ID   PSE1_PHYPR              Reviewed;         145 AA.
AC   P0CV74;
DT   16-OCT-2019, integrated into UniProtKB/Swiss-Prot.
DT   16-OCT-2019, sequence version 1.
DT   25-MAY-2022, entry version 7.
DE   RecName: Full=Secreted RxLR effector protein PSE1 {ECO:0000303|PubMed:23594295};
DE   AltName: Full=Penetration-specific effector 1 {ECO:0000303|PubMed:23594295};
DE   Flags: Precursor;
GN   Name=PSE1 {ECO:0000303|PubMed:23594295};
OS   Phytophthora parasitica (Potato buckeye rot agent).
OC   Eukaryota; Sar; Stramenopiles; Oomycota; Peronosporales; Peronosporaceae;
OC   Phytophthora.
OX   NCBI_TaxID=4792;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], DOMAIN, INDUCTION, AND FUNCTION.
RX   PubMed=19807870; DOI=10.1111/j.1469-8137.2009.03048.x;
RA   Kebdani N., Pieuchot L., Deleury E., Panabieres F., Le Berre J.Y.,
RA   Gourgues M.;
RT   "Cellular and molecular characterization of Phytophthora parasitica
RT   appressorium-mediated penetration.";
RL   New Phytol. 185:248-257(2010).
RN   [2]
RP   FUNCTION, INDUCTION, AND SUBCELLULAR LOCATION.
RX   PubMed=23594295; DOI=10.1111/nph.12270;
RA   Evangelisti E., Govetto B., Minet-Kebdani N., Kuhn M.L., Attard A.,
RA   Ponchet M., Panabieres F., Gourgues M.;
RT   "The Phytophthora parasitica RXLR effector penetration-specific effector 1
RT   favours Arabidopsis thaliana infection by interfering with auxin
RT   physiology.";
RL   New Phytol. 199:476-489(2013).
CC   -!- FUNCTION: Secreted effector that impairs both plant effector-triggered
CC       immunity and pathogen-associated molecular patterns (PAMP)-triggered
CC       immunity (PTI) (PubMed:23594295). Suppresses plant cell death as a part
CC       of the plant defense responses (PubMed:23594295). Facilitates plant
CC       infection by altering the auxin content at the roots penetration points
CC       of the of the pathogen (PubMed:19807870, PubMed:23594295).
CC       {ECO:0000269|PubMed:19807870, ECO:0000269|PubMed:23594295}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:23594295}. Host cell
CC       {ECO:0000269|PubMed:23594295}.
CC   -!- INDUCTION: Specifically expressed during the first hours of infection
CC       of the host plant (PubMed:19807870, PubMed:23594295). Expression is
CC       induced during the appressorium-mediated penetration of host roots and
CC       peaks during the penetration process (PubMed:23594295). Expression then
CC       declines during early biotrophy, and becomes barely detectable during
CC       the invasive growth of the oomycete along the stele, and later during
CC       the necrotrophic phase of the infection (PubMed:23594295).
CC       {ECO:0000269|PubMed:19807870, ECO:0000269|PubMed:23594295}.
CC   -!- DOMAIN: The RxLR-dEER motif acts to carry the protein into the host
CC       cell cytoplasm through binding to cell surface phosphatidylinositol-3-
CC       phosphate. {ECO:0000305|PubMed:19807870}.
CC   -!- SIMILARITY: Belongs to the RxLR effector family. {ECO:0000305}.
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DR   EMBL; FK937603; -; NOT_ANNOTATED_CDS; mRNA.
DR   AlphaFoldDB; P0CV74; -.
DR   VEuPathDB; FungiDB:PPTG_07218; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0043657; C:host cell; IEA:UniProtKB-SubCell.
DR   InterPro; IPR031825; RXLR.
DR   Pfam; PF16810; RXLR; 1.
PE   2: Evidence at transcript level;
KW   Secreted; Signal; Virulence.
FT   SIGNAL          1..21
FT                   /evidence="ECO:0000255"
FT   CHAIN           22..145
FT                   /note="Secreted RxLR effector protein PSE1"
FT                   /id="PRO_0000448276"
FT   MOTIF           53..73
FT                   /note="RxLR-dEER"
FT                   /evidence="ECO:0000305|PubMed:19807870"
SQ   SEQUENCE   145 AA;  16425 MW;  6847F64AE0B07278 CRC64;
     MRLSSFIVVG AAVVNLLTSG SVVVAAFPRV SDVSAMAIAP HRMDQGATNG GKRLLRYHSN
     NNRGGDEDIA EERGIFDFKN LEMLTNLARL NKANNLDSRL DDFFQALIKA KVNPTNIHHT
     RLDQDDYLEL RQLFRTWYTF YHRAS