ID   PSF2_CRYNJ              Reviewed;         185 AA.
AC   P0CQ30; Q55WB8; Q5KJY1;
DT   28-JUN-2011, integrated into UniProtKB/Swiss-Prot.
DT   28-JUN-2011, sequence version 1.
DT   25-MAY-2022, entry version 46.
DE   RecName: Full=DNA replication complex GINS protein PSF2;
GN   Name=PSF2; OrderedLocusNames=CNC04970;
OS   Cryptococcus neoformans var. neoformans serotype D (strain JEC21 / ATCC
OS   MYA-565) (Filobasidiella neoformans).
OC   Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina; Tremellomycetes;
OC   Tremellales; Cryptococcaceae; Cryptococcus;
OC   Cryptococcus neoformans species complex.
OX   NCBI_TaxID=214684;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=JEC21 / ATCC MYA-565;
RX   PubMed=15653466; DOI=10.1126/science.1103773;
RA   Loftus B.J., Fung E., Roncaglia P., Rowley D., Amedeo P., Bruno D.,
RA   Vamathevan J., Miranda M., Anderson I.J., Fraser J.A., Allen J.E.,
RA   Bosdet I.E., Brent M.R., Chiu R., Doering T.L., Donlin M.J., D'Souza C.A.,
RA   Fox D.S., Grinberg V., Fu J., Fukushima M., Haas B.J., Huang J.C.,
RA   Janbon G., Jones S.J.M., Koo H.L., Krzywinski M.I., Kwon-Chung K.J.,
RA   Lengeler K.B., Maiti R., Marra M.A., Marra R.E., Mathewson C.A.,
RA   Mitchell T.G., Pertea M., Riggs F.R., Salzberg S.L., Schein J.E.,
RA   Shvartsbeyn A., Shin H., Shumway M., Specht C.A., Suh B.B., Tenney A.,
RA   Utterback T.R., Wickes B.L., Wortman J.R., Wye N.H., Kronstad J.W.,
RA   Lodge J.K., Heitman J., Davis R.W., Fraser C.M., Hyman R.W.;
RT   "The genome of the basidiomycetous yeast and human pathogen Cryptococcus
RT   neoformans.";
RL   Science 307:1321-1324(2005).
CC   -!- FUNCTION: The GINS complex plays an essential role in the initiation of
CC       DNA replication. Has a role in chromosome segregation (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBUNIT: Component of the GINS complex which is a heterotetramer of
CC       SLD5, PSF1, PSF2 and PSF3. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the GINS2/PSF2 family. {ECO:0000305}.
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DR   EMBL; AE017343; AAW42713.1; -; Genomic_DNA.
DR   RefSeq; XP_570020.1; XM_570020.1.
DR   AlphaFoldDB; P0CQ30; -.
DR   SMR; P0CQ30; -.
DR   STRING; 5207.AAW42713; -.
DR   PaxDb; P0CQ30; -.
DR   eggNOG; KOG4071; Eukaryota.
DR   HOGENOM; CLU_078274_1_0_1; -.
DR   InParanoid; P0CQ30; -.
DR   OMA; PYHWLEL; -.
DR   OrthoDB; 1382842at2759; -.
DR   Proteomes; UP000002149; Chromosome 3.
DR   GO; GO:0000811; C:GINS complex; IBA:GO_Central.
DR   GO; GO:0007059; P:chromosome segregation; IEA:UniProtKB-KW.
DR   GO; GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
DR   GO; GO:0000727; P:double-strand break repair via break-induced replication; IBA:GO_Central.
DR   InterPro; IPR021151; GINS_A.
DR   InterPro; IPR036224; GINS_bundle-like_dom_sf.
DR   InterPro; IPR007257; GINS_Psf2.
DR   PANTHER; PTHR12772; PTHR12772; 1.
DR   Pfam; PF05916; Sld5; 1.
DR   PIRSF; PIRSF028998; GINS_Psf2_subgr; 1.
DR   SUPFAM; SSF158573; SSF158573; 1.
PE   3: Inferred from homology;
KW   Chromosome partition; DNA replication; Nucleus; Reference proteome.
FT   CHAIN           1..185
FT                   /note="DNA replication complex GINS protein PSF2"
FT                   /id="PRO_0000255423"
SQ   SEQUENCE   185 AA;  21138 MW;  1993A13A7529AAED CRC64;
     MALPKTLHPA LTPDELAFLA EHDHISIVPL FSMTRVRLIS GIYGPFRPPS ASRVPLWLGL
     SLKKKRKCRI VPPEWLSAER LQAFLRDEKE NSEGFERLPR RFMEISKVLL DIASDDLSQP
     TLLRSLLKDI REVRQAKIRM GLQSEDVLQN DYLQVMPFSS LCPVALRRHL TRYGIGDQSH
     SLGTV