PSF2_SCHPO
ID PSF2_SCHPO Reviewed; 183 AA.
AC O94329;
DT 24-OCT-2003, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-1999, sequence version 1.
DT 25-MAY-2022, entry version 126.
DE RecName: Full=DNA replication complex GINS protein psf2;
GN Name=psf2; Synonyms=bsh3, dre13; ORFNames=SPBC725.13c;
OS Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC Schizosaccharomyces.
OX NCBI_TaxID=284812;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=972 / ATCC 24843;
RX PubMed=11859360; DOI=10.1038/nature724;
RA Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.,
RA Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S.,
RA Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S.,
RA Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D.,
RA Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P.,
RA Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K.,
RA O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M.,
RA Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N.,
RA Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A.,
RA Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R.,
RA Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M.,
RA Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A.,
RA Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A.,
RA Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H.,
RA Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S.,
RA Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C.,
RA Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A.,
RA Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M.,
RA del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S.,
RA Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R.,
RA Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G.,
RA Nurse P.;
RT "The genome sequence of Schizosaccharomyces pombe.";
RL Nature 415:871-880(2002).
RN [2]
RP FUNCTION, INTERACTION WITH SLD5, SUBCELLULAR LOCATION, AND MUTAGENESIS OF
RP ARG-133.
RX PubMed=16199877; DOI=10.1128/mcb.25.20.9000-9015.2005;
RA Huang H.-K., Bailis J.M., Leverson J.D., Gomez E.B., Forsburg S.L.,
RA Hunter T.;
RT "Suppressors of Bir1p (Survivin) identify roles for the chromosomal
RT passenger protein Pic1p (INCENP) and the replication initiation factor
RT Psf2p in chromosome segregation.";
RL Mol. Cell. Biol. 25:9000-9015(2005).
RN [3]
RP SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
RX PubMed=16823372; DOI=10.1038/nbt1222;
RA Matsuyama A., Arai R., Yashiroda Y., Shirai A., Kamata A., Sekido S.,
RA Kobayashi Y., Hashimoto A., Hamamoto M., Hiraoka Y., Horinouchi S.,
RA Yoshida M.;
RT "ORFeome cloning and global analysis of protein localization in the fission
RT yeast Schizosaccharomyces pombe.";
RL Nat. Biotechnol. 24:841-847(2006).
CC -!- FUNCTION: The GINS complex plays an essential role in the initiation of
CC DNA replication. Has a role in chromosome segregation and is required
CC for bir1 localization. {ECO:0000269|PubMed:16199877}.
CC -!- SUBUNIT: Component of the GINS complex which is a heterotetramer of
CC sld5, psf1, psf2 and psf3. Interacts with sld5.
CC {ECO:0000269|PubMed:16199877}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:16199877,
CC ECO:0000269|PubMed:16823372}.
CC -!- SIMILARITY: Belongs to the GINS2/PSF2 family. {ECO:0000305}.
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DR EMBL; CU329671; CAA22185.1; -; Genomic_DNA.
DR PIR; T40665; T40665.
DR RefSeq; NP_595493.1; NM_001021404.2.
DR AlphaFoldDB; O94329; -.
DR SMR; O94329; -.
DR BioGRID; 277708; 16.
DR IntAct; O94329; 5.
DR MINT; O94329; -.
DR STRING; 4896.SPBC725.13c.1; -.
DR PaxDb; O94329; -.
DR EnsemblFungi; SPBC725.13c.1; SPBC725.13c.1:pep; SPBC725.13c.
DR GeneID; 2541194; -.
DR KEGG; spo:SPBC725.13c; -.
DR PomBase; SPBC725.13c; psf2.
DR VEuPathDB; FungiDB:SPBC725.13c; -.
DR eggNOG; KOG4071; Eukaryota.
DR HOGENOM; CLU_078274_1_0_1; -.
DR InParanoid; O94329; -.
DR OMA; MENTQYL; -.
DR PhylomeDB; O94329; -.
DR Reactome; R-SPO-176974; Unwinding of DNA.
DR PRO; PR:O94329; -.
DR Proteomes; UP000002485; Chromosome II.
DR GO; GO:0000785; C:chromatin; IDA:PomBase.
DR GO; GO:0005829; C:cytosol; HDA:PomBase.
DR GO; GO:0000811; C:GINS complex; ISO:PomBase.
DR GO; GO:0043596; C:nuclear replication fork; IC:PomBase.
DR GO; GO:0005634; C:nucleus; IDA:PomBase.
DR GO; GO:0007059; P:chromosome segregation; IEA:UniProtKB-KW.
DR GO; GO:0000727; P:double-strand break repair via break-induced replication; IBA:GO_Central.
DR GO; GO:1902969; P:mitotic DNA replication; IMP:PomBase.
DR GO; GO:1902975; P:mitotic DNA replication initiation; TAS:PomBase.
DR InterPro; IPR021151; GINS_A.
DR InterPro; IPR036224; GINS_bundle-like_dom_sf.
DR InterPro; IPR007257; GINS_Psf2.
DR PANTHER; PTHR12772; PTHR12772; 1.
DR Pfam; PF05916; Sld5; 1.
DR PIRSF; PIRSF028998; GINS_Psf2_subgr; 1.
DR SUPFAM; SSF158573; SSF158573; 1.
PE 1: Evidence at protein level;
KW Chromosome partition; DNA replication; Nucleus; Reference proteome.
FT CHAIN 1..183
FT /note="DNA replication complex GINS protein psf2"
FT /id="PRO_0000194821"
FT MUTAGEN 133
FT /note="R->K: In psf2-209; temperature-sensitive."
FT /evidence="ECO:0000269|PubMed:16199877"
SQ SEQUENCE 183 AA; 21342 MW; 3A11534AFF3C4D2A CRC64;
MALPRELEIS FSPEEMEFLA GNEYINIVPS ETMDQLPLVS ATIPIMKPPK KCRVPLWLAL
ELKKQNLARI VPPEWMEIGK LENIRDDELE NETFSELPFR WLETAHLLLN FCADDIEDVE
DIRRILLDIR EARQSKARTG LEAINEVQLT LDNLGAMEIN EIRPIFREVM DRMRKIVQVS
QEE
