ID   PSF2_XENLA              Reviewed;         185 AA.
AC   Q7ZT46; Q6GPR6;
DT   24-OCT-2003, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2003, sequence version 1.
DT   03-AUG-2022, entry version 72.
DE   RecName: Full=DNA replication complex GINS protein PSF2;
DE   AltName: Full=GINS complex subunit 2;
GN   Name=gins2; Synonyms=psf2;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION, IDENTIFICATION IN THE GINS
RP   COMPLEX, AND SUBCELLULAR LOCATION.
RX   PubMed=12730133; DOI=10.1101/gad.1070003;
RA   Kubota Y., Takase Y., Komori Y., Hashimoto Y., Arata T., Kamimura Y.,
RA   Araki H., Takisawa H.;
RT   "A novel ring-like complex of Xenopus proteins essential for the initiation
RT   of DNA replication.";
RL   Genes Dev. 17:1141-1152(2003).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Ovary;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.
RN   [3]
RP   IDENTIFICATION IN THE CMG HELICASE COMPLEX.
RX   PubMed=30979826; DOI=10.26508/lsa.201900390;
RA   Priego Moreno S., Jones R.M., Poovathumkadavil D., Scaramuzza S.,
RA   Gambus A.;
RT   "Mitotic replisome disassembly depends on TRAIP ubiquitin ligase
RT   activity.";
RL   Life. Sci Alliance 2:0-0(2019).
RN   [4]
RP   IDENTIFICATION IN THE CMG HELICASE COMPLEX.
RX   PubMed=30842657; DOI=10.1038/s41586-019-1002-0;
RA   Wu R.A., Semlow D.R., Kamimae-Lanning A.N., Kochenova O.V., Chistol G.,
RA   Hodskinson M.R., Amunugama R., Sparks J.L., Wang M., Deng L., Mimoso C.A.,
RA   Low E., Patel K.J., Walter J.C.;
RT   "TRAIP is a master regulator of DNA interstrand crosslink repair.";
RL   Nature 567:267-272(2019).
CC   -!- FUNCTION: The GINS complex plays an essential role in the initiation of
CC       DNA replication. {ECO:0000269|PubMed:12730133}.
CC   -!- SUBUNIT: Component of the GINS complex which is a heterotetramer of
CC       gins1/psf1, gins2/psf2, gins3/psf3 and gins4/sld5 (PubMed:12730133).
CC       Component of the CMG helicase complex, composed of the mcm2-7 complex,
CC       the GINS complex and cdc45 (PubMed:30979826) (Probable).
CC       {ECO:0000269|PubMed:12730133, ECO:0000269|PubMed:30979826,
CC       ECO:0000305|PubMed:30842657}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:12730133}. Chromosome
CC       {ECO:0000269|PubMed:12730133}. Note=Associates with chromatin.
CC       {ECO:0000269|PubMed:12730133}.
CC   -!- SIMILARITY: Belongs to the GINS2/PSF2 family. {ECO:0000305}.
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DR   EMBL; AB097169; BAC66459.1; -; Genomic_DNA.
DR   EMBL; BC073044; AAH73044.1; -; mRNA.
DR   RefSeq; NP_001085627.1; NM_001092158.1.
DR   AlphaFoldDB; Q7ZT46; -.
DR   SMR; Q7ZT46; -.
DR   MaxQB; Q7ZT46; -.
DR   DNASU; 444053; -.
DR   GeneID; 444053; -.
DR   KEGG; xla:444053; -.
DR   CTD; 444053; -.
DR   Xenbase; XB-GENE-6256252; gins2.L.
DR   OMA; PYHWLEL; -.
DR   OrthoDB; 1382842at2759; -.
DR   Proteomes; UP000186698; Chromosome 4L.
DR   Bgee; 444053; Expressed in blastula and 19 other tissues.
DR   GO; GO:0071162; C:CMG complex; IDA:UniProtKB.
DR   GO; GO:0000811; C:GINS complex; IPI:UniProtKB.
DR   GO; GO:0005654; C:nucleoplasm; TAS:Reactome.
DR   GO; GO:0005634; C:nucleus; IDA:UniProtKB.
DR   GO; GO:0003682; F:chromatin binding; IDA:UniProtKB.
DR   GO; GO:0006260; P:DNA replication; IMP:UniProtKB.
DR   GO; GO:0006271; P:DNA strand elongation involved in DNA replication; IDA:UniProtKB.
DR   GO; GO:0032784; P:regulation of DNA-templated transcription, elongation; IDA:UniProtKB.
DR   InterPro; IPR021151; GINS_A.
DR   InterPro; IPR036224; GINS_bundle-like_dom_sf.
DR   InterPro; IPR007257; GINS_Psf2.
DR   PANTHER; PTHR12772; PTHR12772; 1.
DR   Pfam; PF05916; Sld5; 1.
DR   PIRSF; PIRSF028998; GINS_Psf2_subgr; 1.
DR   SUPFAM; SSF158573; SSF158573; 1.
PE   1: Evidence at protein level;
KW   Chromosome; DNA replication; Nucleus; Reference proteome.
FT   CHAIN           1..185
FT                   /note="DNA replication complex GINS protein PSF2"
FT                   /id="PRO_0000194815"
SQ   SEQUENCE   185 AA;  21324 MW;  F6DAC1CC608F5FD0 CRC64;
     MDASEVEFLA EKEQVTVIPN FSLDKVYLIG GDLGPFNPSL PVEVPLWLAI NLKQRQKCRI
     VPPEWMDVEK LEAIRDQERR EETFTPMPSP YYMELTKLLL NHAADNIPKA DEIRTLVKDT
     WDTRIAKLRL SADSFVKGQE AHAKLDNLTL MEINTIGTFF TESLNHMYKL RTSLQNPEEG
     QSQDY