ID   PSF1_BOVIN              Reviewed;         196 AA.
AC   A4IFH4;
DT   08-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-2007, sequence version 1.
DT   03-AUG-2022, entry version 80.
DE   RecName: Full=DNA replication complex GINS protein PSF1;
DE   AltName: Full=GINS complex subunit 1;
GN   Name=GINS1; Synonyms=PSF1;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Hereford; TISSUE=Hypothalamus;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (MAR-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Required for correct functioning of the GINS complex, a
CC       complex that plays an essential role in the initiation of DNA
CC       replication, and progression of DNA replication forks. GINS complex
CC       seems to bind preferentially to single-stranded DNA.
CC       {ECO:0000250|UniProtKB:Q14691}.
CC   -!- SUBUNIT: Component of the GINS complex which is a heterotetramer of
CC       GINS1, GINS2, GINS3 and GINS4. Forms a stable subcomplex with GINS4.
CC       GINS complex interacts with DNA primase in vitro (By similarity).
CC       Component of the CMG helicase complex, composed of the MCM2-7 complex,
CC       the GINS complex and CDC45 (By similarity).
CC       {ECO:0000250|UniProtKB:Q14691, ECO:0000250|UniProtKB:Q7ZT47}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q7ZT47}.
CC       Chromosome {ECO:0000250|UniProtKB:Q7ZT47}. Note=Associates with
CC       chromatin. {ECO:0000250|UniProtKB:Q7ZT47}.
CC   -!- SIMILARITY: Belongs to the GINS1/PSF1 family. {ECO:0000305}.
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DR   EMBL; BC134582; AAI34583.1; -; mRNA.
DR   RefSeq; NP_001077170.1; NM_001083701.2.
DR   AlphaFoldDB; A4IFH4; -.
DR   SMR; A4IFH4; -.
DR   STRING; 9913.ENSBTAP00000026619; -.
DR   PaxDb; A4IFH4; -.
DR   PRIDE; A4IFH4; -.
DR   Ensembl; ENSBTAT00000026619; ENSBTAP00000026619; ENSBTAG00000019984.
DR   GeneID; 523427; -.
DR   KEGG; bta:523427; -.
DR   CTD; 9837; -.
DR   VEuPathDB; HostDB:ENSBTAG00000019984; -.
DR   VGNC; VGNC:29360; GINS1.
DR   eggNOG; KOG3303; Eukaryota.
DR   GeneTree; ENSGT00390000013968; -.
DR   HOGENOM; CLU_079191_1_1_1; -.
DR   InParanoid; A4IFH4; -.
DR   OMA; NHLCMRR; -.
DR   OrthoDB; 1249159at2759; -.
DR   TreeFam; TF312848; -.
DR   Reactome; R-BTA-176974; Unwinding of DNA.
DR   Proteomes; UP000009136; Chromosome 13.
DR   Bgee; ENSBTAG00000019984; Expressed in oocyte and 109 other tissues.
DR   GO; GO:0071162; C:CMG complex; ISS:UniProtKB.
DR   GO; GO:0000811; C:GINS complex; IBA:GO_Central.
DR   GO; GO:1902983; P:DNA strand elongation involved in mitotic DNA replication; IBA:GO_Central.
DR   CDD; cd11710; GINS_A_psf1; 1.
DR   InterPro; IPR036224; GINS_bundle-like_dom_sf.
DR   InterPro; IPR005339; GINS_Psf1.
DR   PANTHER; PTHR12914; PTHR12914; 1.
DR   SUPFAM; SSF158573; SSF158573; 1.
PE   2: Evidence at transcript level;
KW   Chromosome; DNA replication; Nucleus; Reference proteome.
FT   CHAIN           1..196
FT                   /note="DNA replication complex GINS protein PSF1"
FT                   /id="PRO_0000327217"
SQ   SEQUENCE   196 AA;  22951 MW;  EEF993C80E759CBC CRC64;
     MFCEKAMELV RELHRAAEGR LPAFNEDGLR QVLEEMKALY EQNQSDVNEA KSSGRGDLIP
     TIKFRHCSLL RNQRCTVAYL YDRLLRIRAL RWEYGSVLPS ALRFHMSAEE MDWFNRYKKS
     LATYMRSLGG DEGLDITQDM KPPKSLYIEV RCLKDYGEFE VEDGTSVLLK KNSQHFLPRW
     KCEQLIRQGI LEHVLS