ATHB4_ARATH
ID ATHB4_ARATH Reviewed; 318 AA.
AC P92953; Q546G8;
DT 15-JUL-1998, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-1997, sequence version 1.
DT 03-AUG-2022, entry version 159.
DE RecName: Full=Homeobox-leucine zipper protein ATHB-4;
DE AltName: Full=HD-ZIP protein ATHB-4;
DE AltName: Full=Homeodomain transcription factor ATHB-4;
GN Name=ATHB-4; OrderedLocusNames=At2g44910; ORFNames=T13E15.8;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=cv. Columbia;
RA Steindler C., Morelli G., Ruberti I.;
RT "Nucleotide sequence of the Arabidopsis ATHB-4 gene encoding an HD-Zip
RT protein related to ATHB-2.";
RL (er) Plant Gene Register PGR97-021(1997).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=cv. Columbia;
RA Steindler C., Carabelli M., Ciarbelli A.R., Ruzza V., Sessa G., Ruberti I.;
RT "Nucleotide sequence of the Arabidopsis ATHB-4 mRNA, encoding an HD-Zip II
RT protein related to ATHB-2.";
RL Submitted (APR-2002) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=10617197; DOI=10.1038/45471;
RA Lin X., Kaul S., Rounsley S.D., Shea T.P., Benito M.-I., Town C.D.,
RA Fujii C.Y., Mason T.M., Bowman C.L., Barnstead M.E., Feldblyum T.V.,
RA Buell C.R., Ketchum K.A., Lee J.J., Ronning C.M., Koo H.L., Moffat K.S.,
RA Cronin L.A., Shen M., Pai G., Van Aken S., Umayam L., Tallon L.J.,
RA Gill J.E., Adams M.D., Carrera A.J., Creasy T.H., Goodman H.M.,
RA Somerville C.R., Copenhaver G.P., Preuss D., Nierman W.C., White O.,
RA Eisen J.A., Salzberg S.L., Fraser C.M., Venter J.C.;
RT "Sequence and analysis of chromosome 2 of the plant Arabidopsis thaliana.";
RL Nature 402:761-768(1999).
RN [4]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [5]
RP INDUCTION.
RX PubMed=8106086; DOI=10.1046/j.1365-313x.1993.04030469.x;
RA Carabelli M., Sessa G., Baima S., Morelli G., Ruberti I.;
RT "The Arabidopsis Athb-2 and -4 genes are strongly induced by far-red-rich
RT light.";
RL Plant J. 4:469-479(1993).
RN [6]
RP GENE FAMILY.
RX PubMed=16055682; DOI=10.1104/pp.105.063461;
RA Henriksson E., Olsson A.S.B., Johannesson H., Johansson H., Hanson J.,
RA Engstroem P., Soederman E.;
RT "Homeodomain leucine zipper class I genes in Arabidopsis. Expression
RT patterns and phylogenetic relationships.";
RL Plant Physiol. 139:509-518(2005).
CC -!- FUNCTION: Probable transcription factor. {ECO:0000250}.
CC -!- INTERACTION:
CC P92953; O04292: ATHB-9; NbExp=4; IntAct=EBI-15192259, EBI-1536772;
CC P92953; Q8GXM7: ATHB-X; NbExp=5; IntAct=EBI-15192259, EBI-3133795;
CC P92953; P46600: HAT1; NbExp=4; IntAct=EBI-15192259, EBI-15195911;
CC P92953; Q9LXU1: PIM1; NbExp=3; IntAct=EBI-15192259, EBI-15193025;
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC -!- INDUCTION: By transition from light to far-red light.
CC {ECO:0000269|PubMed:8106086}.
CC -!- SIMILARITY: Belongs to the HD-ZIP homeobox family. Class II subfamily.
CC {ECO:0000305}.
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DR EMBL; Y09582; CAA70771.1; -; Genomic_DNA.
DR EMBL; AJ441251; CAD29650.1; -; mRNA.
DR EMBL; AC002388; AAC31833.1; -; Genomic_DNA.
DR EMBL; CP002685; AEC10483.1; -; Genomic_DNA.
DR PIR; T00402; T00402.
DR RefSeq; NP_182018.1; NM_130055.2.
DR AlphaFoldDB; P92953; -.
DR SMR; P92953; -.
DR BioGRID; 4436; 13.
DR IntAct; P92953; 13.
DR STRING; 3702.AT2G44910.1; -.
DR PaxDb; P92953; -.
DR PRIDE; P92953; -.
DR EnsemblPlants; AT2G44910.1; AT2G44910.1; AT2G44910.
DR GeneID; 819100; -.
DR Gramene; AT2G44910.1; AT2G44910.1; AT2G44910.
DR KEGG; ath:AT2G44910; -.
DR Araport; AT2G44910; -.
DR TAIR; locus:2055028; AT2G44910.
DR eggNOG; KOG0483; Eukaryota.
DR HOGENOM; CLU_049516_2_1_1; -.
DR InParanoid; P92953; -.
DR OMA; WTHLFQS; -.
DR OrthoDB; 1358464at2759; -.
DR PhylomeDB; P92953; -.
DR PRO; PR:P92953; -.
DR Proteomes; UP000006548; Chromosome 2.
DR ExpressionAtlas; P92953; baseline and differential.
DR Genevisible; P92953; AT.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0009506; C:plasmodesma; HDA:TAIR.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; ISS:TAIR.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IEA:InterPro.
DR GO; GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.
DR GO; GO:0006355; P:regulation of transcription, DNA-templated; IMP:TAIR.
DR GO; GO:0010218; P:response to far red light; IEP:TAIR.
DR GO; GO:0009725; P:response to hormone; IMP:TAIR.
DR GO; GO:0009641; P:shade avoidance; IEP:TAIR.
DR CDD; cd00086; homeodomain; 1.
DR InterPro; IPR006712; HD-ZIP_N.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR017970; Homeobox_CS.
DR InterPro; IPR001356; Homeobox_dom.
DR InterPro; IPR003106; Leu_zip_homeo.
DR Pfam; PF02183; HALZ; 1.
DR Pfam; PF04618; HD-ZIP_N; 1.
DR Pfam; PF00046; Homeodomain; 1.
DR SMART; SM00340; HALZ; 1.
DR SMART; SM00389; HOX; 1.
DR SUPFAM; SSF46689; SSF46689; 1.
DR PROSITE; PS00027; HOMEOBOX_1; 1.
DR PROSITE; PS50071; HOMEOBOX_2; 1.
PE 1: Evidence at protein level;
KW DNA-binding; Homeobox; Nucleus; Reference proteome; Transcription;
KW Transcription regulation.
FT CHAIN 1..318
FT /note="Homeobox-leucine zipper protein ATHB-4"
FT /id="PRO_0000048822"
FT DNA_BIND 160..219
FT /note="Homeobox"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT REGION 1..23
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 128..165
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 227..248
FT /note="Leucine-zipper"
SQ SEQUENCE 318 AA; 34816 MW; 2D9B1CADFCF43D41 CRC64;
MGERDDGLGL SLSLGNSQQK EPSLRLNLMP LTTSSSSSSF QHMHNQNNNS HPQKIHNISW
THLFQSSGIK RTTAERNSDA GSFLRGFNVN RAQSSVAVVD LEEEAAVVSS PNSAVSSLSG
NKRDLAVARG GDENEAERAS CSRGGGSGGS DDEDGGNGDG SRKKLRLSKD QALVLEETFK
EHSTLNPKQK LALAKQLNLR ARQVEVWFQN RRARTKLKQT EVDCEYLKRC CDNLTEENRR
LQKEVSELRA LKLSPHLYMH MTPPTTLTMC PSCERVSSSA ATVTAAPSTT TTPTVVGRPS
PQRLTPWTAI SLQQKSGR
