ATHB7_ARATH
ID ATHB7_ARATH Reviewed; 258 AA.
AC P46897; Q9SLF9;
DT 01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT 06-JUN-2002, sequence version 2.
DT 03-AUG-2022, entry version 165.
DE RecName: Full=Homeobox-leucine zipper protein ATHB-7;
DE AltName: Full=HD-ZIP protein ATHB-7;
DE AltName: Full=Homeodomain transcription factor ATHB-7;
GN Name=ATHB-7; OrderedLocusNames=At2g46680; ORFNames=T3A4.6;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=cv. Columbia;
RX PubMed=7948864; DOI=10.1007/bf00039527;
RA Soederman E., Mattsson J., Svenson M., Borkird C., Engstroem P.;
RT "Expression patterns of novel genes encoding homeodomain leucine-zipper
RT proteins in Arabidopsis thaliana.";
RL Plant Mol. Biol. 26:145-154(1994).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=10617197; DOI=10.1038/45471;
RA Lin X., Kaul S., Rounsley S.D., Shea T.P., Benito M.-I., Town C.D.,
RA Fujii C.Y., Mason T.M., Bowman C.L., Barnstead M.E., Feldblyum T.V.,
RA Buell C.R., Ketchum K.A., Lee J.J., Ronning C.M., Koo H.L., Moffat K.S.,
RA Cronin L.A., Shen M., Pai G., Van Aken S., Umayam L., Tallon L.J.,
RA Gill J.E., Adams M.D., Carrera A.J., Creasy T.H., Goodman H.M.,
RA Somerville C.R., Copenhaver G.P., Preuss D., Nierman W.C., White O.,
RA Eisen J.A., Salzberg S.L., Fraser C.M., Venter J.C.;
RT "Sequence and analysis of chromosome 2 of the plant Arabidopsis thaliana.";
RL Nature 402:761-768(1999).
RN [3]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RX PubMed=14593172; DOI=10.1126/science.1088305;
RA Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M.,
RA Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G.,
RA Liu S.X., Lam B., Sakano H., Wu T., Yu G., Miranda M., Quach H.L.,
RA Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C.,
RA Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J.,
RA Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A.,
RA Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C.,
RA Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X.,
RA Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M.,
RA Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K.,
RA Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A.,
RA Ecker J.R.;
RT "Empirical analysis of transcriptional activity in the Arabidopsis
RT genome.";
RL Science 302:842-846(2003).
RN [5]
RP TISSUE SPECIFICITY, INDUCTION, AND FUNCTION.
RX PubMed=8771791; DOI=10.1046/j.1365-313x.1996.10020375.x;
RA Soederman E., Mattsson J., Engstroem P.;
RT "The Arabidopsis homeobox gene ATHB-7 is induced by water deficit and by
RT abscisic acid.";
RL Plant J. 10:375-381(1996).
RN [6]
RP FUNCTION.
RX PubMed=15604708; DOI=10.1007/s11103-004-1581-4;
RA Olsson A.S.B., Engstroem P., Seoderman E.;
RT "The homeobox genes ATHB12 and ATHB7 encode potential regulators of growth
RT in response to water deficit in Arabidopsis.";
RL Plant Mol. Biol. 55:663-677(2004).
RN [7]
RP GENE FAMILY, TISSUE SPECIFICITY, AND INDUCTION.
RX PubMed=16055682; DOI=10.1104/pp.105.063461;
RA Henriksson E., Olsson A.S.B., Johannesson H., Johansson H., Hanson J.,
RA Engstroem P., Soederman E.;
RT "Homeodomain leucine zipper class I genes in Arabidopsis. Expression
RT patterns and phylogenetic relationships.";
RL Plant Physiol. 139:509-518(2005).
RN [8]
RP INTERACTION WITH TBP2 AND TFIIB1.
RX PubMed=24531799; DOI=10.1007/s00299-014-1576-9;
RA Capella M., Re D.A., Arce A.L., Chan R.L.;
RT "Plant homeodomain-leucine zipper I transcription factors exhibit different
RT functional AHA motifs that selectively interact with TBP or/and TFIIB.";
RL Plant Cell Rep. 33:955-967(2014).
CC -!- FUNCTION: Probable transcription activator that may act as growth
CC regulators in response to water deficit. {ECO:0000269|PubMed:15604708,
CC ECO:0000269|PubMed:8771791}.
CC -!- SUBUNIT: Interacts with TBP2 and TFIIB1. {ECO:0000269|PubMed:24531799}.
CC -!- INTERACTION:
CC P46897; F4JI72: At4g03250; NbExp=3; IntAct=EBI-15193277, EBI-15192535;
CC P46897; Q8LA53: MBD2; NbExp=3; IntAct=EBI-15193277, EBI-4425826;
CC -!- SUBCELLULAR LOCATION: Nucleus.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=1;
CC Comment=A number of isoforms are produced. According to EST
CC sequences.;
CC Name=1;
CC IsoId=P46897-1; Sequence=Displayed;
CC -!- TISSUE SPECIFICITY: Widely expressed. {ECO:0000269|PubMed:16055682,
CC ECO:0000269|PubMed:8771791}.
CC -!- INDUCTION: By water deficit, by abscisic acid (ABA) and by salt stress.
CC {ECO:0000269|PubMed:16055682, ECO:0000269|PubMed:8771791}.
CC -!- SIMILARITY: Belongs to the HD-ZIP homeobox family. Class I subfamily.
CC {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=CAA47425.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
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DR EMBL; X67032; CAA47425.1; ALT_INIT; mRNA.
DR EMBL; AC005819; AAC69925.1; -; Genomic_DNA.
DR EMBL; CP002685; AEC10739.1; -; Genomic_DNA.
DR EMBL; AY045826; AAK76500.1; -; mRNA.
DR EMBL; AY091364; AAM14303.1; -; mRNA.
DR PIR; H84905; H84905.
DR PIR; S47137; S47137.
DR RefSeq; NP_182191.1; NM_130233.5. [P46897-1]
DR AlphaFoldDB; P46897; -.
DR SMR; P46897; -.
DR BioGRID; 4615; 15.
DR IntAct; P46897; 12.
DR STRING; 3702.AT2G46680.1; -.
DR PaxDb; P46897; -.
DR PRIDE; P46897; -.
DR ProteomicsDB; 246628; -. [P46897-1]
DR EnsemblPlants; AT2G46680.1; AT2G46680.1; AT2G46680. [P46897-1]
DR GeneID; 819280; -.
DR Gramene; AT2G46680.1; AT2G46680.1; AT2G46680. [P46897-1]
DR KEGG; ath:AT2G46680; -.
DR Araport; AT2G46680; -.
DR TAIR; locus:2062754; AT2G46680.
DR eggNOG; KOG0483; Eukaryota.
DR HOGENOM; CLU_060842_3_0_1; -.
DR InParanoid; P46897; -.
DR OMA; NSHIKRE; -.
DR OrthoDB; 1130773at2759; -.
DR PhylomeDB; P46897; -.
DR PRO; PR:P46897; -.
DR Proteomes; UP000006548; Chromosome 2.
DR ExpressionAtlas; P46897; baseline and differential.
DR Genevisible; P46897; AT.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; ISS:TAIR.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IEA:InterPro.
DR GO; GO:0043565; F:sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0000976; F:transcription cis-regulatory region binding; IPI:TAIR.
DR GO; GO:0045893; P:positive regulation of transcription, DNA-templated; IDA:TAIR.
DR GO; GO:0009737; P:response to abscisic acid; IEP:TAIR.
DR GO; GO:0009414; P:response to water deprivation; IEP:TAIR.
DR CDD; cd00086; homeodomain; 1.
DR InterPro; IPR045224; HDZip_class_I_plant.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR017970; Homeobox_CS.
DR InterPro; IPR001356; Homeobox_dom.
DR InterPro; IPR000047; HTH_motif.
DR InterPro; IPR003106; Leu_zip_homeo.
DR PANTHER; PTHR24326; PTHR24326; 1.
DR Pfam; PF02183; HALZ; 1.
DR Pfam; PF00046; Homeodomain; 1.
DR PRINTS; PR00031; HTHREPRESSR.
DR SMART; SM00389; HOX; 1.
DR SUPFAM; SSF46689; SSF46689; 1.
DR PROSITE; PS00027; HOMEOBOX_1; 1.
DR PROSITE; PS50071; HOMEOBOX_2; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; DNA-binding; Homeobox; Nucleus; Reference proteome;
KW Stress response; Transcription; Transcription regulation.
FT CHAIN 1..258
FT /note="Homeobox-leucine zipper protein ATHB-7"
FT /id="PRO_0000048825"
FT DNA_BIND 29..88
FT /note="Homeobox"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT REGION 89..124
FT /note="Leucine-zipper"
FT REGION 149..183
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 152..183
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 258 AA; 30511 MW; E2E69664759C1FC9 CRC64;
MTEGGEYSPA MMSAEPFLTM KKMKKSNHNK NNQRRFSDEQ IKSLEMMFES ETRLEPRKKV
QLARELGLQP RQVAIWFQNK RARWKSKQLE TEYNILRQNY DNLASQFESL KKEKQALVSE
LQRLKEATQK KTQEEERQCS GDQAVVALSS THHESENEEN RRRKPEEVRP EMEMKDDKGH
HGVMCDHHDY EDDDNGYSNN IKREYFGGFE EEPDHLMNIV EPADSCLTSS DDWRGFKSDT
TTLLDQSSNN YPWRDFWS
