PSAP3_CAEEL
ID PSAP3_CAEEL Reviewed; 275 AA.
AC Q0G825; A0A0K3ASQ5; D5MNM8; G5EFB3;
DT 03-AUG-2022, integrated into UniProtKB/Swiss-Prot.
DT 11-NOV-2015, sequence version 2.
DT 03-AUG-2022, entry version 97.
DE RecName: Full=Transcriptional coregulator psa-3 {ECO:0000305};
DE AltName: Full=Phasmid socket absent protein 3 {ECO:0000312|WormBase:F39D8.2a};
GN Name=psa-3 {ECO:0000312|WormBase:F39D8.2a};
GN ORFNames=F39D8.2 {ECO:0000312|WormBase:F39D8.2a};
OS Caenorhabditis elegans.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6239 {ECO:0000312|Proteomes:UP000001940};
RN [1] {ECO:0000312|EMBL:AAZ23152.1}
RP NUCLEOTIDE SEQUENCE (ISOFORM B), FUNCTION, INTERACTION WITH CEH-20,
RP SUBCELLULAR LOCATION, DEVELOPMENTAL STAGE, AND DISRUPTION PHENOTYPE.
RX PubMed=16824957; DOI=10.1016/j.devcel.2006.04.020;
RA Arata Y., Kouike H., Zhang Y., Herman M.A., Okano H., Sawa H.;
RT "Wnt signaling and a Hox protein cooperatively regulate psa-3/Meis to
RT determine daughter cell fate after asymmetric cell division in C.
RT elegans.";
RL Dev. Cell 11:105-115(2006).
RN [2] {ECO:0000312|Proteomes:UP000001940}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bristol N2 {ECO:0000312|Proteomes:UP000001940};
RX PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG The C. elegans sequencing consortium;
RT "Genome sequence of the nematode C. elegans: a platform for investigating
RT biology.";
RL Science 282:2012-2018(1998).
CC -!- FUNCTION: Probable transcription coregulator (PubMed:16824957).
CC Required for asymmetric cell divisions of the T hypodermal cells, and
CC cell fate determination, in concert with homeobox proteins nob-1 and
CC ceh-20 (PubMed:16824957). Acts downstream of the Wnt signaling pathway,
CC and of ceh-20 and nob-1 (PubMed:16824957).
CC {ECO:0000269|PubMed:16824957, ECO:0000303|PubMed:16824957}.
CC -!- SUBUNIT: Interacts with homeobox protein ceh-20; the interaction is
CC direct, facilitates nuclear localization of ceh-20 and may stabilize
CC interaction of a ceh-20-nob-1 complex with DNA.
CC {ECO:0000269|PubMed:16824957}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305|PubMed:16824957}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=4;
CC Name=a {ECO:0000312|WormBase:F39D8.2a};
CC IsoId=Q0G825-1; Sequence=Displayed;
CC Name=b {ECO:0000312|WormBase:F39D8.2b};
CC IsoId=Q0G825-2; Sequence=VSP_061535;
CC Name=c {ECO:0000312|WormBase:F39D8.2c};
CC IsoId=Q0G825-3; Sequence=VSP_061534;
CC Name=d {ECO:0000312|WormBase:F39D8.2d};
CC IsoId=Q0G825-4; Sequence=VSP_061533;
CC -!- DEVELOPMENTAL STAGE: Expressed in the T cell, head neurons, posterior
CC gut cells, hypodermal cells (hyp7, hyp9, and hyp10), and P blast cells
CC (PubMed:16824957). During T cell division, expressed asymmetrically,
CC becoming up-regulated in posterior daughter cells (PubMed:16824957).
CC {ECO:0000269|PubMed:16824957}.
CC -!- DISRUPTION PHENOTYPE: RNAi-mediated knockdown results in absence of
CC phasmid socket cells. {ECO:0000269|PubMed:16824957}.
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DR EMBL; DQ118141; AAZ23152.1; -; mRNA.
DR EMBL; BX284606; CAA93659.2; -; Genomic_DNA.
DR EMBL; BX284606; CAL36513.2; -; Genomic_DNA.
DR EMBL; BX284606; CAL36514.1; -; Genomic_DNA.
DR EMBL; BX284606; CTQ87058.1; -; Genomic_DNA.
DR RefSeq; NP_001076765.2; NM_001083296.2.
DR RefSeq; NP_001076766.1; NM_001083297.1.
DR RefSeq; NP_001257263.1; NM_001270334.1.
DR RefSeq; NP_001300347.1; NM_001313418.1.
DR SMR; Q0G825; -.
DR STRING; 6239.F39D8.2a; -.
DR EPD; Q0G825; -.
DR PaxDb; Q0G825; -.
DR EnsemblMetazoa; F39D8.2a.1; F39D8.2a.1; WBGene00009560.
DR GeneID; 181631; -.
DR KEGG; cel:CELE_F39D8.2; -.
DR UCSC; F39D8.2a; c. elegans.
DR CTD; 181631; -.
DR WormBase; F39D8.2a; CE50352; WBGene00009560; psa-3.
DR WormBase; F39D8.2b; CE40387; WBGene00009560; psa-3.
DR WormBase; F39D8.2c; CE34185; WBGene00009560; psa-3.
DR WormBase; F39D8.2d; CE50444; WBGene00009560; psa-3.
DR eggNOG; KOG0773; Eukaryota.
DR HOGENOM; CLU_086461_0_0_1; -.
DR InParanoid; Q0G825; -.
DR OMA; RRTVCHE; -.
DR OrthoDB; 1543237at2759; -.
DR Proteomes; UP000001940; Chromosome X.
DR Bgee; WBGene00009560; Expressed in embryo and 3 other tissues.
DR ExpressionAtlas; Q0G825; baseline and differential.
DR GO; GO:0005634; C:nucleus; IDA:WormBase.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0001223; F:transcription coactivator binding; IPI:WormBase.
DR GO; GO:0009786; P:regulation of asymmetric cell division; IMP:WormBase.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR InterPro; IPR032453; PKNOX/Meis_N.
DR Pfam; PF16493; Meis_PKNOX_N; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Nucleus; Reference proteome; Transcription;
KW Transcription regulation.
FT CHAIN 1..275
FT /note="Transcriptional coregulator psa-3"
FT /id="PRO_0000455832"
FT DOMAIN 91..161
FT /note="MEIS N-terminal"
FT /evidence="ECO:0000305|PubMed:16824957"
FT VAR_SEQ 1..118
FT /note="Missing (in isoform d)"
FT /evidence="ECO:0000305"
FT /id="VSP_061533"
FT VAR_SEQ 1..66
FT /note="Missing (in isoform c)"
FT /evidence="ECO:0000305"
FT /id="VSP_061534"
FT VAR_SEQ 1..40
FT /note="MTSEPSTSSEAGSSSLLDADKTNLLQEALVRAGVIRSQRQ -> MSPNIK
FT (in isoform b)"
FT /evidence="ECO:0000305"
FT /id="VSP_061535"
SQ SEQUENCE 275 AA; 30256 MW; 21AD0B4F19D7B065 CRC64;
MTSEPSTSSE AGSSSLLDAD KTNLLQEALV RAGVIRSQRQ GISPTATNIK SPKKSALFEK
IASHPLMPIV ELLLEKCETA ATTFDRKAFE TDDIKRLFQS LEQRGVQLSS NRDEVDELME
TAILALRTCM VELERVYSLM ESFKAKYLAT LRRTVCHEAL VGNNGDSDDE LSDNPLMPVL
EMSEAAFQAQ NKAMESALAT LQSVSGSLSL PLQFTHQSIT AAQIERNLEF LKQCGFPTQL
PPNFLKPSNE KSPEKSEEEK SQKPSSSPKS PSLSD
