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ATG9B_HUMAN
ID   ATG9B_HUMAN             Reviewed;         924 AA.
AC   Q674R7; A1A5D3; Q6JRW5; Q8N8I8;
DT   15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT   11-OCT-2004, sequence version 1.
DT   03-AUG-2022, entry version 126.
DE   RecName: Full=Autophagy-related protein 9B {ECO:0000305};
DE   AltName: Full=APG9-like 2 {ECO:0000303|PubMed:15755735};
DE   AltName: Full=Nitric oxide synthase 3-overlapping antisense gene protein {ECO:0000303|PubMed:15234981};
DE            Short=Protein sONE {ECO:0000303|PubMed:15234981};
GN   Name=ATG9B;
GN   Synonyms=APG9L2 {ECO:0000303|PubMed:15755735},
GN   NOS3AS {ECO:0000303|PubMed:15234981};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), AND TISSUE SPECIFICITY.
RC   TISSUE=Testis;
RX   PubMed=15234981; DOI=10.1074/jbc.m400271200;
RA   Robb G.B., Carson A.R., Tai S.C., Fish J.E., Singh S., Yamada T.,
RA   Scherer S.W., Nakabayashi K., Marsden P.A.;
RT   "Post-transcriptional regulation of endothelial nitric-oxide synthase by an
RT   overlapping antisense mRNA transcript.";
RL   J. Biol. Chem. 279:37982-37996(2004).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
RC   TISSUE=Placenta;
RX   PubMed=14702039; DOI=10.1038/ng1285;
RA   Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA   Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA   Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA   Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA   Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA   Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA   Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA   Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA   Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA   Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA   Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA   Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA   Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA   Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA   Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA   Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA   Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA   Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA   Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA   Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA   Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA   Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA   Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA   Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA   Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA   Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA   Isogai T., Sugano S.;
RT   "Complete sequencing and characterization of 21,243 full-length human
RT   cDNAs.";
RL   Nat. Genet. 36:40-45(2004).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=12853948; DOI=10.1038/nature01782;
RA   Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H.,
RA   Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K.,
RA   Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A.,
RA   Delehaunty K.D., Miner T.L., Nash W.E., Cordes M., Du H., Sun H.,
RA   Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A.,
RA   Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P.,
RA   Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M.,
RA   Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S.,
RA   Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R.,
RA   Strowmatt C., Latreille P., Miller N., Johnson D., Murray J.,
RA   Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W.,
RA   Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E.,
RA   Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A.,
RA   Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E.,
RA   Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E.,
RA   Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A.,
RA   Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A.,
RA   Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R.,
RA   McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H.,
RA   Wilson R.K.;
RT   "The DNA sequence of human chromosome 7.";
RL   Nature 424:157-164(2003).
RN   [4]
RP   IDENTIFICATION.
RX   PubMed=15755735; DOI=10.1074/jbc.m413957200;
RA   Yamada T., Carson A.R., Caniggia I., Umebayashi K., Yoshimori T.,
RA   Nakabayashi K., Scherer S.W.;
RT   "Endothelial nitric-oxide synthase antisense (NOS3AS) gene encodes an
RT   autophagy-related protein (APG9-like2) highly expressed in trophoblast.";
RL   J. Biol. Chem. 280:18283-18290(2005).
RN   [5]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [6]
RP   INDUCTION.
RX   PubMed=17403686; DOI=10.1074/jbc.m608318200;
RA   Fish J.E., Matouk C.C., Yeboah E., Bevan S.C., Khan M., Patil K., Ohh M.,
RA   Marsden P.A.;
RT   "Hypoxia-inducible expression of a natural cis-antisense transcript
RT   inhibits endothelial nitric-oxide synthase.";
RL   J. Biol. Chem. 282:15652-15666(2007).
RN   [7]
RP   SUBCELLULAR LOCATION.
RX   PubMed=18936157; DOI=10.1128/mcb.01082-08;
RA   Chan E.Y.W., Longatti A., McKnight N.C., Tooze S.A.;
RT   "Kinase-inactivated ULK proteins inhibit autophagy via their conserved C-
RT   terminal domains using an Atg13-independent mechanism.";
RL   Mol. Cell. Biol. 29:157-171(2009).
CC   -!- FUNCTION: Phospholipid scramblase involved in autophagy by mediating
CC       autophagosomal membrane expansion. Cycles between the preautophagosomal
CC       structure/phagophore assembly site (PAS) and the cytoplasmic vesicle
CC       pool and supplies membrane for the growing autophagosome. Lipid
CC       scramblase activity plays a key role in preautophagosomal
CC       structure/phagophore assembly by distributing the phospholipids that
CC       arrive through ATG2 (ATG2A or ATG2B) from the cytoplasmic to the
CC       luminal leaflet of the bilayer, thereby driving autophagosomal membrane
CC       expansion (By similarity). In addition to autophagy, also plays a role
CC       in necrotic cell death (By similarity). {ECO:0000250|UniProtKB:Q68FE2,
CC       ECO:0000250|UniProtKB:Q7Z3C6}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a 1,2-diacyl-sn-glycero-3-phosphocholine(in) = a 1,2-diacyl-
CC         sn-glycero-3-phosphocholine(out); Xref=Rhea:RHEA:38571,
CC         ChEBI:CHEBI:57643; Evidence={ECO:0000250|UniProtKB:Q7Z3C6};
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a 1,2-diacyl-sn-glycero-3-phospho-L-serine(in) = a 1,2-diacyl-
CC         sn-glycero-3-phospho-L-serine(out); Xref=Rhea:RHEA:38663,
CC         ChEBI:CHEBI:57262; Evidence={ECO:0000250|UniProtKB:Q7Z3C6};
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a 1,2-diacyl-sn-glycero-3-phosphoethanolamine(in) = a 1,2-
CC         diacyl-sn-glycero-3-phosphoethanolamine(out); Xref=Rhea:RHEA:38895,
CC         ChEBI:CHEBI:64612; Evidence={ECO:0000250|UniProtKB:Q7Z3C6};
CC   -!- SUBUNIT: Homotrimer; forms a homotrimer with a central pore that forms
CC       a path between the two membrane leaflets.
CC       {ECO:0000250|UniProtKB:Q7Z3C6}.
CC   -!- INTERACTION:
CC       Q674R7-2; P49639: HOXA1; NbExp=3; IntAct=EBI-12837280, EBI-740785;
CC       Q674R7-2; P32242: OTX1; NbExp=3; IntAct=EBI-12837280, EBI-740446;
CC   -!- SUBCELLULAR LOCATION: Preautophagosomal structure membrane
CC       {ECO:0000269|PubMed:18936157}; Multi-pass membrane protein
CC       {ECO:0000269|PubMed:18936157}. Note=Under amino acid starvation or
CC       rapamycin treatment, redistributes from a juxtanuclear clustered pool
CC       to a dispersed peripheral cytosolic pool (PubMed:18936157). The
CC       starvation-induced redistribution depends on ULK1 and ATG13
CC       (PubMed:18936157). {ECO:0000269|PubMed:18936157}.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=3;
CC       Name=1;
CC         IsoId=Q674R7-1; Sequence=Displayed;
CC       Name=2;
CC         IsoId=Q674R7-2; Sequence=VSP_030410, VSP_030413;
CC       Name=3;
CC         IsoId=Q674R7-3; Sequence=VSP_030411, VSP_030412;
CC   -!- TISSUE SPECIFICITY: Highly expressed in placenta (trophoblast cells)
CC       and pituitary gland. Not expressed in vascular endothelial.
CC       {ECO:0000269|PubMed:15234981}.
CC   -!- INDUCTION: By hypoxia, leading to inhibit NOS3 expression.
CC       {ECO:0000269|PubMed:17403686}.
CC   -!- DOMAIN: Forms a homotrimer with a solvated central pore, which is
CC       connected laterally to the cytosol through the cavity within each
CC       protomer. Acts as a lipid scramblase that uses its central pore to
CC       function: the central pore opens laterally to accommodate lipid
CC       headgroups, thereby enabling lipid flipping and redistribution of
CC       lipids added to the outer leaflet of ATG9B-containing vesicles, thereby
CC       enabling growth into autophagosomes. {ECO:0000250|UniProtKB:Q7Z3C6}.
CC   -!- DOMAIN: The tyrosine-based sorting signal motif, also named YXX-psi
CC       motif, promotes interaction with the AP-4 complex.
CC       {ECO:0000250|UniProtKB:Q7Z3C6}.
CC   -!- MISCELLANEOUS: ATG9B gene is located on the opposite DNA strand of the
CC       NOS3 gene at chromosome 7q36. The genes are oriented in a tail-to-tail
CC       configuration and the mRNAs encoding ATG9B and NOS3 are complementary
CC       for 662 nucleotides. ATG9B transcription may a role in NOS3
CC       transcription regulation. {ECO:0000269|PubMed:15234981}.
CC   -!- SIMILARITY: Belongs to the ATG9 family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAQ86941.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC       Sequence=AC010973; Type=Frameshift; Evidence={ECO:0000305};
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DR   EMBL; AY515311; AAS87212.1; -; mRNA.
DR   EMBL; AY316116; AAQ86941.1; ALT_INIT; mRNA.
DR   EMBL; AK096734; BAC04853.1; -; mRNA.
DR   EMBL; AC010973; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; BC128587; AAI28588.1; -; mRNA.
DR   EMBL; BK004019; DAA05200.1; -; mRNA.
DR   CCDS; CCDS83242.1; -. [Q674R7-1]
DR   RefSeq; NP_001303985.1; NM_001317056.1. [Q674R7-1]
DR   RefSeq; XP_011514367.1; XM_011516065.1.
DR   RefSeq; XP_011514368.1; XM_011516066.2.
DR   AlphaFoldDB; Q674R7; -.
DR   SMR; Q674R7; -.
DR   BioGRID; 130263; 21.
DR   IntAct; Q674R7; 5.
DR   TCDB; 9.A.15.2.1; the autophagy-related phagophore-formation transporter (apt) family.
DR   GlyGen; Q674R7; 1 site, 1 O-linked glycan (1 site).
DR   iPTMnet; Q674R7; -.
DR   PhosphoSitePlus; Q674R7; -.
DR   BioMuta; ATG9B; -.
DR   DMDM; 74708555; -.
DR   EPD; Q674R7; -.
DR   jPOST; Q674R7; -.
DR   MassIVE; Q674R7; -.
DR   MaxQB; Q674R7; -.
DR   PeptideAtlas; Q674R7; -.
DR   PRIDE; Q674R7; -.
DR   ProteomicsDB; 65973; -. [Q674R7-1]
DR   ProteomicsDB; 65974; -. [Q674R7-2]
DR   ProteomicsDB; 65975; -. [Q674R7-3]
DR   Antibodypedia; 32933; 270 antibodies from 25 providers.
DR   DNASU; 285973; -.
DR   Ensembl; ENST00000469530.4; ENSP00000479879.1; ENSG00000181652.20. [Q674R7-1]
DR   Ensembl; ENST00000605952.5; ENSP00000475737.2; ENSG00000181652.20. [Q674R7-1]
DR   Ensembl; ENST00000639579.2; ENSP00000491504.1; ENSG00000181652.20. [Q674R7-1]
DR   GeneID; 285973; -.
DR   KEGG; hsa:285973; -.
DR   MANE-Select; ENST00000639579.2; ENSP00000491504.1; NM_001317056.2; NP_001303985.1.
DR   UCSC; uc064jfi.1; human. [Q674R7-1]
DR   CTD; 285973; -.
DR   DisGeNET; 285973; -.
DR   GeneCards; ATG9B; -.
DR   HGNC; HGNC:21899; ATG9B.
DR   HPA; ENSG00000181652; Tissue enhanced (esophagus, skin).
DR   MIM; 612205; gene.
DR   neXtProt; NX_Q674R7; -.
DR   OpenTargets; ENSG00000181652; -.
DR   PharmGKB; PA134883165; -.
DR   VEuPathDB; HostDB:ENSG00000181652; -.
DR   GeneTree; ENSGT00390000014839; -.
DR   HOGENOM; CLU_006200_2_0_1; -.
DR   InParanoid; Q674R7; -.
DR   OMA; PSHQCPQ; -.
DR   OrthoDB; 712239at2759; -.
DR   PhylomeDB; Q674R7; -.
DR   PathwayCommons; Q674R7; -.
DR   Reactome; R-HSA-1632852; Macroautophagy.
DR   SignaLink; Q674R7; -.
DR   BioGRID-ORCS; 285973; 8 hits in 206 CRISPR screens.
DR   GenomeRNAi; 285973; -.
DR   Pharos; Q674R7; Tbio.
DR   PRO; PR:Q674R7; -.
DR   Proteomes; UP000005640; Chromosome 7.
DR   RNAct; Q674R7; protein.
DR   Bgee; ENSG00000181652; Expressed in lower esophagus mucosa and 112 other tissues.
DR   Genevisible; Q674R7; HS.
DR   GO; GO:0005776; C:autophagosome; IBA:GO_Central.
DR   GO; GO:0005789; C:endoplasmic reticulum membrane; ISS:UniProtKB.
DR   GO; GO:0000139; C:Golgi membrane; ISS:UniProtKB.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0000407; C:phagophore assembly site; IBA:GO_Central.
DR   GO; GO:0034045; C:phagophore assembly site membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0055038; C:recycling endosome membrane; ISS:UniProtKB.
DR   GO; GO:0005802; C:trans-Golgi network; ISS:UniProtKB.
DR   GO; GO:0017128; F:phospholipid scramblase activity; ISS:UniProtKB.
DR   GO; GO:0000045; P:autophagosome assembly; IDA:MGI.
DR   GO; GO:0000422; P:autophagy of mitochondrion; IBA:GO_Central.
DR   GO; GO:0060349; P:bone morphogenesis; ISS:UniProtKB.
DR   GO; GO:0044805; P:late nucleophagy; IBA:GO_Central.
DR   GO; GO:0010940; P:positive regulation of necrotic cell death; ISS:UniProtKB.
DR   GO; GO:0034497; P:protein localization to phagophore assembly site; IBA:GO_Central.
DR   InterPro; IPR007241; Autophagy-rel_prot_9.
DR   PANTHER; PTHR13038; PTHR13038; 1.
DR   Pfam; PF04109; ATG9; 1.
PE   1: Evidence at protein level;
KW   Alternative splicing; Autophagy; Lipid transport; Membrane;
KW   Reference proteome; Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..924
FT                   /note="Autophagy-related protein 9B"
FT                   /id="PRO_0000314867"
FT   TOPO_DOM        1..207
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000305"
FT   TRANSMEM        208..228
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        229..276
FT                   /note="Lumenal"
FT                   /evidence="ECO:0000305"
FT   TRANSMEM        277..297
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        298..438
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000305"
FT   INTRAMEM        439..459
FT                   /evidence="ECO:0000250|UniProtKB:Q7Z3C6"
FT   TOPO_DOM        460..526
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000305"
FT   TRANSMEM        527..547
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        548..551
FT                   /note="Lumenal"
FT                   /evidence="ECO:0000305"
FT   TRANSMEM        552..572
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        573..624
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000305"
FT   INTRAMEM        625..645
FT                   /evidence="ECO:0000250|UniProtKB:Q7Z3C6"
FT   TOPO_DOM        646..924
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000305"
FT   REGION          1..144
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          847..924
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOTIF           151..154
FT                   /note="Tyrosine-based sorting signal"
FT                   /evidence="ECO:0000250|UniProtKB:Q7Z3C6"
FT   COMPBIAS        26..42
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        54..95
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        102..121
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        874..916
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   VAR_SEQ         1..514
FT                   /note="Missing (in isoform 2)"
FT                   /evidence="ECO:0000303|PubMed:15489334"
FT                   /id="VSP_030410"
FT   VAR_SEQ         322..340
FT                   /note="EELSSVPWAEVQSRLLALQ -> GKGREDTGMYWRGQPGGLD (in
FT                   isoform 3)"
FT                   /evidence="ECO:0000303|PubMed:14702039"
FT                   /id="VSP_030411"
FT   VAR_SEQ         341..924
FT                   /note="Missing (in isoform 3)"
FT                   /evidence="ECO:0000303|PubMed:14702039"
FT                   /id="VSP_030412"
FT   VAR_SEQ         515..572
FT                   /note="RTAAPPAPLRTLLARQLVFFAGALFAALLVLTVYDEDVLAVEHVLTAMTALG
FT                   VTATVA -> MPSYPQPSVLRGSAPARCWSSSWSWLPASGWSNCFAQSATSSATGTSRC
FT                   FTGRPCTSP (in isoform 2)"
FT                   /evidence="ECO:0000303|PubMed:15489334"
FT                   /id="VSP_030413"
FT   VARIANT         166
FT                   /note="P -> L (in dbSNP:rs61078191)"
FT                   /id="VAR_061030"
FT   CONFLICT        12
FT                   /note="R -> K (in Ref. 2; BAC04853)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        751
FT                   /note="S -> P (in Ref. 1; AAQ86941)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        752
FT                   /note="T -> P (in Ref. 1; AAQ86941)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        760
FT                   /note="T -> A (in Ref. 1; AAQ86941)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   924 AA;  101019 MW;  80C242069DF3D91E CRC64;
     MVSRMGWGGR RRRLGRWGDL GPGSVPLLPM PLPPPPPPSC RGPGGGRISI FSLSPAPHTR
     SSPSSFSPPT AGPPCSVLQG TGASQSCHSA LPIPATPPTQ AQPAMTPASA SPSWGSHSTP
     PLAPATPTPS QQCPQDSPGL RVGPLIPEQD YERLEDCDPE GSQDSPIHGE EQQPLLHVPE
     GLRGSWHHIQ NLDSFFTKIY SYHQRNGFAC ILLEDVFQLG QFIFIVTFTT FLLRCVDYNV
     LFANQPSNHT RPGPFHSKVT LSDAILPSAQ CAERIRSSPL LVLLLVLAAG FWLVQLLRSV
     CNLFSYWDIQ VFYREALHIP PEELSSVPWA EVQSRLLALQ RSGGLCVQPR PLTELDIHHR
     ILRYTNYQVA LANKGLLPAR CPLPWGGSAA FLSRGLALNV DLLLFRGPFS LFRGGWELPH
     AYKRSDQRGA LAARWGRTVL LLAALNLALS PLVLAWQVLH VFYSHVELLR REPGALGARG
     WSRLARLQLR HFNELPHELR ARLARAYRPA AAFLRTAAPP APLRTLLARQ LVFFAGALFA
     ALLVLTVYDE DVLAVEHVLT AMTALGVTAT VARSFIPEEQ CQGRAPQLLL QTALAHMHYL
     PEEPGPGGRD RAYRQMAQLL QYRAVSLLEE LLSPLLTPLF LLFWFRPRAL EIIDFFHHFT
     VDVAGVGDIC SFALMDVKRH GHPQWLSAGQ TEASLSQRAE DGKTELSLMR FSLAHPLWRP
     PGHSSKFLGH LWGRVQQDAA AWGATSARGP STPGVLSNCT SPLPEAFLAN LFVHPLLPPR
     DLSPTAPCPA AATASLLASI SRIAQDPSSV SPGGTGGQKL AQLPELASAE MSLHVIYLHQ
     LHQQQQQQEP WGEAAASILS RPCSSPSQPP SPDEEKPSWS SDGSSPASSP RQQWGTQKAR
     NLFPGGFQVT TDTQKEPDRA SCTD
 
 
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