ATHB5_ARATH
ID ATHB5_ARATH Reviewed; 312 AA.
AC P46667;
DT 01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1995, sequence version 1.
DT 25-MAY-2022, entry version 159.
DE RecName: Full=Homeobox-leucine zipper protein ATHB-5;
DE AltName: Full=HD-ZIP protein ATHB-5;
DE AltName: Full=Homeodomain transcription factor ATHB-5;
GN Name=ATHB-5; OrderedLocusNames=At5g65310; ORFNames=MNA5.4;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=cv. Columbia;
RX PubMed=7948864; DOI=10.1007/bf00039527;
RA Soederman E., Mattsson J., Svenson M., Borkird C., Engstroem P.;
RT "Expression patterns of novel genes encoding homeodomain leucine-zipper
RT proteins in Arabidopsis thaliana.";
RL Plant Mol. Biol. 26:145-154(1994).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=9679202; DOI=10.1093/dnares/5.2.131;
RA Kaneko T., Kotani H., Nakamura Y., Sato S., Asamizu E., Miyajima N.,
RA Tabata S.;
RT "Structural analysis of Arabidopsis thaliana chromosome 5. V. Sequence
RT features of the regions of 1,381,565 bp covered by twenty one physically
RT assigned P1 and TAC clones.";
RL DNA Res. 5:131-145(1998).
RN [3]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RX PubMed=14593172; DOI=10.1126/science.1088305;
RA Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M.,
RA Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G.,
RA Liu S.X., Lam B., Sakano H., Wu T., Yu G., Miranda M., Quach H.L.,
RA Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C.,
RA Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J.,
RA Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A.,
RA Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C.,
RA Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X.,
RA Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M.,
RA Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K.,
RA Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A.,
RA Ecker J.R.;
RT "Empirical analysis of transcriptional activity in the Arabidopsis
RT genome.";
RL Science 302:842-846(2003).
RN [5]
RP INDUCTION, DEVELOPMENTAL STAGE, AND FUNCTION.
RX PubMed=12678559; DOI=10.1023/a:1022567625228;
RA Johannesson H., Wang Y., Hanson J., Engstroem P.;
RT "The Arabidopsis thaliana homeobox gene ATHB5 is a potential regulator of
RT abscisic acid responsiveness in developing seedlings.";
RL Plant Mol. Biol. 51:719-729(2003).
RN [6]
RP DNA-BINDING.
RX PubMed=11247607; DOI=10.1023/a:1006423324025;
RA Johannesson H., Wang Y., Engstroem P.;
RT "DNA-binding and dimerization preferences of Arabidopsis homeodomain-
RT leucine zipper transcription factors in vitro.";
RL Plant Mol. Biol. 45:63-73(2001).
RN [7]
RP GENE FAMILY, TISSUE SPECIFICITY, AND INDUCTION.
RX PubMed=16055682; DOI=10.1104/pp.105.063461;
RA Henriksson E., Olsson A.S.B., Johannesson H., Johansson H., Hanson J.,
RA Engstroem P., Soederman E.;
RT "Homeodomain leucine zipper class I genes in Arabidopsis. Expression
RT patterns and phylogenetic relationships.";
RL Plant Physiol. 139:509-518(2005).
CC -!- FUNCTION: Probable transcription factor that acts as a positive
CC regulator of ABA-responsiveness, mediating the inhibitory effect of ABA
CC on growth during seedling establishment. Binds to the DNA sequence 5'-
CC CAATNATTG-3'. {ECO:0000269|PubMed:12678559}.
CC -!- SUBUNIT: Interacts with DNA as homodimer.
CC -!- SUBCELLULAR LOCATION: Nucleus.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=1;
CC Comment=A number of isoforms are produced. According to EST
CC sequences.;
CC Name=1;
CC IsoId=P46667-1; Sequence=Displayed;
CC -!- TISSUE SPECIFICITY: Widely expressed. {ECO:0000269|PubMed:16055682}.
CC -!- DEVELOPMENTAL STAGE: Localized primarily to the hypocotyl of
CC germinating seedlings. {ECO:0000269|PubMed:12678559}.
CC -!- INDUCTION: Down-regulated by abscisic acid (ABA) and by salt stress.
CC {ECO:0000269|PubMed:12678559, ECO:0000269|PubMed:16055682}.
CC -!- SIMILARITY: Belongs to the HD-ZIP homeobox family. Class I subfamily.
CC {ECO:0000305}.
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DR EMBL; X67033; CAA47426.1; -; mRNA.
DR EMBL; AB011479; BAB11553.1; -; Genomic_DNA.
DR EMBL; CP002688; AED98037.1; -; Genomic_DNA.
DR EMBL; AF325054; AAG40406.1; -; mRNA.
DR EMBL; AY074293; AAL66990.1; -; mRNA.
DR EMBL; AY091340; AAM14279.1; -; mRNA.
DR PIR; S47135; S47135.
DR RefSeq; NP_201334.1; NM_125929.3. [P46667-1]
DR AlphaFoldDB; P46667; -.
DR SMR; P46667; -.
DR BioGRID; 21898; 7.
DR STRING; 3702.AT5G65310.1; -.
DR PaxDb; P46667; -.
DR PRIDE; P46667; -.
DR EnsemblPlants; AT5G65310.1; AT5G65310.1; AT5G65310. [P46667-1]
DR GeneID; 836656; -.
DR Gramene; AT5G65310.1; AT5G65310.1; AT5G65310. [P46667-1]
DR KEGG; ath:AT5G65310; -.
DR Araport; AT5G65310; -.
DR TAIR; locus:2168225; AT5G65310.
DR eggNOG; KOG0483; Eukaryota.
DR InParanoid; P46667; -.
DR OMA; IYHSTAD; -.
DR OrthoDB; 1135658at2759; -.
DR PhylomeDB; P46667; -.
DR PRO; PR:P46667; -.
DR Proteomes; UP000006548; Chromosome 5.
DR ExpressionAtlas; P46667; baseline and differential.
DR Genevisible; P46667; AT.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; ISS:TAIR.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IEA:InterPro.
DR GO; GO:0042803; F:protein homodimerization activity; IDA:TAIR.
DR GO; GO:0043565; F:sequence-specific DNA binding; IDA:TAIR.
DR GO; GO:0000976; F:transcription cis-regulatory region binding; IPI:TAIR.
DR GO; GO:0009738; P:abscisic acid-activated signaling pathway; TAS:TAIR.
DR GO; GO:0045893; P:positive regulation of transcription, DNA-templated; IDA:TAIR.
DR GO; GO:0009737; P:response to abscisic acid; IDA:TAIR.
DR CDD; cd00086; homeodomain; 1.
DR InterPro; IPR045224; HDZip_class_I_plant.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR017970; Homeobox_CS.
DR InterPro; IPR001356; Homeobox_dom.
DR InterPro; IPR000047; HTH_motif.
DR InterPro; IPR003106; Leu_zip_homeo.
DR PANTHER; PTHR24326; PTHR24326; 1.
DR Pfam; PF02183; HALZ; 1.
DR Pfam; PF00046; Homeodomain; 1.
DR PRINTS; PR00031; HTHREPRESSR.
DR SMART; SM00389; HOX; 1.
DR SUPFAM; SSF46689; SSF46689; 1.
DR PROSITE; PS00027; HOMEOBOX_1; 1.
DR PROSITE; PS50071; HOMEOBOX_2; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; DNA-binding; Homeobox; Nucleus; Reference proteome;
KW Transcription; Transcription regulation.
FT CHAIN 1..312
FT /note="Homeobox-leucine zipper protein ATHB-5"
FT /id="PRO_0000048823"
FT DNA_BIND 69..128
FT /note="Homeobox"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT REGION 1..33
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 129..164
FT /note="Leucine-zipper"
FT COMPBIAS 7..33
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 312 AA; 34791 MW; B4C3FACC3351797E CRC64;
MKRSRGSSDS LSGFLPIRHS TTDKQISPRP TTTGFLYSGA GDYSQMFDAL EDDGSLEDLG
GVGHASSTAA EKKRRLGVEQ VKALEKNFEI DNKLEPERKV KLAQELGLQP RQVAIWFQNR
RARWKTKQLE RDYGVLKSNF DALKRNRDSL QRDNDSLLGQ IKELKAKLNV EGVKGIEENG
ALKAVEANQS VMANNEVLEL SHRSPSPPPH IPTDAPTSEL AFEMFSIFPR TENFRDDPAD
SSDSSAVLNE EYSPNTVEAA GAVAATTVEM STMGCFSQFV KMEEHEDLFS GEEACKLFAD
NEQWYCSDQW NS
