2976; Eukaryota.
DR   HOGENOM; CLU_051894_2_0_1; -.
DR   OMA; KWHYPLG; -.
DR   OrthoDB; 457861at2759; -.
DR   BioCyc; PCHR:PC18G04440-MON; -.
DR   Proteomes; UP000000724; Contig Pc00c18.
DR   GO; GO:0034045; C:phagophore assembly site membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0006914; P:autophagy; IEA:UniProtKB-KW.
DR   GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR   Gene3D; 1.10.246.190; -; 1.
DR   Gene3D; 3.10.20.620; -; 1.
DR   InterPro; IPR007239; Atg5.
DR   InterPro; IPR042526; Atg5_HR.
DR   InterPro; IPR042527; Atg5_UblA_dom.
DR   PANTHER; PTHR13040; PTHR13040; 1.
DR   Pfam; PF04106; APG5; 1.
PE   3: Inferred from homology;
KW   Autophagy; Isopeptide bond; Membrane; Protein transport;
KW   Reference proteome; Transport; Ubl conjugation.
FT   CHAIN           1..317
FT                   /note="Autophagy protein 5"
FT                   /id="PRO_0000317857"
FT   CROSSLNK        153
FT                   /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
FT                   G-Cter in atg12)"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   317 AA;  35033 MW;  239B3EA6B6597C72 CRC64;
     MENRVSLGSI QKAVWDGRLP LEIVLASSES RTFDKTDPYL ISYPRISYLP SLLPKLRAFF
     SNFLIDPNSQ SHDGWFEFEG VPLKWHYPVG LLFDLYAGVD PASKTAARDN ESPGDGSSLP
     WRLIVHFSDW PPDLVRLDAY GMVMNDAFIN SVKEADFLRN GTAKGIMSLS KEDSSGLWNA
     VQEVDLLSFQ RISNILLPQP SQPFRNVPIR VFLPLLPDAE SSSLKVVQTP LPPSIPASSM
     QSSQILTSRS GSTLQPQTVG TVLHTLLPNL FPSRRTPVLA KPVLHGAVIP MSAPIEEVVR
     SSAYGDGWAY IVVRMMG