PSD13_CHICK
ID PSD13_CHICK Reviewed; 376 AA.
AC P84169;
DT 21-FEB-2006, integrated into UniProtKB/Swiss-Prot.
DT 21-FEB-2006, sequence version 1.
DT 03-AUG-2022, entry version 67.
DE RecName: Full=26S proteasome non-ATPase regulatory subunit 13;
DE AltName: Full=26S proteasome regulatory subunit RPN9;
DE AltName: Full=26S proteasome regulatory subunit S11;
DE AltName: Full=26S proteasome regulatory subunit p40.5;
GN Name=PSMD13 {ECO:0000250|UniProtKB:Q9UNM6};
OS Gallus gallus (Chicken).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC Phasianinae; Gallus.
OX NCBI_TaxID=9031;
RN [1] {ECO:0000305}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-180.
RA Morgan R.W., Burnside J.;
RT "Chicken ESTs from lymphoid tissue.";
RL Submitted (JAN-2003) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000305}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 88-336.
RC STRAIN=Red jungle fowl {ECO:0000269|PubMed:16093725};
RC TISSUE=Brain {ECO:0000269|PubMed:16093725};
RX PubMed=16093725; DOI=10.1159/000085674;
RA Savolainen P., Fitzsimmons C., Arvestad L., Andersson L., Lundeberg J.;
RT "ESTs from brain and testis of White Leghorn and red junglefowl:
RT annotation, bioinformatic classification of unknown transcripts and
RT analysis of expression levels.";
RL Cytogenet. Genome Res. 111:79-87(2005).
RN [3] {ECO:0000305}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 246-376.
RC TISSUE=Chondrocyte {ECO:0000269|PubMed:12445392};
RX PubMed=12445392; DOI=10.1016/s0960-9822(02)01296-4;
RA Boardman P.E., Sanz-Ezquerro J., Overton I.M., Burt D.W., Bosch E.,
RA Fong W.T., Tickle C., Brown W.R., Wilson S.A., Hubbard S.J.;
RT "A comprehensive collection of chicken cDNAs.";
RL Curr. Biol. 12:1965-1969(2002).
RN [4] {ECO:0000305}
RP IDENTIFICATION, AND MASS SPECTROMETRY.
RC TISSUE=Embryo {ECO:0000269|PubMed:16287166};
RX PubMed=16287166; DOI=10.1002/pmic.200402056;
RA Agudo D., Gomez-Esquer F., Diaz-Gil G., Martinez-Arribas F., Delcan J.,
RA Schneider J., Palomar M.A., Linares R.;
RT "Proteomic analysis of the Gallus gallus embryo at stage-29 of
RT development.";
RL Proteomics 5:4946-4957(2005).
CC -!- FUNCTION: Component of the 26S proteasome, a multiprotein complex
CC involved in the ATP-dependent degradation of ubiquitinated proteins.
CC This complex plays a key role in the maintenance of protein homeostasis
CC by removing misfolded or damaged proteins, which could impair cellular
CC functions, and by removing proteins whose functions are no longer
CC required. Therefore, the proteasome participates in numerous cellular
CC processes, including cell cycle progression, apoptosis, or DNA damage
CC repair. {ECO:0000250|UniProtKB:Q9UNM6}.
CC -!- SUBUNIT: Component of the 19S proteasome regulatory particle complex.
CC The 26S proteasome consists of a 20S core particle (CP) and two 19S
CC regulatory subunits (RP). The regulatory particle is made of a lid
CC composed of 9 subunits including PSMD13, a base containing 6 ATPases
CC and few additional components. {ECO:0000250|UniProtKB:Q9UNM6}.
CC -!- MASS SPECTROMETRY: Mass=42810; Mass_error=2; Method=MALDI;
CC Evidence={ECO:0000269|PubMed:16287166};
CC -!- SIMILARITY: Belongs to the proteasome subunit S11 family.
CC {ECO:0000305}.
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DR EMBL; CB017092; -; NOT_ANNOTATED_CDS; mRNA.
DR EMBL; CN218176; -; NOT_ANNOTATED_CDS; mRNA.
DR EMBL; BU427099; -; NOT_ANNOTATED_CDS; mRNA.
DR RefSeq; XP_015141752.1; XM_015286266.1.
DR AlphaFoldDB; P84169; -.
DR SMR; P84169; -.
DR STRING; 9031.ENSGALP00000039552; -.
DR Ensembl; ENSGALT00000082342; ENSGALP00000054631; ENSGALG00000043684.
DR GeneID; 422990; -.
DR KEGG; gga:422990; -.
DR CTD; 5719; -.
DR VEuPathDB; HostDB:geneid_422990; -.
DR eggNOG; KOG2908; Eukaryota.
DR GeneTree; ENSGT00390000001802; -.
DR InParanoid; P84169; -.
DR OMA; TWVQPRI; -.
DR OrthoDB; 919955at2759; -.
DR PhylomeDB; P84169; -.
DR PRO; PR:P84169; -.
DR Proteomes; UP000000539; Chromosome 5.
DR Bgee; ENSGALG00000043684; Expressed in muscle tissue and 14 other tissues.
DR GO; GO:0005829; C:cytosol; IBA:GO_Central.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0022624; C:proteasome accessory complex; ISS:UniProtKB.
DR GO; GO:0008541; C:proteasome regulatory particle, lid subcomplex; IBA:GO_Central.
DR GO; GO:0005198; F:structural molecule activity; IBA:GO_Central.
DR GO; GO:0006511; P:ubiquitin-dependent protein catabolic process; IBA:GO_Central.
DR InterPro; IPR000717; PCI_dom.
DR InterPro; IPR035298; PSMD13.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR10539; PTHR10539; 1.
DR Pfam; PF01399; PCI; 1.
DR SMART; SM00088; PINT; 1.
DR SUPFAM; SSF46785; SSF46785; 1.
DR PROSITE; PS50250; PCI; 1.
PE 1: Evidence at protein level;
KW Proteasome; Reference proteome.
FT CHAIN 1..376
FT /note="26S proteasome non-ATPase regulatory subunit 13"
FT /evidence="ECO:0000305"
FT /id="PRO_0000223482"
FT DOMAIN 171..338
FT /note="PCI"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01185"
SQ SEQUENCE 376 AA; 42751 MW; 9983A04807AD567F CRC64;
MKDVPGFLQQ SQSAGPGQAA VWHRLEELYN KKLWHQLTLQ VLDFVQDPCF AQGDGLIKLY
ENFISEFEHR VNPLSLVEII LHVVRQMTDP TVALTFLEKT REKVKSSDEA VILCKTAIGA
LKLNIGDLQV TKETIEEVEE MLNNLPGVTS VHSRFYDLSS KYYQTIGNHA SYYKDALRFL
GCIDVKDLPV SEQQERAFTL GLAGLLGEGV YNFGELLMHP VLESLRSTDR QWLIDTLYAF
NSGNVETFQA LKSAWGQQPD LAANEALLLQ KIQLLCLMEM TFTRPANHRQ LTFEEIAKSA
KVTVNEVELL VMKALSVGLV KGSIDEVDKR VHMTWVQPRV LDLQQIKGMK DRLEFWCTDV
RSMEMLVEHQ AHDILT
