ID   PSF3_BOVIN              Reviewed;         216 AA.
AC   Q08E12;
DT   08-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT   31-OCT-2006, sequence version 1.
DT   03-AUG-2022, entry version 80.
DE   RecName: Full=DNA replication complex GINS protein PSF3;
DE   AltName: Full=GINS complex subunit 3;
GN   Name=GINS3; Synonyms=PSF3;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Hereford; TISSUE=Fetal skin;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (SEP-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: The GINS complex plays an essential role in the initiation of
CC       DNA replication, and progression of DNA replication forks. GINS complex
CC       seems to bind preferentially to single-stranded DNA.
CC       {ECO:0000250|UniProtKB:Q9BRX5}.
CC   -!- SUBUNIT: Component of the GINS complex which is a heterotetramer of
CC       GINS1, GINS2, GINS3 and GINS4. Forms a stable subcomplex with GINS2.
CC       GINS complex interacts with DNA primase in vitro (By similarity).
CC       Component of the CMG helicase complex, composed of the MCM2-7 complex,
CC       the GINS complex and CDC45 (By similarity).
CC       {ECO:0000250|UniProtKB:Q7ZT01, ECO:0000250|UniProtKB:Q9BRX5}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q7ZT01}.
CC       Chromosome {ECO:0000250|UniProtKB:Q7ZT01}. Note=Associates with
CC       chromatin. {ECO:0000250|UniProtKB:Q7ZT01}.
CC   -!- SIMILARITY: Belongs to the GINS3/PSF3 family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; BC123472; AAI23473.1; -; mRNA.
DR   RefSeq; NP_001069604.1; NM_001076136.1.
DR   AlphaFoldDB; Q08E12; -.
DR   SMR; Q08E12; -.
DR   STRING; 9913.ENSBTAP00000012322; -.
DR   PaxDb; Q08E12; -.
DR   PRIDE; Q08E12; -.
DR   Ensembl; ENSBTAT00000012322; ENSBTAP00000012322; ENSBTAG00000009363.
DR   GeneID; 538943; -.
DR   KEGG; bta:538943; -.
DR   CTD; 64785; -.
DR   VEuPathDB; HostDB:ENSBTAG00000009363; -.
DR   VGNC; VGNC:29362; GINS3.
DR   eggNOG; KOG1106; Eukaryota.
DR   GeneTree; ENSGT00390000001622; -.
DR   HOGENOM; CLU_081646_2_0_1; -.
DR   InParanoid; Q08E12; -.
DR   OMA; IYKEGWR; -.
DR   OrthoDB; 1291729at2759; -.
DR   TreeFam; TF314626; -.
DR   Reactome; R-BTA-176974; Unwinding of DNA.
DR   Proteomes; UP000009136; Chromosome 18.
DR   Bgee; ENSBTAG00000009363; Expressed in oocyte and 103 other tissues.
DR   GO; GO:0071162; C:CMG complex; ISS:UniProtKB.
DR   GO; GO:0000811; C:GINS complex; IBA:GO_Central.
DR   GO; GO:0006268; P:DNA unwinding involved in DNA replication; IEA:Ensembl.
DR   GO; GO:1902975; P:mitotic DNA replication initiation; IBA:GO_Central.
DR   GO; GO:1903934; P:positive regulation of DNA primase activity; IEA:Ensembl.
DR   GO; GO:1900264; P:positive regulation of DNA-directed DNA polymerase activity; IEA:Ensembl.
DR   Gene3D; 1.20.58.2050; -; 1.
DR   InterPro; IPR021151; GINS_A.
DR   InterPro; IPR036224; GINS_bundle-like_dom_sf.
DR   InterPro; IPR010492; GINS_Psf3.
DR   InterPro; IPR038437; GINS_Psf3_sf.
DR   PANTHER; PTHR22768; PTHR22768; 1.
DR   Pfam; PF05916; Sld5; 1.
DR   SUPFAM; SSF158573; SSF158573; 1.
PE   2: Evidence at transcript level;
KW   Chromosome; DNA replication; Nucleus; Reference proteome.
FT   CHAIN           1..216
FT                   /note="DNA replication complex GINS protein PSF3"
FT                   /id="PRO_0000327614"
FT   REGION          1..16
FT                   /note="Not essential for folding and stability of GINS
FT                   complex, but may regulate accessibility to the central
FT                   complex pore"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   216 AA;  24476 MW;  798C4D9B1D5F02EF CRC64;
     MSEAYFRVES GALGPEENFL SLDDILMSHE KLSVRTEIPM PRLGAFFLDR SGGAETDNAI
     PEGTKLELPL WLAKGLFDNK RRILSVELPK IYQEGWRTVF SADANVVDLH KMGPHFYGFG
     SQLLHFDSPE NADISHSLLQ TFVGRFRRIM DSSQNAYNED TSALVARLDE MERGLFQTGQ
     KGLNDFQCWE KGQASQLTAS NLVQNYAKRK FTDMED