ID   ATGA1_BOVIN             Reviewed;         218 AA.
AC   Q2HJE0;
DT   10-JUL-2007, integrated into UniProtKB/Swiss-Prot.
DT   21-MAR-2006, sequence version 1.
DT   03-AUG-2022, entry version 80.
DE   RecName: Full=Autophagy-related protein 101;
GN   Name=ATG101;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Hereford; TISSUE=Uterus;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Autophagy factor required for autophagosome formation.
CC       Stabilizes ATG13, protecting it from proteasomal degradation.
CC       {ECO:0000250|UniProtKB:Q9BSB4}.
CC   -!- SUBUNIT: Interacts with ATG13. Associates with a complex composed of
CC       ATG13, ULK1 and RB1CC1; the association with this complex requires the
CC       presence of ATG13. {ECO:0000250|UniProtKB:Q9BSB4}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q9BSB4}.
CC       Preautophagosomal structure {ECO:0000250|UniProtKB:Q9BSB4}. Note=Under
CC       starvation conditions, it is localized to puncate structures primarily
CC       representing the isolation membrane; the isolation membrane sequesters
CC       a portion of the cytoplasm resulting in autophagosome formation.
CC       {ECO:0000250|UniProtKB:Q9BSB4}.
CC   -!- SIMILARITY: Belongs to the ATG101 family. {ECO:0000305}.
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DR   EMBL; BC105530; AAI05531.1; -; mRNA.
DR   RefSeq; NP_001039599.1; NM_001046134.1.
DR   RefSeq; XP_005206266.1; XM_005206209.3.
DR   RefSeq; XP_005206267.1; XM_005206210.3.
DR   AlphaFoldDB; Q2HJE0; -.
DR   SMR; Q2HJE0; -.
DR   STRING; 9913.ENSBTAP00000000651; -.
DR   PaxDb; Q2HJE0; -.
DR   PRIDE; Q2HJE0; -.
DR   Ensembl; ENSBTAT00000000651; ENSBTAP00000000651; ENSBTAG00000000510.
DR   GeneID; 513049; -.
DR   KEGG; bta:513049; -.
DR   CTD; 60673; -.
DR   VEuPathDB; HostDB:ENSBTAG00000000510; -.
DR   VGNC; VGNC:26249; ATG101.
DR   eggNOG; KOG4493; Eukaryota.
DR   GeneTree; ENSGT00390000016511; -.
DR   HOGENOM; CLU_110397_0_0_1; -.
DR   InParanoid; Q2HJE0; -.
DR   OMA; PWEVWNL; -.
DR   OrthoDB; 1539728at2759; -.
DR   TreeFam; TF320996; -.
DR   Reactome; R-BTA-1632852; Macroautophagy.
DR   Proteomes; UP000009136; Chromosome 5.
DR   Bgee; ENSBTAG00000000510; Expressed in ureter and 105 other tissues.
DR   GO; GO:1990316; C:Atg1/ULK1 kinase complex; IEA:Ensembl.
DR   GO; GO:0000407; C:phagophore assembly site; IBA:GO_Central.
DR   GO; GO:0042802; F:identical protein binding; IEA:Ensembl.
DR   GO; GO:0044877; F:protein-containing complex binding; IEA:Ensembl.
DR   GO; GO:0000045; P:autophagosome assembly; IBA:GO_Central.
DR   GO; GO:0008285; P:negative regulation of cell population proliferation; IEA:Ensembl.
DR   GO; GO:0010508; P:positive regulation of autophagy; IEA:Ensembl.
DR   GO; GO:0046777; P:protein autophosphorylation; IEA:Ensembl.
DR   GO; GO:1903059; P:regulation of protein lipidation; IEA:Ensembl.
DR   InterPro; IPR012445; ATG101.
DR   PANTHER; PTHR13292; PTHR13292; 1.
DR   Pfam; PF07855; ATG101; 1.
PE   2: Evidence at transcript level;
KW   Autophagy; Cytoplasm; Reference proteome.
FT   CHAIN           1..218
FT                   /note="Autophagy-related protein 101"
FT                   /id="PRO_0000294321"
FT   REGION          152..156
FT                   /note="Important for interaction with ATG13"
FT                   /evidence="ECO:0000250|UniProtKB:Q9BSB4"
SQ   SEQUENCE   218 AA;  25017 MW;  7395D1EAE69D7E54 CRC64;
     MNCRSEVLEV SVEGRQVEEA MLAVLHTVLL HRSTGKFHYK KEGTYSIGTV GTQDVDCDFI
     DFTYVRVSSE ELDRALRKVV GEFRDALRNS GGDGLGQMSL EFYQKKKSRW PFSDECIPWE
     VWTVKVHVVA LATEQERQIC REKVGEKLCE KIINIVEVMN RHEYLPKMPT QSEVDNVFDT
     GLRDVQPYLY KISFQITDAL GSSVTTTMRR LIKDTLAL