ID   PSD13_BOVIN             Reviewed;         376 AA.
AC   Q5E964; Q3T0Z1;
DT   10-MAY-2005, integrated into UniProtKB/Swiss-Prot.
DT   15-MAR-2005, sequence version 1.
DT   03-AUG-2022, entry version 75.
DE   RecName: Full=26S proteasome non-ATPase regulatory subunit 13;
DE   AltName: Full=26S proteasome regulatory subunit RPN9;
DE   AltName: Full=26S proteasome regulatory subunit S11;
DE   AltName: Full=26S proteasome regulatory subunit p40.5;
GN   Name=PSMD13;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX   PubMed=16305752; DOI=10.1186/1471-2164-6-166;
RA   Harhay G.P., Sonstegard T.S., Keele J.W., Heaton M.P., Clawson M.L.,
RA   Snelling W.M., Wiedmann R.T., Van Tassell C.P., Smith T.P.L.;
RT   "Characterization of 954 bovine full-CDS cDNA sequences.";
RL   BMC Genomics 6:166-166(2005).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Crossbred X Angus; TISSUE=Ileum;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Component of the 26S proteasome, a multiprotein complex
CC       involved in the ATP-dependent degradation of ubiquitinated proteins.
CC       This complex plays a key role in the maintenance of protein homeostasis
CC       by removing misfolded or damaged proteins, which could impair cellular
CC       functions, and by removing proteins whose functions are no longer
CC       required. Therefore, the proteasome participates in numerous cellular
CC       processes, including cell cycle progression, apoptosis, or DNA damage
CC       repair. {ECO:0000250|UniProtKB:Q9UNM6}.
CC   -!- SUBUNIT: Component of the 19S proteasome regulatory particle complex.
CC       The 26S proteasome consists of a 20S core particle (CP) and two 19S
CC       regulatory subunits (RP). The regulatory particle is made of a lid
CC       composed of 9 subunits including PSMD13, a base containing 6 ATPases
CC       and few additional components. {ECO:0000250|UniProtKB:Q9UNM6}.
CC   -!- SIMILARITY: Belongs to the proteasome subunit S11 family.
CC       {ECO:0000305}.
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DR   EMBL; BT021056; AAX09073.1; -; mRNA.
DR   EMBL; BC102200; AAI02201.1; -; mRNA.
DR   RefSeq; NP_001019703.1; NM_001024532.2.
DR   AlphaFoldDB; Q5E964; -.
DR   SMR; Q5E964; -.
DR   STRING; 9913.ENSBTAP00000002650; -.
DR   PaxDb; Q5E964; -.
DR   PeptideAtlas; Q5E964; -.
DR   PRIDE; Q5E964; -.
DR   Ensembl; ENSBTAT00000002650; ENSBTAP00000002650; ENSBTAG00000002045.
DR   GeneID; 513525; -.
DR   KEGG; bta:513525; -.
DR   CTD; 5719; -.
DR   VEuPathDB; HostDB:ENSBTAG00000002045; -.
DR   VGNC; VGNC:33464; PSMD13.
DR   eggNOG; KOG2908; Eukaryota.
DR   GeneTree; ENSGT00390000001802; -.
DR   InParanoid; Q5E964; -.
DR   OMA; TWVQPRI; -.
DR   OrthoDB; 919955at2759; -.
DR   Proteomes; UP000009136; Chromosome 11.
DR   Bgee; ENSBTAG00000002045; Expressed in choroid plexus and 105 other tissues.
DR   GO; GO:0005829; C:cytosol; IBA:GO_Central.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0022624; C:proteasome accessory complex; ISS:UniProtKB.
DR   GO; GO:0008541; C:proteasome regulatory particle, lid subcomplex; IBA:GO_Central.
DR   GO; GO:0005198; F:structural molecule activity; IBA:GO_Central.
DR   GO; GO:0007127; P:meiosis I; IEA:Ensembl.
DR   GO; GO:0006511; P:ubiquitin-dependent protein catabolic process; IBA:GO_Central.
DR   InterPro; IPR000717; PCI_dom.
DR   InterPro; IPR035298; PSMD13.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   PANTHER; PTHR10539; PTHR10539; 1.
DR   Pfam; PF01399; PCI; 1.
DR   SMART; SM00088; PINT; 1.
DR   SUPFAM; SSF46785; SSF46785; 1.
DR   PROSITE; PS50250; PCI; 1.
PE   2: Evidence at transcript level;
KW   Proteasome; Reference proteome.
FT   CHAIN           1..376
FT                   /note="26S proteasome non-ATPase regulatory subunit 13"
FT                   /id="PRO_0000173866"
FT   DOMAIN          171..338
FT                   /note="PCI"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01185"
SQ   SEQUENCE   376 AA;  42866 MW;  C98C5049858A3395 CRC64;
     MKDVPGFLQQ SQSSGPGQAA VWHRLEELYT KKLWHQLTLQ VLDFVQDPCF AQGDGLIKLY
     ENFISEFEHR VNPLSLVEII LHVVRQMTDP NVALSFLEKT REKVKSSDEA VILCKTAIGA
     LKLNIGDLQV TKETIEDVEE MLSNLPGVTS VHSRFYDLSS KYYQTIGNHA SYYKDALRFL
     GCVDIKDLPV SEQQERAFTL GLAGLLGDGV FNFGELLMHP VLESLRDTDR QWLIDTLYAF
     NSGNVERFQT LKTAWGQQPD LAANEAQLLR KIQLLCLMEM TFTRPANHRQ LTFEEIARSA
     KITVNEVELL VMKALSVGLV KGSIDEVDKR VHMTWVQPRV LDLQQIKGMK DRLEFWCTDV
     KSMEMLVEHQ AHDILT