ATGA1_RAT
ID ATGA1_RAT Reviewed; 218 AA.
AC Q6AY69;
DT 10-JUL-2007, integrated into UniProtKB/Swiss-Prot.
DT 13-SEP-2004, sequence version 1.
DT 03-AUG-2022, entry version 97.
DE RecName: Full=Autophagy-related protein 101;
GN Name=Atg101;
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Kidney;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: Autophagy factor required for autophagosome formation.
CC Stabilizes ATG13, protecting it from proteasomal degradation.
CC {ECO:0000250|UniProtKB:Q9BSB4}.
CC -!- SUBUNIT: Interacts with ATG13. Associates with a complex composed of
CC ATG13, ULK1 and RB1CC1; the association with this complex requires the
CC presence of ATG13. {ECO:0000250|UniProtKB:Q9BSB4}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q9BSB4}.
CC Preautophagosomal structure {ECO:0000250|UniProtKB:Q9BSB4}. Note=Under
CC starvation conditions, it is localized to puncate structures primarily
CC representing the isolation membrane; the isolation membrane sequesters
CC a portion of the cytoplasm resulting in autophagosome formation.
CC {ECO:0000250|UniProtKB:Q9BSB4}.
CC -!- SIMILARITY: Belongs to the ATG101 family. {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; BC079170; AAH79170.1; -; mRNA.
DR RefSeq; NP_001007660.2; NM_001007659.2.
DR RefSeq; NP_001258043.1; NM_001271114.1.
DR RefSeq; XP_006242386.1; XM_006242324.3.
DR AlphaFoldDB; Q6AY69; -.
DR SMR; Q6AY69; -.
DR STRING; 10116.ENSRNOP00000010195; -.
DR PhosphoSitePlus; Q6AY69; -.
DR jPOST; Q6AY69; -.
DR PaxDb; Q6AY69; -.
DR PRIDE; Q6AY69; -.
DR GeneID; 300240; -.
DR KEGG; rno:300240; -.
DR UCSC; RGD:1359310; rat.
DR CTD; 60673; -.
DR RGD; 1359310; Atg101.
DR VEuPathDB; HostDB:ENSRNOG00000007756; -.
DR eggNOG; KOG4493; Eukaryota.
DR InParanoid; Q6AY69; -.
DR OMA; PWEVWNL; -.
DR OrthoDB; 1539728at2759; -.
DR PhylomeDB; Q6AY69; -.
DR TreeFam; TF320996; -.
DR Reactome; R-RNO-1632852; Macroautophagy.
DR PRO; PR:Q6AY69; -.
DR Proteomes; UP000002494; Chromosome 7.
DR Bgee; ENSRNOG00000007756; Expressed in skeletal muscle tissue and 20 other tissues.
DR Genevisible; Q6AY69; RN.
DR GO; GO:1990316; C:Atg1/ULK1 kinase complex; ISO:RGD.
DR GO; GO:0000407; C:phagophore assembly site; ISO:RGD.
DR GO; GO:0042802; F:identical protein binding; ISO:RGD.
DR GO; GO:0044877; F:protein-containing complex binding; ISO:RGD.
DR GO; GO:0000045; P:autophagosome assembly; ISO:RGD.
DR GO; GO:0008285; P:negative regulation of cell population proliferation; ISO:RGD.
DR GO; GO:0010508; P:positive regulation of autophagy; ISO:RGD.
DR GO; GO:0046777; P:protein autophosphorylation; ISO:RGD.
DR GO; GO:0006468; P:protein phosphorylation; ISO:RGD.
DR GO; GO:1903059; P:regulation of protein lipidation; ISO:RGD.
DR InterPro; IPR012445; ATG101.
DR PANTHER; PTHR13292; PTHR13292; 1.
DR Pfam; PF07855; ATG101; 1.
PE 2: Evidence at transcript level;
KW Autophagy; Cytoplasm; Reference proteome.
FT CHAIN 1..218
FT /note="Autophagy-related protein 101"
FT /id="PRO_0000294324"
FT REGION 152..156
FT /note="Important for interaction with ATG13"
FT /evidence="ECO:0000250|UniProtKB:Q9BSB4"
SQ SEQUENCE 218 AA; 25016 MW; 41E2844EFED0CB56 CRC64;
MNCRSEVLEV SVEGRQVEEA MLAVLHTVLL HRSTGKFHYK KEGTYSIGTV GIQDVDCDFI
DFTYVRVSSE ELDRALRKVV GEFKDALRNS GGDGLGQMSL EFYQKKKSRW PFSDECIPWE
VWTVKVHVVA LATEQERQIC REKVGEKLCE KIINIVEVMS RHEYLPKMPT QSELDNVFDT
GLRDVQPYLY KISFQITEAL GTSVTTTMRR LIKDTLAL
