ID   AACS_XENTR              Reviewed;         672 AA.
AC   Q28BL6;
DT   15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT   04-APR-2006, sequence version 1.
DT   03-AUG-2022, entry version 67.
DE   RecName: Full=Acetoacetyl-CoA synthetase;
DE            EC=6.2.1.16;
GN   Name=aacs; ORFNames=TEgg036g05.1;
OS   Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX   NCBI_TaxID=8364;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Egg;
RG   Sanger Xenopus tropicalis EST/cDNA project;
RL   Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Activates acetoacetate to acetoacetyl-CoA. {ECO:0000250}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=acetoacetate + ATP + CoA = acetoacetyl-CoA + AMP +
CC         diphosphate; Xref=Rhea:RHEA:16117, ChEBI:CHEBI:13705,
CC         ChEBI:CHEBI:30616, ChEBI:CHEBI:33019, ChEBI:CHEBI:57286,
CC         ChEBI:CHEBI:57287, ChEBI:CHEBI:456215; EC=6.2.1.16;
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the ATP-dependent AMP-binding enzyme family.
CC       {ECO:0000305}.
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DR   EMBL; CR942772; CAJ81897.1; -; mRNA.
DR   RefSeq; NP_001039244.1; NM_001045779.1.
DR   AlphaFoldDB; Q28BL6; -.
DR   SMR; Q28BL6; -.
DR   STRING; 8364.ENSXETP00000060617; -.
DR   PaxDb; Q28BL6; -.
DR   PRIDE; Q28BL6; -.
DR   GeneID; 734109; -.
DR   KEGG; xtr:734109; -.
DR   CTD; 65985; -.
DR   Xenbase; XB-GENE-490085; aacs.
DR   eggNOG; KOG1175; Eukaryota.
DR   InParanoid; Q28BL6; -.
DR   OrthoDB; 899666at2759; -.
DR   Reactome; R-XTR-77111; Synthesis of Ketone Bodies.
DR   Proteomes; UP000008143; Chromosome 1.
DR   Proteomes; UP000790000; Unplaced.
DR   GO; GO:0005829; C:cytosol; IBA:GO_Central.
DR   GO; GO:0030729; F:acetoacetate-CoA ligase activity; IBA:GO_Central.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0006631; P:fatty acid metabolic process; IEA:UniProtKB-KW.
DR   GO; GO:0032024; P:positive regulation of insulin secretion; IBA:GO_Central.
DR   Gene3D; 3.30.300.30; -; 1.
DR   Gene3D; 3.40.50.12780; -; 1.
DR   InterPro; IPR005914; Acac_CoA_synth.
DR   InterPro; IPR032387; ACAS_N.
DR   InterPro; IPR045851; AMP-bd_C_sf.
DR   InterPro; IPR020845; AMP-binding_CS.
DR   InterPro; IPR000873; AMP-dep_Synth/Lig.
DR   InterPro; IPR042099; ANL_N_sf.
DR   Pfam; PF16177; ACAS_N; 1.
DR   Pfam; PF00501; AMP-binding; 1.
DR   TIGRFAMs; TIGR01217; ac_ac_CoA_syn; 1.
DR   PROSITE; PS00455; AMP_BINDING; 1.
PE   2: Evidence at transcript level;
KW   ATP-binding; Cytoplasm; Fatty acid metabolism; Ligase; Lipid metabolism;
KW   Nucleotide-binding; Reference proteome.
FT   CHAIN           1..672
FT                   /note="Acetoacetyl-CoA synthetase"
FT                   /id="PRO_0000315790"
SQ   SEQUENCE   672 AA;  75168 MW;  5C2A9077295F3D2A CRC64;
     MSDKGELMEE IMEAKVMWYP DSKKITQMDQ FRNRVNRNLG LRLANYNELY QWSVEFYPEF
     WAEFWDFSGI VYSKTYDEVI DRSKGIADVP EWFKGSRLNY AENLLKHKEN DKIALYSARE
     GKENIEKVTF AELRRDVALF AAAMRKMGIK TGDRVAGYLP NCIQTVEAML AAASIGAIWS
     ATSPDFGVNG VLDRFSQIQP KLILSVESVI YNGKEHCHLE KLQHVVKGLP DLKKVVVIPY
     VLPKEKIDIS KIPNSMFLDE FLATGKVGDQ SPQLEFEQLP FNHPLYIMYS SGTTGAPKCM
     VHSAGGTLIK HLTEHILHGS TTSSDVIMYY TTAGWMMWNW LITAVATGAS LVLYDGSPLV
     PSLNVLWDLV DRLGITILGT GAKWLAVLED KGLKPCNTHS LQTLHTILST GSPLKPQSYE
     YVYKHIKSNV LLGSVSGGTD IIACFMGQNV SVPVYKGEIQ ARHLGMAIEA WNEEGEAVLG
     ESGELVCLKP LPSQPTHFWN DENGSKYQKA YFAKFPGVWA HGDYCKINPK TGGIVMLGRS
     DGTLNPNGVR FGSSEIYNIV EAFVEVSDSL CVPQYNKDGD ERVILFLKMA DKFEFSKELL
     KRIKDAIRVA LSARHVPALI LETKDIPYTI SGKKVEVAVK QVIAGKEVPH RGAFSNPQSL
     DLYRNIPELQ NF