ID   ATGTP_HELPY             Reviewed;         370 AA.
AC   O25711;
DT   11-DEC-2013, integrated into UniProtKB/Swiss-Prot.
DT   01-JAN-1998, sequence version 1.
DT   25-MAY-2022, entry version 114.
DE   RecName: Full=ATP/GTP phosphatase;
DE            Short=ATPase/GTPase;
DE            EC=3.6.1.-;
GN   OrderedLocusNames=HP_1079, C694_05575;
OS   Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori).
OC   Bacteria; Proteobacteria; Epsilonproteobacteria; Campylobacterales;
OC   Helicobacteraceae; Helicobacter.
OX   NCBI_TaxID=85962;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 700392 / 26695;
RX   PubMed=9252185; DOI=10.1038/41483;
RA   Tomb J.-F., White O., Kerlavage A.R., Clayton R.A., Sutton G.G.,
RA   Fleischmann R.D., Ketchum K.A., Klenk H.-P., Gill S.R., Dougherty B.A.,
RA   Nelson K.E., Quackenbush J., Zhou L., Kirkness E.F., Peterson S.N.,
RA   Loftus B.J., Richardson D.L., Dodson R.J., Khalak H.G., Glodek A.,
RA   McKenney K., FitzGerald L.M., Lee N., Adams M.D., Hickey E.K., Berg D.E.,
RA   Gocayne J.D., Utterback T.R., Peterson J.D., Kelley J.M., Cotton M.D.,
RA   Weidman J.F., Fujii C., Bowman C., Watthey L., Wallin E., Hayes W.S.,
RA   Borodovsky M., Karp P.D., Smith H.O., Fraser C.M., Venter J.C.;
RT   "The complete genome sequence of the gastric pathogen Helicobacter
RT   pylori.";
RL   Nature 388:539-547(1997).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 700392 / 26695;
RA   Manolov A., Prihodko E., Larin A., Karpova I., Semashko T., Alexeev D.,
RA   Kostrjukova E., Govorun V.;
RT   "Draft genome of Helicobacter pylori.";
RL   Submitted (OCT-2012) to the EMBL/GenBank/DDBJ databases.
RN   [3]
RP   IDENTIFICATION BY MASS SPECTROMETRY, FUNCTION, CATALYTIC ACTIVITY,
RP   SUBSTRATE SPECIFICITY, AND BIOPHYSICOCHEMICAL PROPERTIES.
RC   STRAIN=ATCC 700392 / 26695;
RX   PubMed=23825549; DOI=10.1371/journal.pone.0066605;
RA   Choi H.P., Juarez S., Ciordia S., Fernandez M., Bargiela R., Albar J.P.,
RA   Mazumdar V., Anton B.P., Kasif S., Ferrer M., Steffen M.;
RT   "Biochemical characterization of hypothetical proteins from Helicobacter
RT   pylori.";
RL   PLoS ONE 8:E66605-E66605(2013).
CC   -!- FUNCTION: Has nucleotide phosphatase activity toward ATP and GTP, but
CC       not toward CTP, TTP and ADP. {ECO:0000269|PubMed:23825549}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC         ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC         ChEBI:CHEBI:43474, ChEBI:CHEBI:456216;
CC         Evidence={ECO:0000269|PubMed:23825549};
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=GTP + H2O = GDP + H(+) + phosphate; Xref=Rhea:RHEA:19669,
CC         ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:37565,
CC         ChEBI:CHEBI:43474, ChEBI:CHEBI:58189;
CC         Evidence={ECO:0000269|PubMed:23825549};
CC   -!- BIOPHYSICOCHEMICAL PROPERTIES:
CC       Kinetic parameters:
CC         KM=1.02 mM for ATP {ECO:0000269|PubMed:23825549};
CC         KM=0.58 mM for GTP {ECO:0000269|PubMed:23825549};
CC         Note=kcat is 9.3 min(-1) and 0.57 min(-1) with ATP and GTP as
CC         substrate, respectively.;
CC       pH dependence:
CC         Optimum pH is 6.0. {ECO:0000269|PubMed:23825549};
CC       Temperature dependence:
CC         Optimum temperature is 45 degrees Celsius.
CC         {ECO:0000269|PubMed:23825549};
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DR   EMBL; AE000511; AAD08125.1; -; Genomic_DNA.
DR   EMBL; CP003904; AFV42292.1; -; Genomic_DNA.
DR   PIR; G64654; G64654.
DR   RefSeq; NP_207870.1; NC_000915.1.
DR   RefSeq; WP_000616490.1; NC_018939.1.
DR   AlphaFoldDB; O25711; -.
DR   DIP; DIP-3250N; -.
DR   IntAct; O25711; 1.
DR   MINT; O25711; -.
DR   STRING; 85962.C694_05575; -.
DR   PaxDb; O25711; -.
DR   DNASU; 899615; -.
DR   EnsemblBacteria; AAD08125; AAD08125; HP_1079.
DR   KEGG; heo:C694_05575; -.
DR   KEGG; hpy:HP_1079; -.
DR   PATRIC; fig|85962.47.peg.1158; -.
DR   eggNOG; COG1106; Bacteria.
DR   HOGENOM; CLU_063816_0_0_7; -.
DR   OMA; FMTTHSQ; -.
DR   PhylomeDB; O25711; -.
DR   SABIO-RK; O25711; -.
DR   Proteomes; UP000000429; Chromosome.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR   GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR   GO; GO:0003924; F:GTPase activity; IEA:RHEA.
DR   Gene3D; 3.40.50.300; -; 1.
DR   InterPro; IPR003959; ATPase_AAA_core.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   Pfam; PF13304; AAA_21; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
PE   1: Evidence at protein level;
KW   ATP-binding; GTP-binding; Hydrolase; Nucleotide-binding;
KW   Reference proteome.
FT   CHAIN           1..370
FT                   /note="ATP/GTP phosphatase"
FT                   /id="PRO_0000424563"
SQ   SEQUENCE   370 AA;  42920 MW;  7A8B5E5C839DDEDB CRC64;
     MIQSVRIKNF KNFKNTKIDG FTKLNIITGQ NNAGKSNLLE ALYYLVGKSM HPCTNVLEIY
     DNIRKEPLTS ESKSLMFYGL DTKEEIQIVT TLDNNQTLDL QIKFIASENQ KVIESQIIPT
     AEQTQMSSQL NFTLKKNNEE IYNDHLNIAK VPNFPPIPNQ SGYNRQFKNF DSNQLQKLLP
     FESAVIIPSD VVYRQAHMIQ AVSKICSNNQ LEEELNKHLN QFDNNIQAIS FNTNNQLKLK
     VKDIKEKVPL SVFGDGLKKY LHIVSAFMAD NAKTIYIDEV ENGLHFSRMR LLLKNTIDFI
     NNNKDGNLQV FMTTHSQEFI EILDQVIREK DFAHQTKLFC LKQDDQYVIP RTYYGENLEY
     YFENEENLFG