ID   PSF1_NEUCR              Reviewed;         216 AA.
AC   Q7SDH9;
DT   20-FEB-2007, integrated into UniProtKB/Swiss-Prot.
DT   15-DEC-2003, sequence version 1.
DT   25-MAY-2022, entry version 92.
DE   RecName: Full=DNA replication complex GINS protein psf1;
DE   AltName: Full=DNA replication complex protein 1;
GN   Name=drc-1; Synonyms=psf1; ORFNames=NCU02631;
OS   Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 /
OS   FGSC 987).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC   Sordariomycetidae; Sordariales; Sordariaceae; Neurospora.
OX   NCBI_TaxID=367110;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987;
RX   PubMed=12712197; DOI=10.1038/nature01554;
RA   Galagan J.E., Calvo S.E., Borkovich K.A., Selker E.U., Read N.D.,
RA   Jaffe D.B., FitzHugh W., Ma L.-J., Smirnov S., Purcell S., Rehman B.,
RA   Elkins T., Engels R., Wang S., Nielsen C.B., Butler J., Endrizzi M.,
RA   Qui D., Ianakiev P., Bell-Pedersen D., Nelson M.A., Werner-Washburne M.,
RA   Selitrennikoff C.P., Kinsey J.A., Braun E.L., Zelter A., Schulte U.,
RA   Kothe G.O., Jedd G., Mewes H.-W., Staben C., Marcotte E., Greenberg D.,
RA   Roy A., Foley K., Naylor J., Stange-Thomann N., Barrett R., Gnerre S.,
RA   Kamal M., Kamvysselis M., Mauceli E.W., Bielke C., Rudd S., Frishman D.,
RA   Krystofova S., Rasmussen C., Metzenberg R.L., Perkins D.D., Kroken S.,
RA   Cogoni C., Macino G., Catcheside D.E.A., Li W., Pratt R.J., Osmani S.A.,
RA   DeSouza C.P.C., Glass N.L., Orbach M.J., Berglund J.A., Voelker R.,
RA   Yarden O., Plamann M., Seiler S., Dunlap J.C., Radford A., Aramayo R.,
RA   Natvig D.O., Alex L.A., Mannhaupt G., Ebbole D.J., Freitag M., Paulsen I.,
RA   Sachs M.S., Lander E.S., Nusbaum C., Birren B.W.;
RT   "The genome sequence of the filamentous fungus Neurospora crassa.";
RL   Nature 422:859-868(2003).
CC   -!- FUNCTION: The GINS complex plays an essential role in the initiation of
CC       DNA replication. {ECO:0000250}.
CC   -!- SUBUNIT: Component of the GINS complex which is a heterotetramer of
CC       div-26/sld5, drc-1/psf1, drc-2/psf2 and drc-3/psf3. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the GINS1/PSF1 family. {ECO:0000305}.
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DR   EMBL; CM002236; EAA34820.1; -; Genomic_DNA.
DR   RefSeq; XP_964056.1; XM_958963.2.
DR   AlphaFoldDB; Q7SDH9; -.
DR   SMR; Q7SDH9; -.
DR   STRING; 5141.EFNCRP00000002169; -.
DR   EnsemblFungi; EAA34820; EAA34820; NCU02631.
DR   GeneID; 3880205; -.
DR   KEGG; ncr:NCU02631; -.
DR   VEuPathDB; FungiDB:NCU02631; -.
DR   HOGENOM; CLU_079191_0_0_1; -.
DR   InParanoid; Q7SDH9; -.
DR   Proteomes; UP000001805; Chromosome 1, Linkage Group I.
DR   GO; GO:0071162; C:CMG complex; IEA:EnsemblFungi.
DR   GO; GO:0000811; C:GINS complex; IBA:GO_Central.
DR   GO; GO:0031298; C:replication fork protection complex; IEA:EnsemblFungi.
DR   GO; GO:1902983; P:DNA strand elongation involved in mitotic DNA replication; IBA:GO_Central.
DR   GO; GO:0006268; P:DNA unwinding involved in DNA replication; IEA:EnsemblFungi.
DR   GO; GO:0000727; P:double-strand break repair via break-induced replication; IEA:EnsemblFungi.
DR   GO; GO:1902975; P:mitotic DNA replication initiation; IEA:EnsemblFungi.
DR   CDD; cd11710; GINS_A_psf1; 1.
DR   InterPro; IPR021151; GINS_A.
DR   InterPro; IPR036224; GINS_bundle-like_dom_sf.
DR   InterPro; IPR005339; GINS_Psf1.
DR   PANTHER; PTHR12914; PTHR12914; 1.
DR   Pfam; PF05916; Sld5; 1.
DR   SUPFAM; SSF158573; SSF158573; 1.
PE   3: Inferred from homology;
KW   DNA replication; Nucleus; Reference proteome.
FT   CHAIN           1..216
FT                   /note="DNA replication complex GINS protein psf1"
FT                   /id="PRO_0000278404"
FT   REGION          110..133
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   216 AA;  24153 MW;  88E1AE3394567079 CRC64;
     MPMYGDLGNK LVQHAKRTQN LSHLPPYQTE LVRAVAREIR DLDKDVASLL EPFQGSFDPS
     AEQATACTLL VNHLSMRRNK RCLLAYHRIR TDKLEELVWN GADILDLAGQ TTGGPKGVTE
     GNEGGGTTSS LSPQEEDYFR QFGDLLALYK GQWTDIDLTG SLEPPRDLFI DVRVLKDAGE
     IQTEYGAINL TKNSQFYVRQ GDVERLIVQG YLQKLG