ID   PSD11_DICDI             Reviewed;         413 AA.
AC   Q54UB5;
DT   08-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT   24-MAY-2005, sequence version 1.
DT   03-AUG-2022, entry version 110.
DE   RecName: Full=26S proteasome non-ATPase regulatory subunit 11;
DE   AltName: Full=26S proteasome regulatory subunit RPN6;
DE   AltName: Full=26S proteasome regulatory subunit S9;
GN   Name=psmD11; ORFNames=DDB_G0281315;
OS   Dictyostelium discoideum (Slime mold).
OC   Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC   Dictyosteliaceae; Dictyostelium.
OX   NCBI_TaxID=44689;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AX4;
RX   PubMed=15875012; DOI=10.1038/nature03481;
RA   Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA   Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA   Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA   Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA   Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA   Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA   Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA   Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA   Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA   Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA   Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA   Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA   Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA   Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA   Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA   Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA   Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT   "The genome of the social amoeba Dictyostelium discoideum.";
RL   Nature 435:43-57(2005).
CC   -!- FUNCTION: Component of the lid subcomplex of the 26S proteasome, a
CC       multiprotein complex involved in the ATP-dependent degradation of
CC       ubiquitinated proteins. In the complex, psmD11 is required for
CC       proteasome assembly (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Component of the lid subcomplex of the 19S proteasome
CC       regulatory particle complex (also named PA700 complex). The 26S
CC       proteasome consists of a 20S proteasome core and two 19S regulatory
CC       subunits (By similarity). {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the proteasome subunit S9 family. {ECO:0000305}.
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DR   EMBL; AAFI02000040; EAL66954.1; -; Genomic_DNA.
DR   RefSeq; XP_640861.1; XM_635769.1.
DR   AlphaFoldDB; Q54UB5; -.
DR   SMR; Q54UB5; -.
DR   STRING; 44689.DDB0232994; -.
DR   PaxDb; Q54UB5; -.
DR   EnsemblProtists; EAL66954; EAL66954; DDB_G0281315.
DR   GeneID; 8622917; -.
DR   KEGG; ddi:DDB_G0281315; -.
DR   dictyBase; DDB_G0281315; psmD11.
DR   eggNOG; KOG1463; Eukaryota.
DR   HOGENOM; CLU_029573_2_1_1; -.
DR   InParanoid; Q54UB5; -.
DR   OMA; LYFDTGM; -.
DR   PhylomeDB; Q54UB5; -.
DR   Reactome; R-DDI-1236978; Cross-presentation of soluble exogenous antigens (endosomes).
DR   Reactome; R-DDI-174084; Autodegradation of Cdh1 by Cdh1:APC/C.
DR   Reactome; R-DDI-174113; SCF-beta-TrCP mediated degradation of Emi1.
DR   Reactome; R-DDI-174154; APC/C:Cdc20 mediated degradation of Securin.
DR   Reactome; R-DDI-174178; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1.
DR   Reactome; R-DDI-187577; SCF(Skp2)-mediated degradation of p27/p21.
DR   Reactome; R-DDI-2467813; Separation of Sister Chromatids.
DR   Reactome; R-DDI-349425; Autodegradation of the E3 ubiquitin ligase COP1.
DR   Reactome; R-DDI-450408; AUF1 (hnRNP D0) binds and destabilizes mRNA.
DR   Reactome; R-DDI-4641258; Degradation of DVL.
DR   Reactome; R-DDI-5632684; Hedgehog 'on' state.
DR   Reactome; R-DDI-5658442; Regulation of RAS by GAPs.
DR   Reactome; R-DDI-5687128; MAPK6/MAPK4 signaling.
DR   Reactome; R-DDI-5689603; UCH proteinases.
DR   Reactome; R-DDI-5689880; Ub-specific processing proteases.
DR   Reactome; R-DDI-6798695; Neutrophil degranulation.
DR   Reactome; R-DDI-68949; Orc1 removal from chromatin.
DR   Reactome; R-DDI-69017; CDK-mediated phosphorylation and removal of Cdc6.
DR   Reactome; R-DDI-69601; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A.
DR   Reactome; R-DDI-75815; Ubiquitin-dependent degradation of Cyclin D.
DR   Reactome; R-DDI-8854050; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis.
DR   Reactome; R-DDI-8948751; Regulation of PTEN stability and activity.
DR   Reactome; R-DDI-8951664; Neddylation.
DR   Reactome; R-DDI-9755511; KEAP1-NFE2L2 pathway.
DR   Reactome; R-DDI-9762114; GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2.
DR   Reactome; R-DDI-983168; Antigen processing: Ubiquitination & Proteasome degradation.
DR   PRO; PR:Q54UB5; -.
DR   Proteomes; UP000002195; Chromosome 3.
DR   GO; GO:0005838; C:proteasome regulatory particle; ISS:dictyBase.
DR   GO; GO:0008541; C:proteasome regulatory particle, lid subcomplex; IBA:GO_Central.
DR   GO; GO:0005198; F:structural molecule activity; IBA:GO_Central.
DR   GO; GO:0006972; P:hyperosmotic response; IEP:dictyBase.
DR   GO; GO:0006511; P:ubiquitin-dependent protein catabolic process; IBA:GO_Central.
DR   InterPro; IPR000717; PCI_dom.
DR   InterPro; IPR040780; Rpn6_C_helix.
DR   InterPro; IPR040773; Rpn6_N.
DR   InterPro; IPR011990; TPR-like_helical_dom_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   Pfam; PF01399; PCI; 1.
DR   Pfam; PF18503; RPN6_C_helix; 1.
DR   Pfam; PF18055; RPN6_N; 1.
DR   SMART; SM00088; PINT; 1.
DR   SUPFAM; SSF46785; SSF46785; 1.
DR   SUPFAM; SSF48452; SSF48452; 1.
DR   PROSITE; PS50250; PCI; 1.
PE   2: Evidence at transcript level;
KW   Proteasome; Reference proteome.
FT   CHAIN           1..413
FT                   /note="26S proteasome non-ATPase regulatory subunit 11"
FT                   /id="PRO_0000327459"
FT   DOMAIN          217..383
FT                   /note="PCI"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01185"
SQ   SEQUENCE   413 AA;  47618 MW;  95082D15D15A241F CRC64;
     MNWKEQLEEI GNCQDSNKAI QDYNKILTIQ ESPDDIKEEA ILRLAKLFVK IGKGDQLPTL
     LRSVRPFFDK ISKPKTDKIV RNFIDIFSTV PDNLTTLIEF VKENIQWCKD TNRIYLRQRL
     ETKLFTLMFE AKDYANALSG LTTLLTEIKR LDDKPLLVEI QLVESRIQHA LKNIPKARAA
     LTSARTNANT IYCPPKLQAE IDMQSGILHS EEKDYKTAFS YFFESYETYD SLEDPFAMKA
     LKYMLLCKIM TNQTDDVHAL VNGKIGLKYH NNRSIEAITQ ISKSHAKRSL HMFQEVTKEF
     SDQLSDDPII HSHLTELYSN LLEQNLCRII EPFSRVEISH IAKLIDLPVD VVERKLSLMI
     LDKKYNGILD QGTGTLIVFE EQKEDKLFNC SLETIGALSR VVDLLYEKTN KLS