ID   PSF1_DICDI              Reviewed;         191 AA.
AC   Q54HR6;
DT   08-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT   24-MAY-2005, sequence version 1.
DT   25-MAY-2022, entry version 87.
DE   RecName: Full=Probable DNA replication complex GINS protein PSF1;
DE   AltName: Full=GINS complex subunit 1;
GN   Name=gins1; ORFNames=DDB_G0289271;
OS   Dictyostelium discoideum (Slime mold).
OC   Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC   Dictyosteliaceae; Dictyostelium.
OX   NCBI_TaxID=44689;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AX4;
RX   PubMed=15875012; DOI=10.1038/nature03481;
RA   Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA   Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA   Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA   Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA   Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA   Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA   Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA   Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA   Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA   Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA   Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA   Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA   Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA   Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA   Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA   Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA   Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT   "The genome of the social amoeba Dictyostelium discoideum.";
RL   Nature 435:43-57(2005).
CC   -!- FUNCTION: The GINS complex plays an essential role in the initiation of
CC       DNA replication. {ECO:0000250}.
CC   -!- SUBUNIT: Component of the GINS complex which is a heterotetramer of
CC       gins1, gins2, gins3 and gins4. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the GINS1/PSF1 family. {ECO:0000305}.
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DR   EMBL; AAFI02000133; EAL62807.1; -; Genomic_DNA.
DR   RefSeq; XP_636320.1; XM_631228.1.
DR   AlphaFoldDB; Q54HR6; -.
DR   SMR; Q54HR6; -.
DR   STRING; 44689.DDB0266353; -.
DR   PaxDb; Q54HR6; -.
DR   EnsemblProtists; EAL62807; EAL62807; DDB_G0289271.
DR   GeneID; 8627047; -.
DR   KEGG; ddi:DDB_G0289271; -.
DR   dictyBase; DDB_G0289271; gins1.
DR   eggNOG; KOG3303; Eukaryota.
DR   HOGENOM; CLU_079191_1_0_1; -.
DR   InParanoid; Q54HR6; -.
DR   OMA; NHLCMRR; -.
DR   PhylomeDB; Q54HR6; -.
DR   Reactome; R-DDI-176974; Unwinding of DNA.
DR   PRO; PR:Q54HR6; -.
DR   Proteomes; UP000002195; Chromosome 5.
DR   GO; GO:0000811; C:GINS complex; ISS:dictyBase.
DR   GO; GO:0006260; P:DNA replication; ISS:dictyBase.
DR   GO; GO:1902983; P:DNA strand elongation involved in mitotic DNA replication; IBA:GO_Central.
DR   CDD; cd11710; GINS_A_psf1; 1.
DR   InterPro; IPR021151; GINS_A.
DR   InterPro; IPR036224; GINS_bundle-like_dom_sf.
DR   InterPro; IPR005339; GINS_Psf1.
DR   PANTHER; PTHR12914; PTHR12914; 1.
DR   Pfam; PF05916; Sld5; 1.
DR   SUPFAM; SSF158573; SSF158573; 1.
PE   3: Inferred from homology;
KW   DNA replication; Nucleus; Reference proteome.
FT   CHAIN           1..191
FT                   /note="Probable DNA replication complex GINS protein PSF1"
FT                   /id="PRO_0000327218"
SQ   SEQUENCE   191 AA;  22297 MW;  8D3D0CBF635D1F99 CRC64;
     MFTKTAIELI KELRGTDSIP HYNDTSIKAT IDEMIALYED LIKTITEHKE QKKEPFYLQH
     AITFHNSINR DKRCILAYLN ERLNRIKEYR WSSGQSLLPD QLKERLSQNE IQFFSEYDKI
     LTEYNSKVGL DLTIDPQPPK ELYIEVRVIK ELGEVVLNSG CTVNLNLNTT HFLKRSDITN
     LVKNGSLEHI I