PSB5_YEAST
ID PSB5_YEAST Reviewed; 287 AA.
AC P30656; D6W4A1;
DT 01-APR-1993, integrated into UniProtKB/Swiss-Prot.
DT 01-FEB-1995, sequence version 3.
DT 03-AUG-2022, entry version 217.
DE RecName: Full=Proteasome subunit beta type-5;
DE EC=3.4.25.1;
DE AltName: Full=Macropain subunit PRE2;
DE AltName: Full=Multicatalytic endopeptidase complex subunit PRE2;
DE AltName: Full=Proteasome component PRE2;
DE AltName: Full=Proteinase YSCE subunit PRE2;
DE Flags: Precursor;
GN Name=PRE2; Synonyms=DOA3, PRG1; OrderedLocusNames=YPR103W;
GN ORFNames=P8283.10;
OS Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Saccharomycetaceae; Saccharomyces.
OX NCBI_TaxID=559292;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=1452031; DOI=10.1016/0378-1119(92)90051-p;
RA Friedman H., Goebel M., Snyder M.;
RT "A homolog of the proteasome-related RING10 gene is essential for yeast
RT cell growth.";
RL Gene 122:203-206(1992).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=5288C;
RX PubMed=8383129; DOI=10.1016/s0021-9258(18)53509-2;
RA Heinemeyer W., Gruhler A., Moehrle V., Mahe Y., Wolf D.H.;
RT "PRE2, highly homologous to the human major histocompatibility complex-
RT linked RING10 gene, codes for a yeast proteasome subunit necessary for
RT chrymotryptic activity and degradation of ubiquitinated proteins.";
RL J. Biol. Chem. 268:5115-5120(1993).
RN [3]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], PROTEIN SEQUENCE OF 76-90, AND
RP MUTAGENESIS OF ASP-126.
RX PubMed=7781614; DOI=10.1002/j.1460-2075.1995.tb07260.x;
RA Chen P., Hochstrasser M.;
RT "Biogenesis, structure and function of the yeast 20S proteasome.";
RL EMBO J. 14:2620-2630(1995).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=9169875;
RA Bussey H., Storms R.K., Ahmed A., Albermann K., Allen E., Ansorge W.,
RA Araujo R., Aparicio A., Barrell B.G., Badcock K., Benes V., Botstein D.,
RA Bowman S., Brueckner M., Carpenter J., Cherry J.M., Chung E.,
RA Churcher C.M., Coster F., Davis K., Davis R.W., Dietrich F.S., Delius H.,
RA DiPaolo T., Dubois E., Duesterhoeft A., Duncan M., Floeth M., Fortin N.,
RA Friesen J.D., Fritz C., Goffeau A., Hall J., Hebling U., Heumann K.,
RA Hilbert H., Hillier L.W., Hunicke-Smith S., Hyman R.W., Johnston M.,
RA Kalman S., Kleine K., Komp C., Kurdi O., Lashkari D., Lew H., Lin A.,
RA Lin D., Louis E.J., Marathe R., Messenguy F., Mewes H.-W., Mirtipati S.,
RA Moestl D., Mueller-Auer S., Namath A., Nentwich U., Oefner P., Pearson D.,
RA Petel F.X., Pohl T.M., Purnelle B., Rajandream M.A., Rechmann S.,
RA Rieger M., Riles L., Roberts D., Schaefer M., Scharfe M., Scherens B.,
RA Schramm S., Schroeder M., Sdicu A.-M., Tettelin H., Urrestarazu L.A.,
RA Ushinsky S., Vierendeels F., Vissers S., Voss H., Walsh S.V., Wambutt R.,
RA Wang Y., Wedler E., Wedler H., Winnett E., Zhong W.-W., Zollner A.,
RA Vo D.H., Hani J.;
RT "The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI.";
RL Nature 387:103-105(1997).
RN [5]
RP GENOME REANNOTATION.
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=24374639; DOI=10.1534/g3.113.008995;
RA Engel S.R., Dietrich F.S., Fisk D.G., Binkley G., Balakrishnan R.,
RA Costanzo M.C., Dwight S.S., Hitz B.C., Karra K., Nash R.S., Weng S.,
RA Wong E.D., Lloyd P., Skrzypek M.S., Miyasato S.R., Simison M., Cherry J.M.;
RT "The reference genome sequence of Saccharomyces cerevisiae: Then and now.";
RL G3 (Bethesda) 4:389-398(2014).
RN [6]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 176-287.
RC STRAIN=ATCC 28383 / FL100 / VTT C-80102;
RX PubMed=8164651; DOI=10.1128/mcb.14.5.2905-2913.1994;
RA Hermann-Ledenmat S., Werner M., Sentenac A., Thuriaux P.;
RT "Suppression of yeast RNA polymerase III mutations by FHL1, a gene coding
RT for a fork head protein involved in rRNA processing.";
RL Mol. Cell. Biol. 14:2905-2913(1994).
RN [7]
RP LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
RX PubMed=14562106; DOI=10.1038/nature02046;
RA Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N.,
RA O'Shea E.K., Weissman J.S.;
RT "Global analysis of protein expression in yeast.";
RL Nature 425:737-741(2003).
RN [8]
RP X-RAY CRYSTALLOGRAPHY (1.9 ANGSTROMS) OF 76-287 OF COMPLEX WITH THE 20S
RP PROTEASOME, PROTEOLYTIC PROCESSING, AND ACTIVE SITE.
RX PubMed=9087403; DOI=10.1038/386463a0;
RA Groll M., Ditzel L., Loewe J., Stock D., Bochtler M., Bartunik H.D.,
RA Huber R.;
RT "Structure of 20S proteasome from yeast at 2.4-A resolution.";
RL Nature 386:463-471(1997).
RN [9]
RP X-RAY CRYSTALLOGRAPHY (3.2 ANGSTROMS) OF 76-287 OF COMPLEX WITH THE 20S
RP PROTEASOME AND A 11S REGULATORY COMPLEX.
RX PubMed=11081519; DOI=10.1038/35040607;
RA Whitby F.G., Masters E.I., Kramer L., Knowlton J.R., Yao Y., Wang C.C.,
RA Hill C.P.;
RT "Structural basis for the activation of 20S proteasomes by 11S
RT regulators.";
RL Nature 408:115-120(2000).
RN [10]
RP X-RAY CRYSTALLOGRAPHY (2.4 ANGSTROMS) OF 76-287 OF COMPLEX WITH THE 20S
RP PROTEASOME.
RX PubMed=11062564; DOI=10.1038/80992;
RA Groll M., Bajorek M., Koehler A., Moroder L., Rubin D.M., Huber R.,
RA Glickman M.H., Finley D.;
RT "A gated channel into the proteasome core particle.";
RL Nat. Struct. Biol. 7:1062-1067(2000).
RN [11]
RP X-RAY CRYSTALLOGRAPHY (2.81 ANGSTROMS) OF 76-287 OF COMPLEX WITH THE 20S
RP PROTEASOME AND A TMC-95-BASED INHIBITOR.
RX PubMed=16793518; DOI=10.1016/j.chembiol.2006.04.005;
RA Groll M., Goetz M., Kaiser M., Weyher E., Moroder L.;
RT "TMC-95-based inhibitor design provides evidence for the catalytic
RT versatility of the proteasome.";
RL Chem. Biol. 13:607-614(2006).
RN [12]
RP X-RAY CRYSTALLOGRAPHY (2.8 ANGSTROMS) OF 76-287 OF COMPLEX WITH THE 20S
RP PROTEASOME AND SALINOSPORAMIDE.
RX PubMed=16608349; DOI=10.1021/ja058320b;
RA Groll M., Huber R., Potts B.C.M.;
RT "Crystal structures of salinosporamide A (NPI-0052) and B (NPI-0047) in
RT complex with the 20S proteasome reveal important consequences of beta-
RT lactone ring opening and a mechanism for irreversible binding.";
RL J. Am. Chem. Soc. 128:5136-5141(2006).
RN [13]
RP X-RAY CRYSTALLOGRAPHY (2.8 ANGSTROMS) OF 76-287 OF COMPLEX WITH THE 20S
RP PROTEASOME AND BORTEZOMIB.
RX PubMed=16531229; DOI=10.1016/j.str.2005.11.019;
RA Groll M., Berkers C.R., Ploegh H.L., Ovaa H.;
RT "Crystal structure of the boronic acid-based proteasome inhibitor
RT bortezomib in complex with the yeast 20S proteasome.";
RL Structure 14:451-456(2006).
RN [14]
RP X-RAY CRYSTALLOGRAPHY (3.0 ANGSTROMS) OF 76-287 IN COMPLEX WITH THE
RP PROTEASOME.
RX PubMed=20227375; DOI=10.1016/j.molcel.2010.02.002;
RA Sadre-Bazzaz K., Whitby F.G., Robinson H., Formosa T., Hill C.P.;
RT "Structure of a Blm10 complex reveals common mechanisms for proteasome
RT binding and gate opening.";
RL Mol. Cell 37:728-735(2010).
RN [15]
RP STRUCTURE BY ELECTRON MICROSCOPY (7.4 ANGSTROMS) OF THE 26S PROTEASOME.
RX PubMed=22927375; DOI=10.1073/pnas.1213333109;
RA Beck F., Unverdorben P., Bohn S., Schweitzer A., Pfeifer G., Sakata E.,
RA Nickell S., Plitzko J.M., Villa E., Baumeister W., Forster F.;
RT "Near-atomic resolution structural model of the yeast 26S proteasome.";
RL Proc. Natl. Acad. Sci. U.S.A. 109:14870-14875(2012).
CC -!- FUNCTION: The proteasome degrades poly-ubiquitinated proteins in the
CC cytoplasm and in the nucleus. It is essential for the regulated
CC turnover of proteins and for the removal of misfolded proteins. The
CC proteasome is a multicatalytic proteinase complex that is characterized
CC by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu
CC adjacent to the leaving group at neutral or slightly basic pH. It has
CC an ATP-dependent proteolytic activity. This unit is responsible of the
CC chymotrypsin-like activity of the proteasome and is one of the
CC principal target of the proteasome inhibitor bortezomib.
CC -!- FUNCTION: This subunit is necessary for chymotryptic activity and
CC degradation of ubiquitinated proteins.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=Cleavage of peptide bonds with very broad specificity.;
CC EC=3.4.25.1;
CC -!- SUBUNIT: The 26S proteasome consists of a 20S proteasome core and two
CC 19S regulatory subunits. The 20S proteasome core is composed of 28
CC subunits that are arranged in four stacked rings, resulting in a
CC barrel-shaped structure. The two end rings are each formed by seven
CC alpha subunits, and the two central rings are each formed by seven beta
CC subunits. The catalytic chamber with the active sites is on the inside
CC of the barrel. {ECO:0000269|PubMed:20227375}.
CC -!- INTERACTION:
CC P30656; P43583: BLM10; NbExp=3; IntAct=EBI-14001, EBI-22761;
CC P30656; P22141: PRE1; NbExp=3; IntAct=EBI-14001, EBI-13988;
CC P30656; P21242: PRE10; NbExp=3; IntAct=EBI-14001, EBI-13963;
CC P30656; P30657: PRE4; NbExp=2; IntAct=EBI-14001, EBI-13997;
CC P30656; P40302: PRE5; NbExp=2; IntAct=EBI-14001, EBI-13955;
CC P30656; P40303: PRE6; NbExp=3; IntAct=EBI-14001, EBI-13980;
CC P30656; P23724: PRE7; NbExp=2; IntAct=EBI-14001, EBI-13984;
CC P30656; P23638: PRE9; NbExp=2; IntAct=EBI-14001, EBI-13967;
CC P30656; P21243: SCL1; NbExp=8; IntAct=EBI-14001, EBI-13975;
CC -!- SUBCELLULAR LOCATION: Cytoplasm. Nucleus.
CC -!- MISCELLANEOUS: The side chain of Thr-76 acts as nucleophile, and the N-
CC terminal amino group acts as proton acceptor.
CC -!- MISCELLANEOUS: Present with 8530 molecules/cell in log phase SD medium.
CC {ECO:0000269|PubMed:14562106}.
CC -!- SIMILARITY: Belongs to the peptidase T1B family. {ECO:0000255|PROSITE-
CC ProRule:PRU00809}.
CC -!- SEQUENCE CAUTION:
CC Sequence=CAA82203.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; M96667; AAA34906.1; -; Genomic_DNA.
DR EMBL; X68662; CAA48628.1; -; Genomic_DNA.
DR EMBL; U32445; AAB68073.1; -; Genomic_DNA.
DR EMBL; Z28348; CAA82203.1; ALT_INIT; Genomic_DNA.
DR EMBL; BK006949; DAA11517.1; -; Genomic_DNA.
DR PIR; A45411; A45411.
DR RefSeq; NP_015428.1; NM_001184200.1.
DR PDB; 1FNT; X-ray; 3.20 A; L/Z=76-287.
DR PDB; 1G0U; X-ray; 2.40 A; K/Y=76-287.
DR PDB; 1G65; X-ray; 2.25 A; K/Y=76-287.
DR PDB; 1JD2; X-ray; 3.00 A; K/R=76-287.
DR PDB; 1RYP; X-ray; 1.90 A; L/Z=76-287.
DR PDB; 1Z7Q; X-ray; 3.22 A; L/Z=76-287.
DR PDB; 2F16; X-ray; 2.80 A; K/Y=76-287.
DR PDB; 2FAK; X-ray; 2.80 A; K/Y=76-287.
DR PDB; 2GPL; X-ray; 2.81 A; K/Y=76-287.
DR PDB; 2ZCY; X-ray; 2.90 A; K/Y=76-287.
DR PDB; 3BDM; X-ray; 2.70 A; K/Y=76-287.
DR PDB; 3D29; X-ray; 2.60 A; K/Y=76-287.
DR PDB; 3DY3; X-ray; 2.81 A; K/Y=76-287.
DR PDB; 3DY4; X-ray; 2.80 A; K/Y=76-287.
DR PDB; 3E47; X-ray; 3.00 A; K/Y=76-287.
DR PDB; 3GPJ; X-ray; 2.70 A; K/Y=76-287.
DR PDB; 3GPT; X-ray; 2.41 A; K/Y=76-287.
DR PDB; 3GPW; X-ray; 2.50 A; K/Y=76-287.
DR PDB; 3HYE; X-ray; 2.50 A; K/Y=76-287.
DR PDB; 3JCO; EM; 4.80 A; 7/l=1-287.
DR PDB; 3JCP; EM; 4.60 A; 7/l=1-287.
DR PDB; 3MG0; X-ray; 2.68 A; K/Y=76-287.
DR PDB; 3MG4; X-ray; 3.11 A; K/Y=76-287.
DR PDB; 3MG6; X-ray; 2.60 A; K/Y=76-287.
DR PDB; 3MG7; X-ray; 2.78 A; K/Y=76-287.
DR PDB; 3MG8; X-ray; 2.59 A; K/Y=76-287.
DR PDB; 3NZJ; X-ray; 2.40 A; K/Y=1-287.
DR PDB; 3NZW; X-ray; 2.50 A; K/Y=1-287.
DR PDB; 3NZX; X-ray; 2.70 A; K/Y=1-287.
DR PDB; 3OEU; X-ray; 2.60 A; K/Y=76-287.
DR PDB; 3OEV; X-ray; 2.85 A; K/Y=76-287.
DR PDB; 3OKJ; X-ray; 2.70 A; K/Y=76-287.
DR PDB; 3SDI; X-ray; 2.65 A; K/Y=76-287.
DR PDB; 3SDK; X-ray; 2.70 A; K/Y=76-287.
DR PDB; 3SHJ; X-ray; 2.80 A; K/Y=76-287.
DR PDB; 3TDD; X-ray; 2.70 A; K/Y=76-287.
DR PDB; 3UN4; X-ray; 3.40 A; K/Y=76-287.
DR PDB; 3UN8; X-ray; 2.70 A; K/Y=76-287.
DR PDB; 3WXR; X-ray; 3.15 A; L/Z=1-287.
DR PDB; 4CR2; EM; 7.70 A; 5=1-287.
DR PDB; 4CR3; EM; 9.30 A; 5=1-287.
DR PDB; 4CR4; EM; 8.80 A; 5=1-287.
DR PDB; 4EU2; X-ray; 2.51 A; L/Z=76-287.
DR PDB; 4FZC; X-ray; 2.80 A; K/Y=76-287.
DR PDB; 4FZG; X-ray; 3.00 A; K/Y=76-287.
DR PDB; 4G4S; X-ray; 2.49 A; L=76-287.
DR PDB; 4GK7; X-ray; 2.80 A; K/Y=76-287.
DR PDB; 4HNP; X-ray; 2.80 A; K/Y=76-287.
DR PDB; 4HRC; X-ray; 2.80 A; K/Y=76-287.
DR PDB; 4HRD; X-ray; 2.80 A; K/Y=76-287.
DR PDB; 4INR; X-ray; 2.70 A; K/Y=76-287.
DR PDB; 4INT; X-ray; 2.90 A; K/Y=76-287.
DR PDB; 4INU; X-ray; 3.10 A; K/Y=76-287.
DR PDB; 4J70; X-ray; 2.80 A; K/Y=76-287.
DR PDB; 4JSQ; X-ray; 2.80 A; K/Y=76-287.
DR PDB; 4JSU; X-ray; 2.90 A; K/Y=76-287.
DR PDB; 4JT0; X-ray; 3.10 A; K/Y=76-287.
DR PDB; 4LQI; X-ray; 2.70 A; K/Y=76-287.
DR PDB; 4LTC; X-ray; 2.50 A; K/Y=76-287.
DR PDB; 4NNN; X-ray; 2.50 A; K/Y=76-287.
DR PDB; 4NNW; X-ray; 2.60 A; K/Y=76-287.
DR PDB; 4NO1; X-ray; 2.50 A; K/Y=76-287.
DR PDB; 4NO6; X-ray; 3.00 A; K/Y=76-287.
DR PDB; 4NO8; X-ray; 2.70 A; K/Y=76-287.
DR PDB; 4NO9; X-ray; 2.90 A; K/Y=76-287.
DR PDB; 4Q1S; X-ray; 2.60 A; K/Y=76-287.
DR PDB; 4QBY; X-ray; 3.00 A; K/Y=76-287.
DR PDB; 4QLQ; X-ray; 2.40 A; K/Y=76-287.
DR PDB; 4QLS; X-ray; 2.80 A; K/Y=76-287.
DR PDB; 4QLT; X-ray; 2.80 A; K/Y=76-287.
DR PDB; 4QLU; X-ray; 2.80 A; K/Y=76-287.
DR PDB; 4QLV; X-ray; 2.90 A; K/Y=76-287.
DR PDB; 4QUX; X-ray; 3.00 A; K/Y=76-287.
DR PDB; 4QUY; X-ray; 2.80 A; K/Y=76-287.
DR PDB; 4QV0; X-ray; 3.10 A; K/Y=76-287.
DR PDB; 4QV1; X-ray; 2.50 A; K/Y=76-287.
DR PDB; 4QV3; X-ray; 3.00 A; K/Y=76-287.
DR PDB; 4QV4; X-ray; 2.70 A; K/Y=76-287.
DR PDB; 4QV5; X-ray; 2.70 A; K/Y=76-287.
DR PDB; 4QV6; X-ray; 2.80 A; K/Y=76-287.
DR PDB; 4QV7; X-ray; 2.60 A; K/Y=76-287.
DR PDB; 4QV8; X-ray; 2.90 A; K/Y=76-287.
DR PDB; 4QV9; X-ray; 2.60 A; K/Y=76-287.
DR PDB; 4QVL; X-ray; 2.80 A; K/Y=76-287.
DR PDB; 4QVM; X-ray; 2.80 A; K/Y=76-287.
DR PDB; 4QVN; X-ray; 2.90 A; K/Y=76-287.
DR PDB; 4QVP; X-ray; 2.30 A; K/Y=76-287.
DR PDB; 4QVQ; X-ray; 2.60 A; K/Y=76-287.
DR PDB; 4QVV; X-ray; 2.80 A; K/Y=76-287.
DR PDB; 4QVW; X-ray; 3.00 A; K/Y=76-287.
DR PDB; 4QVY; X-ray; 2.51 A; K/Y=76-287.
DR PDB; 4QW0; X-ray; 2.90 A; K/Y=76-287.
DR PDB; 4QW1; X-ray; 2.90 A; K/Y=76-287.
DR PDB; 4QW3; X-ray; 2.90 A; K/Y=76-287.
DR PDB; 4QW4; X-ray; 2.80 A; K/Y=76-287.
DR PDB; 4QW5; X-ray; 3.00 A; K/Y=76-287.
DR PDB; 4QW6; X-ray; 2.90 A; K/Y=76-287.
DR PDB; 4QW7; X-ray; 2.70 A; K/Y=76-287.
DR PDB; 4QWF; X-ray; 3.00 A; K/Y=76-287.
DR PDB; 4QWG; X-ray; 2.60 A; K/Y=76-287.
DR PDB; 4QWI; X-ray; 2.60 A; K/Y=76-287.
DR PDB; 4QWJ; X-ray; 2.90 A; K/Y=76-287.
DR PDB; 4QWK; X-ray; 2.80 A; K/Y=76-287.
DR PDB; 4QWL; X-ray; 2.60 A; K/Y=76-287.
DR PDB; 4QWR; X-ray; 2.90 A; K/Y=76-287.
DR PDB; 4QWS; X-ray; 3.00 A; K/Y=76-287.
DR PDB; 4QWU; X-ray; 3.00 A; K/Y=76-287.
DR PDB; 4QWX; X-ray; 2.90 A; K/Y=76-287.
DR PDB; 4QXJ; X-ray; 2.80 A; K/Y=76-287.
DR PDB; 4QZ0; X-ray; 3.00 A; K/Y=76-287.
DR PDB; 4QZ1; X-ray; 3.00 A; K/Y=76-287.
DR PDB; 4QZ2; X-ray; 2.70 A; K/Y=76-287.
DR PDB; 4QZ3; X-ray; 2.80 A; K/Y=76-287.
DR PDB; 4QZ4; X-ray; 3.00 A; K/Y=76-287.
DR PDB; 4QZ5; X-ray; 2.80 A; K/Y=76-287.
DR PDB; 4QZ6; X-ray; 2.90 A; K/Y=76-287.
DR PDB; 4QZ7; X-ray; 2.80 A; K/Y=76-287.
DR PDB; 4QZW; X-ray; 3.00 A; K/Y=76-287.
DR PDB; 4QZX; X-ray; 2.60 A; K/Y=76-287.
DR PDB; 4QZZ; X-ray; 2.90 A; K/Y=76-287.
DR PDB; 4R00; X-ray; 2.80 A; K/Y=76-287.
DR PDB; 4R02; X-ray; 2.50 A; K/Y=76-287.
DR PDB; 4R17; X-ray; 2.10 A; K/Y=76-287.
DR PDB; 4R18; X-ray; 2.40 A; K/Y=76-287.
DR PDB; 4RUR; X-ray; 2.50 A; K/Y=76-287.
DR PDB; 4V7O; X-ray; 3.00 A; A2/AP/BL/BZ=76-287.
DR PDB; 4X6Z; X-ray; 2.70 A; L/Z=1-287.
DR PDB; 4Y69; X-ray; 2.90 A; K/Y=76-287.
DR PDB; 4Y6A; X-ray; 2.60 A; K/Y=76-287.
DR PDB; 4Y6V; X-ray; 2.80 A; K/Y=76-287.
DR PDB; 4Y6Z; X-ray; 2.70 A; K/Y=76-287.
DR PDB; 4Y70; X-ray; 2.40 A; K/Y=76-287.
DR PDB; 4Y74; X-ray; 2.70 A; K/Y=76-287.
DR PDB; 4Y75; X-ray; 2.80 A; K/Y=76-287.
DR PDB; 4Y77; X-ray; 2.50 A; K/Y=76-287.
DR PDB; 4Y78; X-ray; 2.80 A; K/Y=76-287.
DR PDB; 4Y7W; X-ray; 2.50 A; K/Y=76-287.
DR PDB; 4Y7X; X-ray; 2.60 A; K/Y=76-287.
DR PDB; 4Y7Y; X-ray; 2.40 A; K/Y=76-287.
DR PDB; 4Y80; X-ray; 2.50 A; K/Y=76-287.
DR PDB; 4Y81; X-ray; 2.80 A; K/Y=76-287.
DR PDB; 4Y82; X-ray; 2.80 A; K/Y=76-287.
DR PDB; 4Y84; X-ray; 2.70 A; K/Y=76-287.
DR PDB; 4Y8G; X-ray; 2.60 A; K/Y=76-287.
DR PDB; 4Y8H; X-ray; 2.50 A; K/Y=76-287.
DR PDB; 4Y8I; X-ray; 2.60 A; K/Y=76-287.
DR PDB; 4Y8J; X-ray; 2.70 A; K/Y=76-287.
DR PDB; 4Y8K; X-ray; 2.60 A; K/Y=76-287.
DR PDB; 4Y8L; X-ray; 2.40 A; K/Y=76-287.
DR PDB; 4Y8M; X-ray; 2.80 A; K/Y=76-287.
DR PDB; 4Y8N; X-ray; 2.60 A; K/Y=76-287.
DR PDB; 4Y8O; X-ray; 2.70 A; K/Y=76-287.
DR PDB; 4Y8P; X-ray; 2.80 A; K/Y=76-287.
DR PDB; 4Y8Q; X-ray; 2.60 A; K/Y=76-287.
DR PDB; 4Y8R; X-ray; 2.70 A; K/Y=76-287.
DR PDB; 4Y8S; X-ray; 2.70 A; K/Y=76-287.
DR PDB; 4Y8T; X-ray; 2.70 A; K/Y=76-287.
DR PDB; 4Y8U; X-ray; 2.90 A; K/Y=76-287.
DR PDB; 4Y9Y; X-ray; 2.80 A; K/Y=76-287.
DR PDB; 4Y9Z; X-ray; 2.80 A; K/Y=76-287.
DR PDB; 4YA0; X-ray; 2.80 A; K/Y=76-287.
DR PDB; 4YA1; X-ray; 2.90 A; K/Y=76-287.
DR PDB; 4YA2; X-ray; 2.70 A; K/Y=76-287.
DR PDB; 4YA3; X-ray; 2.70 A; K/Y=76-287.
DR PDB; 4YA4; X-ray; 2.90 A; K/Y=76-287.
DR PDB; 4YA5; X-ray; 2.50 A; K/Y=76-287.
DR PDB; 4YA7; X-ray; 2.70 A; K/Y=76-287.
DR PDB; 4YA9; X-ray; 2.70 A; K/Y=76-287.
DR PDB; 4Z1L; X-ray; 3.00 A; K/Y=76-287.
DR PDB; 5A5B; EM; 9.50 A; 5=1-287.
DR PDB; 5AHJ; X-ray; 2.80 A; K/Y=76-287.
DR PDB; 5BOU; X-ray; 2.60 A; K/Y=76-287.
DR PDB; 5BXL; X-ray; 2.80 A; K/Y=76-287.
DR PDB; 5BXN; X-ray; 2.80 A; K/Y=76-287.
DR PDB; 5CGF; X-ray; 2.80 A; K/Y=76-287.
DR PDB; 5CGG; X-ray; 2.90 A; K/Y=76-287.
DR PDB; 5CGH; X-ray; 2.50 A; K/Y=76-287.
DR PDB; 5CGI; X-ray; 2.80 A; K/Y=76-287.
DR PDB; 5CZ4; X-ray; 2.30 A; K/Y=76-287.
DR PDB; 5CZ5; X-ray; 2.80 A; K/Y=76-287.
DR PDB; 5CZ6; X-ray; 2.70 A; K/Y=76-287.
DR PDB; 5CZ7; X-ray; 2.50 A; K/Y=71-287.
DR PDB; 5CZ8; X-ray; 2.80 A; K/Y=67-287.
DR PDB; 5CZ9; X-ray; 2.90 A; K/Y=76-287.
DR PDB; 5CZA; X-ray; 2.50 A; K/Y=76-287.
DR PDB; 5D0S; X-ray; 2.50 A; K/Y=76-287.
DR PDB; 5D0T; X-ray; 2.60 A; K/Y=76-287.
DR PDB; 5D0V; X-ray; 2.90 A; K/Y=70-287.
DR PDB; 5D0W; X-ray; 2.80 A; K/Y=76-287.
DR PDB; 5D0X; X-ray; 2.60 A; K/Y=76-287.
DR PDB; 5D0Z; X-ray; 2.90 A; K/Y=76-287.
DR PDB; 5DKI; X-ray; 2.80 A; K/Y=76-287.
DR PDB; 5DKJ; X-ray; 2.80 A; K/Y=76-287.
DR PDB; 5FG7; X-ray; 2.70 A; K/Y=76-287.
DR PDB; 5FG9; X-ray; 2.60 A; K/Y=76-287.
DR PDB; 5FGA; X-ray; 2.70 A; K/Y=76-287.
DR PDB; 5FGD; X-ray; 2.80 A; K/Y=72-287.
DR PDB; 5FGE; X-ray; 2.60 A; K/Y=70-287.
DR PDB; 5FGF; X-ray; 2.60 A; K/Y=74-287.
DR PDB; 5FGG; X-ray; 2.70 A; K/Y=76-287.
DR PDB; 5FGH; X-ray; 2.80 A; K/Y=76-287.
DR PDB; 5FGI; X-ray; 2.90 A; K/Y=76-287.
DR PDB; 5FHS; X-ray; 2.70 A; K/Y=76-287.
DR PDB; 5JHR; X-ray; 2.90 A; K/Y=76-287.
DR PDB; 5JHS; X-ray; 3.00 A; K/Y=76-287.
DR PDB; 5L52; X-ray; 2.70 A; K/Y=76-287.
DR PDB; 5L54; X-ray; 2.80 A; K/Y=76-287.
DR PDB; 5L55; X-ray; 2.90 A; K/Y=76-287.
DR PDB; 5L5A; X-ray; 2.40 A; K/Y=215-287.
DR PDB; 5L5B; X-ray; 2.80 A; K/Y=215-287.
DR PDB; 5L5D; X-ray; 2.80 A; K/Y=215-287.
DR PDB; 5L5E; X-ray; 2.90 A; K/Y=215-287.
DR PDB; 5L5F; X-ray; 2.50 A; K/Y=215-287.
DR PDB; 5L5H; X-ray; 2.60 A; K/Y=215-287.
DR PDB; 5L5I; X-ray; 2.90 A; K/Y=215-287.
DR PDB; 5L5J; X-ray; 2.90 A; K/Y=215-287.
DR PDB; 5L5O; X-ray; 2.60 A; K/Y=215-287.
DR PDB; 5L5P; X-ray; 2.80 A; K/Y=215-287.
DR PDB; 5L5Q; X-ray; 2.80 A; K/Y=215-287.
DR PDB; 5L5R; X-ray; 2.90 A; K/Y=215-287.
DR PDB; 5L5S; X-ray; 2.60 A; K/Y=215-287.
DR PDB; 5L5T; X-ray; 2.90 A; K/Y=215-287.
DR PDB; 5L5U; X-ray; 2.60 A; K/Y=215-287.
DR PDB; 5L5V; X-ray; 2.70 A; K/Y=215-287.
DR PDB; 5L5W; X-ray; 2.80 A; K/Y=215-287.
DR PDB; 5L5X; X-ray; 2.90 A; K/Y=215-287.
DR PDB; 5L5Y; X-ray; 2.70 A; K/Y=215-287.
DR PDB; 5L5Z; X-ray; 2.70 A; K/Y=215-287.
DR PDB; 5L60; X-ray; 2.70 A; K/Y=215-287.
DR PDB; 5L61; X-ray; 2.80 A; K/Y=211-287.
DR PDB; 5L62; X-ray; 2.80 A; K/Y=215-287.
DR PDB; 5L63; X-ray; 2.70 A; K/Y=215-287.
DR PDB; 5L64; X-ray; 2.70 A; K/Y=215-287.
DR PDB; 5L65; X-ray; 2.90 A; K/Y=215-287.
DR PDB; 5L66; X-ray; 2.80 A; K/Y=215-287.
DR PDB; 5L67; X-ray; 2.60 A; K/Y=215-287.
DR PDB; 5L68; X-ray; 2.80 A; K/Y=215-287.
DR PDB; 5L69; X-ray; 2.70 A; K/Y=215-287.
DR PDB; 5L6A; X-ray; 2.80 A; K/Y=215-287.
DR PDB; 5L6B; X-ray; 2.60 A; K/Y=215-287.
DR PDB; 5L6C; X-ray; 2.60 A; K/Y=215-287.
DR PDB; 5LAI; X-ray; 2.50 A; K/Y=76-287.
DR PDB; 5LAJ; X-ray; 2.90 A; K/Y=76-287.
DR PDB; 5LTT; X-ray; 2.70 A; K/Y=215-287.
DR PDB; 5M2B; X-ray; 2.70 A; K/Y=215-287.
DR PDB; 5MP9; EM; 4.10 A; 5/l=1-287.
DR PDB; 5MPA; EM; 4.50 A; 5/l=1-287.
DR PDB; 5MPB; EM; 7.80 A; 5/l=1-287.
DR PDB; 5MPC; EM; 7.70 A; 5/l=1-287.
DR PDB; 5NIF; X-ray; 3.00 A; L/Z=1-287.
DR PDB; 5WVI; EM; 6.30 A; 5/f=1-287.
DR PDB; 5WVK; EM; 4.20 A; 5/f=1-287.
DR PDB; 6EF3; EM; 4.17 A; 5=1-287.
DR PDB; 6FVT; EM; 4.10 A; 5/l=76-287.
DR PDB; 6FVU; EM; 4.50 A; 5/l=76-287.
DR PDB; 6FVV; EM; 5.40 A; 5/l=76-287.
DR PDB; 6FVW; EM; 4.50 A; 5/l=76-287.
DR PDB; 6FVX; EM; 4.90 A; 5/l=76-287.
DR PDB; 6FVY; EM; 6.10 A; 5/l=76-287.
DR PDB; 6G7F; X-ray; 2.70 A; K/Y=76-287.
DR PDB; 6G8M; X-ray; 2.70 A; K/Y=76-287.
DR PDB; 6G8N; X-ray; 3.00 A; K/Y=76-287.
DR PDB; 6GOP; X-ray; 2.90 A; K/Y=76-287.
DR PDB; 6H39; X-ray; 2.50 A; K/Y=76-287.
DR PDB; 6HTB; X-ray; 2.70 A; K/Y=76-287.
DR PDB; 6HTC; X-ray; 2.80 A; K/Y=76-287.
DR PDB; 6HTD; X-ray; 3.00 A; K/Y=76-287.
DR PDB; 6HTP; X-ray; 3.00 A; K/Y=76-287.
DR PDB; 6HTR; X-ray; 2.60 A; K/Y=76-287.
DR PDB; 6HUB; X-ray; 2.90 A; K/Y=76-287.
DR PDB; 6HUC; X-ray; 3.00 A; K/Y=76-287.
DR PDB; 6HUQ; X-ray; 3.00 A; K/Y=76-287.
DR PDB; 6HUU; X-ray; 2.80 A; K/Y=76-287.
DR PDB; 6HUV; X-ray; 3.10 A; K/Y=76-287.
DR PDB; 6HV3; X-ray; 2.70 A; K/Y=76-287.
DR PDB; 6HV4; X-ray; 3.00 A; K/Y=76-287.
DR PDB; 6HV5; X-ray; 3.00 A; K/Y=76-287.
DR PDB; 6HV7; X-ray; 3.40 A; K/Y=76-287.
DR PDB; 6HVA; X-ray; 2.90 A; K/Y=76-287.
DR PDB; 6HVR; X-ray; 2.70 A; K/Y=76-287.
DR PDB; 6HVS; X-ray; 3.10 A; K/Y=76-287.
DR PDB; 6HVT; X-ray; 2.90 A; K/Y=76-287.
DR PDB; 6HVU; X-ray; 2.90 A; K/Y=76-287.
DR PDB; 6HVV; X-ray; 2.70 A; K/Y=76-287.
DR PDB; 6HVW; X-ray; 3.00 A; K/Y=76-287.
DR PDB; 6HVX; X-ray; 2.80 A; K/Y=76-287.
DR PDB; 6HVY; X-ray; 2.70 A; K/Y=76-287.
DR PDB; 6HW0; X-ray; 2.80 A; K/Y=76-287.
DR PDB; 6HW3; X-ray; 2.60 A; K/Y=76-287.
DR PDB; 6HW4; X-ray; 2.90 A; K/Y=76-287.
DR PDB; 6HW5; X-ray; 2.90 A; K/Y=76-287.
DR PDB; 6HW6; X-ray; 2.70 A; K/Y=76-287.
DR PDB; 6HW7; X-ray; 2.70 A; K/Y=76-287.
DR PDB; 6HW8; X-ray; 2.80 A; K/Y=76-287.
DR PDB; 6HW9; X-ray; 2.80 A; K/Y=76-287.
DR PDB; 6HWA; X-ray; 2.80 A; K/Y=76-287.
DR PDB; 6HWB; X-ray; 2.60 A; K/Y=76-287.
DR PDB; 6HWC; X-ray; 2.80 A; K/Y=76-287.
DR PDB; 6HWD; X-ray; 2.80 A; K/Y=76-287.
DR PDB; 6HWE; X-ray; 2.30 A; K/Y=76-287.
DR PDB; 6HWF; X-ray; 2.50 A; K/Y=76-287.
DR PDB; 6J2C; EM; 7.00 A; 5/f=1-287.
DR PDB; 6J2N; EM; 7.50 A; 5/f=1-287.
DR PDB; 6J2Q; EM; 3.80 A; 5/f=1-287.
DR PDB; 6J2X; EM; 3.80 A; 5/f=1-287.
DR PDB; 6J30; EM; 4.50 A; 5/f=1-287.
DR PDB; 6ZOU; X-ray; 2.90 A; K/Y=76-287.
DR PDB; 6ZP6; X-ray; 2.80 A; K/Y=76-287.
DR PDB; 6ZP8; X-ray; 3.00 A; K/Y=76-287.
DR PDB; 7LS5; EM; 2.74 A; L/Z=1-287.
DR PDB; 7LS6; EM; 3.17 A; L=1-287.
DR PDB; 7QO3; EM; 6.10 A; 5/l=1-287.
DR PDB; 7QO5; EM; 6.00 A; 5/l=1-287.
DR PDBsum; 1FNT; -.
DR PDBsum; 1G0U; -.
DR PDBsum; 1G65; -.
DR PDBsum; 1JD2; -.
DR PDBsum; 1RYP; -.
DR PDBsum; 1Z7Q; -.
DR PDBsum; 2F16; -.
DR PDBsum; 2FAK; -.
DR PDBsum; 2GPL; -.
DR PDBsum; 2ZCY; -.
DR PDBsum; 3BDM; -.
DR PDBsum; 3D29; -.
DR PDBsum; 3DY3; -.
DR PDBsum; 3DY4; -.
DR PDBsum; 3E47; -.
DR PDBsum; 3GPJ; -.
DR PDBsum; 3GPT; -.
DR PDBsum; 3GPW; -.
DR PDBsum; 3HYE; -.
DR PDBsum; 3JCO; -.
DR PDBsum; 3JCP; -.
DR PDBsum; 3MG0; -.
DR PDBsum; 3MG4; -.
DR PDBsum; 3MG6; -.
DR PDBsum; 3MG7; -.
DR PDBsum; 3MG8; -.
DR PDBsum; 3NZJ; -.
DR PDBsum; 3NZW; -.
DR PDBsum; 3NZX; -.
DR PDBsum; 3OEU; -.
DR PDBsum; 3OEV; -.
DR PDBsum; 3OKJ; -.
DR PDBsum; 3SDI; -.
DR PDBsum; 3SDK; -.
DR PDBsum; 3SHJ; -.
DR PDBsum; 3TDD; -.
DR PDBsum; 3UN4; -.
DR PDBsum; 3UN8; -.
DR PDBsum; 3WXR; -.
DR PDBsum; 4CR2; -.
DR PDBsum; 4CR3; -.
DR PDBsum; 4CR4; -.
DR PDBsum; 4EU2; -.
DR PDBsum; 4FZC; -.
DR PDBsum; 4FZG; -.
DR PDBsum; 4G4S; -.
DR PDBsum; 4GK7; -.
DR PDBsum; 4HNP; -.
DR PDBsum; 4HRC; -.
DR PDBsum; 4HRD; -.
DR PDBsum; 4INR; -.
DR PDBsum; 4INT; -.
DR PDBsum; 4INU; -.
DR PDBsum; 4J70; -.
DR PDBsum; 4JSQ; -.
DR PDBsum; 4JSU; -.
DR PDBsum; 4JT0; -.
DR PDBsum; 4LQI; -.
DR PDBsum; 4LTC; -.
DR PDBsum; 4NNN; -.
DR PDBsum; 4NNW; -.
DR PDBsum; 4NO1; -.
DR PDBsum; 4NO6; -.
DR PDBsum; 4NO8; -.
DR PDBsum; 4NO9; -.
DR PDBsum; 4Q1S; -.
DR PDBsum; 4QBY; -.
DR PDBsum; 4QLQ; -.
DR PDBsum; 4QLS; -.
DR PDBsum; 4QLT; -.
DR PDBsum; 4QLU; -.
DR PDBsum; 4QLV; -.
DR PDBsum; 4QUX; -.
DR PDBsum; 4QUY; -.
DR PDBsum; 4QV0; -.
DR PDBsum; 4QV1; -.
DR PDBsum; 4QV3; -.
DR PDBsum; 4QV4; -.
DR PDBsum; 4QV5; -.
DR PDBsum; 4QV6; -.
DR PDBsum; 4QV7; -.
DR PDBsum; 4QV8; -.
DR PDBsum; 4QV9; -.
DR PDBsum; 4QVL; -.
DR PDBsum; 4QVM; -.
DR PDBsum; 4QVN; -.
DR PDBsum; 4QVP; -.
DR PDBsum; 4QVQ; -.
DR PDBsum; 4QVV; -.
DR PDBsum; 4QVW; -.
DR PDBsum; 4QVY; -.
DR PDBsum; 4QW0; -.
DR PDBsum; 4QW1; -.
DR PDBsum; 4QW3; -.
DR PDBsum; 4QW4; -.
DR PDBsum; 4QW5; -.
DR PDBsum; 4QW6; -.
DR PDBsum; 4QW7; -.
DR PDBsum; 4QWF; -.
DR PDBsum; 4QWG; -.
DR PDBsum; 4QWI; -.
DR PDBsum; 4QWJ; -.
DR PDBsum; 4QWK; -.
DR PDBsum; 4QWL; -.
DR PDBsum; 4QWR; -.
DR PDBsum; 4QWS; -.
DR PDBsum; 4QWU; -.
DR PDBsum; 4QWX; -.
DR PDBsum; 4QXJ; -.
DR PDBsum; 4QZ0; -.
DR PDBsum; 4QZ1; -.
DR PDBsum; 4QZ2; -.
DR PDBsum; 4QZ3; -.
DR PDBsum; 4QZ4; -.
DR PDBsum; 4QZ5; -.
DR PDBsum; 4QZ6; -.
DR PDBsum; 4QZ7; -.
DR PDBsum; 4QZW; -.
DR PDBsum; 4QZX; -.
DR PDBsum; 4QZZ; -.
DR PDBsum; 4R00; -.
DR PDBsum; 4R02; -.
DR PDBsum; 4R17; -.
DR PDBsum; 4R18; -.
DR PDBsum; 4RUR; -.
DR PDBsum; 4V7O; -.
DR PDBsum; 4X6Z; -.
DR PDBsum; 4Y69; -.
DR PDBsum; 4Y6A; -.
DR PDBsum; 4Y6V; -.
DR PDBsum; 4Y6Z; -.
DR PDBsum; 4Y70; -.
DR PDBsum; 4Y74; -.
DR PDBsum; 4Y75; -.
DR PDBsum; 4Y77; -.
DR PDBsum; 4Y78; -.
DR PDBsum; 4Y7W; -.
DR PDBsum; 4Y7X; -.
DR PDBsum; 4Y7Y; -.
DR PDBsum; 4Y80; -.
DR PDBsum; 4Y81; -.
DR PDBsum; 4Y82; -.
DR PDBsum; 4Y84; -.
DR PDBsum; 4Y8G; -.
DR PDBsum; 4Y8H; -.
DR PDBsum; 4Y8I; -.
DR PDBsum; 4Y8J; -.
DR PDBsum; 4Y8K; -.
DR PDBsum; 4Y8L; -.
DR PDBsum; 4Y8M; -.
DR PDBsum; 4Y8N; -.
DR PDBsum; 4Y8O; -.
DR PDBsum; 4Y8P; -.
DR PDBsum; 4Y8Q; -.
DR PDBsum; 4Y8R; -.
DR PDBsum; 4Y8S; -.
DR PDBsum; 4Y8T; -.
DR PDBsum; 4Y8U; -.
DR PDBsum; 4Y9Y; -.
DR PDBsum; 4Y9Z; -.
DR PDBsum; 4YA0; -.
DR PDBsum; 4YA1; -.
DR PDBsum; 4YA2; -.
DR PDBsum; 4YA3; -.
DR PDBsum; 4YA4; -.
DR PDBsum; 4YA5; -.
DR PDBsum; 4YA7; -.
DR PDBsum; 4YA9; -.
DR PDBsum; 4Z1L; -.
DR PDBsum; 5A5B; -.
DR PDBsum; 5AHJ; -.
DR PDBsum; 5BOU; -.
DR PDBsum; 5BXL; -.
DR PDBsum; 5BXN; -.
DR PDBsum; 5CGF; -.
DR PDBsum; 5CGG; -.
DR PDBsum; 5CGH; -.
DR PDBsum; 5CGI; -.
DR PDBsum; 5CZ4; -.
DR PDBsum; 5CZ5; -.
DR PDBsum; 5CZ6; -.
DR PDBsum; 5CZ7; -.
DR PDBsum; 5CZ8; -.
DR PDBsum; 5CZ9; -.
DR PDBsum; 5CZA; -.
DR PDBsum; 5D0S; -.
DR PDBsum; 5D0T; -.
DR PDBsum; 5D0V; -.
DR PDBsum; 5D0W; -.
DR PDBsum; 5D0X; -.
DR PDBsum; 5D0Z; -.
DR PDBsum; 5DKI; -.
DR PDBsum; 5DKJ; -.
DR PDBsum; 5FG7; -.
DR PDBsum; 5FG9; -.
DR PDBsum; 5FGA; -.
DR PDBsum; 5FGD; -.
DR PDBsum; 5FGE; -.
DR PDBsum; 5FGF; -.
DR PDBsum; 5FGG; -.
DR PDBsum; 5FGH; -.
DR PDBsum; 5FGI; -.
DR PDBsum; 5FHS; -.
DR PDBsum; 5JHR; -.
DR PDBsum; 5JHS; -.
DR PDBsum; 5L52; -.
DR PDBsum; 5L54; -.
DR PDBsum; 5L55; -.
DR PDBsum; 5L5A; -.
DR PDBsum; 5L5B; -.
DR PDBsum; 5L5D; -.
DR PDBsum; 5L5E; -.
DR PDBsum; 5L5F; -.
DR PDBsum; 5L5H; -.
DR PDBsum; 5L5I; -.
DR PDBsum; 5L5J; -.
DR PDBsum; 5L5O; -.
DR PDBsum; 5L5P; -.
DR PDBsum; 5L5Q; -.
DR PDBsum; 5L5R; -.
DR PDBsum; 5L5S; -.
DR PDBsum; 5L5T; -.
DR PDBsum; 5L5U; -.
DR PDBsum; 5L5V; -.
DR PDBsum; 5L5W; -.
DR PDBsum; 5L5X; -.
DR PDBsum; 5L5Y; -.
DR PDBsum; 5L5Z; -.
DR PDBsum; 5L60; -.
DR PDBsum; 5L61; -.
DR PDBsum; 5L62; -.
DR PDBsum; 5L63; -.
DR PDBsum; 5L64; -.
DR PDBsum; 5L65; -.
DR PDBsum; 5L66; -.
DR PDBsum; 5L67; -.
DR PDBsum; 5L68; -.
DR PDBsum; 5L69; -.
DR PDBsum; 5L6A; -.
DR PDBsum; 5L6B; -.
DR PDBsum; 5L6C; -.
DR PDBsum; 5LAI; -.
DR PDBsum; 5LAJ; -.
DR PDBsum; 5LTT; -.
DR PDBsum; 5M2B; -.
DR PDBsum; 5MP9; -.
DR PDBsum; 5MPA; -.
DR PDBsum; 5MPB; -.
DR PDBsum; 5MPC; -.
DR PDBsum; 5NIF; -.
DR PDBsum; 5WVI; -.
DR PDBsum; 5WVK; -.
DR PDBsum; 6EF3; -.
DR PDBsum; 6FVT; -.
DR PDBsum; 6FVU; -.
DR PDBsum; 6FVV; -.
DR PDBsum; 6FVW; -.
DR PDBsum; 6FVX; -.
DR PDBsum; 6FVY; -.
DR PDBsum; 6G7F; -.
DR PDBsum; 6G8M; -.
DR PDBsum; 6G8N; -.
DR PDBsum; 6GOP; -.
DR PDBsum; 6H39; -.
DR PDBsum; 6HTB; -.
DR PDBsum; 6HTC; -.
DR PDBsum; 6HTD; -.
DR PDBsum; 6HTP; -.
DR PDBsum; 6HTR; -.
DR PDBsum; 6HUB; -.
DR PDBsum; 6HUC; -.
DR PDBsum; 6HUQ; -.
DR PDBsum; 6HUU; -.
DR PDBsum; 6HUV; -.
DR PDBsum; 6HV3; -.
DR PDBsum; 6HV4; -.
DR PDBsum; 6HV5; -.
DR PDBsum; 6HV7; -.
DR PDBsum; 6HVA; -.
DR PDBsum; 6HVR; -.
DR PDBsum; 6HVS; -.
DR PDBsum; 6HVT; -.
DR PDBsum; 6HVU; -.
DR PDBsum; 6HVV; -.
DR PDBsum; 6HVW; -.
DR PDBsum; 6HVX; -.
DR PDBsum; 6HVY; -.
DR PDBsum; 6HW0; -.
DR PDBsum; 6HW3; -.
DR PDBsum; 6HW4; -.
DR PDBsum; 6HW5; -.
DR PDBsum; 6HW6; -.
DR PDBsum; 6HW7; -.
DR PDBsum; 6HW8; -.
DR PDBsum; 6HW9; -.
DR PDBsum; 6HWA; -.
DR PDBsum; 6HWB; -.
DR PDBsum; 6HWC; -.
DR PDBsum; 6HWD; -.
DR PDBsum; 6HWE; -.
DR PDBsum; 6HWF; -.
DR PDBsum; 6J2C; -.
DR PDBsum; 6J2N; -.
DR PDBsum; 6J2Q; -.
DR PDBsum; 6J2X; -.
DR PDBsum; 6J30; -.
DR PDBsum; 6ZOU; -.
DR PDBsum; 6ZP6; -.
DR PDBsum; 6ZP8; -.
DR PDBsum; 7LS5; -.
DR PDBsum; 7LS6; -.
DR PDBsum; 7QO3; -.
DR PDBsum; 7QO5; -.
DR AlphaFoldDB; P30656; -.
DR SMR; P30656; -.
DR BioGRID; 36269; 721.
DR ComplexPortal; CPX-2262; 26S Proteasome complex.
DR DIP; DIP-2806N; -.
DR IntAct; P30656; 21.
DR MINT; P30656; -.
DR STRING; 4932.YPR103W; -.
DR BindingDB; P30656; -.
DR ChEMBL; CHEMBL4659; -.
DR MEROPS; T01.012; -.
DR iPTMnet; P30656; -.
DR MaxQB; P30656; -.
DR PaxDb; P30656; -.
DR PRIDE; P30656; -.
DR EnsemblFungi; YPR103W_mRNA; YPR103W; YPR103W.
DR GeneID; 856218; -.
DR KEGG; sce:YPR103W; -.
DR SGD; S000006307; PRE2.
DR VEuPathDB; FungiDB:YPR103W; -.
DR eggNOG; KOG0175; Eukaryota.
DR GeneTree; ENSGT00940000166784; -.
DR HOGENOM; CLU_035750_7_1_1; -.
DR InParanoid; P30656; -.
DR OMA; NLGMAMQ; -.
DR BioCyc; YEAST:G3O-34243-MON; -.
DR Reactome; R-SCE-1236978; Cross-presentation of soluble exogenous antigens (endosomes).
DR Reactome; R-SCE-382556; ABC-family proteins mediated transport.
DR Reactome; R-SCE-5668541; TNFR2 non-canonical NF-kB pathway.
DR Reactome; R-SCE-5687128; MAPK6/MAPK4 signaling.
DR Reactome; R-SCE-5689880; Ub-specific processing proteases.
DR Reactome; R-SCE-68949; Orc1 removal from chromatin.
DR Reactome; R-SCE-69017; CDK-mediated phosphorylation and removal of Cdc6.
DR Reactome; R-SCE-69601; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A.
DR Reactome; R-SCE-75815; Ubiquitin-dependent degradation of Cyclin D.
DR Reactome; R-SCE-8854050; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis.
DR Reactome; R-SCE-8948751; Regulation of PTEN stability and activity.
DR Reactome; R-SCE-8951664; Neddylation.
DR Reactome; R-SCE-9755511; KEAP1-NFE2L2 pathway.
DR Reactome; R-SCE-983168; Antigen processing: Ubiquitination & Proteasome degradation.
DR EvolutionaryTrace; P30656; -.
DR PRO; PR:P30656; -.
DR Proteomes; UP000002311; Chromosome XVI.
DR RNAct; P30656; protein.
DR GO; GO:0005829; C:cytosol; HDA:SGD.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; IC:SGD.
DR GO; GO:0005634; C:nucleus; HDA:SGD.
DR GO; GO:0000502; C:proteasome complex; IPI:ComplexPortal.
DR GO; GO:0005839; C:proteasome core complex; IBA:GO_Central.
DR GO; GO:0019774; C:proteasome core complex, beta-subunit complex; IDA:SGD.
DR GO; GO:0034515; C:proteasome storage granule; IC:SGD.
DR GO; GO:0004175; F:endopeptidase activity; IMP:SGD.
DR GO; GO:0004298; F:threonine-type endopeptidase activity; IEA:UniProtKB-KW.
DR GO; GO:0010498; P:proteasomal protein catabolic process; IBA:GO_Central.
DR GO; GO:0010499; P:proteasomal ubiquitin-independent protein catabolic process; IDA:SGD.
DR GO; GO:0080129; P:proteasome core complex assembly; IMP:SGD.
DR GO; GO:0043161; P:proteasome-mediated ubiquitin-dependent protein catabolic process; IDA:SGD.
DR Gene3D; 3.60.20.10; -; 1.
DR InterPro; IPR029055; Ntn_hydrolases_N.
DR InterPro; IPR000243; Pept_T1A_subB.
DR InterPro; IPR037558; Proteasome_beta_5.
DR InterPro; IPR016050; Proteasome_bsu_CS.
DR InterPro; IPR001353; Proteasome_sua/b.
DR InterPro; IPR023333; Proteasome_suB-type.
DR PANTHER; PTHR11599:SF51; PTHR11599:SF51; 1.
DR Pfam; PF00227; Proteasome; 1.
DR PRINTS; PR00141; PROTEASOME.
DR SUPFAM; SSF56235; SSF56235; 1.
DR PROSITE; PS00854; PROTEASOME_BETA_1; 1.
DR PROSITE; PS51476; PROTEASOME_BETA_2; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Cytoplasm; Direct protein sequencing; Hydrolase; Nucleus;
KW Protease; Proteasome; Reference proteome; Threonine protease; Zymogen.
FT PROPEP 1..75
FT /note="Removed in mature form"
FT /evidence="ECO:0000269|PubMed:7781614"
FT /id="PRO_0000026611"
FT CHAIN 76..287
FT /note="Proteasome subunit beta type-5"
FT /id="PRO_0000026612"
FT ACT_SITE 76
FT /note="Nucleophile"
FT /evidence="ECO:0000269|PubMed:9087403"
FT BINDING 124
FT /ligand="bortezomib"
FT /ligand_id="ChEBI:CHEBI:52717"
FT MUTAGEN 126
FT /note="D->N: In DOA3-1; decrease in activity."
FT /evidence="ECO:0000269|PubMed:7781614"
FT CONFLICT 282..287
FT /note="FNNVIG -> STTLLAK (in Ref. 1; AAA34906)"
FT /evidence="ECO:0000305"
FT HELIX 2..9
FT /evidence="ECO:0007829|PDB:7LS6"
FT STRAND 78..83
FT /evidence="ECO:0007829|PDB:1RYP"
FT STRAND 86..91
FT /evidence="ECO:0007829|PDB:1RYP"
FT STRAND 95..97
FT /evidence="ECO:0007829|PDB:1RYP"
FT STRAND 100..104
FT /evidence="ECO:0007829|PDB:1RYP"
FT STRAND 109..113
FT /evidence="ECO:0007829|PDB:1RYP"
FT STRAND 116..119
FT /evidence="ECO:0007829|PDB:1RYP"
FT STRAND 121..123
FT /evidence="ECO:0007829|PDB:3GPJ"
FT HELIX 124..145
FT /evidence="ECO:0007829|PDB:1RYP"
FT HELIX 151..164
FT /evidence="ECO:0007829|PDB:1RYP"
FT TURN 165..167
FT /evidence="ECO:0007829|PDB:1RYP"
FT STRAND 172..180
FT /evidence="ECO:0007829|PDB:1RYP"
FT TURN 181..183
FT /evidence="ECO:0007829|PDB:1RYP"
FT STRAND 184..191
FT /evidence="ECO:0007829|PDB:1RYP"
FT TURN 192..194
FT /evidence="ECO:0007829|PDB:1G0U"
FT STRAND 196..198
FT /evidence="ECO:0007829|PDB:1RYP"
FT STRAND 200..205
FT /evidence="ECO:0007829|PDB:1RYP"
FT HELIX 208..218
FT /evidence="ECO:0007829|PDB:1RYP"
FT HELIX 225..242
FT /evidence="ECO:0007829|PDB:1RYP"
FT STRAND 243..246
FT /evidence="ECO:0007829|PDB:4EU2"
FT STRAND 248..256
FT /evidence="ECO:0007829|PDB:1RYP"
FT STRAND 259..267
FT /evidence="ECO:0007829|PDB:1RYP"
FT HELIX 268..279
FT /evidence="ECO:0007829|PDB:1RYP"
SQ SEQUENCE 287 AA; 31637 MW; D0EBAC611F7A4F37 CRC64;
MQAIADSFSV PNRLVKELQY DNEQNLESDF VTGASQFQRL APSLTVPPIA SPQQFLRAHT
DDSRNPDCKI KIAHGTTTLA FRFQGGIIVA VDSRATAGNW VASQTVKKVI EINPFLLGTM
AGGAADCQFW ETWLGSQCRL HELREKERIS VAAASKILSN LVYQYKGAGL SMGTMICGYT
RKEGPTIYYV DSDGTRLKGD IFCVGSGQTF AYGVLDSNYK WDLSVEDALY LGKRSILAAA
HRDAYSGGSV NLYHVTEDGW IYHGNHDVGE LFWKVKEEEG SFNNVIG
