ATL40_ARATH
ID ATL40_ARATH Reviewed; 217 AA.
AC Q9SLC4;
DT 05-JUL-2005, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-2000, sequence version 1.
DT 03-AUG-2022, entry version 126.
DE RecName: Full=RING-H2 finger protein ATL40;
DE EC=2.3.2.27 {ECO:0000305};
DE AltName: Full=RING-type E3 ubiquitin transferase ATL40 {ECO:0000305};
GN Name=ATL40; OrderedLocusNames=At2g42350; ORFNames=MHK10.7;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=10617197; DOI=10.1038/45471;
RA Lin X., Kaul S., Rounsley S.D., Shea T.P., Benito M.-I., Town C.D.,
RA Fujii C.Y., Mason T.M., Bowman C.L., Barnstead M.E., Feldblyum T.V.,
RA Buell C.R., Ketchum K.A., Lee J.J., Ronning C.M., Koo H.L., Moffat K.S.,
RA Cronin L.A., Shen M., Pai G., Van Aken S., Umayam L., Tallon L.J.,
RA Gill J.E., Adams M.D., Carrera A.J., Creasy T.H., Goodman H.M.,
RA Somerville C.R., Copenhaver G.P., Preuss D., Nierman W.C., White O.,
RA Eisen J.A., Salzberg S.L., Fraser C.M., Venter J.C.;
RT "Sequence and analysis of chromosome 2 of the plant Arabidopsis thaliana.";
RL Nature 402:761-768(1999).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RA Cheuk R.F., Chen H., Kim C.J., Shinn P., Ecker J.R.;
RT "Arabidopsis ORF clones.";
RL Submitted (JAN-2004) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP GENE FAMILY ORGANIZATION.
RX PubMed=11983057; DOI=10.1186/gb-2002-3-4-research0016;
RA Kosarev P., Mayer K.F.X., Hardtke C.S.;
RT "Evaluation and classification of RING-finger domains encoded by the
RT Arabidopsis genome.";
RL Genome Biol. 3:RESEARCH0016.1-RESEARCH0016.12(2002).
RN [5]
RP NOMENCLATURE, AND GENE FAMILY ORGANIZATION.
RX PubMed=16557337; DOI=10.1007/s00239-005-0038-y;
RA Serrano M., Parra S., Alcaraz L.D., Guzman P.;
RT "The ATL gene family from Arabidopsis thaliana and Oryza sativa comprises a
RT large number of putative ubiquitin ligases of the RING-H2 type.";
RL J. Mol. Evol. 62:434-445(2006).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine +
CC [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-
CC cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.;
CC EC=2.3.2.27; Evidence={ECO:0000305};
CC -!- PATHWAY: Protein modification; protein ubiquitination.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane
CC protein {ECO:0000305}.
CC -!- DOMAIN: The RING-type zinc finger domain mediates binding to an E2
CC ubiquitin-conjugating enzyme. {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the RING-type zinc finger family. ATL subfamily.
CC {ECO:0000305}.
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DR EMBL; AC005956; AAD23718.1; -; Genomic_DNA.
DR EMBL; CP002685; AEC10110.1; -; Genomic_DNA.
DR EMBL; BT010853; AAR24220.1; -; mRNA.
DR EMBL; BT011323; AAR92359.1; -; mRNA.
DR PIR; H84852; H84852.
DR RefSeq; NP_181764.1; NM_129797.3.
DR AlphaFoldDB; Q9SLC4; -.
DR SMR; Q9SLC4; -.
DR STRING; 3702.AT2G42350.1; -.
DR PaxDb; Q9SLC4; -.
DR PRIDE; Q9SLC4; -.
DR EnsemblPlants; AT2G42350.1; AT2G42350.1; AT2G42350.
DR GeneID; 818836; -.
DR Gramene; AT2G42350.1; AT2G42350.1; AT2G42350.
DR KEGG; ath:AT2G42350; -.
DR Araport; AT2G42350; -.
DR TAIR; locus:2053776; AT2G42350.
DR eggNOG; KOG0800; Eukaryota.
DR HOGENOM; CLU_066543_2_1_1; -.
DR InParanoid; Q9SLC4; -.
DR OMA; FTHHHKN; -.
DR OrthoDB; 1248481at2759; -.
DR PhylomeDB; Q9SLC4; -.
DR UniPathway; UPA00143; -.
DR PRO; PR:Q9SLC4; -.
DR Proteomes; UP000006548; Chromosome 2.
DR ExpressionAtlas; Q9SLC4; baseline and differential.
DR Genevisible; Q9SLC4; AT.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0016740; F:transferase activity; IEA:UniProtKB-KW.
DR GO; GO:0016567; P:protein ubiquitination; IEA:UniProtKB-UniPathway.
DR Gene3D; 3.30.40.10; -; 1.
DR InterPro; IPR001841; Znf_RING.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR Pfam; PF13639; zf-RING_2; 1.
DR SMART; SM00184; RING; 1.
DR PROSITE; PS50089; ZF_RING_2; 1.
PE 2: Evidence at transcript level;
KW Membrane; Metal-binding; Reference proteome; Transferase; Transmembrane;
KW Transmembrane helix; Ubl conjugation pathway; Zinc; Zinc-finger.
FT CHAIN 1..217
FT /note="RING-H2 finger protein ATL40"
FT /id="PRO_0000055783"
FT TRANSMEM 28..48
FT /note="Helical"
FT /evidence="ECO:0000255"
FT ZN_FING 100..142
FT /note="RING-type; atypical"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00175"
FT REGION 143..217
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 188..217
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 217 AA; 24422 MW; 4415A863255E6D25 CRC64;
MSSNNKTDDS DDRSFWQNST SYDASSKIFL VTTVSFSIII IIVFVYYLYA KFVLHRRSAF
QDLSFSVVSQ PPKRGLDSLV IASLPTFVVG IKNDVAGTEC AVCLSLLEEK DNARMLPNCK
HVFHVSCVDT WLTTQSTCPV CRTEAEPSHP RLEPEPREGP VGDFAPPLDF AGVDNKTGGS
SVSRLDSFRR ILTRERSSNR RDHSRVDQDR ELDIERQ
