PSF2_DICDI
ID PSF2_DICDI Reviewed; 223 AA.
AC Q54BL9;
DT 08-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT 24-MAY-2005, sequence version 1.
DT 25-MAY-2022, entry version 91.
DE RecName: Full=Probable DNA replication complex GINS protein PSF2;
DE AltName: Full=GINS complex subunit 2;
GN Name=gins2; ORFNames=DDB_G0293564;
OS Dictyostelium discoideum (Slime mold).
OC Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC Dictyosteliaceae; Dictyostelium.
OX NCBI_TaxID=44689;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4;
RX PubMed=15875012; DOI=10.1038/nature03481;
RA Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT "The genome of the social amoeba Dictyostelium discoideum.";
RL Nature 435:43-57(2005).
CC -!- FUNCTION: The GINS complex plays an essential role in the initiation of
CC DNA replication. {ECO:0000250}.
CC -!- SUBUNIT: Component of the GINS complex which is a heterotetramer of
CC gins1, gins2, gins3 and gins4. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the GINS2/PSF2 family. {ECO:0000305}.
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DR EMBL; AAFI02000218; EAL60594.1; -; Genomic_DNA.
DR RefSeq; XP_629010.1; XM_629008.1.
DR AlphaFoldDB; Q54BL9; -.
DR SMR; Q54BL9; -.
DR STRING; 44689.DDB0266354; -.
DR PaxDb; Q54BL9; -.
DR EnsemblProtists; EAL60594; EAL60594; DDB_G0293564.
DR GeneID; 8629294; -.
DR KEGG; ddi:DDB_G0293564; -.
DR dictyBase; DDB_G0293564; gins2.
DR eggNOG; KOG4071; Eukaryota.
DR HOGENOM; CLU_078274_1_1_1; -.
DR InParanoid; Q54BL9; -.
DR OMA; PYHWLEL; -.
DR PhylomeDB; Q54BL9; -.
DR Reactome; R-DDI-176974; Unwinding of DNA.
DR PRO; PR:Q54BL9; -.
DR Proteomes; UP000002195; Chromosome 6.
DR GO; GO:0000811; C:GINS complex; ISS:dictyBase.
DR GO; GO:0043138; F:3'-5' DNA helicase activity; ISS:dictyBase.
DR GO; GO:0006260; P:DNA replication; ISS:dictyBase.
DR GO; GO:0000727; P:double-strand break repair via break-induced replication; IBA:GO_Central.
DR InterPro; IPR021151; GINS_A.
DR InterPro; IPR036224; GINS_bundle-like_dom_sf.
DR InterPro; IPR007257; GINS_Psf2.
DR PANTHER; PTHR12772; PTHR12772; 1.
DR Pfam; PF05916; Sld5; 1.
DR PIRSF; PIRSF028998; GINS_Psf2_subgr; 1.
DR SUPFAM; SSF158573; SSF158573; 1.
PE 3: Inferred from homology;
KW DNA replication; Nucleus; Reference proteome.
FT CHAIN 1..223
FT /note="Probable DNA replication complex GINS protein PSF2"
FT /id="PRO_0000327219"
FT REGION 179..223
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 223 AA; 25318 MW; A6F14C8544373108 CRC64;
MEDIGLLPSQ IEFLAEDTTI TVVPNFKMES LIFLSGEYGP FVPSFPIEIP LWLAISLKKK
KKCTITPPDW MTYNKLKAKF QEENKIKDGF IELPENFDEI SSLLLANCPD DIKDINKIRI
LKGDILSRRE KKLEESLKSH LNSLTDGESV TTMEFKNFSM MEINKIRASY VSGINDLNKI
QNSDNDNNNN NNNNNSNNNN NNNNSQQSQS ASNASSRSLF SKK