ID   ATI_CAMPS               Reviewed;         726 AA.
AC   Q775Q2;
DT   07-DEC-2004, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   25-MAY-2022, entry version 45.
DE   RecName: Full=A-type inclusion protein A25 homolog;
DE            Short=ATI;
GN   OrderedLocusNames=CMP142L;
OS   Camelpox virus (strain CMS).
OC   Viruses; Varidnaviria; Bamfordvirae; Nucleocytoviricota; Pokkesviricetes;
OC   Chitovirales; Poxviridae; Chordopoxvirinae; Orthopoxvirus.
OX   NCBI_TaxID=203172;
OH   NCBI_TaxID=9836; Camelus.
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=11907336; DOI=10.1099/0022-1317-83-4-855;
RA   Gubser C., Smith G.L.;
RT   "The sequence of camelpox virus shows it is most closely related to variola
RT   virus, the cause of smallpox.";
RL   J. Gen. Virol. 83:855-872(2002).
CC   -!- FUNCTION: Structural protein that forms a matrix surrounding the mature
CC       virion (MV) through interaction with protein A26. Presence of protein
CC       A25 in the virion structurally prevents direct virus-cell fusion
CC       mechanism (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Interacts (via N-terminus) with protein A26. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Virion. Note=Present above the membrane of mature
CC       virions (MV). {ECO:0000250}.
CC   -!- MISCELLANEOUS: Some orthopoxviruses such as cowpox, ectromelia, and
CC       raccoonpox viruses, form large cytoplasmic inclusions within which
CC       mature virions are embedded by a process called occlusion. In those
CC       viruses, A26 bridges mature virion with inclusion bodies through
CC       interactions with proteins A25 and A27 on the mature virion membrane.
CC       In camelpox virus, the protein A25 is deleted in its C-terminal region
CC       and no inclusion body is observed.
CC   -!- SIMILARITY: Belongs to the poxviridae A25 protein family.
CC       {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AY009089; AAG37635.1; -; Genomic_DNA.
DR   SMR; Q775Q2; -.
DR   Proteomes; UP000107153; Genome.
DR   GO; GO:0016032; P:viral process; IEA:InterPro.
DR   InterPro; IPR007596; Pox_A_type_inc.
DR   Pfam; PF04508; Pox_A_type_inc; 4.
PE   3: Inferred from homology;
KW   Late protein; Repeat; Virion.
FT   CHAIN           1..726
FT                   /note="A-type inclusion protein A25 homolog"
FT                   /id="PRO_0000099283"
FT   REPEAT          612..634
FT                   /note="1"
FT   REPEAT          639..661
FT                   /note="2"
FT   REPEAT          667..689
FT                   /note="3"
FT   REPEAT          691..713
FT                   /note="4"
FT   REGION          342..361
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          426..713
FT                   /note="4 X approximate tandem repeats"
SQ   SEQUENCE   726 AA;  84285 MW;  A7F4687BAAC6701D CRC64;
     MELTNLIEKC TKHSKDFATE VEKLWNDELS SESGLSRKTR NVIRNILRDI TKSLTTDKKS
     KCFCILERST INGEQIKDVY KTIFNNGVDV ESRINTTGKY VLFTVMTYAA AELRLIKSDE
     IFALLSRFFN MICDIHRKYG CGNMFVGIPA ALIVLLEIDH INKLFSVFST RYDAKAYLYT
     EYFLFLNINH YLLSGSDLFI NVAYGAVSFS SPISVPDYIM EALTFKACDH IMKSGDLIYI
     YAFTKKVKDL FNTKSDSIYQ YVRLHEMSYD GVSEDTDDDD EVFAILNLSI DSSVDRYRNR
     VLLLTPEVAS LRKEYSEAEP DYKYLMDEEV SAYDKHLPKP ITNTGIEEPH ATGGDKEDQP
     IKVVYPPNND KDDAIKPHNP LEDPNYVPTI TRTDIGIADY QLVINKLIEW LDKCEEECGN
     GGEFKTELEE AKRKLTELNA ELSDKLSKIM SLERDSVNKT ERIDRLTKEI KELRDIQNGT
     DDGSDSSEID KKIIRELRES LDREREMRSK LEKELDTIRD GKVDGSCQRE LELRRMWLKQ
     RDDDLRAEID KRRNVEWELS RLRRDIKECD KYKEDLDKAK ATISNYVSRI STLESEIAKY
     QQDRDTLSVV RRELEEERRR VKDLESRLDE CTRNQEDTQE VDALRSRIRE LENKLTDCIE
     SGGGNLTEIS RLQSRISDLE RQLNECRGNV TEISRLESRI SDLERQLNDC RRNNETNAET
     ERDATS