ID   PSF1_CRYNB              Reviewed;         218 AA.
AC   P0CQ29; Q55PE3; Q5KE14;
DT   28-JUN-2011, integrated into UniProtKB/Swiss-Prot.
DT   28-JUN-2011, sequence version 1.
DT   25-MAY-2022, entry version 40.
DE   RecName: Full=DNA replication complex GINS protein PSF1;
GN   Name=PSF1; OrderedLocusNames=CNBG2690;
OS   Cryptococcus neoformans var. neoformans serotype D (strain B-3501A)
OS   (Filobasidiella neoformans).
OC   Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina; Tremellomycetes;
OC   Tremellales; Cryptococcaceae; Cryptococcus;
OC   Cryptococcus neoformans species complex.
OX   NCBI_TaxID=283643;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=B-3501A;
RX   PubMed=15653466; DOI=10.1126/science.1103773;
RA   Loftus B.J., Fung E., Roncaglia P., Rowley D., Amedeo P., Bruno D.,
RA   Vamathevan J., Miranda M., Anderson I.J., Fraser J.A., Allen J.E.,
RA   Bosdet I.E., Brent M.R., Chiu R., Doering T.L., Donlin M.J., D'Souza C.A.,
RA   Fox D.S., Grinberg V., Fu J., Fukushima M., Haas B.J., Huang J.C.,
RA   Janbon G., Jones S.J.M., Koo H.L., Krzywinski M.I., Kwon-Chung K.J.,
RA   Lengeler K.B., Maiti R., Marra M.A., Marra R.E., Mathewson C.A.,
RA   Mitchell T.G., Pertea M., Riggs F.R., Salzberg S.L., Schein J.E.,
RA   Shvartsbeyn A., Shin H., Shumway M., Specht C.A., Suh B.B., Tenney A.,
RA   Utterback T.R., Wickes B.L., Wortman J.R., Wye N.H., Kronstad J.W.,
RA   Lodge J.K., Heitman J., Davis R.W., Fraser C.M., Hyman R.W.;
RT   "The genome of the basidiomycetous yeast and human pathogen Cryptococcus
RT   neoformans.";
RL   Science 307:1321-1324(2005).
CC   -!- FUNCTION: The GINS complex plays an essential role in the initiation of
CC       DNA replication. {ECO:0000250}.
CC   -!- SUBUNIT: Component of the GINS complex which is a heterotetramer of
CC       SLD5, PSF1, PSF2 and PSF3. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the GINS1/PSF1 family. {ECO:0000305}.
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DR   EMBL; AAEY01000038; EAL19641.1; -; Genomic_DNA.
DR   RefSeq; XP_774288.1; XM_769195.1.
DR   AlphaFoldDB; P0CQ29; -.
DR   SMR; P0CQ29; -.
DR   EnsemblFungi; AAW44861; AAW44861; CNG02090.
DR   EnsemblFungi; EAL19641; EAL19641; CNBG2690.
DR   GeneID; 4937304; -.
DR   KEGG; cnb:CNBG2690; -.
DR   VEuPathDB; FungiDB:CNBG2690; -.
DR   HOGENOM; CLU_079191_0_0_1; -.
DR   Proteomes; UP000001435; Chromosome 7.
DR   GO; GO:0071162; C:CMG complex; IEA:EnsemblFungi.
DR   GO; GO:0000811; C:GINS complex; IEA:EnsemblFungi.
DR   GO; GO:0031298; C:replication fork protection complex; IEA:EnsemblFungi.
DR   GO; GO:0006268; P:DNA unwinding involved in DNA replication; IEA:EnsemblFungi.
DR   GO; GO:0000727; P:double-strand break repair via break-induced replication; IEA:EnsemblFungi.
DR   CDD; cd11710; GINS_A_psf1; 1.
DR   InterPro; IPR021151; GINS_A.
DR   InterPro; IPR036224; GINS_bundle-like_dom_sf.
DR   InterPro; IPR005339; GINS_Psf1.
DR   PANTHER; PTHR12914; PTHR12914; 1.
DR   Pfam; PF05916; Sld5; 1.
DR   SUPFAM; SSF158573; SSF158573; 1.
PE   3: Inferred from homology;
KW   DNA replication; Nucleus.
FT   CHAIN           1..218
FT                   /note="DNA replication complex GINS protein PSF1"
FT                   /id="PRO_0000410224"
SQ   SEQUENCE   218 AA;  24124 MW;  A2749652AE85DE29 CRC64;
     MYGDLALQLV NSSHRTTLSS TPQLPLPKYA LPLILSICLE TRQLGTSIAS IAESHGQLSL
     TQDRGLVCNL TVQHLAARRN KRCMLAYLAT RVGGIKERWW DAGGGLAYLL SPAASASVNP
     EADAPDLRSA LSPQELDFLR GYNNLLLDYK SDFLDVLDLT AGIEKPPGEI MVDVRVVRDA
     GEVFLDSGER VDFRKGQRFR LERAQVERLI IQGYLEEV