ID   PSF2_COCIM              Reviewed;         268 AA.
AC   Q1DNY1; J3K586;
DT   20-FEB-2007, integrated into UniProtKB/Swiss-Prot.
DT   11-JUL-2006, sequence version 1.
DT   03-AUG-2022, entry version 69.
DE   RecName: Full=DNA replication complex GINS protein PSF2;
GN   Name=PSF2; ORFNames=CIMG_07982;
OS   Coccidioides immitis (strain RS) (Valley fever fungus).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Onygenales; Onygenaceae; Coccidioides.
OX   NCBI_TaxID=246410;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=RS;
RX   PubMed=19717792; DOI=10.1101/gr.087551.108;
RA   Sharpton T.J., Stajich J.E., Rounsley S.D., Gardner M.J., Wortman J.R.,
RA   Jordar V.S., Maiti R., Kodira C.D., Neafsey D.E., Zeng Q., Hung C.-Y.,
RA   McMahan C., Muszewska A., Grynberg M., Mandel M.A., Kellner E.M.,
RA   Barker B.M., Galgiani J.N., Orbach M.J., Kirkland T.N., Cole G.T.,
RA   Henn M.R., Birren B.W., Taylor J.W.;
RT   "Comparative genomic analyses of the human fungal pathogens Coccidioides
RT   and their relatives.";
RL   Genome Res. 19:1722-1731(2009).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=RS;
RX   PubMed=20516208; DOI=10.1101/gr.103911.109;
RA   Neafsey D.E., Barker B.M., Sharpton T.J., Stajich J.E., Park D.J.,
RA   Whiston E., Hung C.-Y., McMahan C., White J., Sykes S., Heiman D.,
RA   Young S., Zeng Q., Abouelleil A., Aftuck L., Bessette D., Brown A.,
RA   FitzGerald M., Lui A., Macdonald J.P., Priest M., Orbach M.J.,
RA   Galgiani J.N., Kirkland T.N., Cole G.T., Birren B.W., Henn M.R.,
RA   Taylor J.W., Rounsley S.D.;
RT   "Population genomic sequencing of Coccidioides fungi reveals recent
RT   hybridization and transposon control.";
RL   Genome Res. 20:938-946(2010).
CC   -!- FUNCTION: The GINS complex plays an essential role in the initiation of
CC       DNA replication. Has a role in chromosome segregation (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBUNIT: Component of the GINS complex which is a heterotetramer of
CC       SLD5, PSF1, PSF2 and PSF3. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the GINS2/PSF2 family. {ECO:0000305}.
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DR   EMBL; GG704913; EAS29236.3; -; Genomic_DNA.
DR   RefSeq; XP_001240819.1; XM_001240818.2.
DR   AlphaFoldDB; Q1DNY1; -.
DR   SMR; Q1DNY1; -.
DR   STRING; 246410.Q1DNY1; -.
DR   EnsemblFungi; EAS29236; EAS29236; CIMG_07982.
DR   GeneID; 4559422; -.
DR   KEGG; cim:CIMG_07982; -.
DR   VEuPathDB; FungiDB:CIMG_07982; -.
DR   InParanoid; Q1DNY1; -.
DR   OMA; PYHWLEL; -.
DR   OrthoDB; 1382842at2759; -.
DR   Proteomes; UP000001261; Unassembled WGS sequence.
DR   GO; GO:0000228; C:nuclear chromosome; IEA:UniProt.
DR   GO; GO:0007059; P:chromosome segregation; IEA:UniProtKB-KW.
DR   GO; GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
DR   InterPro; IPR021151; GINS_A.
DR   InterPro; IPR036224; GINS_bundle-like_dom_sf.
DR   InterPro; IPR007257; GINS_Psf2.
DR   PANTHER; PTHR12772; PTHR12772; 1.
DR   Pfam; PF05916; Sld5; 1.
DR   PIRSF; PIRSF028998; GINS_Psf2_subgr; 1.
DR   SUPFAM; SSF158573; SSF158573; 1.
PE   3: Inferred from homology;
KW   Chromosome partition; DNA replication; Nucleus; Reference proteome.
FT   CHAIN           1..268
FT                   /note="DNA replication complex GINS protein PSF2"
FT                   /id="PRO_0000278409"
FT   REGION          245..268
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   268 AA;  30128 MW;  E7150983C2766929 CRC64;
     MAFPLPRGVT PSEITFLCEM EMVTIVPRQR LEGLELLGGP TEPLIPPRRS SLPLWLALLL
     KRQRRANILP PPWLNTEWLS EFLKAETDHD VFLPPPPLDC ASYTGSVARR DARRSGHSGP
     RRTLDGQRYI PSAPFLLQNV VDDESTAPRN PWLPYHWLEL ATMLLETASD DLVEPDQIRR
     IIRDIREIRM AKMRKFTEYV DATAIGGGEG LPLTGVGAME IGEARGFMSG AAETLRQIGA
     SKEEALREQA EAGDDLRNDY DEDDEMEL