ATHBX_ARATH
ID ATHBX_ARATH Reviewed; 206 AA.
AC Q8GXM7;
DT 31-OCT-2006, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2003, sequence version 1.
DT 25-MAY-2022, entry version 125.
DE RecName: Full=Homeobox-leucine zipper protein ATHB-X;
DE AltName: Full=HD-ZIP protein ATHB-X;
DE AltName: Full=Homeodomain transcription factor ATHB-X;
GN Name=ATHB-X; OrderedLocusNames=At1g70920; ORFNames=F15H11_25;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=11130712; DOI=10.1038/35048500;
RA Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O.,
RA Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E.,
RA Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K., Conn L.,
RA Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P.,
RA Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D.,
RA Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J.,
RA Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L.,
RA Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A.,
RA Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A.,
RA Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M.,
RA Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M.,
RA Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P.,
RA Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D.,
RA Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D.,
RA Yu G., Fraser C.M., Venter J.C., Davis R.W.;
RT "Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana.";
RL Nature 408:816-820(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RX PubMed=11910074; DOI=10.1126/science.1071006;
RA Seki M., Narusaka M., Kamiya A., Ishida J., Satou M., Sakurai T.,
RA Nakajima M., Enju A., Akiyama K., Oono Y., Muramatsu M., Hayashizaki Y.,
RA Kawai J., Carninci P., Itoh M., Ishii Y., Arakawa T., Shibata K.,
RA Shinagawa A., Shinozaki K.;
RT "Functional annotation of a full-length Arabidopsis cDNA collection.";
RL Science 296:141-145(2002).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RX PubMed=14593172; DOI=10.1126/science.1088305;
RA Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M.,
RA Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G.,
RA Liu S.X., Lam B., Sakano H., Wu T., Yu G., Miranda M., Quach H.L.,
RA Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C.,
RA Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J.,
RA Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A.,
RA Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C.,
RA Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X.,
RA Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M.,
RA Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K.,
RA Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A.,
RA Ecker J.R.;
RT "Empirical analysis of transcriptional activity in the Arabidopsis
RT genome.";
RL Science 302:842-846(2003).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RA Totoki Y., Seki M., Ishida J., Nakajima M., Enju A., Kamiya A.,
RA Narusaka M., Shin-i T., Nakagawa M., Sakamoto N., Oishi K., Kohara Y.,
RA Kobayashi M., Toyoda A., Sakaki Y., Sakurai T., Iida K., Akiyama K.,
RA Satou M., Toyoda T., Konagaya A., Carninci P., Kawai J., Hayashizaki Y.,
RA Shinozaki K.;
RT "Large-scale analysis of RIKEN Arabidopsis full-length (RAFL) cDNAs.";
RL Submitted (SEP-2004) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Probable transcription factor. {ECO:0000250}.
CC -!- INTERACTION:
CC Q8GXM7; P92953: ATHB-4; NbExp=5; IntAct=EBI-3133795, EBI-15192259;
CC Q8GXM7; P46600: HAT1; NbExp=5; IntAct=EBI-3133795, EBI-15195911;
CC Q8GXM7; P46601: HAT2; NbExp=5; IntAct=EBI-3133795, EBI-4448195;
CC Q8GXM7; P46604: HAT22; NbExp=3; IntAct=EBI-3133795, EBI-4448318;
CC Q8GXM7; P46602: HAT3; NbExp=5; IntAct=EBI-3133795, EBI-4450405;
CC Q8GXM7; Q05466: HAT4; NbExp=5; IntAct=EBI-3133795, EBI-4428728;
CC Q8GXM7; P46603: HAT9; NbExp=4; IntAct=EBI-3133795, EBI-15192157;
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the HD-ZIP homeobox family. Class II subfamily.
CC {ECO:0000305}.
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DR EMBL; AC008148; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CP002684; AEE35139.1; -; Genomic_DNA.
DR EMBL; AK118149; BAC42774.1; -; mRNA.
DR EMBL; BT005594; AAO64014.1; -; mRNA.
DR EMBL; AK175837; BAD43600.1; -; mRNA.
DR EMBL; AK175965; BAD43728.1; -; mRNA.
DR RefSeq; NP_177248.3; NM_105760.6.
DR AlphaFoldDB; Q8GXM7; -.
DR SMR; Q8GXM7; -.
DR BioGRID; 28651; 10.
DR IntAct; Q8GXM7; 10.
DR STRING; 3702.AT1G70920.1; -.
DR PaxDb; Q8GXM7; -.
DR ProteomicsDB; 246558; -.
DR EnsemblPlants; AT1G70920.1; AT1G70920.1; AT1G70920.
DR GeneID; 843431; -.
DR Gramene; AT1G70920.1; AT1G70920.1; AT1G70920.
DR KEGG; ath:AT1G70920; -.
DR Araport; AT1G70920; -.
DR TAIR; locus:2013980; AT1G70920.
DR eggNOG; KOG0483; Eukaryota.
DR HOGENOM; CLU_049516_6_0_1; -.
DR InParanoid; Q8GXM7; -.
DR OrthoDB; 1227444at2759; -.
DR PhylomeDB; Q8GXM7; -.
DR PRO; PR:Q8GXM7; -.
DR Proteomes; UP000006548; Chromosome 1.
DR ExpressionAtlas; Q8GXM7; baseline and differential.
DR Genevisible; Q8GXM7; AT.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; ISS:TAIR.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IEA:InterPro.
DR GO; GO:0000976; F:transcription cis-regulatory region binding; IPI:TAIR.
DR CDD; cd00086; homeodomain; 1.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR017970; Homeobox_CS.
DR InterPro; IPR001356; Homeobox_dom.
DR InterPro; IPR003106; Leu_zip_homeo.
DR Pfam; PF02183; HALZ; 1.
DR Pfam; PF00046; Homeodomain; 1.
DR SMART; SM00340; HALZ; 1.
DR SMART; SM00389; HOX; 1.
DR SUPFAM; SSF46689; SSF46689; 1.
DR PROSITE; PS00027; HOMEOBOX_1; 1.
DR PROSITE; PS50071; HOMEOBOX_2; 1.
PE 1: Evidence at protein level;
KW DNA-binding; Homeobox; Nucleus; Reference proteome; Transcription;
KW Transcription regulation.
FT CHAIN 1..206
FT /note="Homeobox-leucine zipper protein ATHB-X"
FT /id="PRO_0000257806"
FT DNA_BIND 66..125
FT /note="Homeobox"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT REGION 20..68
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 133..154
FT /note="Leucine-zipper"
FT COMPBIAS 28..53
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 206 AA; 23519 MW; DA744977152179DA CRC64;
MALSPNSSSL DLTISIPSFS PSPSLGDHHG MRDFDINQTP KTEEDREWMI GATPHVNEDD
SNSGGRRRKK LRLTKEQSHL LEESFIQNHT LTPKQKKDLA TFLKLSQRQV EVWFQNRRAR
SKLKHTEMEC EYLKRWFGSL KEQNRRLQIE VEELRALKPS STSALTMCPR CERVTDAVDN
DSNAVQEGAV LSSRSRMTIS SSSSLC
