ATL4_MOUSE
ID ATL4_MOUSE Reviewed; 1036 AA.
AC Q80T21; Q148X6;
DT 31-OCT-2006, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2003, sequence version 1.
DT 03-AUG-2022, entry version 128.
DE RecName: Full=ADAMTS-like protein 4;
DE Short=ADAMTSL-4;
DE AltName: Full=Thrombospondin repeat-containing protein 1;
DE Flags: Precursor;
GN Name=Adamtsl4 {ECO:0000312|MGI:MGI:2389008};
GN Synonyms=Tsrc1 {ECO:0000312|EMBL:AAO17738.1, ECO:0000312|MGI:MGI:2389008};
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1] {ECO:0000305, ECO:0000312|EMBL:AAO17738.1}
RP NUCLEOTIDE SEQUENCE [MRNA], AND TISSUE SPECIFICITY.
RC STRAIN=C57BL/6J {ECO:0000312|EMBL:AAO17738.1};
RX PubMed=12706885; DOI=10.1016/s0378-1119(03)00423-2;
RA Buchner D.A., Meisler M.H.;
RT "TSRC1, a widely expressed gene containing seven thrombospondin type I
RT repeats.";
RL Gene 307:23-30(2003).
RN [2] {ECO:0000312|EMBL:AAI17926.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: Positive regulation of apoptosis. May facilitate FBN1
CC microfibril biogenesis (By similarity). {ECO:0000250}.
CC -!- SUBUNIT: Interacts with CTSB. Interacts with FBN1 (By similarity).
CC {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular
CC matrix {ECO:0000250}. Note=Colocalizes with FMN1 microfibrils in the
CC eye ECM. {ECO:0000250}.
CC -!- TISSUE SPECIFICITY: Widely expressed in a range of tissues. Especially
CC prevalent in brain, spinal cord, muscle, lung and heart.
CC {ECO:0000269|PubMed:12706885}.
CC -!- PTM: Glycosylated (By similarity). Can be O-fucosylated by POFUT2 on a
CC serine or a threonine residue found within the consensus sequence C1-
CC X(2)-(S/T)-C2-G of the TSP type-1 repeat domains where C1 and C2 are
CC the first and second cysteine residue of the repeat, respectively.
CC Fucosylated repeats can then be further glycosylated by the addition of
CC a beta-1,3-glucose residue by the glucosyltransferase, B3GALTL.
CC Fucosylation mediates the efficient secretion of ADAMTS family members.
CC Can also be C-glycosylated with one or two mannose molecules on
CC tryptophan residues within the consensus sequence W-X-X-W of the TPRs,
CC and N-glycosylated. These other glycosylations can also facilitate
CC secretion (By similarity). {ECO:0000250}.
CC -!- CAUTION: Although similar to members of the ADAMTS family, it lacks the
CC metalloprotease and disintegrin-like domains which are typical of that
CC family. {ECO:0000305}.
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DR EMBL; AY158701; AAO17738.1; -; mRNA.
DR EMBL; BC117925; AAI17926.1; -; mRNA.
DR CCDS; CCDS17618.1; -.
DR RefSeq; NP_001288634.1; NM_001301705.1.
DR RefSeq; NP_659148.2; NM_144899.3.
DR AlphaFoldDB; Q80T21; -.
DR SMR; Q80T21; -.
DR BioGRID; 230868; 3.
DR STRING; 10090.ENSMUSP00000015994; -.
DR GlyGen; Q80T21; 2 sites.
DR iPTMnet; Q80T21; -.
DR PhosphoSitePlus; Q80T21; -.
DR CPTAC; non-CPTAC-3560; -.
DR MaxQB; Q80T21; -.
DR PaxDb; Q80T21; -.
DR PeptideAtlas; Q80T21; -.
DR PRIDE; Q80T21; -.
DR ProteomicsDB; 265150; -.
DR Antibodypedia; 1665; 98 antibodies from 20 providers.
DR DNASU; 229595; -.
DR Ensembl; ENSMUST00000015994; ENSMUSP00000015994; ENSMUSG00000015850.
DR Ensembl; ENSMUST00000117782; ENSMUSP00000113424; ENSMUSG00000015850.
DR GeneID; 229595; -.
DR KEGG; mmu:229595; -.
DR UCSC; uc008qkm.2; mouse.
DR CTD; 54507; -.
DR MGI; MGI:2389008; Adamtsl4.
DR VEuPathDB; HostDB:ENSMUSG00000015850; -.
DR eggNOG; KOG3538; Eukaryota.
DR eggNOG; KOG4597; Eukaryota.
DR GeneTree; ENSGT00940000161136; -.
DR HOGENOM; CLU_000660_6_0_1; -.
DR InParanoid; Q80T21; -.
DR OMA; SCTHVLE; -.
DR OrthoDB; 414258at2759; -.
DR PhylomeDB; Q80T21; -.
DR TreeFam; TF316874; -.
DR Reactome; R-MMU-5173214; O-glycosylation of TSR domain-containing proteins.
DR BioGRID-ORCS; 229595; 5 hits in 71 CRISPR screens.
DR ChiTaRS; Adamtsl4; mouse.
DR PRO; PR:Q80T21; -.
DR Proteomes; UP000000589; Chromosome 3.
DR RNAct; Q80T21; protein.
DR Bgee; ENSMUSG00000015850; Expressed in interventricular septum and 150 other tissues.
DR ExpressionAtlas; Q80T21; baseline and differential.
DR Genevisible; Q80T21; MM.
DR GO; GO:0031012; C:extracellular matrix; IDA:MGI.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-KW.
DR GO; GO:0005614; C:interstitial matrix; IDA:MGI.
DR GO; GO:0042802; F:identical protein binding; ISO:MGI.
DR GO; GO:0002020; F:protease binding; ISS:UniProtKB.
DR GO; GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.
DR GO; GO:0002064; P:epithelial cell development; IMP:MGI.
DR GO; GO:0030198; P:extracellular matrix organization; IDA:MGI.
DR GO; GO:0070285; P:pigment cell development; IMP:MGI.
DR GO; GO:0043065; P:positive regulation of apoptotic process; ISS:UniProtKB.
DR Gene3D; 2.20.100.10; -; 6.
DR InterPro; IPR045371; ADAMTS_CR_3.
DR InterPro; IPR010294; ADAMTS_spacer1.
DR InterPro; IPR010909; PLAC.
DR InterPro; IPR000884; TSP1_rpt.
DR InterPro; IPR036383; TSP1_rpt_sf.
DR Pfam; PF19236; ADAM_CR_3; 1.
DR Pfam; PF05986; ADAM_spacer1; 1.
DR Pfam; PF08686; PLAC; 1.
DR Pfam; PF00090; TSP_1; 1.
DR SMART; SM00209; TSP1; 7.
DR SUPFAM; SSF82895; SSF82895; 6.
DR PROSITE; PS50900; PLAC; 1.
DR PROSITE; PS50092; TSP1; 6.
PE 2: Evidence at transcript level;
KW Apoptosis; Extracellular matrix; Glycoprotein; Reference proteome; Repeat;
KW Secreted; Signal.
FT SIGNAL 1..24
FT /evidence="ECO:0000255"
FT CHAIN 25..1036
FT /note="ADAMTS-like protein 4"
FT /evidence="ECO:0000255"
FT /id="PRO_0000257967"
FT DOMAIN 47..91
FT /note="TSP type-1 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00210"
FT DOMAIN 687..748
FT /note="TSP type-1 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00210"
FT DOMAIN 750..804
FT /note="TSP type-1 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00210"
FT DOMAIN 805..871
FT /note="TSP type-1 4"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00210"
FT DOMAIN 872..931
FT /note="TSP type-1 5"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00210"
FT DOMAIN 932..988
FT /note="TSP type-1 6"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00210"
FT DOMAIN 991..1028
FT /note="PLAC"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00233"
FT REGION 73..149
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 163..308
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 174..194
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 211..251
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CARBOHYD 454
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 737
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CONFLICT 93
FT /note="G -> R (in Ref. 2; AAI17926)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 1036 AA; 113225 MW; F018D59E71018714 CRC64;
MESWLGRLWL CMMLLLPLPQ PCQDQELFGP SHQLPSEEGQ VPEGLWGPWG RWASCSQPCG
VGVQRRSRTC ELHPALPLPP RPPRHPEAHR PRGQGSRPQT PRDPQSLYRP QPRGRGGPLR
APASQVGREE TQEPQGAQRF RVRDPIKPGM FGYGRVPFAL PLHRSRRHPH RPGQPKNSST
GEGMVPSQPP STELASEKHG PHMQPPEPRS HSAETPRSGT AQTEVLPRTS SAPSYTGTPA
PTSSFGDSRS FQGSLGPRMP PSPGSWSSPQ GAERRHPPPF SPVPRSQQSR RHWRPPGPHR
SPDGWLPLTR DSSPLWSIFA PSIPAPNCSG ESEQMRACSQ EPCPPEQPDP RALQCAAFDS
QEFMGQLYQW EPFTEVQGSQ RCELNCRPRG FRFYVRHTEK VQDGTLCQPG SLDICVAGRC
LSPGCDGVLG SGRRPDGCGV CGGDGSTCRL VSGNLTDRGG PLGYQKILWI PAGASHLHIS
QLRPSSNYLA LRGPGGRSII NGNWAVDPPG SYTAIGTVFQ YNRPPREEGK GESLSAEGPT
TQPVDVYMIF QEDNPGVFYQ YVISSPPAVL ESPSTKPPAL QPQPEMLRGE PLLPSAPRPV
RAPGTLQRQV RIPQVPPPTR VRTAMGSSAG YWKQVGHSEC SASCGKGVWH PIFLCISRES
GEELDEQSCA VGARPPASPE PCHGPPCPPY WEAGEWTSCS RSCGPGTQHR QLLCRQEFGG
GGSSVPPERC GHLPRPNITQ PCQLHLCGHW EISSPWSQCS VRCGRGQRSR QVRCVGSNGD
EVDKQECASG PPPPPSREAC DMGPCTTAWF YSDWSSKCSA ECGTGIQRRA VVCLRSGETL
QGDPEAGSTE QGCPLRSRPP DMRACSLGPC ERTWRWFTGP WSECSSECGS GTQHRDIICV
SKLGAEFNVT SPSNCSHLPR PPALQPCQGQ ACEDKWFSTL WSPCSRSCQG GMQTREVQCL
SGNQTLSSRC PPHLRPSRKR PCNSQPCNQR PDDQCKDSSP HCPLVVQARL CVYPYYTTTC
CRSCAHVLEQ SQLEPA
