PSF2_NEUCR
ID PSF2_NEUCR Reviewed; 273 AA.
AC Q7SAA9; V5IM97;
DT 20-FEB-2007, integrated into UniProtKB/Swiss-Prot.
DT 15-DEC-2003, sequence version 1.
DT 25-MAY-2022, entry version 98.
DE RecName: Full=DNA replication complex GINS protein psf2;
DE AltName: Full=DNA replication complex protein 2;
GN Name=drc-2; Synonyms=psf2; ORFNames=NCU06322;
OS Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 /
OS FGSC 987).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC Sordariomycetidae; Sordariales; Sordariaceae; Neurospora.
OX NCBI_TaxID=367110;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987;
RX PubMed=12712197; DOI=10.1038/nature01554;
RA Galagan J.E., Calvo S.E., Borkovich K.A., Selker E.U., Read N.D.,
RA Jaffe D.B., FitzHugh W., Ma L.-J., Smirnov S., Purcell S., Rehman B.,
RA Elkins T., Engels R., Wang S., Nielsen C.B., Butler J., Endrizzi M.,
RA Qui D., Ianakiev P., Bell-Pedersen D., Nelson M.A., Werner-Washburne M.,
RA Selitrennikoff C.P., Kinsey J.A., Braun E.L., Zelter A., Schulte U.,
RA Kothe G.O., Jedd G., Mewes H.-W., Staben C., Marcotte E., Greenberg D.,
RA Roy A., Foley K., Naylor J., Stange-Thomann N., Barrett R., Gnerre S.,
RA Kamal M., Kamvysselis M., Mauceli E.W., Bielke C., Rudd S., Frishman D.,
RA Krystofova S., Rasmussen C., Metzenberg R.L., Perkins D.D., Kroken S.,
RA Cogoni C., Macino G., Catcheside D.E.A., Li W., Pratt R.J., Osmani S.A.,
RA DeSouza C.P.C., Glass N.L., Orbach M.J., Berglund J.A., Voelker R.,
RA Yarden O., Plamann M., Seiler S., Dunlap J.C., Radford A., Aramayo R.,
RA Natvig D.O., Alex L.A., Mannhaupt G., Ebbole D.J., Freitag M., Paulsen I.,
RA Sachs M.S., Lander E.S., Nusbaum C., Birren B.W.;
RT "The genome sequence of the filamentous fungus Neurospora crassa.";
RL Nature 422:859-868(2003).
CC -!- FUNCTION: The GINS complex plays an essential role in the initiation of
CC DNA replication. Has a role in chromosome segregation (By similarity).
CC {ECO:0000250}.
CC -!- SUBUNIT: Component of the GINS complex which is a heterotetramer of
CC div-26/sld5, drc-1/psf1, drc-2/psf2 and drc-3/psf3. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the GINS2/PSF2 family. {ECO:0000305}.
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DR EMBL; CM002239; ESA42918.1; -; Genomic_DNA.
DR EMBL; CM002239; ESA42919.1; -; Genomic_DNA.
DR RefSeq; XP_011394164.1; XM_011395862.1.
DR RefSeq; XP_011394165.1; XM_011395863.1.
DR AlphaFoldDB; Q7SAA9; -.
DR SMR; Q7SAA9; -.
DR STRING; 5141.EFNCRP00000006084; -.
DR EnsemblFungi; ESA42918; ESA42918; NCU06322.
DR EnsemblFungi; ESA42919; ESA42919; NCU06322.
DR GeneID; 3878718; -.
DR KEGG; ncr:NCU06322; -.
DR VEuPathDB; FungiDB:NCU06322; -.
DR HOGENOM; CLU_078274_0_0_1; -.
DR InParanoid; Q7SAA9; -.
DR OMA; PYHWLEL; -.
DR Proteomes; UP000001805; Chromosome 4, Linkage Group IV.
DR GO; GO:0000811; C:GINS complex; IBA:GO_Central.
DR GO; GO:0007059; P:chromosome segregation; IEA:UniProtKB-KW.
DR GO; GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
DR GO; GO:0000727; P:double-strand break repair via break-induced replication; IBA:GO_Central.
DR InterPro; IPR021151; GINS_A.
DR InterPro; IPR036224; GINS_bundle-like_dom_sf.
DR InterPro; IPR007257; GINS_Psf2.
DR PANTHER; PTHR12772; PTHR12772; 1.
DR Pfam; PF05916; Sld5; 1.
DR PIRSF; PIRSF028998; GINS_Psf2_subgr; 1.
DR SUPFAM; SSF158573; SSF158573; 1.
PE 3: Inferred from homology;
KW Chromosome partition; DNA replication; Nucleus; Reference proteome.
FT CHAIN 1..273
FT /note="DNA replication complex GINS protein psf2"
FT /id="PRO_0000278411"
FT REGION 88..110
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 240..273
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 240..261
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 273 AA; 29830 MW; 3750580045E23CF6 CRC64;
MALPLPPGLT QNEVAFLAEM EMVTVVPRQR LDSIDLLGGK TPQLRPPHRA QLPLWLALLL
KKQRRANIVP PAWMHPASLA EIIHRETKED PEAFSPPPPP PSRALYSQPG TARRLNPSYL
DDFTQTQQDS QQDPNSILSP PFLPSNVAES PAGYLPYHWL EVAEALLTHA GDDMPAPAGE
VRSLLRDLVE VRAAKMRSST SALEGFGDAY LTLRGVGAME LAENRAFLAG LVDGVRKIGA
SAEATRREEE EEARRGGDYG GDGDEDSDED MGL