PSF1_XENLA
ID PSF1_XENLA Reviewed; 196 AA.
AC Q7ZT47;
DT 02-DEC-2020, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2003, sequence version 1.
DT 03-AUG-2022, entry version 99.
DE RecName: Full=DNA replication complex GINS protein PSF1;
DE AltName: Full=GINS complex subunit 1;
GN Name=gins1 {ECO:0000312|Xenbase:XB-GENE-6251527};
GN Synonyms=Psf1 {ECO:0000312|EMBL:BAC66458.1};
GN ORFNames=XELAEV_18028879mg {ECO:0000312|EMBL:OCT77784.1};
OS Xenopus laevis (African clawed frog).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX NCBI_TaxID=8355;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION, IDENTIFICATION IN THE GINS
RP COMPLEX, AND SUBCELLULAR LOCATION.
RX PubMed=12730133; DOI=10.1101/gad.1070003;
RA Kubota Y., Takase Y., Komori Y., Hashimoto Y., Arata T., Kamimura Y.,
RA Araki H., Takisawa H.;
RT "A novel ring-like complex of Xenopus proteins essential for the initiation
RT of DNA replication.";
RL Genes Dev. 17:1141-1152(2003).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=J;
RX PubMed=27762356; DOI=10.1038/nature19840;
RA Session A.M., Uno Y., Kwon T., Chapman J.A., Toyoda A., Takahashi S.,
RA Fukui A., Hikosaka A., Suzuki A., Kondo M., van Heeringen S.J., Quigley I.,
RA Heinz S., Ogino H., Ochi H., Hellsten U., Lyons J.B., Simakov O.,
RA Putnam N., Stites J., Kuroki Y., Tanaka T., Michiue T., Watanabe M.,
RA Bogdanovic O., Lister R., Georgiou G., Paranjpe S.S., van Kruijsbergen I.,
RA Shu S., Carlson J., Kinoshita T., Ohta Y., Mawaribuchi S., Jenkins J.,
RA Grimwood J., Schmutz J., Mitros T., Mozaffari S.V., Suzuki Y., Haramoto Y.,
RA Yamamoto T.S., Takagi C., Heald R., Miller K., Haudenschild C., Kitzman J.,
RA Nakayama T., Izutsu Y., Robert J., Fortriede J., Burns K., Lotay V.,
RA Karimi K., Yasuoka Y., Dichmann D.S., Flajnik M.F., Houston D.W.,
RA Shendure J., DuPasquier L., Vize P.D., Zorn A.M., Ito M., Marcotte E.M.,
RA Wallingford J.B., Ito Y., Asashima M., Ueno N., Matsuda Y., Veenstra G.J.,
RA Fujiyama A., Harland R.M., Taira M., Rokhsar D.S.;
RT "Genome evolution in the allotetraploid frog Xenopus laevis.";
RL Nature 538:336-343(2016).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Ovary;
RG NIH - Xenopus Gene Collection (XGC) project;
RL Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP IDENTIFICATION IN THE CMG HELICASE COMPLEX.
RX PubMed=30979826; DOI=10.26508/lsa.201900390;
RA Priego Moreno S., Jones R.M., Poovathumkadavil D., Scaramuzza S.,
RA Gambus A.;
RT "Mitotic replisome disassembly depends on TRAIP ubiquitin ligase
RT activity.";
RL Life. Sci Alliance 2:0-0(2019).
RN [5]
RP IDENTIFICATION IN THE CMG HELICASE COMPLEX.
RX PubMed=30842657; DOI=10.1038/s41586-019-1002-0;
RA Wu R.A., Semlow D.R., Kamimae-Lanning A.N., Kochenova O.V., Chistol G.,
RA Hodskinson M.R., Amunugama R., Sparks J.L., Wang M., Deng L., Mimoso C.A.,
RA Low E., Patel K.J., Walter J.C.;
RT "TRAIP is a master regulator of DNA interstrand crosslink repair.";
RL Nature 567:267-272(2019).
CC -!- FUNCTION: Required for correct functioning of the GINS complex, a
CC complex that plays an essential role in the initiation of DNA
CC replication, and progression of DNA replication forks
CC (PubMed:12730133). GINS complex seems to bind preferentially to single-
CC stranded DNA (By similarity). {ECO:0000250|UniProtKB:Q14691,
CC ECO:0000269|PubMed:12730133}.
CC -!- SUBUNIT: Component of the GINS complex which is a heterotetramer of
CC gins1/psf1, gins2/psf2, gins3/psf3 and gins4/sld5 (PubMed:12730133).
CC Component of the CMG helicase complex, composed of the mcm2-7 complex,
CC the GINS complex and cdc45 (PubMed:30979826, PubMed:30842657).
CC {ECO:0000269|PubMed:12730133, ECO:0000269|PubMed:30842657,
CC ECO:0000269|PubMed:30979826}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:12730133}. Chromosome
CC {ECO:0000269|PubMed:12730133}. Note=Associates with chromatin.
CC {ECO:0000269|PubMed:12730133}.
CC -!- SIMILARITY: Belongs to the GINS1/PSF1 family. {ECO:0000305}.
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DR EMBL; AB097168; BAC66458.1; -; Genomic_DNA.
DR EMBL; CM004475; OCT77784.1; -; Genomic_DNA.
DR EMBL; BC072857; AAH72857.1; -; mRNA.
DR RefSeq; NP_001085502.1; NM_001092033.1.
DR AlphaFoldDB; Q7ZT47; -.
DR SMR; Q7ZT47; -.
DR STRING; 8355.Q7ZT47; -.
DR MaxQB; Q7ZT47; -.
DR DNASU; 443928; -.
DR GeneID; 443928; -.
DR KEGG; xla:443928; -.
DR CTD; 443928; -.
DR Xenbase; XB-GENE-6251527; gins1.S.
DR OMA; NHLCMRR; -.
DR OrthoDB; 1249159at2759; -.
DR Proteomes; UP000186698; Chromosome 5S.
DR Bgee; 443928; Expressed in oocyte and 19 other tissues.
DR GO; GO:0071162; C:CMG complex; IDA:UniProtKB.
DR GO; GO:0000811; C:GINS complex; IPI:UniProtKB.
DR GO; GO:0003682; F:chromatin binding; IDA:UniProtKB.
DR GO; GO:0006260; P:DNA replication; IMP:UniProtKB.
DR CDD; cd11710; GINS_A_psf1; 1.
DR InterPro; IPR021151; GINS_A.
DR InterPro; IPR036224; GINS_bundle-like_dom_sf.
DR InterPro; IPR005339; GINS_Psf1.
DR PANTHER; PTHR12914; PTHR12914; 1.
DR Pfam; PF05916; Sld5; 1.
DR SUPFAM; SSF158573; SSF158573; 1.
PE 1: Evidence at protein level;
KW Chromosome; DNA replication; Nucleus; Reference proteome.
FT CHAIN 1..196
FT /note="DNA replication complex GINS protein PSF1"
FT /id="PRO_0000451423"
SQ SEQUENCE 196 AA; 23139 MW; 18EDCE6DD79128F3 CRC64;
MFCEKAIELI RELQRASDGQ LPAFNEDGIR QILEEMKALY EQNQADVNEA KTEGRSDLIP
TIKFRHCCLL RNRRCIVAYL YDRLLRIRAL RWEYGSVLPS ALRFHMSTEE MDWFNQYKRS
LATYMRSLGG EEGLDITQDM KPPKSLYIEV RCLRDYGEFE IDDGTTILLK KNSQHFLPRW
KCEQLIRQGV LEHVLS
