ATL4_HUMAN
ID ATL4_HUMAN Reviewed; 1074 AA.
AC Q6UY14; B2RTT0; F8WAD0; Q5T5F7; Q6IPM6; Q8N643; Q9HBS6;
DT 31-OCT-2006, integrated into UniProtKB/Swiss-Prot.
DT 31-OCT-2006, sequence version 2.
DT 03-AUG-2022, entry version 163.
DE RecName: Full=ADAMTS-like protein 4;
DE Short=ADAMTSL-4;
DE AltName: Full=Thrombospondin repeat-containing protein 1;
DE Flags: Precursor;
GN Name=ADAMTSL4; Synonyms=TSRC1 {ECO:0000312|EMBL:CAI15499.1};
GN ORFNames=PP1396, UNQ2803/PRO34012;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1] {ECO:0000305, ECO:0000312|EMBL:AAQ88489.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RX PubMed=12975309; DOI=10.1101/gr.1293003;
RA Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J.,
RA Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P.,
RA Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E., Heldens S., Huang A.,
RA Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J., Lewis L., Liao D.,
RA Mark M.R., Robbie E., Sanchez C., Schoenfeld J., Seshagiri S., Simmons L.,
RA Singh J., Smith V., Stinson J., Vagts A., Vandlen R.L., Watanabe C.,
RA Wieand D., Woods K., Xie M.-H., Yansura D.G., Yi S., Yu G., Yuan J.,
RA Zhang M., Zhang Z., Goddard A.D., Wood W.I., Godowski P.J., Gray A.M.;
RT "The secreted protein discovery initiative (SPDI), a large-scale effort to
RT identify novel human secreted and transmembrane proteins: a bioinformatics
RT assessment.";
RL Genome Res. 13:2265-2270(2003).
RN [2] {ECO:0000312|EMBL:CAI15499.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16710414; DOI=10.1038/nature04727;
RA Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A.,
RA Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C.,
RA Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.,
RA Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C.,
RA Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W.,
RA Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J.,
RA Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J.,
RA Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y.,
RA Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J.,
RA Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H.,
RA Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L.,
RA Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J.,
RA Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S.,
RA Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K.,
RA Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R.,
RA Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M.,
RA Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S.,
RA Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J.,
RA Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W.,
RA McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N.,
RA Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V.,
RA Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J.,
RA Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E.,
RA Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S.,
RA Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M.,
RA White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H.,
RA Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E.,
RA Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G.,
RA Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.;
RT "The DNA sequence and biological annotation of human chromosome 1.";
RL Nature 441:315-321(2006).
RN [3] {ECO:0000305, ECO:0000312|EMBL:AAH71852.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), NUCLEOTIDE SEQUENCE
RP [LARGE SCALE MRNA] OF 425-1074 (ISOFORM 1), AND VARIANT PRO-193.
RC TISSUE=Lung {ECO:0000312|EMBL:AAH71852.1}, and Placenta;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 638-1074.
RX PubMed=15498874; DOI=10.1073/pnas.0404089101;
RA Wan D., Gong Y., Qin W., Zhang P., Li J., Wei L., Zhou X., Li H., Qiu X.,
RA Zhong F., He L., Yu J., Yao G., Jiang H., Qian L., Yu Y., Shu H., Chen X.,
RA Xu H., Guo M., Pan Z., Chen Y., Ge C., Yang S., Gu J.;
RT "Large-scale cDNA transfection screening for genes related to cancer
RT development and progression.";
RL Proc. Natl. Acad. Sci. U.S.A. 101:15724-15729(2004).
RN [5] {ECO:0000305}
RP IDENTIFICATION (ISOFORM 1).
RX PubMed=12706885; DOI=10.1016/s0378-1119(03)00423-2;
RA Buchner D.A., Meisler M.H.;
RT "TSRC1, a widely expressed gene containing seven thrombospondin type I
RT repeats.";
RL Gene 307:23-30(2003).
RN [6]
RP GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-490.
RC TISSUE=Plasma;
RX PubMed=16335952; DOI=10.1021/pr0502065;
RA Liu T., Qian W.-J., Gritsenko M.A., Camp D.G. II, Monroe M.E., Moore R.J.,
RA Smith R.D.;
RT "Human plasma N-glycoproteome analysis by immunoaffinity subtraction,
RT hydrazide chemistry, and mass spectrometry.";
RL J. Proteome Res. 4:2070-2080(2005).
RN [7] {ECO:0000305}
RP FUNCTION, AND INTERACTION WITH CTSB.
RX PubMed=16364318; DOI=10.1016/j.febslet.2005.12.005;
RA Liu J., Guo Q., Chen B., Yu Y., Lu H., Li Y.-Y.;
RT "Cathepsin B and its interacting proteins, bikunin and TSRC1, correlate
RT with TNF-induced apoptosis of ovarian cancer cells OV-90.";
RL FEBS Lett. 580:245-250(2006).
RN [8]
RP TISSUE SPECIFICITY, AND INVOLVEMENT IN ECTOL2.
RX PubMed=19200529; DOI=10.1016/j.ajhg.2009.01.007;
RA Ahram D., Sato T.S., Kohilan A., Tayeh M., Chen S., Leal S., Al-Salem M.,
RA El-Shanti H.;
RT "A homozygous mutation in ADAMTSL4 causes autosomal-recessive isolated
RT ectopia lentis.";
RL Am. J. Hum. Genet. 84:274-278(2009).
RN [9]
RP GLYCOSYLATION AT ASN-490.
RX PubMed=19139490; DOI=10.1074/mcp.m800504-mcp200;
RA Jia W., Lu Z., Fu Y., Wang H.P., Wang L.H., Chi H., Yuan Z.F., Zheng Z.B.,
RA Song L.N., Han H.H., Liang Y.M., Wang J.L., Cai Y., Zhang Y.K., Deng Y.L.,
RA Ying W.T., He S.M., Qian X.H.;
RT "A strategy for precise and large scale identification of core fucosylated
RT glycoproteins.";
RL Mol. Cell. Proteomics 8:913-923(2009).
RN [10]
RP INVOLVEMENT IN ECTOLP.
RX PubMed=20702823; DOI=10.1167/iovs.10-5597;
RA Christensen A.E., Fiskerstrand T., Knappskog P.M., Boman H., Roedahl E.;
RT "A novel ADAMTSL4 mutation in autosomal recessive ectopia lentis et
RT pupillae.";
RL Invest. Ophthalmol. Vis. Sci. 51:6369-6373(2010).
RN [11]
RP FUNCTION, SUBCELLULAR LOCATION, INTERACTION WITH FBN1, AND GLYCOSYLATION.
RX PubMed=21989719; DOI=10.1167/iovs.10-5955;
RA Gabriel L.A., Wang L.W., Bader H., Ho J.C., Majors A.K., Hollyfield J.G.,
RA Traboulsi E.I., Apte S.S.;
RT "ADAMTSL4, a secreted glycoprotein widely distributed in the eye, binds
RT Fibrillin-1 microfibrils and accelerates microfibril biogenesis.";
RL Invest. Ophthalmol. Vis. Sci. 53:461-469(2012).
RN [12]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Liver;
RX PubMed=24275569; DOI=10.1016/j.jprot.2013.11.014;
RA Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., Wang L.,
RA Ye M., Zou H.;
RT "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver
RT phosphoproteome.";
RL J. Proteomics 96:253-262(2014).
CC -!- FUNCTION: Positive regulation of apoptosis. May facilitate FBN1
CC microfibril biogenesis. {ECO:0000269|PubMed:16364318,
CC ECO:0000269|PubMed:21989719}.
CC -!- SUBUNIT: Interacts with CTSB. Interacts with FBN1.
CC {ECO:0000269|PubMed:16364318, ECO:0000269|PubMed:21989719}.
CC -!- INTERACTION:
CC Q6UY14; P07858: CTSB; NbExp=3; IntAct=EBI-742002, EBI-715062;
CC Q6UY14; O75716: STK16; NbExp=3; IntAct=EBI-742002, EBI-749295;
CC Q6UY14; P09022: Hoxa1; Xeno; NbExp=3; IntAct=EBI-742002, EBI-3957603;
CC Q6UY14; P28301: Lox; Xeno; NbExp=2; IntAct=EBI-742002, EBI-642911;
CC Q6UY14-3; O43184-4: ADAM12; NbExp=3; IntAct=EBI-10173507, EBI-12006944;
CC Q6UY14-3; Q6UY14-3: ADAMTSL4; NbExp=3; IntAct=EBI-10173507, EBI-10173507;
CC Q6UY14-3; Q6ZMM2-2: ADAMTSL5; NbExp=3; IntAct=EBI-10173507, EBI-10254938;
CC Q6UY14-3; P31749: AKT1; NbExp=3; IntAct=EBI-10173507, EBI-296087;
CC Q6UY14-3; P05187: ALPP; NbExp=3; IntAct=EBI-10173507, EBI-1211484;
CC Q6UY14-3; Q9Y4X0: AMMECR1; NbExp=3; IntAct=EBI-10173507, EBI-8583355;
CC Q6UY14-3; Q9Y4X0-3: AMMECR1; NbExp=3; IntAct=EBI-10173507, EBI-12823597;
CC Q6UY14-3; B3KTP4: ApoL6; NbExp=3; IntAct=EBI-10173507, EBI-10175904;
CC Q6UY14-3; Q9BWW8: APOL6; NbExp=3; IntAct=EBI-10173507, EBI-11574440;
CC Q6UY14-3; Q9BZE9: ASPSCR1; NbExp=3; IntAct=EBI-10173507, EBI-1993677;
CC Q6UY14-3; Q7Z3C6-3: ATG9A; NbExp=3; IntAct=EBI-10173507, EBI-12006308;
CC Q6UY14-3; P54252: ATXN3; NbExp=3; IntAct=EBI-10173507, EBI-946046;
CC Q6UY14-3; O95429: BAG4; NbExp=3; IntAct=EBI-10173507, EBI-2949658;
CC Q6UY14-3; Q9H503-2: BANF2; NbExp=3; IntAct=EBI-10173507, EBI-11977289;
CC Q6UY14-3; P23560-2: BDNF; NbExp=3; IntAct=EBI-10173507, EBI-12275524;
CC Q6UY14-3; A0A087WZT3: BOLA2B; NbExp=3; IntAct=EBI-10173507, EBI-12006120;
CC Q6UY14-3; Q0VDD7-2: BRME1; NbExp=3; IntAct=EBI-10173507, EBI-12040255;
CC Q6UY14-3; P55212: CASP6; NbExp=3; IntAct=EBI-10173507, EBI-718729;
CC Q6UY14-3; Q8NEC5: CATSPER1; NbExp=3; IntAct=EBI-10173507, EBI-744545;
CC Q6UY14-3; Q13185: CBX3; NbExp=3; IntAct=EBI-10173507, EBI-78176;
CC Q6UY14-3; Q8TAB7: CCDC26; NbExp=3; IntAct=EBI-10173507, EBI-10271580;
CC Q6UY14-3; P06307: CCK; NbExp=3; IntAct=EBI-10173507, EBI-6624398;
CC Q6UY14-3; Q8IYR0: CFAP206; NbExp=6; IntAct=EBI-10173507, EBI-749051;
CC Q6UY14-3; Q9Y6H1: CHCHD2; NbExp=3; IntAct=EBI-10173507, EBI-2321769;
CC Q6UY14-3; Q8IWX8: CHERP; NbExp=3; IntAct=EBI-10173507, EBI-2555370;
CC Q6UY14-3; Q9UKJ5: CHIC2; NbExp=3; IntAct=EBI-10173507, EBI-741528;
CC Q6UY14-3; Q9H2X0: CHRD; NbExp=3; IntAct=EBI-10173507, EBI-947551;
CC Q6UY14-3; P43681: CHRNA4; NbExp=3; IntAct=EBI-10173507, EBI-7132379;
CC Q6UY14-3; P07510-2: CHRNG; NbExp=3; IntAct=EBI-10173507, EBI-11979451;
CC Q6UY14-3; A5D8T8: CLEC18A; NbExp=3; IntAct=EBI-10173507, EBI-10173491;
CC Q6UY14-3; Q9UBL6: CPNE7; NbExp=3; IntAct=EBI-10173507, EBI-744841;
CC Q6UY14-3; Q9UBL6-2: CPNE7; NbExp=3; IntAct=EBI-10173507, EBI-12012272;
CC Q6UY14-3; Q02930-3: CREB5; NbExp=6; IntAct=EBI-10173507, EBI-10192698;
CC Q6UY14-3; P02511: CRYAB; NbExp=3; IntAct=EBI-10173507, EBI-739060;
CC Q6UY14-3; P09228: CST2; NbExp=3; IntAct=EBI-10173507, EBI-8832659;
CC Q6UY14-3; Q96SQ9: CYP2S1; NbExp=3; IntAct=EBI-10173507, EBI-8633740;
CC Q6UY14-3; A8MQ03: CYSRT1; NbExp=3; IntAct=EBI-10173507, EBI-3867333;
CC Q6UY14-3; Q9BY27: DGCR6L; NbExp=3; IntAct=EBI-10173507, EBI-742953;
CC Q6UY14-3; Q14689-6: DIP2A; NbExp=3; IntAct=EBI-10173507, EBI-10233719;
CC Q6UY14-3; G5E9A7: DMWD; NbExp=3; IntAct=EBI-10173507, EBI-10976677;
CC Q6UY14-3; Q96T75: DSCR8; NbExp=3; IntAct=EBI-10173507, EBI-10294182;
CC Q6UY14-3; O95967: EFEMP2; NbExp=3; IntAct=EBI-10173507, EBI-743414;
CC Q6UY14-3; O60573: EIF4E2; NbExp=3; IntAct=EBI-10173507, EBI-398610;
CC Q6UY14-3; Q9UM22: EPDR1; NbExp=3; IntAct=EBI-10173507, EBI-946972;
CC Q6UY14-3; P19447: ERCC3; NbExp=3; IntAct=EBI-10173507, EBI-1183307;
CC Q6UY14-3; Q9NQT4: EXOSC5; NbExp=3; IntAct=EBI-10173507, EBI-371876;
CC Q6UY14-3; P16930: FAH; NbExp=3; IntAct=EBI-10173507, EBI-4397076;
CC Q6UY14-3; Q9H5Z6: FAM124B; NbExp=3; IntAct=EBI-10173507, EBI-741626;
CC Q6UY14-3; O95363: FARS2; NbExp=3; IntAct=EBI-10173507, EBI-2513774;
CC Q6UY14-3; Q96EF6: FBXO17; NbExp=3; IntAct=EBI-10173507, EBI-2510157;
CC Q6UY14-3; Q969U6: FBXW5; NbExp=6; IntAct=EBI-10173507, EBI-741068;
CC Q6UY14-3; P22607: FGFR3; NbExp=3; IntAct=EBI-10173507, EBI-348399;
CC Q6UY14-3; P68106: FKBP1B; NbExp=3; IntAct=EBI-10173507, EBI-6693977;
CC Q6UY14-3; P21333-2: FLNA; NbExp=6; IntAct=EBI-10173507, EBI-9641086;
CC Q6UY14-3; P01100: FOS; NbExp=3; IntAct=EBI-10173507, EBI-852851;
CC Q6UY14-3; O43559: FRS3; NbExp=3; IntAct=EBI-10173507, EBI-725515;
CC Q6UY14-3; P04406: GAPDH; NbExp=3; IntAct=EBI-10173507, EBI-354056;
CC Q6UY14-3; P23769: GATA2; NbExp=3; IntAct=EBI-10173507, EBI-2806671;
CC Q6UY14-3; P50440: GATM; NbExp=3; IntAct=EBI-10173507, EBI-2552594;
CC Q6UY14-3; P09681: GIP; NbExp=3; IntAct=EBI-10173507, EBI-8588553;
CC Q6UY14-3; Q8IVS8: GLYCTK; NbExp=3; IntAct=EBI-10173507, EBI-748515;
CC Q6UY14-3; Q8NEA9: GMCL2; NbExp=3; IntAct=EBI-10173507, EBI-745707;
CC Q6UY14-3; Q9Y223: GNE; NbExp=3; IntAct=EBI-10173507, EBI-4291090;
CC Q6UY14-3; Q9Y223-2: GNE; NbExp=3; IntAct=EBI-10173507, EBI-11975289;
CC Q6UY14-3; Q9P2W3: GNG13; NbExp=3; IntAct=EBI-10173507, EBI-11427343;
CC Q6UY14-3; Q0D2H9: GOLGA8DP; NbExp=3; IntAct=EBI-10173507, EBI-10181276;
CC Q6UY14-3; P62993: GRB2; NbExp=3; IntAct=EBI-10173507, EBI-401755;
CC Q6UY14-3; Q14957: GRIN2C; NbExp=3; IntAct=EBI-10173507, EBI-8285963;
CC Q6UY14-3; P28799: GRN; NbExp=3; IntAct=EBI-10173507, EBI-747754;
CC Q6UY14-3; P06396: GSN; NbExp=3; IntAct=EBI-10173507, EBI-351506;
CC Q6UY14-3; P09211: GSTP1; NbExp=3; IntAct=EBI-10173507, EBI-353467;
CC Q6UY14-3; Q96NT3-2: GUCD1; NbExp=3; IntAct=EBI-10173507, EBI-11978177;
CC Q6UY14-3; A0A024R8L2: hCG_1987119; NbExp=3; IntAct=EBI-10173507, EBI-14103818;
CC Q6UY14-3; V9HW60: HEL-S-182mP; NbExp=3; IntAct=EBI-10173507, EBI-10180762;
CC Q6UY14-3; Q96MH2: HEXIM2; NbExp=3; IntAct=EBI-10173507, EBI-5460660;
CC Q6UY14-3; P14210: HGF; NbExp=3; IntAct=EBI-10173507, EBI-1039104;
CC Q6UY14-3; P49639: HOXA1; NbExp=10; IntAct=EBI-10173507, EBI-740785;
CC Q6UY14-3; P31273: HOXC8; NbExp=3; IntAct=EBI-10173507, EBI-1752118;
CC Q6UY14-3; Q9H2F3: HSD3B7; NbExp=3; IntAct=EBI-10173507, EBI-3918847;
CC Q6UY14-3; P07900: HSP90AA1; NbExp=3; IntAct=EBI-10173507, EBI-296047;
CC Q6UY14-3; P04792: HSPB1; NbExp=3; IntAct=EBI-10173507, EBI-352682;
CC Q6UY14-3; P01308: INS; NbExp=3; IntAct=EBI-10173507, EBI-7090529;
CC Q6UY14-3; Q92551: IP6K1; NbExp=3; IntAct=EBI-10173507, EBI-751911;
CC Q6UY14-3; P05107: ITGB2; NbExp=3; IntAct=EBI-10173507, EBI-300173;
CC Q6UY14-3; P16144-2: ITGB4; NbExp=3; IntAct=EBI-10173507, EBI-11051601;
CC Q6UY14-3; Q15040: JOSD1; NbExp=3; IntAct=EBI-10173507, EBI-2510602;
CC Q6UY14-3; Q96MP8-2: KCTD7; NbExp=3; IntAct=EBI-10173507, EBI-11954971;
CC Q6UY14-3; Q7L273: KCTD9; NbExp=3; IntAct=EBI-10173507, EBI-4397613;
CC Q6UY14-3; O60333-2: KIF1B; NbExp=3; IntAct=EBI-10173507, EBI-10975473;
CC Q6UY14-3; Q2WGJ6: KLHL38; NbExp=3; IntAct=EBI-10173507, EBI-6426443;
CC Q6UY14-3; Q07627: KRTAP1-1; NbExp=3; IntAct=EBI-10173507, EBI-11959885;
CC Q6UY14-3; Q9BYS1: KRTAP1-5; NbExp=3; IntAct=EBI-10173507, EBI-11741292;
CC Q6UY14-3; P60412: KRTAP10-11; NbExp=3; IntAct=EBI-10173507, EBI-10217483;
CC Q6UY14-3; P60370: KRTAP10-5; NbExp=6; IntAct=EBI-10173507, EBI-10172150;
CC Q6UY14-3; P60410: KRTAP10-8; NbExp=6; IntAct=EBI-10173507, EBI-10171774;
CC Q6UY14-3; P60411: KRTAP10-9; NbExp=8; IntAct=EBI-10173507, EBI-10172052;
CC Q6UY14-3; P60328: KRTAP12-3; NbExp=3; IntAct=EBI-10173507, EBI-11953334;
CC Q6UY14-3; Q3LHN2: KRTAP19-2; NbExp=3; IntAct=EBI-10173507, EBI-12196745;
CC Q6UY14-3; Q3LI59: KRTAP21-2; NbExp=3; IntAct=EBI-10173507, EBI-18395721;
CC Q6UY14-3; Q9BYQ6: KRTAP4-11; NbExp=6; IntAct=EBI-10173507, EBI-10302392;
CC Q6UY14-3; Q9BQ66: KRTAP4-12; NbExp=3; IntAct=EBI-10173507, EBI-739863;
CC Q6UY14-3; Q9BYR5: KRTAP4-2; NbExp=6; IntAct=EBI-10173507, EBI-10172511;
CC Q6UY14-3; Q9BYR3: KRTAP4-4; NbExp=3; IntAct=EBI-10173507, EBI-11958132;
CC Q6UY14-3; Q701N4: KRTAP5-2; NbExp=3; IntAct=EBI-10173507, EBI-11958178;
CC Q6UY14-3; Q6L8H2: KRTAP5-3; NbExp=3; IntAct=EBI-10173507, EBI-11974251;
CC Q6UY14-3; Q6L8H1: KRTAP5-4; NbExp=3; IntAct=EBI-10173507, EBI-11963072;
CC Q6UY14-3; Q6L8G9: KRTAP5-6; NbExp=3; IntAct=EBI-10173507, EBI-10250562;
CC Q6UY14-3; Q6L8G8: KRTAP5-7; NbExp=3; IntAct=EBI-10173507, EBI-11987425;
CC Q6UY14-3; P26371: KRTAP5-9; NbExp=8; IntAct=EBI-10173507, EBI-3958099;
CC Q6UY14-3; Q3LI66: KRTAP6-2; NbExp=3; IntAct=EBI-10173507, EBI-11962084;
CC Q6UY14-3; Q9BYQ4: KRTAP9-2; NbExp=6; IntAct=EBI-10173507, EBI-1044640;
CC Q6UY14-3; Q9BYQ3: KRTAP9-3; NbExp=3; IntAct=EBI-10173507, EBI-1043191;
CC Q6UY14-3; Q9BYQ2: KRTAP9-4; NbExp=3; IntAct=EBI-10173507, EBI-10185730;
CC Q6UY14-3; P13473-2: LAMP2; NbExp=3; IntAct=EBI-10173507, EBI-21591415;
CC Q6UY14-3; Q5T7P2: LCE1A; NbExp=3; IntAct=EBI-10173507, EBI-11962058;
CC Q6UY14-3; Q5T7P3: LCE1B; NbExp=6; IntAct=EBI-10173507, EBI-10245913;
CC Q6UY14-3; Q5T751: LCE1C; NbExp=3; IntAct=EBI-10173507, EBI-12224199;
CC Q6UY14-3; Q5T754: LCE1F; NbExp=3; IntAct=EBI-10173507, EBI-11958008;
CC Q6UY14-3; Q5TA79: LCE2A; NbExp=3; IntAct=EBI-10173507, EBI-10246607;
CC Q6UY14-3; O14633: LCE2B; NbExp=6; IntAct=EBI-10173507, EBI-11478468;
CC Q6UY14-3; Q5TA81: LCE2C; NbExp=3; IntAct=EBI-10173507, EBI-11973993;
CC Q6UY14-3; Q5TA82: LCE2D; NbExp=6; IntAct=EBI-10173507, EBI-10246750;
CC Q6UY14-3; Q5TA76: LCE3A; NbExp=3; IntAct=EBI-10173507, EBI-9394625;
CC Q6UY14-3; Q5T5A8: LCE3C; NbExp=6; IntAct=EBI-10173507, EBI-10245291;
CC Q6UY14-3; Q9BYE3: LCE3D; NbExp=3; IntAct=EBI-10173507, EBI-6658837;
CC Q6UY14-3; Q5T5B0: LCE3E; NbExp=6; IntAct=EBI-10173507, EBI-10245456;
CC Q6UY14-3; Q5TA78: LCE4A; NbExp=6; IntAct=EBI-10173507, EBI-10246358;
CC Q6UY14-3; Q8TCE9: LGALS14; NbExp=3; IntAct=EBI-10173507, EBI-10274069;
CC Q6UY14-3; A0A0S2Z5S9: LHX4; NbExp=3; IntAct=EBI-10173507, EBI-16429099;
CC Q6UY14-3; P25800: LMO1; NbExp=3; IntAct=EBI-10173507, EBI-8639312;
CC Q6UY14-3; P25791: LMO2; NbExp=3; IntAct=EBI-10173507, EBI-739696;
CC Q6UY14-3; P25791-3: LMO2; NbExp=3; IntAct=EBI-10173507, EBI-11959475;
CC Q6UY14-3; P61968: LMO4; NbExp=3; IntAct=EBI-10173507, EBI-2798728;
CC Q6UY14-3; Q8TBB1: LNX1; NbExp=3; IntAct=EBI-10173507, EBI-739832;
CC Q6UY14-3; Q17RB8: LONRF1; NbExp=6; IntAct=EBI-10173507, EBI-2341787;
CC Q6UY14-3; Q6PJG9: LRFN4; NbExp=3; IntAct=EBI-10173507, EBI-7910762;
CC Q6UY14-3; Q8WV35: LRRC29; NbExp=3; IntAct=EBI-10173507, EBI-10276755;
CC Q6UY14-3; Q96A72: MAGOHB; NbExp=3; IntAct=EBI-10173507, EBI-746778;
CC Q6UY14-3; O60336: MAPKBP1; NbExp=6; IntAct=EBI-10173507, EBI-947402;
CC Q6UY14-3; Q9UJV3-2: MID2; NbExp=6; IntAct=EBI-10173507, EBI-10172526;
CC Q6UY14-3; Q13064: MKRN3; NbExp=3; IntAct=EBI-10173507, EBI-2340269;
CC Q6UY14-3; Q6PF18: MORN3; NbExp=3; IntAct=EBI-10173507, EBI-9675802;
CC Q6UY14-3; Q8WY64: MYLIP; NbExp=3; IntAct=EBI-10173507, EBI-6952711;
CC Q6UY14-3; Q8N6N6: NATD1; NbExp=6; IntAct=EBI-10173507, EBI-8656665;
CC Q6UY14-3; Q86SG6: NEK8; NbExp=3; IntAct=EBI-10173507, EBI-1752987;
CC Q6UY14-3; Q8NI38: NFKBID; NbExp=3; IntAct=EBI-10173507, EBI-10271199;
CC Q6UY14-3; Q9GZQ4: NMUR2; NbExp=3; IntAct=EBI-10173507, EBI-10303844;
CC Q6UY14-3; P0DPK4: NOTCH2NLC; NbExp=3; IntAct=EBI-10173507, EBI-22310682;
CC Q6UY14-3; Q92570: NR4A3; NbExp=3; IntAct=EBI-10173507, EBI-13644623;
CC Q6UY14-3; Q96HA8: NTAQ1; NbExp=3; IntAct=EBI-10173507, EBI-741158;
CC Q6UY14-3; P34130: NTF4; NbExp=3; IntAct=EBI-10173507, EBI-3907456;
CC Q6UY14-3; Q7Z417: NUFIP2; NbExp=3; IntAct=EBI-10173507, EBI-1210753;
CC Q6UY14-3; Q96PB7: OLFM3; NbExp=3; IntAct=EBI-10173507, EBI-10292253;
CC Q6UY14-3; P32242: OTX1; NbExp=3; IntAct=EBI-10173507, EBI-740446;
CC Q6UY14-3; Q92824-2: PCSK5; NbExp=3; IntAct=EBI-10173507, EBI-11956269;
CC Q6UY14-3; Q7Z2X4: PID1; NbExp=3; IntAct=EBI-10173507, EBI-10256685;
CC Q6UY14-3; Q13526: PIN1; NbExp=3; IntAct=EBI-10173507, EBI-714158;
CC Q6UY14-3; Q16512: PKN1; NbExp=3; IntAct=EBI-10173507, EBI-602382;
CC Q6UY14-3; Q9NRQ2: PLSCR4; NbExp=3; IntAct=EBI-10173507, EBI-769257;
CC Q6UY14-3; D3DTS7: PMP22; NbExp=3; IntAct=EBI-10173507, EBI-25882629;
CC Q6UY14-3; P28340: POLD1; NbExp=3; IntAct=EBI-10173507, EBI-716569;
CC Q6UY14-3; O15160: POLR1C; NbExp=3; IntAct=EBI-10173507, EBI-1055079;
CC Q6UY14-3; Q12837: POU4F2; NbExp=3; IntAct=EBI-10173507, EBI-17236143;
CC Q6UY14-3; O43741: PRKAB2; NbExp=4; IntAct=EBI-10173507, EBI-1053424;
CC Q6UY14-3; A6NJB7-2: PRR19; NbExp=3; IntAct=EBI-10173507, EBI-11998870;
CC Q6UY14-3; P43115-12: PTGER3; NbExp=3; IntAct=EBI-10173507, EBI-10234038;
CC Q6UY14-3; Q8WUK0: PTPMT1; NbExp=3; IntAct=EBI-10173507, EBI-7199479;
CC Q6UY14-3; Q15274: QPRT; NbExp=3; IntAct=EBI-10173507, EBI-739851;
CC Q6UY14-3; Q9Y2K5: R3HDM2; NbExp=3; IntAct=EBI-10173507, EBI-948428;
CC Q6UY14-3; Q8WUD1: RAB2B; NbExp=3; IntAct=EBI-10173507, EBI-5542466;
CC Q6UY14-3; P62826: RAN; NbExp=3; IntAct=EBI-10173507, EBI-286642;
CC Q6UY14-3; Q96PM5: RCHY1; NbExp=3; IntAct=EBI-10173507, EBI-947779;
CC Q6UY14-3; O15211: RGL2; NbExp=3; IntAct=EBI-10173507, EBI-712355;
CC Q6UY14-3; Q9H4E5: RHOJ; NbExp=3; IntAct=EBI-10173507, EBI-6285694;
CC Q6UY14-3; Q9Y3C5: RNF11; NbExp=3; IntAct=EBI-10173507, EBI-396669;
CC Q6UY14-3; Q86WX3: RPS19BP1; NbExp=3; IntAct=EBI-10173507, EBI-4479407;
CC Q6UY14-3; Q06455-2: RUNX1T1; NbExp=3; IntAct=EBI-10173507, EBI-11984663;
CC Q6UY14-3; Q9BWG6: SCNM1; NbExp=3; IntAct=EBI-10173507, EBI-748391;
CC Q6UY14-3; Q9NUL5: SHFL; NbExp=3; IntAct=EBI-10173507, EBI-10313866;
CC Q6UY14-3; Q9NUL5-4: SHFL; NbExp=3; IntAct=EBI-10173507, EBI-11955083;
CC Q6UY14-3; Q86YT5: SLC13A5; NbExp=3; IntAct=EBI-10173507, EBI-12002412;
CC Q6UY14-3; Q9UHI7: SLC23A1; NbExp=3; IntAct=EBI-10173507, EBI-1759386;
CC Q6UY14-3; Q9NP91: SLC6A20; NbExp=3; IntAct=EBI-10173507, EBI-10311198;
CC Q6UY14-3; O75093: SLIT1; NbExp=3; IntAct=EBI-10173507, EBI-947791;
CC Q6UY14-3; Q92922: SMARCC1; NbExp=6; IntAct=EBI-10173507, EBI-355653;
CC Q6UY14-3; Q6RVD6: SPATA8; NbExp=3; IntAct=EBI-10173507, EBI-8635958;
CC Q6UY14-3; P20155: SPINK2; NbExp=3; IntAct=EBI-10173507, EBI-10200479;
CC Q6UY14-3; Q7Z699: SPRED1; NbExp=3; IntAct=EBI-10173507, EBI-5235340;
CC Q6UY14-3; O43609: SPRY1; NbExp=3; IntAct=EBI-10173507, EBI-3866665;
CC Q6UY14-3; O75716: STK16; NbExp=3; IntAct=EBI-10173507, EBI-749295;
CC Q6UY14-3; Q92537: SUSD6; NbExp=3; IntAct=EBI-10173507, EBI-2866213;
CC Q6UY14-3; Q15560: TCEA2; NbExp=3; IntAct=EBI-10173507, EBI-710310;
CC Q6UY14-3; Q7Z6R9: TFAP2D; NbExp=3; IntAct=EBI-10173507, EBI-11952651;
CC Q6UY14-3; P01137: TGFB1; NbExp=3; IntAct=EBI-10173507, EBI-779636;
CC Q6UY14-3; Q8TBB0: THAP6; NbExp=3; IntAct=EBI-10173507, EBI-3925505;
CC Q6UY14-3; Q86TG1: TMEM150A; NbExp=3; IntAct=EBI-10173507, EBI-2799342;
CC Q6UY14-3; O95985: TOP3B; NbExp=3; IntAct=EBI-10173507, EBI-373403;
CC Q6UY14-3; Q8IWZ5: TRIM42; NbExp=3; IntAct=EBI-10173507, EBI-5235829;
CC Q6UY14-3; Q15654: TRIP6; NbExp=3; IntAct=EBI-10173507, EBI-742327;
CC Q6UY14-3; Q96PN8: TSSK3; NbExp=3; IntAct=EBI-10173507, EBI-3918381;
CC Q6UY14-3; Q9UK80: USP21; NbExp=3; IntAct=EBI-10173507, EBI-373242;
CC Q6UY14-3; Q6EMK4: VASN; NbExp=3; IntAct=EBI-10173507, EBI-10249550;
CC Q6UY14-3; O95231: VENTX; NbExp=3; IntAct=EBI-10173507, EBI-10191303;
CC Q6UY14-3; Q2TAL6: VWC2; NbExp=6; IntAct=EBI-10173507, EBI-11957238;
CC Q6UY14-3; O76024: WFS1; NbExp=3; IntAct=EBI-10173507, EBI-720609;
CC Q6UY14-3; A2RRC6: ZFHX2; NbExp=3; IntAct=EBI-10173507, EBI-11994144;
CC Q6UY14-3; Q9Y3S2: ZNF330; NbExp=3; IntAct=EBI-10173507, EBI-373456;
CC Q6UY14-3; Q96IQ9: ZNF414; NbExp=3; IntAct=EBI-10173507, EBI-744257;
CC Q6UY14-3; Q8TAU3: ZNF417; NbExp=6; IntAct=EBI-10173507, EBI-740727;
CC Q6UY14-3; Q96SQ5: ZNF587; NbExp=3; IntAct=EBI-10173507, EBI-6427977;
CC Q6UY14-3; Q53FW8; NbExp=3; IntAct=EBI-10173507, EBI-10242473;
CC -!- SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular
CC matrix {ECO:0000269|PubMed:21989719}. Note=Colocalizes with FMN1
CC microfibrils in the eye ECM.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=3;
CC Name=1 {ECO:0000269|PubMed:12706885};
CC IsoId=Q6UY14-1; Sequence=Displayed;
CC Name=2 {ECO:0000269|PubMed:12975309};
CC IsoId=Q6UY14-2; Sequence=VSP_052183, VSP_052184;
CC Name=3;
CC IsoId=Q6UY14-3; Sequence=VSP_055759;
CC -!- TISSUE SPECIFICITY: Expressed in colon, heart, leukocyte, liver, lung,
CC skeletal muscle, spleen, testis and placenta. Weaker expression in bone
CC marrow, brain tissue, kidney and pancreas. Expression studies in fetal
CC tissues reveal strong expression in heart, kidney, liver, lung and
CC skeletal muscle, but weaker expression in fetal brain and skin.
CC {ECO:0000269|PubMed:19200529}.
CC -!- PTM: N-glycosylated. Can be O-fucosylated by POFUT2 on a serine or a
CC threonine residue found within the consensus sequence C1-X(2)-(S/T)-C2-
CC G of the TSP type-1 repeat domains where C1 and C2 are the first and
CC second cysteine residue of the repeat, respectively. Fucosylated
CC repeats can then be further glycosylated by the addition of a beta-1,3-
CC glucose residue by the glucosyltransferase, B3GALTL. Fucosylation
CC mediates the efficient secretion of ADAMTS family members. Can also be
CC C-glycosylated with one or two mannose molecules on tryptophan residues
CC within the consensus sequence W-X-X-W of the TPRs. N- and C-
CC glycosylations can also facilitate secretion (By similarity).
CC {ECO:0000250}.
CC -!- DISEASE: Ectopia lentis 2, isolated, autosomal recessive (ECTOL2)
CC [MIM:225100]: An ocular abnormality characterized by partial or
CC complete displacement of the lens from its space resulting from
CC defective zonule formation. {ECO:0000269|PubMed:19200529}. Note=The
CC disease is caused by variants affecting the gene represented in this
CC entry.
CC -!- DISEASE: Ectopia lentis et pupillae (ECTOLP) [MIM:225200]: An ocular
CC abnormality characterized by displacement of the lenses and the pupils,
CC associated with other ocular anomalies, but without systemic
CC manifestations. The condition is usually bilateral, with the lenses and
CC pupils displaced in opposite directions. Additional signs include
CC enlarged corneal diameter, increased corneal astigmatism, increased
CC anterior chamber depth, thinning and flattening of the iris with loss
CC of crypts, angle malformation caused by enlarged iris processes,
CC persistent pupillary membrane, loss of zonular fibers, tilted disk, and
CC increased axial length. Secondary manifestations include refractive
CC errors, glaucoma, early cataract development, and retinal detachment.
CC Membrane formation on the posterior aspect of the iris has been
CC observed both in histologic sections and on ultrasound biomicroscopy.
CC {ECO:0000269|PubMed:20702823}. Note=The disease is caused by variants
CC affecting the gene represented in this entry.
CC -!- CAUTION: Although similar to members of the ADAMTS family, it lacks the
CC metalloprotease and disintegrin-like domains which are typical of that
CC family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAG17217.1; Type=Frameshift; Evidence={ECO:0000305};
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DR EMBL; AY358122; AAQ88489.1; -; mRNA.
DR EMBL; AL356356; CAI15499.1; -; Genomic_DNA.
DR EMBL; AL356356; CAI15500.2; -; Genomic_DNA.
DR EMBL; BC027478; AAH27478.2; -; mRNA.
DR EMBL; BC071852; AAH71852.1; -; mRNA.
DR EMBL; BC094811; AAH94811.1; -; mRNA.
DR EMBL; BC140800; AAI40801.1; -; mRNA.
DR EMBL; AF217974; AAG17217.1; ALT_FRAME; mRNA.
DR CCDS; CCDS30852.1; -. [Q6UY14-2]
DR CCDS; CCDS72908.1; -. [Q6UY14-3]
DR CCDS; CCDS955.1; -. [Q6UY14-1]
DR RefSeq; NP_001275536.1; NM_001288607.1.
DR RefSeq; NP_001275537.1; NM_001288608.1. [Q6UY14-3]
DR RefSeq; NP_061905.2; NM_019032.5. [Q6UY14-1]
DR RefSeq; NP_079284.2; NM_025008.4. [Q6UY14-2]
DR RefSeq; XP_011507950.1; XM_011509648.2. [Q6UY14-3]
DR RefSeq; XP_016856995.1; XM_017001506.1. [Q6UY14-3]
DR AlphaFoldDB; Q6UY14; -.
DR SMR; Q6UY14; -.
DR BioGRID; 120002; 216.
DR IntAct; Q6UY14; 236.
DR MINT; Q6UY14; -.
DR STRING; 9606.ENSP00000358035; -.
DR GlyConnect; 991; 2 N-Linked glycans (1 site).
DR GlyGen; Q6UY14; 14 sites, 2 N-linked glycans (1 site), 3 O-linked glycans (11 sites).
DR iPTMnet; Q6UY14; -.
DR PhosphoSitePlus; Q6UY14; -.
DR BioMuta; ADAMTSL4; -.
DR DMDM; 118573317; -.
DR EPD; Q6UY14; -.
DR MassIVE; Q6UY14; -.
DR PaxDb; Q6UY14; -.
DR PeptideAtlas; Q6UY14; -.
DR PRIDE; Q6UY14; -.
DR ProteomicsDB; 30475; -.
DR ProteomicsDB; 67693; -. [Q6UY14-1]
DR ProteomicsDB; 67694; -. [Q6UY14-2]
DR Antibodypedia; 1665; 98 antibodies from 20 providers.
DR DNASU; 54507; -.
DR Ensembl; ENST00000271643.9; ENSP00000271643.4; ENSG00000143382.16. [Q6UY14-1]
DR Ensembl; ENST00000369038.6; ENSP00000358034.2; ENSG00000143382.16. [Q6UY14-1]
DR Ensembl; ENST00000369039.9; ENSP00000358035.5; ENSG00000143382.16. [Q6UY14-3]
DR Ensembl; ENST00000369041.9; ENSP00000358037.5; ENSG00000143382.16. [Q6UY14-2]
DR Ensembl; ENST00000674043.1; ENSP00000501295.1; ENSG00000143382.16. [Q6UY14-3]
DR GeneID; 54507; -.
DR KEGG; hsa:54507; -.
DR MANE-Select; ENST00000271643.9; ENSP00000271643.4; NM_019032.6; NP_061905.2.
DR UCSC; uc001euw.5; human. [Q6UY14-1]
DR CTD; 54507; -.
DR DisGeNET; 54507; -.
DR GeneCards; ADAMTSL4; -.
DR GeneReviews; ADAMTSL4; -.
DR HGNC; HGNC:19706; ADAMTSL4.
DR HPA; ENSG00000143382; Low tissue specificity.
DR MalaCards; ADAMTSL4; -.
DR MIM; 225100; phenotype.
DR MIM; 225200; phenotype.
DR MIM; 610113; gene.
DR neXtProt; NX_Q6UY14; -.
DR OpenTargets; ENSG00000143382; -.
DR Orphanet; 1885; Isolated ectopia lentis.
DR PharmGKB; PA134879921; -.
DR VEuPathDB; HostDB:ENSG00000143382; -.
DR eggNOG; KOG3538; Eukaryota.
DR eggNOG; KOG4597; Eukaryota.
DR GeneTree; ENSGT00940000161136; -.
DR HOGENOM; CLU_000660_6_0_1; -.
DR InParanoid; Q6UY14; -.
DR OMA; SCTHVLE; -.
DR OrthoDB; 414258at2759; -.
DR PhylomeDB; Q6UY14; -.
DR TreeFam; TF316874; -.
DR PathwayCommons; Q6UY14; -.
DR Reactome; R-HSA-5083635; Defective B3GALTL causes PpS.
DR Reactome; R-HSA-5173214; O-glycosylation of TSR domain-containing proteins.
DR SignaLink; Q6UY14; -.
DR BioGRID-ORCS; 54507; 52 hits in 1078 CRISPR screens.
DR ChiTaRS; ADAMTSL4; human.
DR GeneWiki; ADAMTSL4; -.
DR GenomeRNAi; 54507; -.
DR Pharos; Q6UY14; Tbio.
DR PRO; PR:Q6UY14; -.
DR Proteomes; UP000005640; Chromosome 1.
DR RNAct; Q6UY14; protein.
DR Bgee; ENSG00000143382; Expressed in decidua and 136 other tissues.
DR ExpressionAtlas; Q6UY14; baseline and differential.
DR Genevisible; Q6UY14; HS.
DR GO; GO:0062023; C:collagen-containing extracellular matrix; HDA:BHF-UCL.
DR GO; GO:0005788; C:endoplasmic reticulum lumen; TAS:Reactome.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-KW.
DR GO; GO:0005614; C:interstitial matrix; IEA:Ensembl.
DR GO; GO:0042802; F:identical protein binding; IPI:IntAct.
DR GO; GO:0002020; F:protease binding; IPI:UniProtKB.
DR GO; GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.
DR GO; GO:0002064; P:epithelial cell development; IEA:Ensembl.
DR GO; GO:0030198; P:extracellular matrix organization; IEA:Ensembl.
DR GO; GO:0070285; P:pigment cell development; IEA:Ensembl.
DR GO; GO:0043065; P:positive regulation of apoptotic process; IDA:UniProtKB.
DR Gene3D; 2.20.100.10; -; 6.
DR InterPro; IPR045371; ADAMTS_CR_3.
DR InterPro; IPR010294; ADAMTS_spacer1.
DR InterPro; IPR010909; PLAC.
DR InterPro; IPR000884; TSP1_rpt.
DR InterPro; IPR036383; TSP1_rpt_sf.
DR Pfam; PF19236; ADAM_CR_3; 1.
DR Pfam; PF05986; ADAM_spacer1; 1.
DR Pfam; PF08686; PLAC; 1.
DR Pfam; PF00090; TSP_1; 1.
DR SMART; SM00209; TSP1; 6.
DR SUPFAM; SSF82895; SSF82895; 6.
DR PROSITE; PS50900; PLAC; 1.
DR PROSITE; PS50092; TSP1; 6.
PE 1: Evidence at protein level;
KW Alternative splicing; Apoptosis; Extracellular matrix; Glycoprotein;
KW Reference proteome; Repeat; Secreted; Signal.
FT SIGNAL 1..24
FT /evidence="ECO:0000255"
FT CHAIN 25..1074
FT /note="ADAMTS-like protein 4"
FT /evidence="ECO:0000255"
FT /id="PRO_0000257966"
FT DOMAIN 48..93
FT /note="TSP type-1 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00210"
FT DOMAIN 723..782
FT /note="TSP type-1 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00210"
FT DOMAIN 783..842
FT /note="TSP type-1 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00210"
FT DOMAIN 845..909
FT /note="TSP type-1 4"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00210"
FT DOMAIN 910..969
FT /note="TSP type-1 5"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00210"
FT DOMAIN 970..1026
FT /note="TSP type-1 6"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00210"
FT DOMAIN 1029..1066
FT /note="PLAC"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00233"
FT REGION 77..342
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 79..95
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 132..151
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 202..239
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CARBOHYD 490
FT /note="N-linked (GlcNAc...) (complex) asparagine"
FT /evidence="ECO:0000269|PubMed:16335952,
FT ECO:0000269|PubMed:19139490"
FT CARBOHYD 773
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT VAR_SEQ 411
FT /note="E -> EAPLLPLRHAFFLLPGAGSGDSTG (in isoform 3)"
FT /evidence="ECO:0000305"
FT /id="VSP_055759"
FT VAR_SEQ 854..877
FT /note="CSAECGTGIQRRSVVCLGSGAALG -> VSPEPPAISCILGNHAQDTSAFPA
FT (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:12975309,
FT ECO:0000303|PubMed:15489334"
FT /id="VSP_052183"
FT VAR_SEQ 878..1074
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:12975309,
FT ECO:0000303|PubMed:15489334"
FT /id="VSP_052184"
FT VARIANT 193
FT /note="A -> P (in dbSNP:rs41317515)"
FT /evidence="ECO:0000269|PubMed:15489334"
FT /id="VAR_061918"
FT VARIANT 1028
FT /note="R -> H (in dbSNP:rs56411234)"
FT /id="VAR_061919"
SQ SEQUENCE 1074 AA; 116545 MW; 79AE0E5DF5488CA1 CRC64;
MENWTGRPWL YLLLLLSLPQ LCLDQEVLSG HSLQTPTEEG QGPEGVWGPW VQWASCSQPC
GVGVQRRSRT CQLPTVQLHP SLPLPPRPPR HPEALLPRGQ GPRPQTSPET LPLYRTQSRG
RGGPLRGPAS HLGREETQEI RAARRSRLRD PIKPGMFGYG RVPFALPLHR NRRHPRSPPR
SELSLISSRG EEAIPSPTPR AEPFSANGSP QTELPPTELS VHTPSPQAEP LSPETAQTEV
APRTRPAPLR HHPRAQASGT EPPSPTHSLG EGGFFRASPQ PRRPSSQGWA SPQVAGRRPD
PFPSVPRGRG QQGQGPWGTG GTPHGPRLEP DPQHPGAWLP LLSNGPHASS LWSLFAPSSP
IPRCSGESEQ LRACSQAPCP PEQPDPRALQ CAAFNSQEFM GQLYQWEPFT EVQGSQRCEL
NCRPRGFRFY VRHTEKVQDG TLCQPGAPDI CVAGRCLSPG CDGILGSGRR PDGCGVCGGD
DSTCRLVSGN LTDRGGPLGY QKILWIPAGA LRLQIAQLRP SSNYLALRGP GGRSIINGNW
AVDPPGSYRA GGTVFRYNRP PREEGKGESL SAEGPTTQPV DVYMIFQEEN PGVFYQYVIS
SPPPILENPT PEPPVPQLQP EILRVEPPLA PAPRPARTPG TLQRQVRIPQ MPAPPHPRTP
LGSPAAYWKR VGHSACSASC GKGVWRPIFL CISRESGEEL DERSCAAGAR PPASPEPCHG
TPCPPYWEAG EWTSCSRSCG PGTQHRQLQC RQEFGGGGSS VPPERCGHLP RPNITQSCQL
RLCGHWEVGS PWSQCSVRCG RGQRSRQVRC VGNNGDEVSE QECASGPPQP PSREACDMGP
CTTAWFHSDW SSKCSAECGT GIQRRSVVCL GSGAALGPGQ GEAGAGTGQS CPTGSRPPDM
RACSLGPCER TWRWYTGPWG ECSSECGSGT QRRDIICVSK LGTEFNVTSP SNCSHLPRPP
ALQPCQGQAC QDRWFSTPWS PCSRSCQGGT QTREVQCLST NQTLSTRCPP QLRPSRKRPC
NSQPCSQRPD DQCKDSSPHC PLVVQARLCV YPYYTATCCR SCAHVLERSP QDPS
