PSB2_YEAST
ID PSB2_YEAST Reviewed; 261 AA.
AC P25043; D6W2L4;
DT 01-MAY-1992, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-1992, sequence version 1.
DT 03-AUG-2022, entry version 215.
DE RecName: Full=Proteasome subunit beta type-2;
DE EC=3.4.25.1;
DE AltName: Full=Macropain subunit PUP1;
DE AltName: Full=Multicatalytic endopeptidase complex subunit PUP1;
DE AltName: Full=Proteasome component PUP1;
DE AltName: Full=Proteinase YSCE subunit PUP1;
DE Flags: Precursor;
GN Name=PUP1; OrderedLocusNames=YOR157C;
OS Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Saccharomycetaceae; Saccharomyces.
OX NCBI_TaxID=559292;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=1923775; DOI=10.1093/nar/19.18.5075;
RA Haffter P., Fox T.D.;
RT "Nucleotide sequence of PUP1 encoding a putative proteasome subunit in
RT Saccharomyces cerevisiae.";
RL Nucleic Acids Res. 19:5075-5075(1991).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=S288c / FY1678;
RX PubMed=9046089;
RX DOI=10.1002/(sici)1097-0061(199701)13:1<73::aid-yea52>3.0.co;2-m;
RA Bordonne R., Camasses A., Madania A., Poch O., Tarassov I.A., Winsor B.,
RA Martin R.P.;
RT "Analysis of a 35.6 kb region on the right arm of Saccharomyces cerevisiae
RT chromosome XV.";
RL Yeast 13:73-83(1997).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=9169874;
RA Dujon B., Albermann K., Aldea M., Alexandraki D., Ansorge W., Arino J.,
RA Benes V., Bohn C., Bolotin-Fukuhara M., Bordonne R., Boyer J., Camasses A.,
RA Casamayor A., Casas C., Cheret G., Cziepluch C., Daignan-Fornier B.,
RA Dang V.-D., de Haan M., Delius H., Durand P., Fairhead C., Feldmann H.,
RA Gaillon L., Galisson F., Gamo F.-J., Gancedo C., Goffeau A., Goulding S.E.,
RA Grivell L.A., Habbig B., Hand N.J., Hani J., Hattenhorst U., Hebling U.,
RA Hernando Y., Herrero E., Heumann K., Hiesel R., Hilger F., Hofmann B.,
RA Hollenberg C.P., Hughes B., Jauniaux J.-C., Kalogeropoulos A.,
RA Katsoulou C., Kordes E., Lafuente M.J., Landt O., Louis E.J., Maarse A.C.,
RA Madania A., Mannhaupt G., Marck C., Martin R.P., Mewes H.-W., Michaux G.,
RA Paces V., Parle-McDermott A.G., Pearson B.M., Perrin A., Pettersson B.,
RA Poch O., Pohl T.M., Poirey R., Portetelle D., Pujol A., Purnelle B.,
RA Ramezani Rad M., Rechmann S., Schwager C., Schweizer M., Sor F., Sterky F.,
RA Tarassov I.A., Teodoru C., Tettelin H., Thierry A., Tobiasch E.,
RA Tzermia M., Uhlen M., Unseld M., Valens M., Vandenbol M., Vetter I.,
RA Vlcek C., Voet M., Volckaert G., Voss H., Wambutt R., Wedler H.,
RA Wiemann S., Winsor B., Wolfe K.H., Zollner A., Zumstein E., Kleine K.;
RT "The nucleotide sequence of Saccharomyces cerevisiae chromosome XV.";
RL Nature 387:98-102(1997).
RN [4]
RP GENOME REANNOTATION.
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=24374639; DOI=10.1534/g3.113.008995;
RA Engel S.R., Dietrich F.S., Fisk D.G., Binkley G., Balakrishnan R.,
RA Costanzo M.C., Dwight S.S., Hitz B.C., Karra K., Nash R.S., Weng S.,
RA Wong E.D., Lloyd P., Skrzypek M.S., Miyasato S.R., Simison M., Cherry J.M.;
RT "The reference genome sequence of Saccharomyces cerevisiae: Then and now.";
RL G3 (Bethesda) 4:389-398(2014).
RN [5]
RP LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
RX PubMed=14562106; DOI=10.1038/nature02046;
RA Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N.,
RA O'Shea E.K., Weissman J.S.;
RT "Global analysis of protein expression in yeast.";
RL Nature 425:737-741(2003).
RN [6]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=22814378; DOI=10.1073/pnas.1210303109;
RA Van Damme P., Lasa M., Polevoda B., Gazquez C., Elosegui-Artola A.,
RA Kim D.S., De Juan-Pardo E., Demeyer K., Hole K., Larrea E., Timmerman E.,
RA Prieto J., Arnesen T., Sherman F., Gevaert K., Aldabe R.;
RT "N-terminal acetylome analyses and functional insights of the N-terminal
RT acetyltransferase NatB.";
RL Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012).
RN [7]
RP X-RAY CRYSTALLOGRAPHY (1.9 ANGSTROMS) OF 30-251 OF COMPLEX WITH THE 20S
RP PROTEASOME, PROTEOLYTIC PROCESSING, AND ACTIVE SITE.
RX PubMed=9087403; DOI=10.1038/386463a0;
RA Groll M., Ditzel L., Loewe J., Stock D., Bochtler M., Bartunik H.D.,
RA Huber R.;
RT "Structure of 20S proteasome from yeast at 2.4-A resolution.";
RL Nature 386:463-471(1997).
RN [8]
RP X-RAY CRYSTALLOGRAPHY (3.2 ANGSTROMS) OF 30-261 OF COMPLEX WITH THE 20S
RP PROTEASOME AND A 11S REGULATORY COMPLEX.
RX PubMed=11081519; DOI=10.1038/35040607;
RA Whitby F.G., Masters E.I., Kramer L., Knowlton J.R., Yao Y., Wang C.C.,
RA Hill C.P.;
RT "Structural basis for the activation of 20S proteasomes by 11S
RT regulators.";
RL Nature 408:115-120(2000).
RN [9]
RP X-RAY CRYSTALLOGRAPHY (2.4 ANGSTROMS) OF COMPLEX WITH THE 20S PROTEASOME.
RX PubMed=11062564; DOI=10.1038/80992;
RA Groll M., Bajorek M., Koehler A., Moroder L., Rubin D.M., Huber R.,
RA Glickman M.H., Finley D.;
RT "A gated channel into the proteasome core particle.";
RL Nat. Struct. Biol. 7:1062-1067(2000).
RN [10]
RP X-RAY CRYSTALLOGRAPHY (2.81 ANGSTROMS) OF 30-251 OF COMPLEX WITH THE 20S
RP PROTEASOME AND A TMC-95-BASED INHIBITOR.
RX PubMed=16793518; DOI=10.1016/j.chembiol.2006.04.005;
RA Groll M., Goetz M., Kaiser M., Weyher E., Moroder L.;
RT "TMC-95-based inhibitor design provides evidence for the catalytic
RT versatility of the proteasome.";
RL Chem. Biol. 13:607-614(2006).
RN [11]
RP X-RAY CRYSTALLOGRAPHY (2.8 ANGSTROMS) OF 30-251 OF COMPLEX WITH THE 20S
RP PROTEASOME AND SALINOSPORAMIDE.
RX PubMed=16608349; DOI=10.1021/ja058320b;
RA Groll M., Huber R., Potts B.C.M.;
RT "Crystal structures of salinosporamide A (NPI-0052) and B (NPI-0047) in
RT complex with the 20S proteasome reveal important consequences of beta-
RT lactone ring opening and a mechanism for irreversible binding.";
RL J. Am. Chem. Soc. 128:5136-5141(2006).
RN [12]
RP X-RAY CRYSTALLOGRAPHY (2.8 ANGSTROMS) OF 30-251 OF COMPLEX WITH THE 20S
RP PROTEASOME AND BORTEZOMIB.
RX PubMed=16531229; DOI=10.1016/j.str.2005.11.019;
RA Groll M., Berkers C.R., Ploegh H.L., Ovaa H.;
RT "Crystal structure of the boronic acid-based proteasome inhibitor
RT bortezomib in complex with the yeast 20S proteasome.";
RL Structure 14:451-456(2006).
RN [13]
RP X-RAY CRYSTALLOGRAPHY (3.0 ANGSTROMS) OF 30-251 IN COMPLEX WITH THE
RP PROTEASOME.
RX PubMed=20227375; DOI=10.1016/j.molcel.2010.02.002;
RA Sadre-Bazzaz K., Whitby F.G., Robinson H., Formosa T., Hill C.P.;
RT "Structure of a Blm10 complex reveals common mechanisms for proteasome
RT binding and gate opening.";
RL Mol. Cell 37:728-735(2010).
RN [14]
RP STRUCTURE BY ELECTRON MICROSCOPY (7.4 ANGSTROMS) OF THE 26S PROTEASOME.
RX PubMed=22927375; DOI=10.1073/pnas.1213333109;
RA Beck F., Unverdorben P., Bohn S., Schweitzer A., Pfeifer G., Sakata E.,
RA Nickell S., Plitzko J.M., Villa E., Baumeister W., Forster F.;
RT "Near-atomic resolution structural model of the yeast 26S proteasome.";
RL Proc. Natl. Acad. Sci. U.S.A. 109:14870-14875(2012).
CC -!- FUNCTION: The proteasome degrades poly-ubiquitinated proteins in the
CC cytoplasm and in the nucleus. It is essential for the regulated
CC turnover of proteins and for the removal of misfolded proteins. The
CC proteasome is a multicatalytic proteinase complex that is characterized
CC by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu
CC adjacent to the leaving group at neutral or slightly basic pH. It has
CC an ATP-dependent proteolytic activity.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=Cleavage of peptide bonds with very broad specificity.;
CC EC=3.4.25.1;
CC -!- SUBUNIT: The 26S proteasome consists of a 20S proteasome core and two
CC 19S regulatory subunits. The 20S proteasome core is composed of 28
CC subunits that are arranged in four stacked rings, resulting in a
CC barrel-shaped structure. The two end rings are each formed by seven
CC alpha subunits, and the two central rings are each formed by seven beta
CC subunits. The catalytic chamber with the active sites is on the inside
CC of the barrel. {ECO:0000269|PubMed:20227375}.
CC -!- INTERACTION:
CC P25043; P25451: PUP3; NbExp=3; IntAct=EBI-14009, EBI-13993;
CC -!- SUBCELLULAR LOCATION: Cytoplasm. Nucleus.
CC -!- MISCELLANEOUS: The side chain of Thr-30 acts as nucleophile, and the N-
CC terminal amino group acts as proton acceptor.
CC -!- MISCELLANEOUS: Present with 11400 molecules/cell in log phase SD
CC medium. {ECO:0000269|PubMed:14562106}.
CC -!- SIMILARITY: Belongs to the peptidase T1B family. {ECO:0000255|PROSITE-
CC ProRule:PRU00809}.
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DR EMBL; X61189; CAA43492.1; -; Genomic_DNA.
DR EMBL; U55020; AAC49643.1; -; Genomic_DNA.
DR EMBL; Z75065; CAA99363.1; -; Genomic_DNA.
DR EMBL; BK006948; DAA10930.1; -; Genomic_DNA.
DR PIR; S26996; S26996.
DR RefSeq; NP_014800.3; NM_001183576.3.
DR PDB; 1FNT; X-ray; 3.20 A; I/W=30-261.
DR PDB; 1G0U; X-ray; 2.40 A; H/V=30-251.
DR PDB; 1G65; X-ray; 2.25 A; H/V=30-251.
DR PDB; 1JD2; X-ray; 3.00 A; H/O=30-251.
DR PDB; 1RYP; X-ray; 1.90 A; I/W=30-251.
DR PDB; 1Z7Q; X-ray; 3.22 A; I/W=30-251.
DR PDB; 2F16; X-ray; 2.80 A; H/V=30-251.
DR PDB; 2FAK; X-ray; 2.80 A; H/V=30-251.
DR PDB; 2GPL; X-ray; 2.81 A; H/V=30-251.
DR PDB; 2ZCY; X-ray; 2.90 A; H/V=30-261.
DR PDB; 3BDM; X-ray; 2.70 A; H/V=30-261.
DR PDB; 3D29; X-ray; 2.60 A; H/V=30-251.
DR PDB; 3DY3; X-ray; 2.81 A; H/V=30-251.
DR PDB; 3DY4; X-ray; 2.80 A; H/V=30-251.
DR PDB; 3E47; X-ray; 3.00 A; H/V=30-251.
DR PDB; 3GPJ; X-ray; 2.70 A; H/V=30-251.
DR PDB; 3GPT; X-ray; 2.41 A; H/V=30-251.
DR PDB; 3GPW; X-ray; 2.50 A; H/V=30-251.
DR PDB; 3HYE; X-ray; 2.50 A; H/V=30-251.
DR PDB; 3JCO; EM; 4.80 A; 4/i=1-261.
DR PDB; 3JCP; EM; 4.60 A; 4/i=1-261.
DR PDB; 3MG0; X-ray; 2.68 A; H/V=30-251.
DR PDB; 3MG4; X-ray; 3.11 A; H/V=30-251.
DR PDB; 3MG6; X-ray; 2.60 A; H/V=30-251.
DR PDB; 3MG7; X-ray; 2.78 A; H/V=30-251.
DR PDB; 3MG8; X-ray; 2.59 A; H/V=30-251.
DR PDB; 3NZJ; X-ray; 2.40 A; H/V=1-261.
DR PDB; 3NZW; X-ray; 2.50 A; H/V=1-261.
DR PDB; 3NZX; X-ray; 2.70 A; H/V=1-261.
DR PDB; 3OEU; X-ray; 2.60 A; H/V=30-251.
DR PDB; 3OEV; X-ray; 2.85 A; H/V=30-251.
DR PDB; 3OKJ; X-ray; 2.70 A; H/V=30-251.
DR PDB; 3SDI; X-ray; 2.65 A; H/V=30-251.
DR PDB; 3SDK; X-ray; 2.70 A; H/V=30-251.
DR PDB; 3SHJ; X-ray; 2.80 A; H/V=30-251.
DR PDB; 3TDD; X-ray; 2.70 A; H/V=30-251.
DR PDB; 3UN4; X-ray; 3.40 A; H/V=30-261.
DR PDB; 3UN8; X-ray; 2.70 A; H/V=30-261.
DR PDB; 3WXR; X-ray; 3.15 A; I/W=1-261.
DR PDB; 4CR2; EM; 7.70 A; 2=1-261.
DR PDB; 4CR3; EM; 9.30 A; 2=1-261.
DR PDB; 4CR4; EM; 8.80 A; 2=1-261.
DR PDB; 4EU2; X-ray; 2.51 A; I/W=30-251.
DR PDB; 4FZC; X-ray; 2.80 A; H/V=30-251.
DR PDB; 4FZG; X-ray; 3.00 A; H/V=30-251.
DR PDB; 4G4S; X-ray; 2.49 A; I=30-261.
DR PDB; 4GK7; X-ray; 2.80 A; H/V=30-251.
DR PDB; 4HNP; X-ray; 2.80 A; H/V=30-251.
DR PDB; 4HRC; X-ray; 2.80 A; H/V=30-251.
DR PDB; 4HRD; X-ray; 2.80 A; H/V=30-251.
DR PDB; 4INR; X-ray; 2.70 A; H/V=30-261.
DR PDB; 4INT; X-ray; 2.90 A; H/V=30-261.
DR PDB; 4INU; X-ray; 3.10 A; H/V=30-261.
DR PDB; 4J70; X-ray; 2.80 A; H/V=30-261.
DR PDB; 4JSQ; X-ray; 2.80 A; H/V=30-261.
DR PDB; 4JSU; X-ray; 2.90 A; H/V=30-261.
DR PDB; 4JT0; X-ray; 3.10 A; H/V=30-261.
DR PDB; 4LQI; X-ray; 2.70 A; H/V=30-251.
DR PDB; 4LTC; X-ray; 2.50 A; H/V=30-261.
DR PDB; 4NNN; X-ray; 2.50 A; H/V=30-261.
DR PDB; 4NNW; X-ray; 2.60 A; H/V=30-261.
DR PDB; 4NO1; X-ray; 2.50 A; H/V=30-261.
DR PDB; 4NO6; X-ray; 3.00 A; H/V=30-261.
DR PDB; 4NO8; X-ray; 2.70 A; H/V=30-261.
DR PDB; 4NO9; X-ray; 2.90 A; H/V=30-261.
DR PDB; 4Q1S; X-ray; 2.60 A; H/V=30-261.
DR PDB; 4QBY; X-ray; 3.00 A; H/V=30-261.
DR PDB; 4QLQ; X-ray; 2.40 A; H/V=30-261.
DR PDB; 4QLS; X-ray; 2.80 A; H/V=30-261.
DR PDB; 4QLT; X-ray; 2.80 A; H/V=30-261.
DR PDB; 4QLU; X-ray; 2.80 A; H/V=30-261.
DR PDB; 4QLV; X-ray; 2.90 A; H/V=30-261.
DR PDB; 4QUX; X-ray; 3.00 A; H/V=30-261.
DR PDB; 4QUY; X-ray; 2.80 A; H/V=30-261.
DR PDB; 4QV0; X-ray; 3.10 A; H/V=30-261.
DR PDB; 4QV1; X-ray; 2.50 A; H/V=30-261.
DR PDB; 4QV3; X-ray; 3.00 A; H/V=30-261.
DR PDB; 4QV4; X-ray; 2.70 A; H/V=30-261.
DR PDB; 4QV5; X-ray; 2.70 A; H/V=30-261.
DR PDB; 4QV6; X-ray; 2.80 A; H/V=30-261.
DR PDB; 4QV7; X-ray; 2.60 A; H/V=30-261.
DR PDB; 4QV8; X-ray; 2.90 A; H/V=30-261.
DR PDB; 4QV9; X-ray; 2.60 A; H/V=30-261.
DR PDB; 4QVL; X-ray; 2.80 A; H/V=30-261.
DR PDB; 4QVM; X-ray; 2.80 A; H/V=30-261.
DR PDB; 4QVN; X-ray; 2.90 A; H/V=30-261.
DR PDB; 4QVP; X-ray; 2.30 A; H/V=30-261.
DR PDB; 4QVQ; X-ray; 2.60 A; H/V=30-261.
DR PDB; 4QVV; X-ray; 2.80 A; H/V=30-261.
DR PDB; 4QVW; X-ray; 3.00 A; H/V=30-261.
DR PDB; 4QVY; X-ray; 2.51 A; H/V=30-261.
DR PDB; 4QW0; X-ray; 2.90 A; H/V=30-261.
DR PDB; 4QW1; X-ray; 2.90 A; H/V=30-261.
DR PDB; 4QW3; X-ray; 2.90 A; H/V=30-261.
DR PDB; 4QW4; X-ray; 2.80 A; H/V=30-261.
DR PDB; 4QW5; X-ray; 3.00 A; H/V=30-261.
DR PDB; 4QW6; X-ray; 2.90 A; H/V=30-261.
DR PDB; 4QW7; X-ray; 2.70 A; H/V=30-261.
DR PDB; 4QWF; X-ray; 3.00 A; H/V=30-261.
DR PDB; 4QWG; X-ray; 2.60 A; H/V=30-261.
DR PDB; 4QWI; X-ray; 2.60 A; H/V=30-261.
DR PDB; 4QWJ; X-ray; 2.90 A; H/V=30-261.
DR PDB; 4QWK; X-ray; 2.80 A; H/V=30-261.
DR PDB; 4QWL; X-ray; 2.60 A; H/V=30-261.
DR PDB; 4QWR; X-ray; 2.90 A; H/V=30-261.
DR PDB; 4QWS; X-ray; 3.00 A; H/V=30-261.
DR PDB; 4QWU; X-ray; 3.00 A; H/V=30-261.
DR PDB; 4QWX; X-ray; 2.90 A; H/V=30-261.
DR PDB; 4QXJ; X-ray; 2.80 A; H/V=30-261.
DR PDB; 4QZ0; X-ray; 3.00 A; H/V=30-261.
DR PDB; 4QZ1; X-ray; 3.00 A; H/V=30-261.
DR PDB; 4QZ2; X-ray; 2.70 A; H/V=30-261.
DR PDB; 4QZ3; X-ray; 2.80 A; H/V=30-261.
DR PDB; 4QZ4; X-ray; 3.00 A; H/V=30-261.
DR PDB; 4QZ5; X-ray; 2.80 A; H/V=30-261.
DR PDB; 4QZ6; X-ray; 2.90 A; H/V=30-261.
DR PDB; 4QZ7; X-ray; 2.80 A; H/V=30-261.
DR PDB; 4QZW; X-ray; 3.00 A; H/V=30-261.
DR PDB; 4QZX; X-ray; 2.60 A; H/V=30-261.
DR PDB; 4QZZ; X-ray; 2.90 A; H/V=30-261.
DR PDB; 4R00; X-ray; 2.80 A; H/V=30-261.
DR PDB; 4R02; X-ray; 2.50 A; H/V=30-261.
DR PDB; 4R17; X-ray; 2.10 A; H/V=30-261.
DR PDB; 4R18; X-ray; 2.40 A; H/V=30-261.
DR PDB; 4RUR; X-ray; 2.50 A; H/V=30-261.
DR PDB; 4V7O; X-ray; 3.00 A; AM/AY/BI/BW=30-251.
DR PDB; 4X6Z; X-ray; 2.70 A; I/W=1-261.
DR PDB; 4Y69; X-ray; 2.90 A; H/V=30-261.
DR PDB; 4Y6A; X-ray; 2.60 A; H/V=30-261.
DR PDB; 4Y6V; X-ray; 2.80 A; H/V=30-261.
DR PDB; 4Y6Z; X-ray; 2.70 A; H/V=30-261.
DR PDB; 4Y70; X-ray; 2.40 A; H/V=30-261.
DR PDB; 4Y74; X-ray; 2.70 A; H/V=30-261.
DR PDB; 4Y75; X-ray; 2.80 A; H/V=30-261.
DR PDB; 4Y77; X-ray; 2.50 A; H/V=30-261.
DR PDB; 4Y78; X-ray; 2.80 A; H/V=30-261.
DR PDB; 4Y7W; X-ray; 2.50 A; H/V=30-261.
DR PDB; 4Y7X; X-ray; 2.60 A; H/V=30-261.
DR PDB; 4Y7Y; X-ray; 2.40 A; H/V=30-261.
DR PDB; 4Y80; X-ray; 2.50 A; H/V=30-261.
DR PDB; 4Y81; X-ray; 2.80 A; H/V=30-261.
DR PDB; 4Y82; X-ray; 2.80 A; H/V=30-261.
DR PDB; 4Y84; X-ray; 2.70 A; H/V=30-261.
DR PDB; 4Y8G; X-ray; 2.60 A; H/V=30-261.
DR PDB; 4Y8H; X-ray; 2.50 A; H/V=30-261.
DR PDB; 4Y8I; X-ray; 2.60 A; H/V=30-261.
DR PDB; 4Y8J; X-ray; 2.70 A; H/V=30-261.
DR PDB; 4Y8K; X-ray; 2.60 A; H/V=30-261.
DR PDB; 4Y8L; X-ray; 2.40 A; H/V=30-261.
DR PDB; 4Y8M; X-ray; 2.80 A; H/V=30-261.
DR PDB; 4Y8N; X-ray; 2.60 A; H/V=30-261.
DR PDB; 4Y8O; X-ray; 2.70 A; H/V=30-261.
DR PDB; 4Y8P; X-ray; 2.80 A; H/V=30-261.
DR PDB; 4Y8Q; X-ray; 2.60 A; H/V=30-261.
DR PDB; 4Y8R; X-ray; 2.70 A; H/V=30-261.
DR PDB; 4Y8S; X-ray; 2.70 A; H/V=30-261.
DR PDB; 4Y8T; X-ray; 2.70 A; H/V=30-261.
DR PDB; 4Y8U; X-ray; 2.90 A; H/V=30-261.
DR PDB; 4Y9Y; X-ray; 2.80 A; H/V=30-261.
DR PDB; 4Y9Z; X-ray; 2.80 A; H/V=30-261.
DR PDB; 4YA0; X-ray; 2.80 A; H/V=30-261.
DR PDB; 4YA1; X-ray; 2.90 A; H/V=30-261.
DR PDB; 4YA2; X-ray; 2.70 A; H/V=30-261.
DR PDB; 4YA3; X-ray; 2.70 A; H/V=30-261.
DR PDB; 4YA4; X-ray; 2.90 A; H/V=30-261.
DR PDB; 4YA5; X-ray; 2.50 A; H/V=30-261.
DR PDB; 4YA7; X-ray; 2.70 A; H/V=30-261.
DR PDB; 4YA9; X-ray; 2.70 A; H/V=30-261.
DR PDB; 4Z1L; X-ray; 3.00 A; H/V=30-261.
DR PDB; 5A5B; EM; 9.50 A; 2=1-261.
DR PDB; 5AHJ; X-ray; 2.80 A; H/V=30-261.
DR PDB; 5BOU; X-ray; 2.60 A; H/V=30-261.
DR PDB; 5BXL; X-ray; 2.80 A; H/V=30-261.
DR PDB; 5BXN; X-ray; 2.80 A; H/V=30-261.
DR PDB; 5CGF; X-ray; 2.80 A; H/V=30-261.
DR PDB; 5CGG; X-ray; 2.90 A; H/V=30-261.
DR PDB; 5CGH; X-ray; 2.50 A; H/V=30-261.
DR PDB; 5CGI; X-ray; 2.80 A; H/V=30-261.
DR PDB; 5CZ4; X-ray; 2.30 A; H/V=30-261.
DR PDB; 5CZ5; X-ray; 2.80 A; H/V=30-261.
DR PDB; 5CZ6; X-ray; 2.70 A; H/V=30-261.
DR PDB; 5CZ7; X-ray; 2.50 A; H/V=30-261.
DR PDB; 5CZ8; X-ray; 2.80 A; H/V=30-261.
DR PDB; 5CZ9; X-ray; 2.90 A; H/V=30-261.
DR PDB; 5CZA; X-ray; 2.50 A; H/V=30-261.
DR PDB; 5D0S; X-ray; 2.50 A; H/V=30-261.
DR PDB; 5D0T; X-ray; 2.60 A; H/V=30-261.
DR PDB; 5D0V; X-ray; 2.90 A; H/V=30-261.
DR PDB; 5D0W; X-ray; 2.80 A; H/V=30-261.
DR PDB; 5D0X; X-ray; 2.60 A; H/V=30-261.
DR PDB; 5D0Z; X-ray; 2.90 A; H/V=30-261.
DR PDB; 5DKI; X-ray; 2.80 A; H/V=30-261.
DR PDB; 5DKJ; X-ray; 2.80 A; H/V=30-261.
DR PDB; 5FG7; X-ray; 2.70 A; H/V=24-261.
DR PDB; 5FG9; X-ray; 2.60 A; H/V=26-261.
DR PDB; 5FGA; X-ray; 2.70 A; H/V=30-261.
DR PDB; 5FGD; X-ray; 2.80 A; H/V=30-261.
DR PDB; 5FGE; X-ray; 2.60 A; H/V=30-261.
DR PDB; 5FGF; X-ray; 2.60 A; H/V=30-261.
DR PDB; 5FGG; X-ray; 2.70 A; H/V=30-261.
DR PDB; 5FGH; X-ray; 2.80 A; H/V=30-261.
DR PDB; 5FGI; X-ray; 2.90 A; H/V=18-261.
DR PDB; 5FHS; X-ray; 2.70 A; H/V=30-261.
DR PDB; 5JHR; X-ray; 2.90 A; H/V=30-261.
DR PDB; 5JHS; X-ray; 3.00 A; H/V=30-261.
DR PDB; 5L52; X-ray; 2.70 A; H/V=30-261.
DR PDB; 5L54; X-ray; 2.80 A; H/V=30-261.
DR PDB; 5L55; X-ray; 2.90 A; H/V=30-261.
DR PDB; 5L5A; X-ray; 2.40 A; H/V=30-261.
DR PDB; 5L5B; X-ray; 2.80 A; H/V=30-261.
DR PDB; 5L5D; X-ray; 2.80 A; H/V=30-261.
DR PDB; 5L5E; X-ray; 2.90 A; H/V=30-261.
DR PDB; 5L5F; X-ray; 2.50 A; H/V=30-261.
DR PDB; 5L5H; X-ray; 2.60 A; H/V=30-261.
DR PDB; 5L5I; X-ray; 2.90 A; H/V=30-261.
DR PDB; 5L5J; X-ray; 2.90 A; H/V=30-261.
DR PDB; 5L5O; X-ray; 2.60 A; H/V=30-261.
DR PDB; 5L5P; X-ray; 2.80 A; H/V=30-261.
DR PDB; 5L5Q; X-ray; 2.80 A; H/V=30-261.
DR PDB; 5L5R; X-ray; 2.90 A; H/V=30-261.
DR PDB; 5L5S; X-ray; 2.60 A; H/V=30-261.
DR PDB; 5L5T; X-ray; 2.90 A; H/V=30-261.
DR PDB; 5L5U; X-ray; 2.60 A; H/V=30-261.
DR PDB; 5L5V; X-ray; 2.70 A; H/V=30-261.
DR PDB; 5L5W; X-ray; 2.80 A; H/V=30-261.
DR PDB; 5L5X; X-ray; 2.90 A; H/V=30-261.
DR PDB; 5L5Y; X-ray; 2.70 A; H/V=30-261.
DR PDB; 5L5Z; X-ray; 2.70 A; H/V=30-261.
DR PDB; 5L60; X-ray; 2.70 A; H/V=30-261.
DR PDB; 5L61; X-ray; 2.80 A; H/V=30-261.
DR PDB; 5L62; X-ray; 2.80 A; H/V=30-261.
DR PDB; 5L63; X-ray; 2.70 A; H/V=30-261.
DR PDB; 5L64; X-ray; 2.70 A; H/V=30-261.
DR PDB; 5L65; X-ray; 2.90 A; H/V=30-261.
DR PDB; 5L66; X-ray; 2.80 A; H/V=30-261.
DR PDB; 5L67; X-ray; 2.60 A; H/V=30-261.
DR PDB; 5L68; X-ray; 2.80 A; H/V=30-261.
DR PDB; 5L69; X-ray; 2.70 A; H/V=30-261.
DR PDB; 5L6A; X-ray; 2.80 A; H/V=30-261.
DR PDB; 5L6B; X-ray; 2.60 A; H/V=30-261.
DR PDB; 5L6C; X-ray; 2.60 A; H/V=30-261.
DR PDB; 5LAI; X-ray; 2.50 A; H/V=30-261.
DR PDB; 5LAJ; X-ray; 2.90 A; H/V=30-261.
DR PDB; 5LTT; X-ray; 2.70 A; H/V=30-261.
DR PDB; 5M2B; X-ray; 2.70 A; H/V=30-261.
DR PDB; 5MP9; EM; 4.10 A; 2/i=1-261.
DR PDB; 5MPA; EM; 4.50 A; 2/i=1-261.
DR PDB; 5MPB; EM; 7.80 A; 2/i=1-261.
DR PDB; 5MPC; EM; 7.70 A; 2/i=1-261.
DR PDB; 5NIF; X-ray; 3.00 A; I/W=1-261.
DR PDB; 5WVI; EM; 6.30 A; 2/i=1-261.
DR PDB; 5WVK; EM; 4.20 A; 2/i=1-261.
DR PDB; 6EF3; EM; 4.17 A; 2=1-261.
DR PDB; 6FVT; EM; 4.10 A; 2/i=30-255.
DR PDB; 6FVU; EM; 4.50 A; 2/i=30-255.
DR PDB; 6FVV; EM; 5.40 A; 2/i=30-255.
DR PDB; 6FVW; EM; 4.50 A; 2/i=30-255.
DR PDB; 6FVX; EM; 4.90 A; 2/i=30-255.
DR PDB; 6FVY; EM; 6.10 A; 2/i=30-255.
DR PDB; 6G7F; X-ray; 2.70 A; H/V=30-261.
DR PDB; 6G8M; X-ray; 2.70 A; H/V=30-261.
DR PDB; 6G8N; X-ray; 3.00 A; H/V=30-261.
DR PDB; 6GOP; X-ray; 2.90 A; H/V=30-261.
DR PDB; 6H39; X-ray; 2.50 A; H/V=30-261.
DR PDB; 6HV3; X-ray; 2.70 A; H/V=83-255.
DR PDB; 6HV4; X-ray; 3.00 A; H/V=83-255.
DR PDB; 6HV5; X-ray; 3.00 A; H/V=83-255.
DR PDB; 6HV7; X-ray; 3.40 A; H/V=83-255.
DR PDB; 6HVA; X-ray; 2.90 A; H/V=83-255.
DR PDB; 6HVR; X-ray; 2.70 A; H/V=83-255.
DR PDB; 6HVS; X-ray; 3.10 A; H/V=83-255.
DR PDB; 6HVT; X-ray; 2.90 A; H/V=83-255.
DR PDB; 6HVU; X-ray; 2.90 A; H/V=83-255.
DR PDB; 6HVV; X-ray; 2.70 A; H/V=83-255.
DR PDB; 6HVW; X-ray; 3.00 A; H/V=83-255.
DR PDB; 6HVX; X-ray; 2.80 A; H/V=30-261.
DR PDB; 6HVY; X-ray; 2.70 A; H/V=30-261.
DR PDB; 6HW0; X-ray; 2.80 A; H/V=30-261.
DR PDB; 6HW3; X-ray; 2.60 A; H/V=30-261.
DR PDB; 6HW4; X-ray; 2.90 A; H/V=30-261.
DR PDB; 6HW5; X-ray; 2.90 A; H/V=30-261.
DR PDB; 6HW6; X-ray; 2.70 A; H/V=30-261.
DR PDB; 6HW7; X-ray; 2.70 A; H/V=30-261.
DR PDB; 6HW8; X-ray; 2.80 A; H/V=30-261.
DR PDB; 6HW9; X-ray; 2.80 A; H/V=30-261.
DR PDB; 6HWA; X-ray; 2.80 A; H/V=30-261.
DR PDB; 6HWB; X-ray; 2.60 A; H/V=30-261.
DR PDB; 6HWC; X-ray; 2.80 A; H/V=30-261.
DR PDB; 6HWD; X-ray; 2.80 A; H/V=30-261.
DR PDB; 6HWE; X-ray; 2.30 A; H/V=30-261.
DR PDB; 6HWF; X-ray; 2.50 A; H/V=30-261.
DR PDB; 6J2C; EM; 7.00 A; 2/i=1-261.
DR PDB; 6J2N; EM; 7.50 A; 2/i=1-261.
DR PDB; 6J2Q; EM; 3.80 A; 2/i=1-261.
DR PDB; 6J2X; EM; 3.80 A; 2/i=1-261.
DR PDB; 6J30; EM; 4.50 A; 2/i=1-261.
DR PDB; 6ZOU; X-ray; 2.90 A; H/V=30-261.
DR PDB; 6ZP6; X-ray; 2.80 A; H/V=30-261.
DR PDB; 6ZP8; X-ray; 3.00 A; H/V=30-261.
DR PDB; 7LS5; EM; 2.74 A; I/W=1-261.
DR PDB; 7LS6; EM; 3.17 A; I=1-261.
DR PDB; 7LSX; EM; 3.61 A; I=1-261.
DR PDB; 7QO3; EM; 6.10 A; 2/i=1-261.
DR PDB; 7QO5; EM; 6.00 A; 2/i=1-261.
DR PDBsum; 1FNT; -.
DR PDBsum; 1G0U; -.
DR PDBsum; 1G65; -.
DR PDBsum; 1JD2; -.
DR PDBsum; 1RYP; -.
DR PDBsum; 1Z7Q; -.
DR PDBsum; 2F16; -.
DR PDBsum; 2FAK; -.
DR PDBsum; 2GPL; -.
DR PDBsum; 2ZCY; -.
DR PDBsum; 3BDM; -.
DR PDBsum; 3D29; -.
DR PDBsum; 3DY3; -.
DR PDBsum; 3DY4; -.
DR PDBsum; 3E47; -.
DR PDBsum; 3GPJ; -.
DR PDBsum; 3GPT; -.
DR PDBsum; 3GPW; -.
DR PDBsum; 3HYE; -.
DR PDBsum; 3JCO; -.
DR PDBsum; 3JCP; -.
DR PDBsum; 3MG0; -.
DR PDBsum; 3MG4; -.
DR PDBsum; 3MG6; -.
DR PDBsum; 3MG7; -.
DR PDBsum; 3MG8; -.
DR PDBsum; 3NZJ; -.
DR PDBsum; 3NZW; -.
DR PDBsum; 3NZX; -.
DR PDBsum; 3OEU; -.
DR PDBsum; 3OEV; -.
DR PDBsum; 3OKJ; -.
DR PDBsum; 3SDI; -.
DR PDBsum; 3SDK; -.
DR PDBsum; 3SHJ; -.
DR PDBsum; 3TDD; -.
DR PDBsum; 3UN4; -.
DR PDBsum; 3UN8; -.
DR PDBsum; 3WXR; -.
DR PDBsum; 4CR2; -.
DR PDBsum; 4CR3; -.
DR PDBsum; 4CR4; -.
DR PDBsum; 4EU2; -.
DR PDBsum; 4FZC; -.
DR PDBsum; 4FZG; -.
DR PDBsum; 4G4S; -.
DR PDBsum; 4GK7; -.
DR PDBsum; 4HNP; -.
DR PDBsum; 4HRC; -.
DR PDBsum; 4HRD; -.
DR PDBsum; 4INR; -.
DR PDBsum; 4INT; -.
DR PDBsum; 4INU; -.
DR PDBsum; 4J70; -.
DR PDBsum; 4JSQ; -.
DR PDBsum; 4JSU; -.
DR PDBsum; 4JT0; -.
DR PDBsum; 4LQI; -.
DR PDBsum; 4LTC; -.
DR PDBsum; 4NNN; -.
DR PDBsum; 4NNW; -.
DR PDBsum; 4NO1; -.
DR PDBsum; 4NO6; -.
DR PDBsum; 4NO8; -.
DR PDBsum; 4NO9; -.
DR PDBsum; 4Q1S; -.
DR PDBsum; 4QBY; -.
DR PDBsum; 4QLQ; -.
DR PDBsum; 4QLS; -.
DR PDBsum; 4QLT; -.
DR PDBsum; 4QLU; -.
DR PDBsum; 4QLV; -.
DR PDBsum; 4QUX; -.
DR PDBsum; 4QUY; -.
DR PDBsum; 4QV0; -.
DR PDBsum; 4QV1; -.
DR PDBsum; 4QV3; -.
DR PDBsum; 4QV4; -.
DR PDBsum; 4QV5; -.
DR PDBsum; 4QV6; -.
DR PDBsum; 4QV7; -.
DR PDBsum; 4QV8; -.
DR PDBsum; 4QV9; -.
DR PDBsum; 4QVL; -.
DR PDBsum; 4QVM; -.
DR PDBsum; 4QVN; -.
DR PDBsum; 4QVP; -.
DR PDBsum; 4QVQ; -.
DR PDBsum; 4QVV; -.
DR PDBsum; 4QVW; -.
DR PDBsum; 4QVY; -.
DR PDBsum; 4QW0; -.
DR PDBsum; 4QW1; -.
DR PDBsum; 4QW3; -.
DR PDBsum; 4QW4; -.
DR PDBsum; 4QW5; -.
DR PDBsum; 4QW6; -.
DR PDBsum; 4QW7; -.
DR PDBsum; 4QWF; -.
DR PDBsum; 4QWG; -.
DR PDBsum; 4QWI; -.
DR PDBsum; 4QWJ; -.
DR PDBsum; 4QWK; -.
DR PDBsum; 4QWL; -.
DR PDBsum; 4QWR; -.
DR PDBsum; 4QWS; -.
DR PDBsum; 4QWU; -.
DR PDBsum; 4QWX; -.
DR PDBsum; 4QXJ; -.
DR PDBsum; 4QZ0; -.
DR PDBsum; 4QZ1; -.
DR PDBsum; 4QZ2; -.
DR PDBsum; 4QZ3; -.
DR PDBsum; 4QZ4; -.
DR PDBsum; 4QZ5; -.
DR PDBsum; 4QZ6; -.
DR PDBsum; 4QZ7; -.
DR PDBsum; 4QZW; -.
DR PDBsum; 4QZX; -.
DR PDBsum; 4QZZ; -.
DR PDBsum; 4R00; -.
DR PDBsum; 4R02; -.
DR PDBsum; 4R17; -.
DR PDBsum; 4R18; -.
DR PDBsum; 4RUR; -.
DR PDBsum; 4V7O; -.
DR PDBsum; 4X6Z; -.
DR PDBsum; 4Y69; -.
DR PDBsum; 4Y6A; -.
DR PDBsum; 4Y6V; -.
DR PDBsum; 4Y6Z; -.
DR PDBsum; 4Y70; -.
DR PDBsum; 4Y74; -.
DR PDBsum; 4Y75; -.
DR PDBsum; 4Y77; -.
DR PDBsum; 4Y78; -.
DR PDBsum; 4Y7W; -.
DR PDBsum; 4Y7X; -.
DR PDBsum; 4Y7Y; -.
DR PDBsum; 4Y80; -.
DR PDBsum; 4Y81; -.
DR PDBsum; 4Y82; -.
DR PDBsum; 4Y84; -.
DR PDBsum; 4Y8G; -.
DR PDBsum; 4Y8H; -.
DR PDBsum; 4Y8I; -.
DR PDBsum; 4Y8J; -.
DR PDBsum; 4Y8K; -.
DR PDBsum; 4Y8L; -.
DR PDBsum; 4Y8M; -.
DR PDBsum; 4Y8N; -.
DR PDBsum; 4Y8O; -.
DR PDBsum; 4Y8P; -.
DR PDBsum; 4Y8Q; -.
DR PDBsum; 4Y8R; -.
DR PDBsum; 4Y8S; -.
DR PDBsum; 4Y8T; -.
DR PDBsum; 4Y8U; -.
DR PDBsum; 4Y9Y; -.
DR PDBsum; 4Y9Z; -.
DR PDBsum; 4YA0; -.
DR PDBsum; 4YA1; -.
DR PDBsum; 4YA2; -.
DR PDBsum; 4YA3; -.
DR PDBsum; 4YA4; -.
DR PDBsum; 4YA5; -.
DR PDBsum; 4YA7; -.
DR PDBsum; 4YA9; -.
DR PDBsum; 4Z1L; -.
DR PDBsum; 5A5B; -.
DR PDBsum; 5AHJ; -.
DR PDBsum; 5BOU; -.
DR PDBsum; 5BXL; -.
DR PDBsum; 5BXN; -.
DR PDBsum; 5CGF; -.
DR PDBsum; 5CGG; -.
DR PDBsum; 5CGH; -.
DR PDBsum; 5CGI; -.
DR PDBsum; 5CZ4; -.
DR PDBsum; 5CZ5; -.
DR PDBsum; 5CZ6; -.
DR PDBsum; 5CZ7; -.
DR PDBsum; 5CZ8; -.
DR PDBsum; 5CZ9; -.
DR PDBsum; 5CZA; -.
DR PDBsum; 5D0S; -.
DR PDBsum; 5D0T; -.
DR PDBsum; 5D0V; -.
DR PDBsum; 5D0W; -.
DR PDBsum; 5D0X; -.
DR PDBsum; 5D0Z; -.
DR PDBsum; 5DKI; -.
DR PDBsum; 5DKJ; -.
DR PDBsum; 5FG7; -.
DR PDBsum; 5FG9; -.
DR PDBsum; 5FGA; -.
DR PDBsum; 5FGD; -.
DR PDBsum; 5FGE; -.
DR PDBsum; 5FGF; -.
DR PDBsum; 5FGG; -.
DR PDBsum; 5FGH; -.
DR PDBsum; 5FGI; -.
DR PDBsum; 5FHS; -.
DR PDBsum; 5JHR; -.
DR PDBsum; 5JHS; -.
DR PDBsum; 5L52; -.
DR PDBsum; 5L54; -.
DR PDBsum; 5L55; -.
DR PDBsum; 5L5A; -.
DR PDBsum; 5L5B; -.
DR PDBsum; 5L5D; -.
DR PDBsum; 5L5E; -.
DR PDBsum; 5L5F; -.
DR PDBsum; 5L5H; -.
DR PDBsum; 5L5I; -.
DR PDBsum; 5L5J; -.
DR PDBsum; 5L5O; -.
DR PDBsum; 5L5P; -.
DR PDBsum; 5L5Q; -.
DR PDBsum; 5L5R; -.
DR PDBsum; 5L5S; -.
DR PDBsum; 5L5T; -.
DR PDBsum; 5L5U; -.
DR PDBsum; 5L5V; -.
DR PDBsum; 5L5W; -.
DR PDBsum; 5L5X; -.
DR PDBsum; 5L5Y; -.
DR PDBsum; 5L5Z; -.
DR PDBsum; 5L60; -.
DR PDBsum; 5L61; -.
DR PDBsum; 5L62; -.
DR PDBsum; 5L63; -.
DR PDBsum; 5L64; -.
DR PDBsum; 5L65; -.
DR PDBsum; 5L66; -.
DR PDBsum; 5L67; -.
DR PDBsum; 5L68; -.
DR PDBsum; 5L69; -.
DR PDBsum; 5L6A; -.
DR PDBsum; 5L6B; -.
DR PDBsum; 5L6C; -.
DR PDBsum; 5LAI; -.
DR PDBsum; 5LAJ; -.
DR PDBsum; 5LTT; -.
DR PDBsum; 5M2B; -.
DR PDBsum; 5MP9; -.
DR PDBsum; 5MPA; -.
DR PDBsum; 5MPB; -.
DR PDBsum; 5MPC; -.
DR PDBsum; 5NIF; -.
DR PDBsum; 5WVI; -.
DR PDBsum; 5WVK; -.
DR PDBsum; 6EF3; -.
DR PDBsum; 6FVT; -.
DR PDBsum; 6FVU; -.
DR PDBsum; 6FVV; -.
DR PDBsum; 6FVW; -.
DR PDBsum; 6FVX; -.
DR PDBsum; 6FVY; -.
DR PDBsum; 6G7F; -.
DR PDBsum; 6G8M; -.
DR PDBsum; 6G8N; -.
DR PDBsum; 6GOP; -.
DR PDBsum; 6H39; -.
DR PDBsum; 6HV3; -.
DR PDBsum; 6HV4; -.
DR PDBsum; 6HV5; -.
DR PDBsum; 6HV7; -.
DR PDBsum; 6HVA; -.
DR PDBsum; 6HVR; -.
DR PDBsum; 6HVS; -.
DR PDBsum; 6HVT; -.
DR PDBsum; 6HVU; -.
DR PDBsum; 6HVV; -.
DR PDBsum; 6HVW; -.
DR PDBsum; 6HVX; -.
DR PDBsum; 6HVY; -.
DR PDBsum; 6HW0; -.
DR PDBsum; 6HW3; -.
DR PDBsum; 6HW4; -.
DR PDBsum; 6HW5; -.
DR PDBsum; 6HW6; -.
DR PDBsum; 6HW7; -.
DR PDBsum; 6HW8; -.
DR PDBsum; 6HW9; -.
DR PDBsum; 6HWA; -.
DR PDBsum; 6HWB; -.
DR PDBsum; 6HWC; -.
DR PDBsum; 6HWD; -.
DR PDBsum; 6HWE; -.
DR PDBsum; 6HWF; -.
DR PDBsum; 6J2C; -.
DR PDBsum; 6J2N; -.
DR PDBsum; 6J2Q; -.
DR PDBsum; 6J2X; -.
DR PDBsum; 6J30; -.
DR PDBsum; 6ZOU; -.
DR PDBsum; 6ZP6; -.
DR PDBsum; 6ZP8; -.
DR PDBsum; 7LS5; -.
DR PDBsum; 7LS6; -.
DR PDBsum; 7LSX; -.
DR PDBsum; 7QO3; -.
DR PDBsum; 7QO5; -.
DR AlphaFoldDB; P25043; -.
DR SMR; P25043; -.
DR BioGRID; 34553; 282.
DR ComplexPortal; CPX-2262; 26S Proteasome complex.
DR DIP; DIP-2818N; -.
DR IntAct; P25043; 12.
DR MINT; P25043; -.
DR STRING; 4932.YOR157C; -.
DR ChEMBL; CHEMBL4295577; -.
DR MEROPS; T01.011; -.
DR iPTMnet; P25043; -.
DR MaxQB; P25043; -.
DR PaxDb; P25043; -.
DR PRIDE; P25043; -.
DR EnsemblFungi; YOR157C_mRNA; YOR157C; YOR157C.
DR GeneID; 854328; -.
DR KEGG; sce:YOR157C; -.
DR SGD; S000005683; PUP1.
DR VEuPathDB; FungiDB:YOR157C; -.
DR eggNOG; KOG0173; Eukaryota.
DR GeneTree; ENSGT00940000168368; -.
DR HOGENOM; CLU_035750_3_0_1; -.
DR InParanoid; P25043; -.
DR OMA; VDKTGPH; -.
DR BioCyc; YEAST:G3O-33674-MON; -.
DR Reactome; R-SCE-1236978; Cross-presentation of soluble exogenous antigens (endosomes).
DR Reactome; R-SCE-382556; ABC-family proteins mediated transport.
DR Reactome; R-SCE-5668541; TNFR2 non-canonical NF-kB pathway.
DR Reactome; R-SCE-5687128; MAPK6/MAPK4 signaling.
DR Reactome; R-SCE-5689880; Ub-specific processing proteases.
DR Reactome; R-SCE-6798695; Neutrophil degranulation.
DR Reactome; R-SCE-68949; Orc1 removal from chromatin.
DR Reactome; R-SCE-69017; CDK-mediated phosphorylation and removal of Cdc6.
DR Reactome; R-SCE-69601; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A.
DR Reactome; R-SCE-75815; Ubiquitin-dependent degradation of Cyclin D.
DR Reactome; R-SCE-8854050; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis.
DR Reactome; R-SCE-8948751; Regulation of PTEN stability and activity.
DR Reactome; R-SCE-8951664; Neddylation.
DR Reactome; R-SCE-9755511; KEAP1-NFE2L2 pathway.
DR Reactome; R-SCE-983168; Antigen processing: Ubiquitination & Proteasome degradation.
DR EvolutionaryTrace; P25043; -.
DR PRO; PR:P25043; -.
DR Proteomes; UP000002311; Chromosome XV.
DR RNAct; P25043; protein.
DR GO; GO:0005829; C:cytosol; HDA:SGD.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; IC:SGD.
DR GO; GO:0005634; C:nucleus; IDA:SGD.
DR GO; GO:0000502; C:proteasome complex; IPI:ComplexPortal.
DR GO; GO:0005839; C:proteasome core complex; IBA:GO_Central.
DR GO; GO:0019774; C:proteasome core complex, beta-subunit complex; IDA:SGD.
DR GO; GO:0034515; C:proteasome storage granule; IDA:SGD.
DR GO; GO:0004175; F:endopeptidase activity; IMP:SGD.
DR GO; GO:0004298; F:threonine-type endopeptidase activity; IEA:UniProtKB-KW.
DR GO; GO:0010498; P:proteasomal protein catabolic process; IBA:GO_Central.
DR GO; GO:0010499; P:proteasomal ubiquitin-independent protein catabolic process; IDA:SGD.
DR GO; GO:0043161; P:proteasome-mediated ubiquitin-dependent protein catabolic process; IDA:SGD.
DR Gene3D; 3.60.20.10; -; 1.
DR InterPro; IPR029055; Ntn_hydrolases_N.
DR InterPro; IPR000243; Pept_T1A_subB.
DR InterPro; IPR035216; Proteasome_beta7.
DR InterPro; IPR024689; Proteasome_bsu_C.
DR InterPro; IPR016050; Proteasome_bsu_CS.
DR InterPro; IPR001353; Proteasome_sua/b.
DR InterPro; IPR023333; Proteasome_suB-type.
DR PANTHER; PTHR11599:SF42; PTHR11599:SF42; 1.
DR Pfam; PF12465; Pr_beta_C; 1.
DR Pfam; PF00227; Proteasome; 1.
DR PRINTS; PR00141; PROTEASOME.
DR SUPFAM; SSF56235; SSF56235; 1.
DR PROSITE; PS00854; PROTEASOME_BETA_1; 1.
DR PROSITE; PS51476; PROTEASOME_BETA_2; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Cytoplasm; Hydrolase; Nucleus; Protease; Proteasome;
KW Reference proteome; Threonine protease; Zymogen.
FT PROPEP 1..29
FT /note="Removed in mature form"
FT /id="PRO_0000026657"
FT CHAIN 30..261
FT /note="Proteasome subunit beta type-2"
FT /id="PRO_0000026658"
FT ACT_SITE 30
FT /note="Nucleophile"
FT /evidence="ECO:0000269|PubMed:9087403"
FT HELIX 9..17
FT /evidence="ECO:0007829|PDB:7LS6"
FT STRAND 23..25
FT /evidence="ECO:0007829|PDB:5FGI"
FT STRAND 32..37
FT /evidence="ECO:0007829|PDB:1RYP"
FT STRAND 40..45
FT /evidence="ECO:0007829|PDB:1RYP"
FT STRAND 49..51
FT /evidence="ECO:0007829|PDB:1RYP"
FT STRAND 54..59
FT /evidence="ECO:0007829|PDB:1RYP"
FT STRAND 63..67
FT /evidence="ECO:0007829|PDB:1RYP"
FT STRAND 70..76
FT /evidence="ECO:0007829|PDB:1RYP"
FT HELIX 78..99
FT /evidence="ECO:0007829|PDB:1RYP"
FT HELIX 105..118
FT /evidence="ECO:0007829|PDB:1RYP"
FT TURN 119..121
FT /evidence="ECO:0007829|PDB:1RYP"
FT STRAND 125..133
FT /evidence="ECO:0007829|PDB:1RYP"
FT STRAND 136..142
FT /evidence="ECO:0007829|PDB:1RYP"
FT TURN 144..146
FT /evidence="ECO:0007829|PDB:1G0U"
FT STRAND 148..150
FT /evidence="ECO:0007829|PDB:1RYP"
FT STRAND 152..157
FT /evidence="ECO:0007829|PDB:1RYP"
FT HELIX 160..170
FT /evidence="ECO:0007829|PDB:1RYP"
FT HELIX 177..194
FT /evidence="ECO:0007829|PDB:1RYP"
FT STRAND 195..197
FT /evidence="ECO:0007829|PDB:6HVV"
FT STRAND 202..208
FT /evidence="ECO:0007829|PDB:1RYP"
FT STRAND 213..220
FT /evidence="ECO:0007829|PDB:1RYP"
FT STRAND 241..246
FT /evidence="ECO:0007829|PDB:1RYP"
SQ SEQUENCE 261 AA; 28268 MW; 13A8F2B75584539A CRC64;
MAGLSFDNYQ RNNFLAENSH TQPKATSTGT TIVGVKFNNG VVIAADTRST QGPIVADKNC
AKLHRISPKI WCAGAGTAAD TEAVTQLIGS NIELHSLYTS REPRVVSALQ MLKQHLFKYQ
GHIGAYLIVA GVDPTGSHLF SIHAHGSTDV GYYLSLGSGS LAAMAVLESH WKQDLTKEEA
IKLASDAIQA GIWNDLGSGS NVDVCVMEIG KDAEYLRNYL TPNVREEKQK SYKFPRGTTA
VLKESIVNIC DIQEEQVDIT A
