ID   PSD11_XENTR             Reviewed;         422 AA.
AC   F6XBL2;
DT   31-OCT-2012, integrated into UniProtKB/Swiss-Prot.
DT   31-OCT-2012, sequence version 2.
DT   03-AUG-2022, entry version 54.
DE   RecName: Full=26S proteasome non-ATPase regulatory subunit 11;
DE   AltName: Full=26S proteasome regulatory subunit RPN6;
GN   Name=psmd11;
OS   Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX   NCBI_TaxID=8364;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=20431018; DOI=10.1126/science.1183670;
RA   Hellsten U., Harland R.M., Gilchrist M.J., Hendrix D., Jurka J.,
RA   Kapitonov V., Ovcharenko I., Putnam N.H., Shu S., Taher L., Blitz I.L.,
RA   Blumberg B., Dichmann D.S., Dubchak I., Amaya E., Detter J.C., Fletcher R.,
RA   Gerhard D.S., Goodstein D., Graves T., Grigoriev I.V., Grimwood J.,
RA   Kawashima T., Lindquist E., Lucas S.M., Mead P.E., Mitros T., Ogino H.,
RA   Ohta Y., Poliakov A.V., Pollet N., Robert J., Salamov A., Sater A.K.,
RA   Schmutz J., Terry A., Vize P.D., Warren W.C., Wells D., Wills A.,
RA   Wilson R.K., Zimmerman L.B., Zorn A.M., Grainger R., Grammer T.,
RA   Khokha M.K., Richardson P.M., Rokhsar D.S.;
RT   "The genome of the Western clawed frog Xenopus tropicalis.";
RL   Science 328:633-636(2010).
CC   -!- FUNCTION: Component of the 26S proteasome, a multiprotein complex
CC       involved in the ATP-dependent degradation of ubiquitinated proteins.
CC       This complex plays a key role in the maintenance of protein homeostasis
CC       by removing misfolded or damaged proteins, which could impair cellular
CC       functions, and by removing proteins whose functions are no longer
CC       required. Therefore, the proteasome participates in numerous cellular
CC       processes, including cell cycle progression, apoptosis, or DNA damage
CC       repair. In the complex, PSMD11 is required for proteasome assembly.
CC       Plays a key role in increased proteasome activity in embryonic stem
CC       cells (ESCs): its high expression in ESCs promotes enhanced assembly of
CC       the 26S proteasome, followed by higher proteasome activity.
CC       {ECO:0000250|UniProtKB:O00231}.
CC   -!- SUBUNIT: Component of the 19S proteasome regulatory particle complex.
CC       The 26S proteasome consists of a 20S core particle (CP) and two 19S
CC       regulatory subunits (RP). The regulatory particle is made of a lid
CC       composed of 9 subunits including PSMD11, a base containing 6 ATPases
CC       and few additional components. {ECO:0000250|UniProtKB:O00231}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}. Cytoplasm, cytosol
CC       {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the proteasome subunit S9 family. {ECO:0000305}.
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DR   EMBL; AAMC01047365; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   RefSeq; XP_002935612.1; XM_002935566.4.
DR   AlphaFoldDB; F6XBL2; -.
DR   SMR; F6XBL2; -.
DR   STRING; 8364.ENSXETP00000062737; -.
DR   PaxDb; F6XBL2; -.
DR   Ensembl; ENSXETT00000065710; ENSXETP00000062737; ENSXETG00000029937.
DR   GeneID; 100492225; -.
DR   KEGG; xtr:100492225; -.
DR   CTD; 5717; -.
DR   Xenbase; XB-GENE-922608; psmd11.
DR   eggNOG; KOG1463; Eukaryota.
DR   HOGENOM; CLU_029573_2_1_1; -.
DR   InParanoid; F6XBL2; -.
DR   OrthoDB; 1052430at2759; -.
DR   PhylomeDB; F6XBL2; -.
DR   Reactome; R-XTR-6798695; Neutrophil degranulation.
DR   Proteomes; UP000008143; Chromosome 10.
DR   Proteomes; UP000790000; Unplaced.
DR   Bgee; ENSXETG00000029937; Expressed in neurula embryo and 15 other tissues.
DR   ExpressionAtlas; F6XBL2; differential.
DR   GO; GO:0005829; C:cytosol; IEA:UniProtKB-SubCell.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0022624; C:proteasome accessory complex; ISS:UniProtKB.
DR   GO; GO:0008541; C:proteasome regulatory particle, lid subcomplex; IBA:GO_Central.
DR   GO; GO:0005198; F:structural molecule activity; IBA:GO_Central.
DR   GO; GO:0043248; P:proteasome assembly; ISS:UniProtKB.
DR   GO; GO:0048863; P:stem cell differentiation; ISS:UniProtKB.
DR   GO; GO:0006511; P:ubiquitin-dependent protein catabolic process; ISS:UniProtKB.
DR   InterPro; IPR000717; PCI_dom.
DR   InterPro; IPR035295; PSMD11.
DR   InterPro; IPR040780; Rpn6_C_helix.
DR   InterPro; IPR040773; Rpn6_N.
DR   InterPro; IPR011990; TPR-like_helical_dom_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   PANTHER; PTHR10678:SF6; PTHR10678:SF6; 1.
DR   Pfam; PF01399; PCI; 1.
DR   Pfam; PF18503; RPN6_C_helix; 1.
DR   Pfam; PF18055; RPN6_N; 1.
DR   SMART; SM00088; PINT; 1.
DR   SUPFAM; SSF46785; SSF46785; 1.
DR   SUPFAM; SSF48452; SSF48452; 1.
DR   PROSITE; PS50250; PCI; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; Nucleus; Proteasome; Reference proteome.
FT   CHAIN           1..422
FT                   /note="26S proteasome non-ATPase regulatory subunit 11"
FT                   /id="PRO_0000419981"
FT   DOMAIN          224..392
FT                   /note="PCI"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01185"
SQ   SEQUENCE   422 AA;  47341 MW;  BC42A3B7BC941DB0 CRC64;
     MAAAAVIEFQ RAQEMLVSDR AASIDILQSI VKRDIQESDE EALRVKEQSI LELGGLLAKT
     GQAAELGGLL KYVRPFLNSI SKAKAARLVR SLLDLFLDME AATGQEVELC LECIEWAKAE
     KRTFLRQALE ARLVSLYFDT KRYQEALQLG SQLLRELKKM DDKALLVEVQ LLESKTYHAL
     SNLPKARAAL TSARTTANAI YCPPKLQAAL DMQSGIIHAA EEKDWKTAYS YFYEAFEGND
     SIDSPKAITA LKYMLLCKIM LNTPEDVQAL VSGKLALRYA GRQTEALKCV AQASKNRSLA
     NFEKALTDYK AELRDDPIIS THLAKLYDNL LEQNLIRVIE PFSRVQIDHI SSLIKLPKPE
     VERKLSQMIL DKKFHGILDQ GEGVLIIFDE PPVDKTYEAA LETIQNMSKV VDSLYNKAKK
     LT