ID   PSF1_KLULA              Reviewed;         211 AA.
AC   Q6CW43;
DT   20-FEB-2007, integrated into UniProtKB/Swiss-Prot.
DT   20-FEB-2007, sequence version 2.
DT   25-MAY-2022, entry version 84.
DE   RecName: Full=DNA replication complex GINS protein PSF1;
GN   Name=PSF1; OrderedLocusNames=KLLA0B07095g;
OS   Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 /
OS   NRRL Y-1140 / WM37) (Yeast) (Candida sphaerica).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Kluyveromyces.
OX   NCBI_TaxID=284590;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37;
RX   PubMed=15229592; DOI=10.1038/nature02579;
RA   Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I.,
RA   de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L.,
RA   Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.,
RA   Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J.,
RA   Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E.,
RA   Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C.,
RA   Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M.,
RA   Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S.,
RA   Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F.,
RA   Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M.,
RA   Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M.,
RA   Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C.,
RA   Weissenbach J., Wincker P., Souciet J.-L.;
RT   "Genome evolution in yeasts.";
RL   Nature 430:35-44(2004).
CC   -!- FUNCTION: The GINS complex plays an essential role in the initiation of
CC       DNA replication. {ECO:0000250}.
CC   -!- SUBUNIT: Component of the GINS complex which is a heterotetramer of
CC       SLD5, PSF1, PSF2 and PSF3. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the GINS1/PSF1 family. {ECO:0000305}.
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DR   EMBL; CR382122; CAH02239.2; -; Genomic_DNA.
DR   RefSeq; XP_451846.2; XM_451846.2.
DR   AlphaFoldDB; Q6CW43; -.
DR   SMR; Q6CW43; -.
DR   STRING; 28985.XP_451846.2; -.
DR   EnsemblFungi; CAH02239; CAH02239; KLLA0_B07095g.
DR   GeneID; 2897097; -.
DR   KEGG; kla:KLLA0_B07095g; -.
DR   eggNOG; KOG3303; Eukaryota.
DR   HOGENOM; CLU_079191_0_0_1; -.
DR   InParanoid; Q6CW43; -.
DR   Proteomes; UP000000598; Chromosome B.
DR   GO; GO:0000811; C:GINS complex; IEA:InterPro.
DR   GO; GO:1902983; P:DNA strand elongation involved in mitotic DNA replication; IEA:EnsemblFungi.
DR   GO; GO:1902975; P:mitotic DNA replication initiation; IEA:EnsemblFungi.
DR   CDD; cd11710; GINS_A_psf1; 1.
DR   InterPro; IPR021151; GINS_A.
DR   InterPro; IPR036224; GINS_bundle-like_dom_sf.
DR   InterPro; IPR005339; GINS_Psf1.
DR   PANTHER; PTHR12914; PTHR12914; 1.
DR   Pfam; PF05916; Sld5; 1.
DR   SUPFAM; SSF158573; SSF158573; 1.
PE   3: Inferred from homology;
KW   DNA replication; Nucleus; Reference proteome.
FT   CHAIN           1..211
FT                   /note="DNA replication complex GINS protein PSF1"
FT                   /id="PRO_0000278403"
SQ   SEQUENCE   211 AA;  24246 MW;  288977E5B4649E7B CRC64;
     MYGDLANKLI LEAKRTQQLS QAGFNKQQLP VYQDELVRGI LKEVGSLKKN VDYLREQQLT
     DQDNKVAQCQ YVVAMLSMER NKRCLLAYQK MRSEMLDSMV WDNNGMEFSS AISNHPNLSS
     FDSSVLSHAE QEYLKEYAQL LTELKSGELS EIDLTGMLQP PSDVFIDVRV LKDAGQIETE
     YGVFNLIKDS QFFVRQSDVE RLIQQGYLQK I