ID   AACC2_ACIBA             Reviewed;         286 AA.
AC   P29807;
DT   01-APR-1993, integrated into UniProtKB/Swiss-Prot.
DT   01-APR-1993, sequence version 1.
DT   25-MAY-2022, entry version 68.
DE   RecName: Full=Aminoglycoside N(3)-acetyltransferase III;
DE            EC=2.3.1.81;
DE   AltName: Full=AAC(3)II;
DE   AltName: Full=Gentamicin-(3)-N-acetyl-transferase;
GN   Name=aacC2;
OS   Acinetobacter baumannii.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Moraxellales; Moraxellaceae;
OC   Acinetobacter; Acinetobacter calcoaceticus/baumannii complex.
OX   NCBI_TaxID=470;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=SAK;
RX   PubMed=7868401; DOI=10.1093/jac/34.4.457;
RA   Elisha B.G., Steyn L.M.;
RT   "High level kanamycin resistance associated with the hyperproduction of
RT   AAC(3)II and a generalised reduction in the accumulation of aminoglycosides
RT   in Acinetobacter spp.";
RL   J. Antimicrob. Chemother. 34:457-464(1994).
CC   -!- FUNCTION: Resistance to antibiotics containing the 2-deoxy-streptamine
CC       ring including gentamicin, kanamycin, tobramycin, neomycin and
CC       apramycin.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a 2-deoxystreptamine antibiotic + acetyl-CoA = an N(3')-
CC         acetyl-2-deoxystreptamine antibiotic + CoA + H(+);
CC         Xref=Rhea:RHEA:12665, ChEBI:CHEBI:15378, ChEBI:CHEBI:57287,
CC         ChEBI:CHEBI:57288, ChEBI:CHEBI:57921, ChEBI:CHEBI:77452; EC=2.3.1.81;
CC   -!- SIMILARITY: Belongs to the antibiotic N-acetyltransferase family.
CC       {ECO:0000305}.
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DR   EMBL; M62833; AAA21890.1; -; Genomic_DNA.
DR   RefSeq; WP_002063884.1; NZ_VHHI01000084.1.
DR   AlphaFoldDB; P29807; -.
DR   SMR; P29807; -.
DR   STRING; 470.IX87_12745; -.
DR   eggNOG; COG2746; Bacteria.
DR   BRENDA; 2.3.1.81; 98.
DR   GO; GO:0046353; F:aminoglycoside 3-N-acetyltransferase activity; IEA:UniProtKB-EC.
DR   GO; GO:0046677; P:response to antibiotic; IEA:UniProtKB-KW.
DR   InterPro; IPR003679; Amioglycoside_AcTrfase.
DR   InterPro; IPR028345; Antibiotic_NAT-like.
DR   PANTHER; PTHR11104; PTHR11104; 1.
DR   Pfam; PF02522; Antibiotic_NAT; 1.
DR   SUPFAM; SSF110710; SSF110710; 1.
PE   3: Inferred from homology;
KW   Acyltransferase; Antibiotic resistance; Transferase.
FT   CHAIN           1..286
FT                   /note="Aminoglycoside N(3)-acetyltransferase III"
FT                   /id="PRO_0000068542"
SQ   SEQUENCE   286 AA;  30608 MW;  44D0ADD033CBB71F CRC64;
     MHTRKAITEA IRKLGVQTGD LLMVHASLKA IGPVEGGAET VVAALRSAVG PTGTVMGYAS
     WDRSPYEETL NGARLDDKAR RTWPPFDPAT AGTYRGFGLL NQFLVQAPGA RRSAHPDASM
     VAVGPLAETL TEPHELGHAL GKGSPVERFV RLGGKALLLG APLNSVTALH YAEAVADIPN
     KRWVTYEMPM LGRNGEVAWK TASEYDSNGI LDCFAIEGKP DAVETIANAY VKLGRHREGV
     VGFAQCYLFD AQDIVTFGVT YLEKHFGATP IVPAHEAAQR SCEPSG