ATH1_ARATH
ID ATH1_ARATH Reviewed; 473 AA.
AC P48731; Q7X9S7;
DT 01-FEB-1996, integrated into UniProtKB/Swiss-Prot.
DT 01-FEB-1996, sequence version 1.
DT 03-AUG-2022, entry version 162.
DE RecName: Full=Homeobox protein ATH1;
GN Name=ATH1; OrderedLocusNames=At4g32980; ORFNames=F26P21.100;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
RC STRAIN=cv. Columbia; TISSUE=Rosette leaf, and Seedling;
RX PubMed=7696878; DOI=10.2307/3869842;
RA Quaedvlieg N., Dockx J., Rook F., Weisbeek P.J., Smeekens S.C.M.;
RT "The homeobox gene ATH1 of Arabidopsis is derepressed in the
RT photomorphogenic mutants cop1 and det1.";
RL Plant Cell 7:117-129(1995).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=10617198; DOI=10.1038/47134;
RA Mayer K.F.X., Schueller C., Wambutt R., Murphy G., Volckaert G., Pohl T.,
RA Duesterhoeft A., Stiekema W., Entian K.-D., Terryn N., Harris B.,
RA Ansorge W., Brandt P., Grivell L.A., Rieger M., Weichselgartner M.,
RA de Simone V., Obermaier B., Mache R., Mueller M., Kreis M., Delseny M.,
RA Puigdomenech P., Watson M., Schmidtheini T., Reichert B., Portetelle D.,
RA Perez-Alonso M., Boutry M., Bancroft I., Vos P., Hoheisel J.,
RA Zimmermann W., Wedler H., Ridley P., Langham S.-A., McCullagh B.,
RA Bilham L., Robben J., van der Schueren J., Grymonprez B., Chuang Y.-J.,
RA Vandenbussche F., Braeken M., Weltjens I., Voet M., Bastiaens I., Aert R.,
RA Defoor E., Weitzenegger T., Bothe G., Ramsperger U., Hilbert H., Braun M.,
RA Holzer E., Brandt A., Peters S., van Staveren M., Dirkse W., Mooijman P.,
RA Klein Lankhorst R., Rose M., Hauf J., Koetter P., Berneiser S., Hempel S.,
RA Feldpausch M., Lamberth S., Van den Daele H., De Keyser A., Buysshaert C.,
RA Gielen J., Villarroel R., De Clercq R., van Montagu M., Rogers J.,
RA Cronin A., Quail M.A., Bray-Allen S., Clark L., Doggett J., Hall S.,
RA Kay M., Lennard N., McLay K., Mayes R., Pettett A., Rajandream M.A.,
RA Lyne M., Benes V., Rechmann S., Borkova D., Bloecker H., Scharfe M.,
RA Grimm M., Loehnert T.-H., Dose S., de Haan M., Maarse A.C., Schaefer M.,
RA Mueller-Auer S., Gabel C., Fuchs M., Fartmann B., Granderath K., Dauner D.,
RA Herzl A., Neumann S., Argiriou A., Vitale D., Liguori R., Piravandi E.,
RA Massenet O., Quigley F., Clabauld G., Muendlein A., Felber R., Schnabl S.,
RA Hiller R., Schmidt W., Lecharny A., Aubourg S., Chefdor F., Cooke R.,
RA Berger C., Monfort A., Casacuberta E., Gibbons T., Weber N., Vandenbol M.,
RA Bargues M., Terol J., Torres A., Perez-Perez A., Purnelle B., Bent E.,
RA Johnson S., Tacon D., Jesse T., Heijnen L., Schwarz S., Scholler P.,
RA Heber S., Francs P., Bielke C., Frishman D., Haase D., Lemcke K.,
RA Mewes H.-W., Stocker S., Zaccaria P., Bevan M., Wilson R.K.,
RA de la Bastide M., Habermann K., Parnell L., Dedhia N., Gnoj L., Schutz K.,
RA Huang E., Spiegel L., Sekhon M., Murray J., Sheet P., Cordes M.,
RA Abu-Threideh J., Stoneking T., Kalicki J., Graves T., Harmon G.,
RA Edwards J., Latreille P., Courtney L., Cloud J., Abbott A., Scott K.,
RA Johnson D., Minx P., Bentley D., Fulton B., Miller N., Greco T., Kemp K.,
RA Kramer J., Fulton L., Mardis E., Dante M., Pepin K., Hillier L.W.,
RA Nelson J., Spieth J., Ryan E., Andrews S., Geisel C., Layman D., Du H.,
RA Ali J., Berghoff A., Jones K., Drone K., Cotton M., Joshu C., Antonoiu B.,
RA Zidanic M., Strong C., Sun H., Lamar B., Yordan C., Ma P., Zhong J.,
RA Preston R., Vil D., Shekher M., Matero A., Shah R., Swaby I.K.,
RA O'Shaughnessy A., Rodriguez M., Hoffman J., Till S., Granat S., Shohdy N.,
RA Hasegawa A., Hameed A., Lodhi M., Johnson A., Chen E., Marra M.A.,
RA Martienssen R., McCombie W.R.;
RT "Sequence and analysis of chromosome 4 of the plant Arabidopsis thaliana.";
RL Nature 402:769-777(1999).
RN [3]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RX PubMed=14593172; DOI=10.1126/science.1088305;
RA Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M.,
RA Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G.,
RA Liu S.X., Lam B., Sakano H., Wu T., Yu G., Miranda M., Quach H.L.,
RA Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C.,
RA Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J.,
RA Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A.,
RA Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C.,
RA Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X.,
RA Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M.,
RA Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K.,
RA Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A.,
RA Ecker J.R.;
RT "Empirical analysis of transcriptional activity in the Arabidopsis
RT genome.";
RL Science 302:842-846(2003).
RN [5]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-228.
RC STRAIN=cv. Columbia; TISSUE=Rosette leaf;
RX PubMed=9380515; DOI=10.1093/nar/25.19.3904;
RA van Drunen C.M., Oosterling R.W., Keultjes G.M., Weisbeek P.J.,
RA van Driel R., Smeekens S.C.M.;
RT "Analysis of the chromatin domain organisation around the plastocyanin gene
RT reveals an MAR-specific sequence element in Arabidopsis thaliana.";
RL Nucleic Acids Res. 25:3904-3911(1997).
RN [6]
RP GENE FAMILY ORGANIZATION.
RX PubMed=15120075; DOI=10.1016/j.cub.2004.04.032;
RA Smith H.M.S., Campbell B.C.C., Hake S.;
RT "Competence to respond to floral inductive signals requires the homeobox
RT genes PENNYWISE and POUND-FOOLISH.";
RL Curr. Biol. 14:812-817(2004).
RN [7]
RP INTERACTION WITH STM.
RX PubMed=16513846; DOI=10.1093/nar/gkl016;
RA Cole M., Nolte C., Werr W.;
RT "Nuclear import of the transcription factor SHOOT MERISTEMLESS depends on
RT heterodimerization with BLH proteins expressed in discrete sub-domains of
RT the shoot apical meristem of Arabidopsis thaliana.";
RL Nucleic Acids Res. 34:1281-1292(2006).
RN [8]
RP FUNCTION, AND DEVELOPMENTAL STAGE.
RX PubMed=17908157; DOI=10.1111/j.1365-313x.2007.03285.x;
RA Proveniers M., Rutjens B., Brand M., Smeekens S.C.M.;
RT "The Arabidopsis TALE homeobox gene ATH1 controls floral competency through
RT positive regulation of FLC.";
RL Plant J. 52:899-913(2007).
CC -!- FUNCTION: Transcription factor which may be involved in the signal
CC transduction pathway downstream of the COP1 gene. Controls floral
CC competency as a specific activator of FLC expression. Is responsive of
CC the nuclear import of SHOOT MERISTEMLESS (STM).
CC {ECO:0000269|PubMed:17908157}.
CC -!- SUBUNIT: May form heterodimeric complex with the TALE/KNOX protein STM.
CC -!- INTERACTION:
CC P48731; P46639: KNAT1; NbExp=6; IntAct=EBI-912904, EBI-530486;
CC P48731; Q38874: STM; NbExp=9; IntAct=EBI-912904, EBI-530523;
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC -!- TISSUE SPECIFICITY: Most abundant in flowers.
CC -!- DEVELOPMENTAL STAGE: Down-regulated in the shoot apical meristem (SAM)
CC upon floral induction. {ECO:0000269|PubMed:17908157}.
CC -!- INDUCTION: By light. In etiolated seedlings, maximally expressed after
CC 3 days of illumination.
CC -!- DOMAIN: The SR/KY and BELL domains are responsive for the interaction
CC between the TALE/BELL proteins and the TALE/KNOX proteins.
CC -!- SIMILARITY: Belongs to the TALE/BELL homeobox family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=CAC51426.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR EMBL; X80126; CAA56426.1; -; mRNA.
DR EMBL; X80127; CAC51426.1; ALT_SEQ; Genomic_DNA.
DR EMBL; AL031804; CAA21207.1; -; Genomic_DNA.
DR EMBL; AL161582; CAB80015.1; -; Genomic_DNA.
DR EMBL; CP002687; AEE86154.1; -; Genomic_DNA.
DR EMBL; CP002687; ANM66154.1; -; Genomic_DNA.
DR EMBL; AY072174; AAL59996.1; -; mRNA.
DR EMBL; AY096513; AAM20163.1; -; mRNA.
DR EMBL; Z83320; CAB05910.1; -; Genomic_DNA.
DR PIR; T05306; T05306.
DR RefSeq; NP_001328067.1; NM_001342189.1.
DR RefSeq; NP_195024.1; NM_119452.4.
DR AlphaFoldDB; P48731; -.
DR BioGRID; 14720; 22.
DR IntAct; P48731; 20.
DR STRING; 3702.AT4G32980.1; -.
DR ChEMBL; CHEMBL4295767; -.
DR iPTMnet; P48731; -.
DR PaxDb; P48731; -.
DR PRIDE; P48731; -.
DR ProteomicsDB; 246624; -.
DR EnsemblPlants; AT4G32980.1; AT4G32980.1; AT4G32980.
DR EnsemblPlants; AT4G32980.2; AT4G32980.2; AT4G32980.
DR GeneID; 829435; -.
DR Gramene; AT4G32980.1; AT4G32980.1; AT4G32980.
DR Gramene; AT4G32980.2; AT4G32980.2; AT4G32980.
DR KEGG; ath:AT4G32980; -.
DR Araport; AT4G32980; -.
DR TAIR; locus:2005494; AT4G32980.
DR eggNOG; KOG0773; Eukaryota.
DR HOGENOM; CLU_587099_0_0_1; -.
DR InParanoid; P48731; -.
DR OMA; MWGFEAN; -.
DR OrthoDB; 586845at2759; -.
DR PhylomeDB; P48731; -.
DR PRO; PR:P48731; -.
DR Proteomes; UP000006548; Chromosome 4.
DR ExpressionAtlas; P48731; baseline and differential.
DR Genevisible; P48731; AT.
DR GO; GO:0005634; C:nucleus; IDA:TAIR.
DR GO; GO:0003677; F:DNA binding; ISS:TAIR.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; ISS:TAIR.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0043565; F:sequence-specific DNA binding; IDA:TAIR.
DR GO; GO:0010227; P:floral organ abscission; IMP:TAIR.
DR GO; GO:0010073; P:meristem maintenance; IGI:TAIR.
DR GO; GO:0008285; P:negative regulation of cell population proliferation; IMP:TAIR.
DR GO; GO:0009640; P:photomorphogenesis; IDA:TAIR.
DR GO; GO:0010371; P:regulation of gibberellin biosynthetic process; IMP:TAIR.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR GO; GO:0090470; P:shoot organ boundary specification; IMP:TAIR.
DR GO; GO:0010228; P:vegetative to reproductive phase transition of meristem; IMP:TAIR.
DR CDD; cd00086; homeodomain; 1.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR001356; Homeobox_dom.
DR InterPro; IPR008422; Homeobox_KN_domain.
DR InterPro; IPR006563; POX_dom.
DR Pfam; PF05920; Homeobox_KN; 1.
DR Pfam; PF07526; POX; 1.
DR SMART; SM00389; HOX; 1.
DR SMART; SM00574; POX; 1.
DR SUPFAM; SSF46689; SSF46689; 1.
DR PROSITE; PS00027; HOMEOBOX_1; 1.
DR PROSITE; PS50071; HOMEOBOX_2; 1.
PE 1: Evidence at protein level;
KW DNA-binding; Homeobox; Nucleus; Reference proteome; Transcription;
KW Transcription regulation.
FT CHAIN 1..473
FT /note="Homeobox protein ATH1"
FT /id="PRO_0000048821"
FT DNA_BIND 372..434
FT /note="Homeobox"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT REGION 205..221
FT /note="SR/KY domain"
FT REGION 266..336
FT /note="BELL domain"
FT REGION 448..473
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 473 AA; 53900 MW; ADF8B1DBCA16A10F CRC64;
MDNNNNNNTF SSLDNVMTNQ NPLLMDFIPS REDSTSFSTM LPWNTIRSDP LQMGGFDIFN
SMLTNKYLSS SPRSIDVQDN RNVEFMAPPP HPPPLHPLDH LRHYDDSSNN MWGFEANSEF
QAFSGVVGPS EPMMSTFGEE DFPFLISNKR NNELSLSLAS DVSDECSEIS LCAATRLASE
QASCSSKDIS NNVVTQGFSQ LIFGSKYLHS VQEILSHFAA YSLDYSSRGT ESGAASSAFT
SRFENITEFL DGDSNNSEAG FGSTFQRRAL EAKKTHLLDL LQMVDDRYSH CVDEIHTVIS
AFHAATELDP QLHTRFALQT VSFLYKNLRE RICKKIISMG SVLERGKDKT QETSMFHQHC
LLQQLKRKNH QIWRPQRGLP EKSVSVLRNW MFQNFLHPYP KDSEKHLLAI RSGLTRSQVS
NWFINARVRL WKPMIEEMYA EMNKRKLNNS HIQPNGPTLR MPKSVMMSQA MHK
