PSF1_CRYNJ
ID PSF1_CRYNJ Reviewed; 218 AA.
AC P0CQ28; Q55PE3; Q5KE14;
DT 28-JUN-2011, integrated into UniProtKB/Swiss-Prot.
DT 28-JUN-2011, sequence version 1.
DT 25-MAY-2022, entry version 47.
DE RecName: Full=DNA replication complex GINS protein PSF1;
GN Name=PSF1; OrderedLocusNames=CNG02090;
OS Cryptococcus neoformans var. neoformans serotype D (strain JEC21 / ATCC
OS MYA-565) (Filobasidiella neoformans).
OC Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina; Tremellomycetes;
OC Tremellales; Cryptococcaceae; Cryptococcus;
OC Cryptococcus neoformans species complex.
OX NCBI_TaxID=214684;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JEC21 / ATCC MYA-565;
RX PubMed=15653466; DOI=10.1126/science.1103773;
RA Loftus B.J., Fung E., Roncaglia P., Rowley D., Amedeo P., Bruno D.,
RA Vamathevan J., Miranda M., Anderson I.J., Fraser J.A., Allen J.E.,
RA Bosdet I.E., Brent M.R., Chiu R., Doering T.L., Donlin M.J., D'Souza C.A.,
RA Fox D.S., Grinberg V., Fu J., Fukushima M., Haas B.J., Huang J.C.,
RA Janbon G., Jones S.J.M., Koo H.L., Krzywinski M.I., Kwon-Chung K.J.,
RA Lengeler K.B., Maiti R., Marra M.A., Marra R.E., Mathewson C.A.,
RA Mitchell T.G., Pertea M., Riggs F.R., Salzberg S.L., Schein J.E.,
RA Shvartsbeyn A., Shin H., Shumway M., Specht C.A., Suh B.B., Tenney A.,
RA Utterback T.R., Wickes B.L., Wortman J.R., Wye N.H., Kronstad J.W.,
RA Lodge J.K., Heitman J., Davis R.W., Fraser C.M., Hyman R.W.;
RT "The genome of the basidiomycetous yeast and human pathogen Cryptococcus
RT neoformans.";
RL Science 307:1321-1324(2005).
CC -!- FUNCTION: The GINS complex plays an essential role in the initiation of
CC DNA replication. {ECO:0000250}.
CC -!- SUBUNIT: Component of the GINS complex which is a heterotetramer of
CC SLD5, PSF1, PSF2 and PSF3. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the GINS1/PSF1 family. {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AE017347; AAW44861.1; -; Genomic_DNA.
DR RefSeq; XP_572168.1; XM_572168.1.
DR AlphaFoldDB; P0CQ28; -.
DR SMR; P0CQ28; -.
DR STRING; 5207.AAW44861; -.
DR PaxDb; P0CQ28; -.
DR EnsemblFungi; AAW44861; AAW44861; CNG02090.
DR GeneID; 3258858; -.
DR KEGG; cne:CNG02090; -.
DR VEuPathDB; FungiDB:CNG02090; -.
DR eggNOG; KOG3303; Eukaryota.
DR HOGENOM; CLU_079191_0_0_1; -.
DR InParanoid; P0CQ28; -.
DR OMA; NHLCMRR; -.
DR OrthoDB; 1249159at2759; -.
DR Proteomes; UP000002149; Chromosome 7.
DR GO; GO:0071162; C:CMG complex; IEA:EnsemblFungi.
DR GO; GO:0000811; C:GINS complex; IBA:GO_Central.
DR GO; GO:0031298; C:replication fork protection complex; IEA:EnsemblFungi.
DR GO; GO:1902983; P:DNA strand elongation involved in mitotic DNA replication; IBA:GO_Central.
DR GO; GO:0006268; P:DNA unwinding involved in DNA replication; IEA:EnsemblFungi.
DR GO; GO:0000727; P:double-strand break repair via break-induced replication; IEA:EnsemblFungi.
DR CDD; cd11710; GINS_A_psf1; 1.
DR InterPro; IPR021151; GINS_A.
DR InterPro; IPR036224; GINS_bundle-like_dom_sf.
DR InterPro; IPR005339; GINS_Psf1.
DR PANTHER; PTHR12914; PTHR12914; 1.
DR Pfam; PF05916; Sld5; 1.
DR SUPFAM; SSF158573; SSF158573; 1.
PE 3: Inferred from homology;
KW DNA replication; Nucleus; Reference proteome.
FT CHAIN 1..218
FT /note="DNA replication complex GINS protein PSF1"
FT /id="PRO_0000278399"
SQ SEQUENCE 218 AA; 24124 MW; A2749652AE85DE29 CRC64;
MYGDLALQLV NSSHRTTLSS TPQLPLPKYA LPLILSICLE TRQLGTSIAS IAESHGQLSL
TQDRGLVCNL TVQHLAARRN KRCMLAYLAT RVGGIKERWW DAGGGLAYLL SPAASASVNP
EADAPDLRSA LSPQELDFLR GYNNLLLDYK SDFLDVLDLT AGIEKPPGEI MVDVRVVRDA
GEVFLDSGER VDFRKGQRFR LERAQVERLI IQGYLEEV
