ID   AACC7_STREY             Reviewed;         288 AA.
AC   P30180;
DT   01-APR-1993, integrated into UniProtKB/Swiss-Prot.
DT   01-APR-1993, sequence version 1.
DT   03-AUG-2022, entry version 63.
DE   RecName: Full=Aminoglycoside N(3)-acetyltransferase VII;
DE            EC=2.3.1.81;
DE   AltName: Full=ACC(3)-VII;
DE   AltName: Full=Aminocyclitol 3-N-acetyltransferase type VII;
GN   Name=aacC7;
OS   Streptomyces paromomycinus (Streptomyces rimosus subsp. paromomycinus).
OC   Bacteria; Actinobacteria; Streptomycetales; Streptomycetaceae;
OC   Streptomyces.
OX   NCBI_TaxID=92743;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=ATCC 14827 / DSM 41429 / JCM 4541 / KCC S-0541 / NBRC 15454 / NRRL
RC   2455 / VKM Ac-605;
RX   PubMed=2914849; DOI=10.1128/jb.171.1.321-328.1989;
RA   Lopez-Cabrera M., Perez-Gonzalez J.A., Heinzel P., Piepersberg W.,
RA   Jimenez A.;
RT   "Isolation and nucleotide sequencing of an aminocyclitol acetyltransferase
RT   gene from Streptomyces rimosus forma paromomycinus.";
RL   J. Bacteriol. 171:321-328(1989).
CC   -!- FUNCTION: Resistance to paromomycin.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a 2-deoxystreptamine antibiotic + acetyl-CoA = an N(3')-
CC         acetyl-2-deoxystreptamine antibiotic + CoA + H(+);
CC         Xref=Rhea:RHEA:12665, ChEBI:CHEBI:15378, ChEBI:CHEBI:57287,
CC         ChEBI:CHEBI:57288, ChEBI:CHEBI:57921, ChEBI:CHEBI:77452; EC=2.3.1.81;
CC   -!- SIMILARITY: Belongs to the antibiotic N-acetyltransferase family.
CC       {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; M22999; AAA88552.1; -; Genomic_DNA.
DR   PIR; B32245; B32245.
DR   RefSeq; WP_063840272.1; NG_047261.1.
DR   AlphaFoldDB; P30180; -.
DR   SMR; P30180; -.
DR   KEGG; ag:AAA88552; -.
DR   GO; GO:0046353; F:aminoglycoside 3-N-acetyltransferase activity; IEA:UniProtKB-EC.
DR   GO; GO:0046677; P:response to antibiotic; IEA:UniProtKB-KW.
DR   InterPro; IPR003679; Amioglycoside_AcTrfase.
DR   InterPro; IPR028345; Antibiotic_NAT-like.
DR   PANTHER; PTHR11104; PTHR11104; 1.
DR   Pfam; PF02522; Antibiotic_NAT; 1.
DR   SUPFAM; SSF110710; SSF110710; 1.
PE   3: Inferred from homology;
KW   Acyltransferase; Antibiotic resistance; Transferase.
FT   CHAIN           1..288
FT                   /note="Aminoglycoside N(3)-acetyltransferase VII"
FT                   /id="PRO_0000068549"
SQ   SEQUENCE   288 AA;  31202 MW;  430DCBBF30822382 CRC64;
     MDELALLKRS DGPVTRTRLA RDLTALGLGD GDTVMFHTRM SAVGYVAGGP ETVIGALRDV
     VGERGTLMVT CGWNDAPPYD FTDWPQTWQD ARRAEHPAYD PVLSEADHNN GRLPEALRRR
     PGAVRSRHPD ASFAALGAAA TALTADHPWD DPHGPDSPLA RLVAMGGRVL LLGAPLEALT
     LLHHAEALAD APGKRFVDYE QPILVDGERV WRRFHDIDSE DGAFDYSALV PEGTEAFEII
     GRDMRAAGIG RRGTVGAADS HLFEARDVVD FGVAWMEEKL GRERGPGG