PSB4_YEAST
ID PSB4_YEAST Reviewed; 198 AA.
AC P22141; D3DLQ9;
DT 01-AUG-1991, integrated into UniProtKB/Swiss-Prot.
DT 01-FEB-1995, sequence version 2.
DT 03-AUG-2022, entry version 225.
DE RecName: Full=Proteasome subunit beta type-4;
DE AltName: Full=Macropain subunit C11;
DE AltName: Full=Multicatalytic endopeptidase complex subunit C11;
DE AltName: Full=Proteasome component C11;
DE AltName: Full=Proteinase YSCE subunit 11;
GN Name=PRE1; OrderedLocusNames=YER012W;
OS Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Saccharomycetaceae; Saccharomyces.
OX NCBI_TaxID=559292;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND PARTIAL PROTEIN SEQUENCE.
RX PubMed=2001673; DOI=10.1002/j.1460-2075.1991.tb07982.x;
RA Heinemeyer W., Kleinschmidt J.A., Saidowsky J., Escher C., Wolf D.H.;
RT "Proteinase yscE, the yeast proteasome/multicatalytic-multifunctional
RT proteinase: mutants unravel its function in stress induced proteolysis and
RT uncover its necessity for cell survival.";
RL EMBO J. 10:555-562(1991).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=9169868;
RA Dietrich F.S., Mulligan J.T., Hennessy K.M., Yelton M.A., Allen E.,
RA Araujo R., Aviles E., Berno A., Brennan T., Carpenter J., Chen E.,
RA Cherry J.M., Chung E., Duncan M., Guzman E., Hartzell G., Hunicke-Smith S.,
RA Hyman R.W., Kayser A., Komp C., Lashkari D., Lew H., Lin D., Mosedale D.,
RA Nakahara K., Namath A., Norgren R., Oefner P., Oh C., Petel F.X.,
RA Roberts D., Sehl P., Schramm S., Shogren T., Smith V., Taylor P., Wei Y.,
RA Botstein D., Davis R.W.;
RT "The nucleotide sequence of Saccharomyces cerevisiae chromosome V.";
RL Nature 387:78-81(1997).
RN [3]
RP GENOME REANNOTATION.
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=24374639; DOI=10.1534/g3.113.008995;
RA Engel S.R., Dietrich F.S., Fisk D.G., Binkley G., Balakrishnan R.,
RA Costanzo M.C., Dwight S.S., Hitz B.C., Karra K., Nash R.S., Weng S.,
RA Wong E.D., Lloyd P., Skrzypek M.S., Miyasato S.R., Simison M., Cherry J.M.;
RT "The reference genome sequence of Saccharomyces cerevisiae: Then and now.";
RL G3 (Bethesda) 4:389-398(2014).
RN [4]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=17322287; DOI=10.1101/gr.6037607;
RA Hu Y., Rolfs A., Bhullar B., Murthy T.V.S., Zhu C., Berger M.F.,
RA Camargo A.A., Kelley F., McCarron S., Jepson D., Richardson A., Raphael J.,
RA Moreira D., Taycher E., Zuo D., Mohr S., Kane M.F., Williamson J.,
RA Simpson A.J.G., Bulyk M.L., Harlow E., Marsischky G., Kolodner R.D.,
RA LaBaer J.;
RT "Approaching a complete repository of sequence-verified protein-encoding
RT clones for Saccharomyces cerevisiae.";
RL Genome Res. 17:536-543(2007).
RN [5]
RP LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
RX PubMed=14562106; DOI=10.1038/nature02046;
RA Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N.,
RA O'Shea E.K., Weissman J.S.;
RT "Global analysis of protein expression in yeast.";
RL Nature 425:737-741(2003).
RN [6]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-76, AND IDENTIFICATION BY
RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=18407956; DOI=10.1074/mcp.m700468-mcp200;
RA Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.;
RT "A multidimensional chromatography technology for in-depth phosphoproteome
RT analysis.";
RL Mol. Cell. Proteomics 7:1389-1396(2008).
RN [7]
RP ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1, AND IDENTIFICATION BY MASS
RP SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=22814378; DOI=10.1073/pnas.1210303109;
RA Van Damme P., Lasa M., Polevoda B., Gazquez C., Elosegui-Artola A.,
RA Kim D.S., De Juan-Pardo E., Demeyer K., Hole K., Larrea E., Timmerman E.,
RA Prieto J., Arnesen T., Sherman F., Gevaert K., Aldabe R.;
RT "N-terminal acetylome analyses and functional insights of the N-terminal
RT acetyltransferase NatB.";
RL Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012).
RN [8]
RP X-RAY CRYSTALLOGRAPHY (1.9 ANGSTROMS) OF COMPLEX WITH THE 20S PROTEASOME.
RX PubMed=9087403; DOI=10.1038/386463a0;
RA Groll M., Ditzel L., Loewe J., Stock D., Bochtler M., Bartunik H.D.,
RA Huber R.;
RT "Structure of 20S proteasome from yeast at 2.4-A resolution.";
RL Nature 386:463-471(1997).
RN [9]
RP X-RAY CRYSTALLOGRAPHY (3.2 ANGSTROMS) OF COMPLEX WITH THE 20S PROTEASOME
RP AND A 11S REGULATORY COMPLEX.
RX PubMed=11081519; DOI=10.1038/35040607;
RA Whitby F.G., Masters E.I., Kramer L., Knowlton J.R., Yao Y., Wang C.C.,
RA Hill C.P.;
RT "Structural basis for the activation of 20S proteasomes by 11S
RT regulators.";
RL Nature 408:115-120(2000).
RN [10]
RP X-RAY CRYSTALLOGRAPHY (2.4 ANGSTROMS) OF COMPLEX WITH THE 20S PROTEASOME.
RX PubMed=11062564; DOI=10.1038/80992;
RA Groll M., Bajorek M., Koehler A., Moroder L., Rubin D.M., Huber R.,
RA Glickman M.H., Finley D.;
RT "A gated channel into the proteasome core particle.";
RL Nat. Struct. Biol. 7:1062-1067(2000).
RN [11]
RP X-RAY CRYSTALLOGRAPHY (2.81 ANGSTROMS) OF COMPLEX WITH THE 20S PROTEASOME
RP AND A TMC-95-BASED INHIBITOR.
RX PubMed=16793518; DOI=10.1016/j.chembiol.2006.04.005;
RA Groll M., Goetz M., Kaiser M., Weyher E., Moroder L.;
RT "TMC-95-based inhibitor design provides evidence for the catalytic
RT versatility of the proteasome.";
RL Chem. Biol. 13:607-614(2006).
RN [12]
RP X-RAY CRYSTALLOGRAPHY (2.8 ANGSTROMS) OF COMPLEX WITH THE 20S PROTEASOME
RP AND SALINOSPORAMIDE.
RX PubMed=16608349; DOI=10.1021/ja058320b;
RA Groll M., Huber R., Potts B.C.M.;
RT "Crystal structures of salinosporamide A (NPI-0052) and B (NPI-0047) in
RT complex with the 20S proteasome reveal important consequences of beta-
RT lactone ring opening and a mechanism for irreversible binding.";
RL J. Am. Chem. Soc. 128:5136-5141(2006).
RN [13]
RP X-RAY CRYSTALLOGRAPHY (2.8 ANGSTROMS) OF COMPLEX WITH THE 20S PROTEASOME
RP AND BORTEZOMIB.
RX PubMed=16531229; DOI=10.1016/j.str.2005.11.019;
RA Groll M., Berkers C.R., Ploegh H.L., Ovaa H.;
RT "Crystal structure of the boronic acid-based proteasome inhibitor
RT bortezomib in complex with the yeast 20S proteasome.";
RL Structure 14:451-456(2006).
RN [14]
RP X-RAY CRYSTALLOGRAPHY (3.0 ANGSTROMS) IN COMPLEX WITH THE PROTEASOME.
RX PubMed=20227375; DOI=10.1016/j.molcel.2010.02.002;
RA Sadre-Bazzaz K., Whitby F.G., Robinson H., Formosa T., Hill C.P.;
RT "Structure of a Blm10 complex reveals common mechanisms for proteasome
RT binding and gate opening.";
RL Mol. Cell 37:728-735(2010).
RN [15]
RP STRUCTURE BY ELECTRON MICROSCOPY (7.4 ANGSTROMS) OF THE 26S PROTEASOME.
RX PubMed=22927375; DOI=10.1073/pnas.1213333109;
RA Beck F., Unverdorben P., Bohn S., Schweitzer A., Pfeifer G., Sakata E.,
RA Nickell S., Plitzko J.M., Villa E., Baumeister W., Forster F.;
RT "Near-atomic resolution structural model of the yeast 26S proteasome.";
RL Proc. Natl. Acad. Sci. U.S.A. 109:14870-14875(2012).
CC -!- FUNCTION: Non-catalytic component of the proteasome which degrades
CC poly-ubiquitinated proteins in the cytoplasm and in the nucleus. It is
CC essential for the regulated turnover of proteins and for the removal of
CC misfolded proteins. The proteasome is a multicatalytic proteinase
CC complex that is characterized by its ability to cleave peptides with
CC Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or
CC slightly basic pH. It has an ATP-dependent proteolytic activity. This
CC subunit has a chymotrypsin-like activity.
CC -!- SUBUNIT: The 26S proteasome consists of a 20S proteasome core and two
CC 19S regulatory subunits. The 20S proteasome core is composed of 28
CC subunits that are arranged in four stacked rings, resulting in a
CC barrel-shaped structure. The two end rings are each formed by seven
CC alpha subunits, and the two central rings are each formed by seven beta
CC subunits. The catalytic chamber with the active sites is on the inside
CC of the barrel. {ECO:0000269|PubMed:20227375}.
CC -!- INTERACTION:
CC P22141; P21242: PRE10; NbExp=4; IntAct=EBI-13988, EBI-13963;
CC P22141; P30656: PRE2; NbExp=3; IntAct=EBI-13988, EBI-14001;
CC P22141; P40303: PRE6; NbExp=5; IntAct=EBI-13988, EBI-13980;
CC P22141; P32628: RAD23; NbExp=3; IntAct=EBI-13988, EBI-14668;
CC P22141; P33299: RPT1; NbExp=2; IntAct=EBI-13988, EBI-13910;
CC -!- SUBCELLULAR LOCATION: Cytoplasm. Nucleus.
CC -!- MISCELLANEOUS: Present with 21800 molecules/cell in log phase SD
CC medium. {ECO:0000269|PubMed:14562106}.
CC -!- SIMILARITY: Belongs to the peptidase T1B family. {ECO:0000255|PROSITE-
CC ProRule:PRU00809}.
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DR EMBL; X56812; CAA40149.1; -; Genomic_DNA.
DR EMBL; U18778; AAB64545.1; -; Genomic_DNA.
DR EMBL; AY557807; AAS56133.1; -; Genomic_DNA.
DR EMBL; BK006939; DAA07663.1; -; Genomic_DNA.
DR PIR; S50470; S50470.
DR RefSeq; NP_010928.1; NM_001178903.1.
DR PDB; 1FNT; X-ray; 3.20 A; K/Y=1-198.
DR PDB; 1G0U; X-ray; 2.40 A; J/X=1-198.
DR PDB; 1G65; X-ray; 2.25 A; J/X=1-198.
DR PDB; 1JD2; X-ray; 3.00 A; J/Q=1-198.
DR PDB; 1RYP; X-ray; 1.90 A; K/Y=1-198.
DR PDB; 1Z7Q; X-ray; 3.22 A; K/Y=1-198.
DR PDB; 2F16; X-ray; 2.80 A; J/X=1-198.
DR PDB; 2FAK; X-ray; 2.80 A; J/X=1-198.
DR PDB; 2GPL; X-ray; 2.81 A; J/X=1-198.
DR PDB; 2ZCY; X-ray; 2.90 A; J/X=1-198.
DR PDB; 3BDM; X-ray; 2.70 A; J/X=1-198.
DR PDB; 3D29; X-ray; 2.60 A; J/X=1-198.
DR PDB; 3DY3; X-ray; 2.81 A; J/X=1-198.
DR PDB; 3DY4; X-ray; 2.80 A; J/X=1-198.
DR PDB; 3E47; X-ray; 3.00 A; J/X=1-198.
DR PDB; 3GPJ; X-ray; 2.70 A; J/X=1-198.
DR PDB; 3GPT; X-ray; 2.41 A; J/X=1-198.
DR PDB; 3GPW; X-ray; 2.50 A; J/X=1-198.
DR PDB; 3HYE; X-ray; 2.50 A; J/X=1-198.
DR PDB; 3JCO; EM; 4.80 A; 6/k=1-198.
DR PDB; 3JCP; EM; 4.60 A; 6/k=1-198.
DR PDB; 3MG0; X-ray; 2.68 A; J/X=1-198.
DR PDB; 3MG4; X-ray; 3.11 A; J/X=1-198.
DR PDB; 3MG6; X-ray; 2.60 A; J/X=1-198.
DR PDB; 3MG7; X-ray; 2.78 A; J/X=1-198.
DR PDB; 3MG8; X-ray; 2.59 A; J/X=1-198.
DR PDB; 3NZJ; X-ray; 2.40 A; J/X=1-198.
DR PDB; 3NZW; X-ray; 2.50 A; J/X=1-198.
DR PDB; 3NZX; X-ray; 2.70 A; J/X=1-198.
DR PDB; 3OEU; X-ray; 2.60 A; J/X=1-198.
DR PDB; 3OEV; X-ray; 2.85 A; J/X=1-198.
DR PDB; 3OKJ; X-ray; 2.70 A; J/X=1-198.
DR PDB; 3SDI; X-ray; 2.65 A; J/X=1-198.
DR PDB; 3SDK; X-ray; 2.70 A; J/X=1-198.
DR PDB; 3SHJ; X-ray; 2.80 A; J/X=1-198.
DR PDB; 3TDD; X-ray; 2.70 A; J/X=1-198.
DR PDB; 3UN4; X-ray; 3.40 A; J/X=1-198.
DR PDB; 3UN8; X-ray; 2.70 A; J/X=1-198.
DR PDB; 3WXR; X-ray; 3.15 A; K/Y=1-198.
DR PDB; 4CR2; EM; 7.70 A; 4=1-198.
DR PDB; 4CR3; EM; 9.30 A; 4=1-198.
DR PDB; 4CR4; EM; 8.80 A; 4=1-198.
DR PDB; 4EU2; X-ray; 2.51 A; K/Y=1-198.
DR PDB; 4FZC; X-ray; 2.80 A; J/X=1-198.
DR PDB; 4FZG; X-ray; 3.00 A; J/X=1-198.
DR PDB; 4G4S; X-ray; 2.49 A; K=1-198.
DR PDB; 4GK7; X-ray; 2.80 A; J/X=1-198.
DR PDB; 4HNP; X-ray; 2.80 A; J/X=1-198.
DR PDB; 4HRC; X-ray; 2.80 A; J/X=1-198.
DR PDB; 4HRD; X-ray; 2.80 A; J/X=1-198.
DR PDB; 4INR; X-ray; 2.70 A; J/X=1-198.
DR PDB; 4INT; X-ray; 2.90 A; J/X=1-198.
DR PDB; 4INU; X-ray; 3.10 A; J/X=1-198.
DR PDB; 4J70; X-ray; 2.80 A; J/X=1-198.
DR PDB; 4JSQ; X-ray; 2.80 A; J/X=1-198.
DR PDB; 4JSU; X-ray; 2.90 A; J/X=1-198.
DR PDB; 4JT0; X-ray; 3.10 A; J/X=1-198.
DR PDB; 4LQI; X-ray; 2.70 A; J/X=1-198.
DR PDB; 4LTC; X-ray; 2.50 A; J/X=1-198.
DR PDB; 4NNN; X-ray; 2.50 A; J/X=1-198.
DR PDB; 4NNW; X-ray; 2.60 A; J/X=1-198.
DR PDB; 4NO1; X-ray; 2.50 A; J/X=1-198.
DR PDB; 4NO6; X-ray; 3.00 A; J/X=1-198.
DR PDB; 4NO8; X-ray; 2.70 A; J/X=1-198.
DR PDB; 4NO9; X-ray; 2.90 A; J/X=1-198.
DR PDB; 4Q1S; X-ray; 2.60 A; J/X=1-198.
DR PDB; 4QBY; X-ray; 3.00 A; J/X=1-198.
DR PDB; 4QLQ; X-ray; 2.40 A; J/X=1-198.
DR PDB; 4QLS; X-ray; 2.80 A; J/X=1-198.
DR PDB; 4QLT; X-ray; 2.80 A; J/X=1-198.
DR PDB; 4QLU; X-ray; 2.80 A; J/X=1-198.
DR PDB; 4QLV; X-ray; 2.90 A; J/X=1-198.
DR PDB; 4QUX; X-ray; 3.00 A; J/X=1-198.
DR PDB; 4QUY; X-ray; 2.80 A; J/X=1-198.
DR PDB; 4QV0; X-ray; 3.10 A; J/X=1-198.
DR PDB; 4QV1; X-ray; 2.50 A; J/X=1-198.
DR PDB; 4QV3; X-ray; 3.00 A; J/X=1-198.
DR PDB; 4QV4; X-ray; 2.70 A; J/X=1-198.
DR PDB; 4QV5; X-ray; 2.70 A; J/X=1-198.
DR PDB; 4QV6; X-ray; 2.80 A; J/X=1-198.
DR PDB; 4QV7; X-ray; 2.60 A; J/X=1-198.
DR PDB; 4QV8; X-ray; 2.90 A; J/X=1-198.
DR PDB; 4QV9; X-ray; 2.60 A; J/X=1-198.
DR PDB; 4QVL; X-ray; 2.80 A; J/X=1-198.
DR PDB; 4QVM; X-ray; 2.80 A; J/X=1-198.
DR PDB; 4QVN; X-ray; 2.90 A; J/X=1-198.
DR PDB; 4QVP; X-ray; 2.30 A; J/X=1-198.
DR PDB; 4QVQ; X-ray; 2.60 A; J/X=1-198.
DR PDB; 4QVV; X-ray; 2.80 A; J/X=1-198.
DR PDB; 4QVW; X-ray; 3.00 A; J/X=1-198.
DR PDB; 4QVY; X-ray; 2.51 A; J/X=1-198.
DR PDB; 4QW0; X-ray; 2.90 A; J/X=1-198.
DR PDB; 4QW1; X-ray; 2.90 A; J/X=1-198.
DR PDB; 4QW3; X-ray; 2.90 A; J/X=1-198.
DR PDB; 4QW4; X-ray; 2.80 A; J/X=1-198.
DR PDB; 4QW5; X-ray; 3.00 A; J/X=1-198.
DR PDB; 4QW6; X-ray; 2.90 A; J/X=1-198.
DR PDB; 4QW7; X-ray; 2.70 A; J/X=1-198.
DR PDB; 4QWF; X-ray; 3.00 A; J/X=1-198.
DR PDB; 4QWG; X-ray; 2.60 A; J/X=1-198.
DR PDB; 4QWI; X-ray; 2.60 A; J/X=1-198.
DR PDB; 4QWJ; X-ray; 2.90 A; J/X=1-198.
DR PDB; 4QWK; X-ray; 2.80 A; J/X=1-198.
DR PDB; 4QWL; X-ray; 2.60 A; J/X=1-198.
DR PDB; 4QWR; X-ray; 2.90 A; J/X=1-198.
DR PDB; 4QWS; X-ray; 3.00 A; J/X=1-198.
DR PDB; 4QWU; X-ray; 3.00 A; J/X=1-198.
DR PDB; 4QWX; X-ray; 2.90 A; J/X=1-198.
DR PDB; 4QXJ; X-ray; 2.80 A; J/X=1-198.
DR PDB; 4QZ0; X-ray; 3.00 A; J/X=1-198.
DR PDB; 4QZ1; X-ray; 3.00 A; J/X=1-198.
DR PDB; 4QZ2; X-ray; 2.70 A; J/X=1-198.
DR PDB; 4QZ3; X-ray; 2.80 A; J/X=1-198.
DR PDB; 4QZ4; X-ray; 3.00 A; J/X=1-198.
DR PDB; 4QZ5; X-ray; 2.80 A; J/X=1-198.
DR PDB; 4QZ6; X-ray; 2.90 A; J/X=1-198.
DR PDB; 4QZ7; X-ray; 2.80 A; J/X=1-198.
DR PDB; 4QZW; X-ray; 3.00 A; J/X=1-198.
DR PDB; 4QZX; X-ray; 2.60 A; J/X=1-198.
DR PDB; 4QZZ; X-ray; 2.90 A; J/X=1-198.
DR PDB; 4R00; X-ray; 2.80 A; J/X=1-198.
DR PDB; 4R02; X-ray; 2.50 A; J/X=1-198.
DR PDB; 4R17; X-ray; 2.10 A; J/X=1-198.
DR PDB; 4R18; X-ray; 2.40 A; J/X=1-198.
DR PDB; 4RUR; X-ray; 2.50 A; J/X=1-198.
DR PDB; 4V7O; X-ray; 3.00 A; A1/AO/BK/BY=1-198.
DR PDB; 4X6Z; X-ray; 2.70 A; K/Y=1-198.
DR PDB; 4Y69; X-ray; 2.90 A; J/X=1-198.
DR PDB; 4Y6A; X-ray; 2.60 A; J/X=1-198.
DR PDB; 4Y6V; X-ray; 2.80 A; J/X=1-198.
DR PDB; 4Y6Z; X-ray; 2.70 A; J/X=1-198.
DR PDB; 4Y70; X-ray; 2.40 A; J/X=1-198.
DR PDB; 4Y74; X-ray; 2.70 A; J/X=1-198.
DR PDB; 4Y75; X-ray; 2.80 A; J/X=1-198.
DR PDB; 4Y77; X-ray; 2.50 A; J/X=1-198.
DR PDB; 4Y78; X-ray; 2.80 A; J/X=1-198.
DR PDB; 4Y7W; X-ray; 2.50 A; J/X=1-198.
DR PDB; 4Y7X; X-ray; 2.60 A; J/X=1-198.
DR PDB; 4Y7Y; X-ray; 2.40 A; J/X=1-198.
DR PDB; 4Y80; X-ray; 2.50 A; J/X=1-198.
DR PDB; 4Y81; X-ray; 2.80 A; J/X=1-198.
DR PDB; 4Y82; X-ray; 2.80 A; J/X=1-198.
DR PDB; 4Y84; X-ray; 2.70 A; J/X=1-198.
DR PDB; 4Y8G; X-ray; 2.60 A; J/X=1-198.
DR PDB; 4Y8H; X-ray; 2.50 A; J/X=1-198.
DR PDB; 4Y8I; X-ray; 2.60 A; J/X=1-198.
DR PDB; 4Y8J; X-ray; 2.70 A; J/X=1-198.
DR PDB; 4Y8K; X-ray; 2.60 A; J/X=1-198.
DR PDB; 4Y8L; X-ray; 2.40 A; J/X=1-198.
DR PDB; 4Y8M; X-ray; 2.80 A; J/X=1-198.
DR PDB; 4Y8N; X-ray; 2.60 A; J/X=1-198.
DR PDB; 4Y8O; X-ray; 2.70 A; J/X=1-198.
DR PDB; 4Y8P; X-ray; 2.80 A; J/X=1-198.
DR PDB; 4Y8Q; X-ray; 2.60 A; J/X=1-198.
DR PDB; 4Y8R; X-ray; 2.70 A; J/X=1-198.
DR PDB; 4Y8S; X-ray; 2.70 A; J/X=1-198.
DR PDB; 4Y8T; X-ray; 2.70 A; J/X=1-198.
DR PDB; 4Y8U; X-ray; 2.90 A; J/X=1-198.
DR PDB; 4Y9Y; X-ray; 2.80 A; J/X=1-198.
DR PDB; 4Y9Z; X-ray; 2.80 A; J/X=1-198.
DR PDB; 4YA0; X-ray; 2.80 A; J/X=1-198.
DR PDB; 4YA1; X-ray; 2.90 A; J/X=1-198.
DR PDB; 4YA2; X-ray; 2.70 A; J/X=1-198.
DR PDB; 4YA3; X-ray; 2.70 A; J/X=1-198.
DR PDB; 4YA4; X-ray; 2.90 A; J/X=1-198.
DR PDB; 4YA5; X-ray; 2.50 A; J/X=1-198.
DR PDB; 4YA7; X-ray; 2.70 A; J/X=1-198.
DR PDB; 4YA9; X-ray; 2.70 A; J/X=1-198.
DR PDB; 4Z1L; X-ray; 3.00 A; J/X=1-198.
DR PDB; 5A5B; EM; 9.50 A; 4=1-198.
DR PDB; 5AHJ; X-ray; 2.80 A; J/X=1-198.
DR PDB; 5BOU; X-ray; 2.60 A; J/X=1-198.
DR PDB; 5BXL; X-ray; 2.80 A; J/X=1-198.
DR PDB; 5BXN; X-ray; 2.80 A; J/X=1-198.
DR PDB; 5CGF; X-ray; 2.80 A; J/X=1-198.
DR PDB; 5CGG; X-ray; 2.90 A; J/X=1-198.
DR PDB; 5CGH; X-ray; 2.50 A; J/X=1-198.
DR PDB; 5CGI; X-ray; 2.80 A; J/X=1-198.
DR PDB; 5CZ4; X-ray; 2.30 A; J/X=1-198.
DR PDB; 5CZ5; X-ray; 2.80 A; J/X=1-198.
DR PDB; 5CZ6; X-ray; 2.70 A; J/X=1-198.
DR PDB; 5CZ7; X-ray; 2.50 A; J/X=1-198.
DR PDB; 5CZ8; X-ray; 2.80 A; J/X=1-198.
DR PDB; 5CZ9; X-ray; 2.90 A; J/X=1-198.
DR PDB; 5CZA; X-ray; 2.50 A; J/X=1-198.
DR PDB; 5D0S; X-ray; 2.50 A; J/X=1-198.
DR PDB; 5D0T; X-ray; 2.60 A; J/X=1-198.
DR PDB; 5D0V; X-ray; 2.90 A; J/X=1-198.
DR PDB; 5D0W; X-ray; 2.80 A; J/X=1-198.
DR PDB; 5D0X; X-ray; 2.60 A; J/X=1-198.
DR PDB; 5D0Z; X-ray; 2.90 A; J/X=1-198.
DR PDB; 5DKI; X-ray; 2.80 A; J/X=1-198.
DR PDB; 5DKJ; X-ray; 2.80 A; J/X=1-198.
DR PDB; 5FG7; X-ray; 2.70 A; J/X=1-198.
DR PDB; 5FG9; X-ray; 2.60 A; J/X=1-198.
DR PDB; 5FGA; X-ray; 2.70 A; J/X=1-198.
DR PDB; 5FGD; X-ray; 2.80 A; J/X=1-198.
DR PDB; 5FGE; X-ray; 2.60 A; J/X=1-198.
DR PDB; 5FGF; X-ray; 2.60 A; J/X=1-198.
DR PDB; 5FGG; X-ray; 2.70 A; J/X=1-198.
DR PDB; 5FGH; X-ray; 2.80 A; J/X=1-198.
DR PDB; 5FGI; X-ray; 2.90 A; J/X=1-198.
DR PDB; 5FHS; X-ray; 2.70 A; J/X=1-198.
DR PDB; 5JHR; X-ray; 2.90 A; J/X=1-198.
DR PDB; 5JHS; X-ray; 3.00 A; J/X=1-198.
DR PDB; 5L52; X-ray; 2.70 A; J/X=1-198.
DR PDB; 5L54; X-ray; 2.80 A; J/X=1-198.
DR PDB; 5L55; X-ray; 2.90 A; J/X=1-198.
DR PDB; 5L5A; X-ray; 2.40 A; J/X=1-198.
DR PDB; 5L5B; X-ray; 2.80 A; J/X=1-198.
DR PDB; 5L5D; X-ray; 2.80 A; J/X=1-198.
DR PDB; 5L5E; X-ray; 2.90 A; J/X=1-198.
DR PDB; 5L5F; X-ray; 2.50 A; J/X=1-198.
DR PDB; 5L5H; X-ray; 2.60 A; J/X=1-198.
DR PDB; 5L5I; X-ray; 2.90 A; J/X=1-198.
DR PDB; 5L5J; X-ray; 2.90 A; J/X=1-198.
DR PDB; 5L5O; X-ray; 2.60 A; J/X=1-198.
DR PDB; 5L5P; X-ray; 2.80 A; J/X=1-198.
DR PDB; 5L5Q; X-ray; 2.80 A; J/X=1-198.
DR PDB; 5L5R; X-ray; 2.90 A; J/X=1-198.
DR PDB; 5L5S; X-ray; 2.60 A; J/X=1-198.
DR PDB; 5L5T; X-ray; 2.90 A; J/X=1-198.
DR PDB; 5L5U; X-ray; 2.60 A; J/X=1-198.
DR PDB; 5L5V; X-ray; 2.70 A; J/X=1-198.
DR PDB; 5L5W; X-ray; 2.80 A; J/X=1-198.
DR PDB; 5L5X; X-ray; 2.90 A; J/X=1-198.
DR PDB; 5L5Y; X-ray; 2.70 A; J/X=1-198.
DR PDB; 5L5Z; X-ray; 2.70 A; J/X=1-198.
DR PDB; 5L60; X-ray; 2.70 A; J/X=1-198.
DR PDB; 5L61; X-ray; 2.80 A; J/X=1-198.
DR PDB; 5L62; X-ray; 2.80 A; J/X=1-198.
DR PDB; 5L63; X-ray; 2.70 A; J/X=1-198.
DR PDB; 5L64; X-ray; 2.70 A; J/X=1-198.
DR PDB; 5L65; X-ray; 2.90 A; J/X=1-198.
DR PDB; 5L66; X-ray; 2.80 A; J/X=1-198.
DR PDB; 5L67; X-ray; 2.60 A; J/X=1-198.
DR PDB; 5L68; X-ray; 2.80 A; J/X=1-198.
DR PDB; 5L69; X-ray; 2.70 A; J/X=1-198.
DR PDB; 5L6A; X-ray; 2.80 A; J/X=1-198.
DR PDB; 5L6B; X-ray; 2.60 A; J/X=1-198.
DR PDB; 5L6C; X-ray; 2.60 A; J/X=1-198.
DR PDB; 5LAI; X-ray; 2.50 A; J/X=1-198.
DR PDB; 5LAJ; X-ray; 2.90 A; J/X=1-198.
DR PDB; 5LTT; X-ray; 2.70 A; J/X=1-198.
DR PDB; 5M2B; X-ray; 2.70 A; J/X=1-198.
DR PDB; 5MP9; EM; 4.10 A; 4/k=1-198.
DR PDB; 5MPA; EM; 4.50 A; 4/k=1-198.
DR PDB; 5MPB; EM; 7.80 A; 4/k=1-198.
DR PDB; 5MPC; EM; 7.70 A; 4/k=1-198.
DR PDB; 5NIF; X-ray; 3.00 A; K/Y=1-198.
DR PDB; 5WVI; EM; 6.30 A; 4/g=1-198.
DR PDB; 5WVK; EM; 4.20 A; 4/g=1-198.
DR PDB; 6EF3; EM; 4.17 A; 4=1-198.
DR PDB; 6FVT; EM; 4.10 A; 4/k=1-195.
DR PDB; 6FVU; EM; 4.50 A; 4/k=1-195.
DR PDB; 6FVV; EM; 5.40 A; 4/k=1-195.
DR PDB; 6FVW; EM; 4.50 A; 4/k=1-195.
DR PDB; 6FVX; EM; 4.90 A; 4/k=1-195.
DR PDB; 6FVY; EM; 6.10 A; 4/k=1-195.
DR PDB; 6G7F; X-ray; 2.70 A; J/X=1-198.
DR PDB; 6G8M; X-ray; 2.70 A; J/X=1-198.
DR PDB; 6G8N; X-ray; 3.00 A; J/X=1-198.
DR PDB; 6GOP; X-ray; 2.90 A; J/X=1-198.
DR PDB; 6H39; X-ray; 2.50 A; J/X=1-198.
DR PDB; 6HTB; X-ray; 2.70 A; J/X=1-198.
DR PDB; 6HTC; X-ray; 2.80 A; J/X=1-198.
DR PDB; 6HTD; X-ray; 3.00 A; J/X=1-198.
DR PDB; 6HTP; X-ray; 3.00 A; J/X=1-198.
DR PDB; 6HTR; X-ray; 2.60 A; J/X=1-198.
DR PDB; 6HUB; X-ray; 2.90 A; J/X=1-198.
DR PDB; 6HUC; X-ray; 3.00 A; J/X=1-198.
DR PDB; 6HUQ; X-ray; 3.00 A; J/X=1-198.
DR PDB; 6HUU; X-ray; 2.80 A; J/X=1-198.
DR PDB; 6HUV; X-ray; 3.10 A; J/X=1-198.
DR PDB; 6HV3; X-ray; 2.70 A; J/X=1-198.
DR PDB; 6HV4; X-ray; 3.00 A; J/X=1-198.
DR PDB; 6HV5; X-ray; 3.00 A; J/X=1-198.
DR PDB; 6HV7; X-ray; 3.40 A; J/X=1-198.
DR PDB; 6HVA; X-ray; 2.90 A; J/X=1-198.
DR PDB; 6HVR; X-ray; 2.70 A; J/X=1-198.
DR PDB; 6HVS; X-ray; 3.10 A; J/X=1-198.
DR PDB; 6HVT; X-ray; 2.90 A; J/X=1-198.
DR PDB; 6HVU; X-ray; 2.90 A; J/X=1-198.
DR PDB; 6HVV; X-ray; 2.70 A; J/X=1-198.
DR PDB; 6HVW; X-ray; 3.00 A; J/X=1-198.
DR PDB; 6HVX; X-ray; 2.80 A; J/X=1-198.
DR PDB; 6HVY; X-ray; 2.70 A; J/X=1-198.
DR PDB; 6HW0; X-ray; 2.80 A; J/X=1-198.
DR PDB; 6HW3; X-ray; 2.60 A; J/X=1-198.
DR PDB; 6HW4; X-ray; 2.90 A; J/X=1-198.
DR PDB; 6HW5; X-ray; 2.90 A; J/X=1-198.
DR PDB; 6HW6; X-ray; 2.70 A; J/X=1-198.
DR PDB; 6HW7; X-ray; 2.70 A; J/X=1-198.
DR PDB; 6HW8; X-ray; 2.80 A; J/X=1-198.
DR PDB; 6HW9; X-ray; 2.80 A; J/X=1-198.
DR PDB; 6HWA; X-ray; 2.80 A; J/X=1-198.
DR PDB; 6HWB; X-ray; 2.60 A; J/X=1-198.
DR PDB; 6HWC; X-ray; 2.80 A; J/X=1-198.
DR PDB; 6HWD; X-ray; 2.80 A; J/X=1-198.
DR PDB; 6HWE; X-ray; 2.30 A; J/X=1-198.
DR PDB; 6HWF; X-ray; 2.50 A; J/X=1-198.
DR PDB; 6J2C; EM; 7.00 A; 4/g=1-198.
DR PDB; 6J2N; EM; 7.50 A; 4/g=1-198.
DR PDB; 6J2Q; EM; 3.80 A; 4/g=1-198.
DR PDB; 6J2X; EM; 3.80 A; 4/g=1-198.
DR PDB; 6J30; EM; 4.50 A; 4/g=1-198.
DR PDB; 6ZOU; X-ray; 2.90 A; J/X=1-198.
DR PDB; 6ZP6; X-ray; 2.80 A; J/X=1-198.
DR PDB; 6ZP8; X-ray; 3.00 A; J/X=1-198.
DR PDB; 7LS5; EM; 2.74 A; K/Y=1-198.
DR PDB; 7LS6; EM; 3.17 A; K=1-198.
DR PDB; 7LSX; EM; 3.61 A; K=1-198.
DR PDB; 7QO3; EM; 6.10 A; 4/k=1-198.
DR PDB; 7QO5; EM; 6.00 A; 4/k=1-198.
DR PDBsum; 1FNT; -.
DR PDBsum; 1G0U; -.
DR PDBsum; 1G65; -.
DR PDBsum; 1JD2; -.
DR PDBsum; 1RYP; -.
DR PDBsum; 1Z7Q; -.
DR PDBsum; 2F16; -.
DR PDBsum; 2FAK; -.
DR PDBsum; 2GPL; -.
DR PDBsum; 2ZCY; -.
DR PDBsum; 3BDM; -.
DR PDBsum; 3D29; -.
DR PDBsum; 3DY3; -.
DR PDBsum; 3DY4; -.
DR PDBsum; 3E47; -.
DR PDBsum; 3GPJ; -.
DR PDBsum; 3GPT; -.
DR PDBsum; 3GPW; -.
DR PDBsum; 3HYE; -.
DR PDBsum; 3JCO; -.
DR PDBsum; 3JCP; -.
DR PDBsum; 3MG0; -.
DR PDBsum; 3MG4; -.
DR PDBsum; 3MG6; -.
DR PDBsum; 3MG7; -.
DR PDBsum; 3MG8; -.
DR PDBsum; 3NZJ; -.
DR PDBsum; 3NZW; -.
DR PDBsum; 3NZX; -.
DR PDBsum; 3OEU; -.
DR PDBsum; 3OEV; -.
DR PDBsum; 3OKJ; -.
DR PDBsum; 3SDI; -.
DR PDBsum; 3SDK; -.
DR PDBsum; 3SHJ; -.
DR PDBsum; 3TDD; -.
DR PDBsum; 3UN4; -.
DR PDBsum; 3UN8; -.
DR PDBsum; 3WXR; -.
DR PDBsum; 4CR2; -.
DR PDBsum; 4CR3; -.
DR PDBsum; 4CR4; -.
DR PDBsum; 4EU2; -.
DR PDBsum; 4FZC; -.
DR PDBsum; 4FZG; -.
DR PDBsum; 4G4S; -.
DR PDBsum; 4GK7; -.
DR PDBsum; 4HNP; -.
DR PDBsum; 4HRC; -.
DR PDBsum; 4HRD; -.
DR PDBsum; 4INR; -.
DR PDBsum; 4INT; -.
DR PDBsum; 4INU; -.
DR PDBsum; 4J70; -.
DR PDBsum; 4JSQ; -.
DR PDBsum; 4JSU; -.
DR PDBsum; 4JT0; -.
DR PDBsum; 4LQI; -.
DR PDBsum; 4LTC; -.
DR PDBsum; 4NNN; -.
DR PDBsum; 4NNW; -.
DR PDBsum; 4NO1; -.
DR PDBsum; 4NO6; -.
DR PDBsum; 4NO8; -.
DR PDBsum; 4NO9; -.
DR PDBsum; 4Q1S; -.
DR PDBsum; 4QBY; -.
DR PDBsum; 4QLQ; -.
DR PDBsum; 4QLS; -.
DR PDBsum; 4QLT; -.
DR PDBsum; 4QLU; -.
DR PDBsum; 4QLV; -.
DR PDBsum; 4QUX; -.
DR PDBsum; 4QUY; -.
DR PDBsum; 4QV0; -.
DR PDBsum; 4QV1; -.
DR PDBsum; 4QV3; -.
DR PDBsum; 4QV4; -.
DR PDBsum; 4QV5; -.
DR PDBsum; 4QV6; -.
DR PDBsum; 4QV7; -.
DR PDBsum; 4QV8; -.
DR PDBsum; 4QV9; -.
DR PDBsum; 4QVL; -.
DR PDBsum; 4QVM; -.
DR PDBsum; 4QVN; -.
DR PDBsum; 4QVP; -.
DR PDBsum; 4QVQ; -.
DR PDBsum; 4QVV; -.
DR PDBsum; 4QVW; -.
DR PDBsum; 4QVY; -.
DR PDBsum; 4QW0; -.
DR PDBsum; 4QW1; -.
DR PDBsum; 4QW3; -.
DR PDBsum; 4QW4; -.
DR PDBsum; 4QW5; -.
DR PDBsum; 4QW6; -.
DR PDBsum; 4QW7; -.
DR PDBsum; 4QWF; -.
DR PDBsum; 4QWG; -.
DR PDBsum; 4QWI; -.
DR PDBsum; 4QWJ; -.
DR PDBsum; 4QWK; -.
DR PDBsum; 4QWL; -.
DR PDBsum; 4QWR; -.
DR PDBsum; 4QWS; -.
DR PDBsum; 4QWU; -.
DR PDBsum; 4QWX; -.
DR PDBsum; 4QXJ; -.
DR PDBsum; 4QZ0; -.
DR PDBsum; 4QZ1; -.
DR PDBsum; 4QZ2; -.
DR PDBsum; 4QZ3; -.
DR PDBsum; 4QZ4; -.
DR PDBsum; 4QZ5; -.
DR PDBsum; 4QZ6; -.
DR PDBsum; 4QZ7; -.
DR PDBsum; 4QZW; -.
DR PDBsum; 4QZX; -.
DR PDBsum; 4QZZ; -.
DR PDBsum; 4R00; -.
DR PDBsum; 4R02; -.
DR PDBsum; 4R17; -.
DR PDBsum; 4R18; -.
DR PDBsum; 4RUR; -.
DR PDBsum; 4V7O; -.
DR PDBsum; 4X6Z; -.
DR PDBsum; 4Y69; -.
DR PDBsum; 4Y6A; -.
DR PDBsum; 4Y6V; -.
DR PDBsum; 4Y6Z; -.
DR PDBsum; 4Y70; -.
DR PDBsum; 4Y74; -.
DR PDBsum; 4Y75; -.
DR PDBsum; 4Y77; -.
DR PDBsum; 4Y78; -.
DR PDBsum; 4Y7W; -.
DR PDBsum; 4Y7X; -.
DR PDBsum; 4Y7Y; -.
DR PDBsum; 4Y80; -.
DR PDBsum; 4Y81; -.
DR PDBsum; 4Y82; -.
DR PDBsum; 4Y84; -.
DR PDBsum; 4Y8G; -.
DR PDBsum; 4Y8H; -.
DR PDBsum; 4Y8I; -.
DR PDBsum; 4Y8J; -.
DR PDBsum; 4Y8K; -.
DR PDBsum; 4Y8L; -.
DR PDBsum; 4Y8M; -.
DR PDBsum; 4Y8N; -.
DR PDBsum; 4Y8O; -.
DR PDBsum; 4Y8P; -.
DR PDBsum; 4Y8Q; -.
DR PDBsum; 4Y8R; -.
DR PDBsum; 4Y8S; -.
DR PDBsum; 4Y8T; -.
DR PDBsum; 4Y8U; -.
DR PDBsum; 4Y9Y; -.
DR PDBsum; 4Y9Z; -.
DR PDBsum; 4YA0; -.
DR PDBsum; 4YA1; -.
DR PDBsum; 4YA2; -.
DR PDBsum; 4YA3; -.
DR PDBsum; 4YA4; -.
DR PDBsum; 4YA5; -.
DR PDBsum; 4YA7; -.
DR PDBsum; 4YA9; -.
DR PDBsum; 4Z1L; -.
DR PDBsum; 5A5B; -.
DR PDBsum; 5AHJ; -.
DR PDBsum; 5BOU; -.
DR PDBsum; 5BXL; -.
DR PDBsum; 5BXN; -.
DR PDBsum; 5CGF; -.
DR PDBsum; 5CGG; -.
DR PDBsum; 5CGH; -.
DR PDBsum; 5CGI; -.
DR PDBsum; 5CZ4; -.
DR PDBsum; 5CZ5; -.
DR PDBsum; 5CZ6; -.
DR PDBsum; 5CZ7; -.
DR PDBsum; 5CZ8; -.
DR PDBsum; 5CZ9; -.
DR PDBsum; 5CZA; -.
DR PDBsum; 5D0S; -.
DR PDBsum; 5D0T; -.
DR PDBsum; 5D0V; -.
DR PDBsum; 5D0W; -.
DR PDBsum; 5D0X; -.
DR PDBsum; 5D0Z; -.
DR PDBsum; 5DKI; -.
DR PDBsum; 5DKJ; -.
DR PDBsum; 5FG7; -.
DR PDBsum; 5FG9; -.
DR PDBsum; 5FGA; -.
DR PDBsum; 5FGD; -.
DR PDBsum; 5FGE; -.
DR PDBsum; 5FGF; -.
DR PDBsum; 5FGG; -.
DR PDBsum; 5FGH; -.
DR PDBsum; 5FGI; -.
DR PDBsum; 5FHS; -.
DR PDBsum; 5JHR; -.
DR PDBsum; 5JHS; -.
DR PDBsum; 5L52; -.
DR PDBsum; 5L54; -.
DR PDBsum; 5L55; -.
DR PDBsum; 5L5A; -.
DR PDBsum; 5L5B; -.
DR PDBsum; 5L5D; -.
DR PDBsum; 5L5E; -.
DR PDBsum; 5L5F; -.
DR PDBsum; 5L5H; -.
DR PDBsum; 5L5I; -.
DR PDBsum; 5L5J; -.
DR PDBsum; 5L5O; -.
DR PDBsum; 5L5P; -.
DR PDBsum; 5L5Q; -.
DR PDBsum; 5L5R; -.
DR PDBsum; 5L5S; -.
DR PDBsum; 5L5T; -.
DR PDBsum; 5L5U; -.
DR PDBsum; 5L5V; -.
DR PDBsum; 5L5W; -.
DR PDBsum; 5L5X; -.
DR PDBsum; 5L5Y; -.
DR PDBsum; 5L5Z; -.
DR PDBsum; 5L60; -.
DR PDBsum; 5L61; -.
DR PDBsum; 5L62; -.
DR PDBsum; 5L63; -.
DR PDBsum; 5L64; -.
DR PDBsum; 5L65; -.
DR PDBsum; 5L66; -.
DR PDBsum; 5L67; -.
DR PDBsum; 5L68; -.
DR PDBsum; 5L69; -.
DR PDBsum; 5L6A; -.
DR PDBsum; 5L6B; -.
DR PDBsum; 5L6C; -.
DR PDBsum; 5LAI; -.
DR PDBsum; 5LAJ; -.
DR PDBsum; 5LTT; -.
DR PDBsum; 5M2B; -.
DR PDBsum; 5MP9; -.
DR PDBsum; 5MPA; -.
DR PDBsum; 5MPB; -.
DR PDBsum; 5MPC; -.
DR PDBsum; 5NIF; -.
DR PDBsum; 5WVI; -.
DR PDBsum; 5WVK; -.
DR PDBsum; 6EF3; -.
DR PDBsum; 6FVT; -.
DR PDBsum; 6FVU; -.
DR PDBsum; 6FVV; -.
DR PDBsum; 6FVW; -.
DR PDBsum; 6FVX; -.
DR PDBsum; 6FVY; -.
DR PDBsum; 6G7F; -.
DR PDBsum; 6G8M; -.
DR PDBsum; 6G8N; -.
DR PDBsum; 6GOP; -.
DR PDBsum; 6H39; -.
DR PDBsum; 6HTB; -.
DR PDBsum; 6HTC; -.
DR PDBsum; 6HTD; -.
DR PDBsum; 6HTP; -.
DR PDBsum; 6HTR; -.
DR PDBsum; 6HUB; -.
DR PDBsum; 6HUC; -.
DR PDBsum; 6HUQ; -.
DR PDBsum; 6HUU; -.
DR PDBsum; 6HUV; -.
DR PDBsum; 6HV3; -.
DR PDBsum; 6HV4; -.
DR PDBsum; 6HV5; -.
DR PDBsum; 6HV7; -.
DR PDBsum; 6HVA; -.
DR PDBsum; 6HVR; -.
DR PDBsum; 6HVS; -.
DR PDBsum; 6HVT; -.
DR PDBsum; 6HVU; -.
DR PDBsum; 6HVV; -.
DR PDBsum; 6HVW; -.
DR PDBsum; 6HVX; -.
DR PDBsum; 6HVY; -.
DR PDBsum; 6HW0; -.
DR PDBsum; 6HW3; -.
DR PDBsum; 6HW4; -.
DR PDBsum; 6HW5; -.
DR PDBsum; 6HW6; -.
DR PDBsum; 6HW7; -.
DR PDBsum; 6HW8; -.
DR PDBsum; 6HW9; -.
DR PDBsum; 6HWA; -.
DR PDBsum; 6HWB; -.
DR PDBsum; 6HWC; -.
DR PDBsum; 6HWD; -.
DR PDBsum; 6HWE; -.
DR PDBsum; 6HWF; -.
DR PDBsum; 6J2C; -.
DR PDBsum; 6J2N; -.
DR PDBsum; 6J2Q; -.
DR PDBsum; 6J2X; -.
DR PDBsum; 6J30; -.
DR PDBsum; 6ZOU; -.
DR PDBsum; 6ZP6; -.
DR PDBsum; 6ZP8; -.
DR PDBsum; 7LS5; -.
DR PDBsum; 7LS6; -.
DR PDBsum; 7LSX; -.
DR PDBsum; 7QO3; -.
DR PDBsum; 7QO5; -.
DR AlphaFoldDB; P22141; -.
DR SMR; P22141; -.
DR BioGRID; 36744; 306.
DR ComplexPortal; CPX-2262; 26S Proteasome complex.
DR DIP; DIP-2808N; -.
DR IntAct; P22141; 42.
DR MINT; P22141; -.
DR STRING; 4932.YER012W; -.
DR BindingDB; P22141; -.
DR ChEMBL; CHEMBL4206; -.
DR MEROPS; T01.984; -.
DR iPTMnet; P22141; -.
DR MaxQB; P22141; -.
DR PaxDb; P22141; -.
DR PRIDE; P22141; -.
DR EnsemblFungi; YER012W_mRNA; YER012W; YER012W.
DR GeneID; 856731; -.
DR KEGG; sce:YER012W; -.
DR SGD; S000000814; PRE1.
DR VEuPathDB; FungiDB:YER012W; -.
DR eggNOG; KOG0177; Eukaryota.
DR GeneTree; ENSGT00640000091536; -.
DR HOGENOM; CLU_035750_12_0_1; -.
DR InParanoid; P22141; -.
DR OMA; RMCTDEL; -.
DR BioCyc; YEAST:G3O-30199-MON; -.
DR Reactome; R-SCE-1236978; Cross-presentation of soluble exogenous antigens (endosomes).
DR Reactome; R-SCE-382556; ABC-family proteins mediated transport.
DR Reactome; R-SCE-5668541; TNFR2 non-canonical NF-kB pathway.
DR Reactome; R-SCE-5687128; MAPK6/MAPK4 signaling.
DR Reactome; R-SCE-5689880; Ub-specific processing proteases.
DR Reactome; R-SCE-68949; Orc1 removal from chromatin.
DR Reactome; R-SCE-69017; CDK-mediated phosphorylation and removal of Cdc6.
DR Reactome; R-SCE-69601; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A.
DR Reactome; R-SCE-75815; Ubiquitin-dependent degradation of Cyclin D.
DR Reactome; R-SCE-8854050; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis.
DR Reactome; R-SCE-8948751; Regulation of PTEN stability and activity.
DR Reactome; R-SCE-8951664; Neddylation.
DR Reactome; R-SCE-9755511; KEAP1-NFE2L2 pathway.
DR Reactome; R-SCE-983168; Antigen processing: Ubiquitination & Proteasome degradation.
DR EvolutionaryTrace; P22141; -.
DR PRO; PR:P22141; -.
DR Proteomes; UP000002311; Chromosome V.
DR RNAct; P22141; protein.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; IDA:SGD.
DR GO; GO:0005634; C:nucleus; IDA:SGD.
DR GO; GO:0000502; C:proteasome complex; IPI:ComplexPortal.
DR GO; GO:0005839; C:proteasome core complex; IBA:GO_Central.
DR GO; GO:0019774; C:proteasome core complex, beta-subunit complex; IDA:SGD.
DR GO; GO:0034515; C:proteasome storage granule; IC:SGD.
DR GO; GO:0061133; F:endopeptidase activator activity; IMP:SGD.
DR GO; GO:0010498; P:proteasomal protein catabolic process; IBA:GO_Central.
DR GO; GO:0010499; P:proteasomal ubiquitin-independent protein catabolic process; IDA:SGD.
DR GO; GO:0043161; P:proteasome-mediated ubiquitin-dependent protein catabolic process; IDA:SGD.
DR CDD; cd03758; proteasome_beta_type_2; 1.
DR Gene3D; 3.60.20.10; -; 1.
DR InterPro; IPR029055; Ntn_hydrolases_N.
DR InterPro; IPR035206; Proteasome_beta2.
DR InterPro; IPR016050; Proteasome_bsu_CS.
DR InterPro; IPR001353; Proteasome_sua/b.
DR InterPro; IPR023333; Proteasome_suB-type.
DR PANTHER; PTHR11599:SF6; PTHR11599:SF6; 1.
DR Pfam; PF00227; Proteasome; 1.
DR SUPFAM; SSF56235; SSF56235; 1.
DR PROSITE; PS00854; PROTEASOME_BETA_1; 1.
DR PROSITE; PS51476; PROTEASOME_BETA_2; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Acetylation; Cytoplasm; Direct protein sequencing; Nucleus;
KW Phosphoprotein; Proteasome; Reference proteome.
FT CHAIN 1..198
FT /note="Proteasome subunit beta type-4"
FT /id="PRO_0000148055"
FT MOD_RES 1
FT /note="N-acetylmethionine"
FT /evidence="ECO:0007744|PubMed:22814378"
FT MOD_RES 76
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:18407956"
FT CONFLICT 183
FT /note="I -> T (in Ref. 1)"
FT /evidence="ECO:0000305"
FT CONFLICT 188
FT /note="G -> R (in Ref. 1)"
FT /evidence="ECO:0000305"
FT STRAND 4..8
FT /evidence="ECO:0007829|PDB:1RYP"
FT STRAND 13..18
FT /evidence="ECO:0007829|PDB:1RYP"
FT STRAND 21..23
FT /evidence="ECO:0007829|PDB:1RYP"
FT STRAND 26..30
FT /evidence="ECO:0007829|PDB:1RYP"
FT STRAND 35..39
FT /evidence="ECO:0007829|PDB:1RYP"
FT STRAND 42..49
FT /evidence="ECO:0007829|PDB:1RYP"
FT HELIX 50..71
FT /evidence="ECO:0007829|PDB:1RYP"
FT HELIX 77..91
FT /evidence="ECO:0007829|PDB:1RYP"
FT STRAND 94..96
FT /evidence="ECO:0007829|PDB:1RYP"
FT STRAND 100..108
FT /evidence="ECO:0007829|PDB:1RYP"
FT TURN 109..112
FT /evidence="ECO:0007829|PDB:1RYP"
FT STRAND 113..119
FT /evidence="ECO:0007829|PDB:1RYP"
FT TURN 121..123
FT /evidence="ECO:0007829|PDB:1G65"
FT STRAND 125..127
FT /evidence="ECO:0007829|PDB:1RYP"
FT STRAND 129..132
FT /evidence="ECO:0007829|PDB:1RYP"
FT HELIX 136..147
FT /evidence="ECO:0007829|PDB:1RYP"
FT HELIX 154..171
FT /evidence="ECO:0007829|PDB:1RYP"
FT STRAND 172..174
FT /evidence="ECO:0007829|PDB:7LS6"
FT STRAND 179..185
FT /evidence="ECO:0007829|PDB:1RYP"
FT STRAND 188..192
FT /evidence="ECO:0007829|PDB:1RYP"
FT TURN 194..197
FT /evidence="ECO:0007829|PDB:4HNP"
SQ SEQUENCE 198 AA; 22517 MW; ED43D319A5895B40 CRC64;
MDIILGIRVQ DSVILASSKA VTRGISVLKD SDDKTRQLSP HTLMSFAGEA GDTVQFAEYI
QANIQLYSIR EDYELSPQAV SSFVRQELAK SIRSRRPYQV NVLIGGYDKK KNKPELYQID
YLGTKVELPY GAHGYSGFYT FSLLDHHYRP DMTTEEGLDL LKLCVQELEK RMPMDFKGVI
VKIVDKDGIR QVDDFQAQ
